A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

James D. Mckay; Therese Truong; Valerie Gaborieau; Amelie Chabrier; Shu-Chun Chuang; Graham Byrnes; David Zaridze; Oxana Shangina; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Alexandru Bucur; Vladimir Bencko; Ivana Holcatova; Vladimir Janout; Lenka Foretova; Pagona Lagiou; Dimitrios Trichopoulos; Simone Benhamou; Christine Bouchardy; Wolfgang Ahrens; Franco Merletti; Lorenzo Richiardi; Renato Talamini; Luigi Barzan; Kristina Kjaerheim; Gary J Macfarlane; Tatiana V. Macfarlane; Lorenzo Simonato; Cristina Canova; Antonio Agudo; Xavier Castellsague; Ray Lowry; David I. Conway; Patricia A. McKinney; Claire M. Healy; Mary E. Toner; Ariana Znaor; Maria Paula Curado; Sergio Koifman; Ana M. Menezes; Victor Wuensch-Filho; Jose Eluf Neto; Leticia Fernandez Garrote; Stefania Boccia; Gabriella Cadoni; Dario Arzani; Andrew F. Olshan; Mark C. Weissler; William K. Funkhouser; Jingchun Luo; Jan Lubinski; Joanna Trubicka; Marcin Lener; Dorota Oszutowska; Stephen M. Schwartz; Chu Chen; Sherianne Fish; David R. Doody; Joshua E. Muscat; Philip Lazarus; Carla J. Gallagher; Shen-Chih Chang; Zuo-Feng Zhang; Qingyi Wei; Erich M. Sturgis; Li-E Wang; Silvia Franceschi; Rolando Herrero; Karl T. Kelsey; Michael D. McClean; Carmen J. Marsit; Heather H. Nelson; Marjorie Romkes; Shama Buch; Tomoko Nukui; Shilong Zhong; Martin Lacko; Johannes J. Manni; Wilbert H. M. Peters; Rayjean J. Hung; John R. McLaughlin; Lars Vatten; Inger Njolstad; Gary E. Goodman; John K. Field; Triantafillos Liloglou; Paolo Vineis; Francoise Clavel-Chapelon; Domenico Palli; Rosario Tumino; Vittorio Krogh; Salvatore Panico; Carlos A. Gonzalez; J. Ramon Quiros; Carmen Martinez; Carmen Navarro; Eva Ardanaz; Nerea Larranaga; Kay-Tee Khaw; Timothy J. Key; H. Bas Bueno-de-Mesquita; Petra H M Peeters; Antonia Trichopoulou; Jakob Linseisen; Heiner Boeing; Goran Hallmans; Kim Overvad; Anne Tjonneland; Merethe Kumle; Elio Riboli; Kristjan Vaelk; Tonu Voodern; Andres Metspalu; Diana Zelenika; Anne Boland; Marc Delepine; Mario Foglio; Doris Lechner; Helene Blanche; Ivo G. Gut; Pilar Galan; Simon Heath; Mia Hashibe; Richard B. Hayes; Paolo Boffetta; Mark Lathrop; Paul Brennan

