A "kissing lesion": In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis

Pierre Kolber; Amgad Droby; Alard Roebroeck; Rainer Goebel; Vinzenz Fleischer; Sergiu Groppa; Frauke Zipp

doi:10.1177/1352458516683267

A "kissing lesion": In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis

Pierre Kolber, Amgad Droby, Alard Roebroeck, Rainer Goebel, Vinzenz Fleischer, Sergiu Groppa, Frauke Zipp^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear.

OBJECTIVE: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit.

METHODS: Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed.

RESULTS: A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.

CONCLUSION: This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.

Original language	English
Pages (from-to)	1167-1169
Number of pages	3
Journal	Multiple Sclerosis Journal
Volume	23
Issue number	8
Early online date	1 Apr 2017
DOIs	https://doi.org/10.1177/1352458516683267
Publication status	Published - 1 Jul 2017

Keywords

Multiple sclerosis
7T
atypical cortical lesions
magnetic resonance imaging
CORTICAL DEMYELINATION

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10.1177/1352458516683267

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Cite this

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title = "A {"}kissing lesion{"}: In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis",

abstract = "BACKGROUND: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear.OBJECTIVE: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit.METHODS: Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed.RESULTS: A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.CONCLUSION: This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.",

keywords = "Multiple sclerosis, 7T, atypical cortical lesions, magnetic resonance imaging, CORTICAL DEMYELINATION",

author = "Pierre Kolber and Amgad Droby and Alard Roebroeck and Rainer Goebel and Vinzenz Fleischer and Sergiu Groppa and Frauke Zipp",

year = "2017",

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doi = "10.1177/1352458516683267",

language = "English",

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pages = "1167--1169",

journal = "Multiple Sclerosis Journal",

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T1 - A "kissing lesion"

T2 - In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis

AU - Kolber, Pierre

AU - Droby, Amgad

AU - Roebroeck, Alard

AU - Goebel, Rainer

AU - Fleischer, Vinzenz

AU - Groppa, Sergiu

AU - Zipp, Frauke

PY - 2017/7/1

Y1 - 2017/7/1

N2 - BACKGROUND: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear.OBJECTIVE: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit.METHODS: Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed.RESULTS: A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.CONCLUSION: This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.

AB - BACKGROUND: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear.OBJECTIVE: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit.METHODS: Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed.RESULTS: A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.CONCLUSION: This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.

KW - Multiple sclerosis

KW - 7T

KW - atypical cortical lesions

KW - magnetic resonance imaging

KW - CORTICAL DEMYELINATION

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