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A "kissing lesion": In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis

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Abstract

BACKGROUND: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear.

OBJECTIVE: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit.

METHODS: Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed.

RESULTS: A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus.

CONCLUSION: This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.

    Research areas

  • Multiple sclerosis, 7T, atypical cortical lesions, magnetic resonance imaging, CORTICAL DEMYELINATION
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Details

Original languageEnglish
Pages (from-to)1167-1169
Number of pages3
JournalMultiple Sclerosis Journal
Volume23
Issue number8
Early online date1 Apr 2017
DOIs
Publication statusPublished - 1 Jul 2017