doi:10.1371/journal.pgen.1001333

A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

James D. Mckay^*, Therese Truong, Valerie Gaborieau, Amelie Chabrier, Shu-Chun Chuang, Graham Byrnes, David Zaridze, Oxana Shangina, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Ivana Holcatova, Vladimir Janout, Lenka Foretova, Pagona Lagiou, Dimitrios Trichopoulos, Simone BenhamouChristine Bouchardy, Wolfgang Ahrens, Franco Merletti, Lorenzo Richiardi, Renato Talamini, Luigi Barzan, Kristina Kjaerheim, Gary J Macfarlane, Tatiana V. Macfarlane, Lorenzo Simonato, Cristina Canova, Antonio Agudo, Xavier Castellsague, Ray Lowry, David I. Conway, Patricia A. McKinney, Claire M. Healy, Mary E. Toner, Ariana Znaor, Maria Paula Curado, Sergio Koifman, Ana M. Menezes, Victor Wuensch-Filho, Jose Eluf Neto, Leticia Fernandez Garrote, Stefania Boccia, Gabriella Cadoni, Dario Arzani, Andrew F. Olshan, Mark C. Weissler, William K. Funkhouser, Jingchun Luo, Jan Lubinski, Joanna Trubicka, Marcin Lener, Dorota Oszutowska, Stephen M. Schwartz, Chu Chen, Sherianne Fish, David R. Doody, Joshua E. Muscat, Philip Lazarus, Carla J. Gallagher, Shen-Chih Chang, Zuo-Feng Zhang, Qingyi Wei, Erich M. Sturgis, Li-E Wang, Silvia Franceschi, Rolando Herrero, Karl T. Kelsey, Michael D. McClean, Carmen J. Marsit, Heather H. Nelson, Marjorie Romkes, Shama Buch, Tomoko Nukui, Shilong Zhong, Martin Lacko, Johannes J. Manni, Wilbert H. M. Peters, Rayjean J. Hung, John R. McLaughlin, Lars Vatten, Inger Njolstad, Gary E. Goodman, John K. Field, Triantafillos Liloglou, Paolo Vineis, Francoise Clavel-Chapelon, Domenico Palli, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Carlos A. Gonzalez, J. Ramon Quiros, Carmen Martinez, Carmen Navarro, Eva Ardanaz, Nerea Larranaga, Kay-Tee Khaw, Timothy J. Key, H. Bas Bueno-de-Mesquita, Petra H M Peeters, Antonia Trichopoulou, Jakob Linseisen, Heiner Boeing, Goran Hallmans, Kim Overvad, Anne Tjonneland, Merethe Kumle, Elio Riboli, Kristjan Vaelk, Tonu Voodern, Andres Metspalu, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Helene Blanche, Ivo G. Gut, Pilar Galan, Simon Heath, Mia Hashibe, Richard B. Hayes, Paolo Boffetta, Mark Lathrop, Paul Brennan

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p

Original language	English
Article number	e1001333
Journal	Plos Genetics
Volume	7
Issue number	3
DOIs	https://doi.org/10.1371/journal.pgen.1001333
Publication status	Published - Mar 2011

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10.1371/journal.pgen.1001333Licence: CC BY

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Mckay, J. D., Therese Truong, Gaborieau, V., Chabrier, A., Chuang, S.-C., Byrnes, G., Zaridze, D., Shangina, O., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Holcatova, I., Janout, V., Foretova, L., Lagiou, P., Trichopoulos, D., ... Brennan, P. (2011). A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium. Plos Genetics, 7(3), Article e1001333. https://doi.org/10.1371/journal.pgen.1001333

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title = "A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium",

abstract = "Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p ",

author = "Mckay, {James D.} and {Therese Truong} and Valerie Gaborieau and Amelie Chabrier and Shu-Chun Chuang and Graham Byrnes and David Zaridze and Oxana Shangina and Neonila Szeszenia-Dabrowska and Jolanta Lissowska and Peter Rudnai and Eleonora Fabianova and Alexandru Bucur and Vladimir Bencko and Ivana Holcatova and Vladimir Janout and Lenka Foretova and Pagona Lagiou and Dimitrios Trichopoulos and Simone Benhamou and Christine Bouchardy and Wolfgang Ahrens and Franco Merletti and Lorenzo Richiardi and Renato Talamini and Luigi Barzan and Kristina Kjaerheim and Macfarlane, {Gary J} and Macfarlane, {Tatiana V.} and Lorenzo Simonato and Cristina Canova and Antonio Agudo and Xavier Castellsague and Ray Lowry and Conway, {David I.} and McKinney, {Patricia A.} and Healy, {Claire M.} and Toner, {Mary E.} and Ariana Znaor and Curado, {Maria Paula} and Sergio Koifman and Menezes, {Ana M.} and Victor Wuensch-Filho and Neto, {Jose Eluf} and {Fernandez Garrote}, Leticia and Stefania Boccia and Gabriella Cadoni and Dario Arzani and Olshan, {Andrew F.} and Weissler, {Mark C.} and Funkhouser, {William K.} and Jingchun Luo and Jan Lubinski and Joanna Trubicka and Marcin Lener and Dorota Oszutowska and Schwartz, {Stephen M.} and Chu Chen and Sherianne Fish and Doody, {David R.} and Muscat, {Joshua E.} and Philip Lazarus and Gallagher, {Carla J.} and Shen-Chih Chang and Zuo-Feng Zhang and Qingyi Wei and Sturgis, {Erich M.} and Li-E Wang and Silvia Franceschi and Rolando Herrero and Kelsey, {Karl T.} and McClean, {Michael D.} and Marsit, {Carmen J.} and Nelson, {Heather H.} and Marjorie Romkes and Shama Buch and Tomoko Nukui and Shilong Zhong and Martin Lacko and Manni, {Johannes J.} and Peters, {Wilbert H. M.} and Hung, {Rayjean J.} and McLaughlin, {John R.} and Lars Vatten and Inger Njolstad and Goodman, {Gary E.} and Field, {John K.} and Triantafillos Liloglou and Paolo Vineis and Francoise Clavel-Chapelon and Domenico Palli and Rosario Tumino and Vittorio Krogh and Salvatore Panico and Gonzalez, {Carlos A.} and {Ramon Quiros}, J. and Carmen Martinez and Carmen Navarro and Eva Ardanaz and Nerea Larranaga and Kay-Tee Khaw and Key, {Timothy J.} and Bueno-de-Mesquita, {H. Bas} and Peeters, {Petra H M} and Antonia Trichopoulou and Jakob Linseisen and Heiner Boeing and Goran Hallmans and Kim Overvad and Anne Tjonneland and Merethe Kumle and Elio Riboli and Kristjan Vaelk and Tonu Voodern and Andres Metspalu and Diana Zelenika and Anne Boland and Marc Delepine and Mario Foglio and Doris Lechner and Helene Blanche and Gut, {Ivo G.} and Pilar Galan and Simon Heath and Mia Hashibe and Hayes, {Richard B.} and Paolo Boffetta and Mark Lathrop and Paul Brennan",

