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A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial

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A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma : A Randomized Controlled Trial. / Willeboordse, Maartje; van de Kant, Kim; Tan, Frans E S; Mulkens, Sandra; Schellings, Julia; Crijns, Yvonne; Ploeg, Liesbeth van der; van Schayck, Constant P; Dompeling, Edward.

In: PLOS ONE, Vol. 11, No. 6, e0157158, 13.06.2016.

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@article{b0bb35a015134241a34ced1ea24fd336,
title = "A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma: A Randomized Controlled Trial",
abstract = "BACKGROUND: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.OBJECTIVE: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.METHODS: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.RESULTS: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC{\%} predicted improved over time by 10.1 ± 8.7{\%} in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4{\%} in the control group (p<0.05).CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.TRIAL REGISTRATION: ClinicalTrials.gov NCT00998413.",
keywords = "QUALITY-OF-LIFE, CHILDHOOD OVERWEIGHT, INCIDENT ASTHMA, DUTCH CHILDREN, OBESE CHILDREN, LUNG-FUNCTION, RISK, INTERVENTION, METAANALYSIS, ADOLESCENTS",
author = "Maartje Willeboordse and {van de Kant}, Kim and Tan, {Frans E S} and Sandra Mulkens and Julia Schellings and Yvonne Crijns and Ploeg, {Liesbeth van der} and {van Schayck}, {Constant P} and Edward Dompeling",
year = "2016",
month = "6",
day = "13",
doi = "10.1371/journal.pone.0157158",
language = "English",
volume = "11",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "6",

}

RIS

TY - JOUR

T1 - A Multifactorial Weight Reduction Programme for Children with Overweight and Asthma

T2 - PLOS ONE

AU - Willeboordse, Maartje

AU - van de Kant, Kim

AU - Tan, Frans E S

AU - Mulkens, Sandra

AU - Schellings, Julia

AU - Crijns, Yvonne

AU - Ploeg, Liesbeth van der

AU - van Schayck, Constant P

AU - Dompeling, Edward

PY - 2016/6/13

Y1 - 2016/6/13

N2 - BACKGROUND: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.OBJECTIVE: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.METHODS: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.RESULTS: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC% predicted improved over time by 10.1 ± 8.7% in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4% in the control group (p<0.05).CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.TRIAL REGISTRATION: ClinicalTrials.gov NCT00998413.

AB - BACKGROUND: There is increasing evidence that obesity is related to asthma development and severity. However, it is largely unknown whether weight reduction can influence asthma management, especially in children.OBJECTIVE: To determine the effects of a multifactorial weight reduction intervention on asthma management in overweight/obese children with (a high risk of developing) asthma.METHODS: An 18-month weight-reduction randomized controlled trial was conducted in 87 children with overweight/obesity and asthma. Every six months, measurements of anthropometry, lung function, lifestyle parameters and inflammatory markers were assessed. Analyses were performed with linear mixed models for longitudinal analyses.RESULTS: After 18 months, the body mass index-standard deviation score decreased by -0.14±0.29 points (p<0.01) in the intervention group and -0.12±0.34 points (p<0.01) in the control group. This change over time did not differ between groups (p>0.05). Asthma features (including asthma control and asthma-related quality of life) and lung function indices (static and dynamic) improved significantly over time in both groups. The FVC% predicted improved over time by 10.1 ± 8.7% in the intervention group (p<0.001), which was significantly greater than the 6.1 ± 8.4% in the control group (p<0.05).CONCLUSIONS & CLINICAL RELEVANCE: Clinically relevant improvements in body weight, lung function and asthma features were found in both the intervention and control group, although some effects were more pronounced in the intervention group (FVC, asthma control, and quality of life). This implies that a weight reduction intervention could be clinically beneficial for children with asthma.TRIAL REGISTRATION: ClinicalTrials.gov NCT00998413.

KW - QUALITY-OF-LIFE

KW - CHILDHOOD OVERWEIGHT

KW - INCIDENT ASTHMA

KW - DUTCH CHILDREN

KW - OBESE CHILDREN

KW - LUNG-FUNCTION

KW - RISK

KW - INTERVENTION

KW - METAANALYSIS

KW - ADOLESCENTS

U2 - 10.1371/journal.pone.0157158

DO - 10.1371/journal.pone.0157158

M3 - Article

VL - 11

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 6

M1 - e0157158

ER -