year = "2011",

month = mar,

doi = "10.1371/journal.pgen.1001333",

language = "English",

volume = "7",

journal = "Plos Genetics",

issn = "1553-7390",

publisher = "Public Library of Science",

number = "3",

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Mckay, JD, Therese Truong, Gaborieau, V, Chabrier, A, Chuang, S-C, Byrnes, G, Zaridze, D, Shangina, O, Szeszenia-Dabrowska, N, Lissowska, J, Rudnai, P, Fabianova, E, Bucur, A, Bencko, V, Holcatova, I, Janout, V, Foretova, L, Lagiou, P, Trichopoulos, D, Benhamou, S, Bouchardy, C, Ahrens, W, Merletti, F, Richiardi, L, Talamini, R, Barzan, L, Kjaerheim, K, Macfarlane, GJ, Macfarlane, TV, Simonato, L, Canova, C, Agudo, A, Castellsague, X, Lowry, R, Conway, DI, McKinney, PA, Healy, CM, Toner, ME, Znaor, A, Curado, MP, Koifman, S, Menezes, AM, Wuensch-Filho, V, Neto, JE, Fernandez Garrote, L, Boccia, S, Cadoni, G, Arzani, D, Olshan, AF, Weissler, MC, Funkhouser, WK, Luo, J, Lubinski, J, Trubicka, J, Lener, M, Oszutowska, D, Schwartz, SM, Chen, C, Fish, S, Doody, DR, Muscat, JE, Lazarus, P, Gallagher, CJ, Chang, S-C, Zhang, Z-F, Wei, Q, Sturgis, EM, Wang, L-E, Franceschi, S, Herrero, R, Kelsey, KT, McClean, MD, Marsit, CJ, Nelson, HH, Romkes, M, Buch, S, Nukui, T, Zhong, S, Lacko, M, Manni, JJ, Peters, WHM, Hung, RJ, McLaughlin, JR, Vatten, L, Njolstad, I, Goodman, GE, Field, JK, Liloglou, T, Vineis, P, Clavel-Chapelon, F, Palli, D, Tumino, R, Krogh, V, Panico, S, Gonzalez, CA, Ramon Quiros, J, Martinez, C, Navarro, C, Ardanaz, E, Larranaga, N, Khaw, K-T, Key, TJ, Bueno-de-Mesquita, HB, Peeters, PHM, Trichopoulou, A, Linseisen, J, Boeing, H, Hallmans, G, Overvad, K, Tjonneland, A, Kumle, M, Riboli, E, Vaelk, K, Voodern, T, Metspalu, A, Zelenika, D, Boland, A, Delepine, M, Foglio, M, Lechner, D, Blanche, H, Gut, IG, Galan, P, Heath, S, Hashibe, M, Hayes, RB, Boffetta, P, Lathrop, M & Brennan, P 2011, 'A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium', Plos Genetics, vol. 7, no. 3, e1001333. https://doi.org/10.1371/journal.pgen.1001333

TY - JOUR

T1 - A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

AU - Mckay, James D.

AU - Therese Truong,

AU - Gaborieau, Valerie

AU - Chabrier, Amelie

AU - Chuang, Shu-Chun

AU - Byrnes, Graham

AU - Zaridze, David

AU - Shangina, Oxana

AU - Szeszenia-Dabrowska, Neonila

AU - Lissowska, Jolanta

AU - Rudnai, Peter

AU - Fabianova, Eleonora

AU - Bucur, Alexandru

AU - Bencko, Vladimir

AU - Holcatova, Ivana

AU - Janout, Vladimir

AU - Foretova, Lenka

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Benhamou, Simone

AU - Bouchardy, Christine

AU - Ahrens, Wolfgang

AU - Merletti, Franco

AU - Richiardi, Lorenzo

AU - Talamini, Renato

AU - Barzan, Luigi

AU - Kjaerheim, Kristina

AU - Macfarlane, Gary J

AU - Macfarlane, Tatiana V.

AU - Simonato, Lorenzo

AU - Canova, Cristina

AU - Agudo, Antonio

AU - Castellsague, Xavier

AU - Lowry, Ray

AU - Conway, David I.

AU - McKinney, Patricia A.

AU - Healy, Claire M.

AU - Toner, Mary E.

AU - Znaor, Ariana

AU - Curado, Maria Paula

AU - Koifman, Sergio

AU - Menezes, Ana M.

AU - Wuensch-Filho, Victor

AU - Neto, Jose Eluf

AU - Fernandez Garrote, Leticia

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - Arzani, Dario

AU - Olshan, Andrew F.

AU - Weissler, Mark C.

AU - Funkhouser, William K.

AU - Luo, Jingchun

AU - Lubinski, Jan

AU - Trubicka, Joanna

AU - Lener, Marcin

AU - Oszutowska, Dorota

AU - Schwartz, Stephen M.

AU - Chen, Chu

AU - Fish, Sherianne

AU - Doody, David R.

AU - Muscat, Joshua E.

AU - Lazarus, Philip

AU - Gallagher, Carla J.

AU - Chang, Shen-Chih

AU - Zhang, Zuo-Feng

AU - Wei, Qingyi

AU - Sturgis, Erich M.

AU - Wang, Li-E

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Kelsey, Karl T.

AU - McClean, Michael D.

AU - Marsit, Carmen J.

AU - Nelson, Heather H.

AU - Romkes, Marjorie

AU - Buch, Shama

AU - Nukui, Tomoko

AU - Zhong, Shilong

AU - Lacko, Martin

AU - Manni, Johannes J.

AU - Peters, Wilbert H. M.

AU - Hung, Rayjean J.

AU - McLaughlin, John R.

AU - Vatten, Lars

AU - Njolstad, Inger

AU - Goodman, Gary E.

AU - Field, John K.

AU - Liloglou, Triantafillos

AU - Vineis, Paolo

AU - Clavel-Chapelon, Francoise

AU - Palli, Domenico

AU - Tumino, Rosario

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - Gonzalez, Carlos A.

AU - Ramon Quiros, J.

AU - Martinez, Carmen

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Larranaga, Nerea

AU - Khaw, Kay-Tee

AU - Key, Timothy J.

AU - Bueno-de-Mesquita, H. Bas

AU - Peeters, Petra H M

AU - Trichopoulou, Antonia

AU - Linseisen, Jakob

AU - Boeing, Heiner

AU - Hallmans, Goran

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Kumle, Merethe

AU - Riboli, Elio

AU - Vaelk, Kristjan

AU - Voodern, Tonu

AU - Metspalu, Andres

AU - Zelenika, Diana

AU - Boland, Anne

AU - Delepine, Marc

AU - Foglio, Mario

AU - Lechner, Doris

AU - Blanche, Helene

AU - Gut, Ivo G.

AU - Galan, Pilar

AU - Heath, Simon

AU - Hashibe, Mia

AU - Hayes, Richard B.

AU - Boffetta, Paolo

AU - Lathrop, Mark

AU - Brennan, Paul

PY - 2011/3

Y1 - 2011/3

N2 - Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p

AB - Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p

U2 - 10.1371/journal.pgen.1001333

DO - 10.1371/journal.pgen.1001333

M3 - Article

C2 - 21437268

SN - 1553-7390

VL - 7

JO - Plos Genetics

JF - Plos Genetics

IS - 3

M1 - e1001333

ER -