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Researcher

Schotten, U.

Full professor - Personal chair

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  1. 2019
  2. Published
    Chua, W., Easter, C. L., Guasch, E., Sitch, A., Casadei, B., Crijns, H. J. G. M., ... Fabritz, L. (2019). Development and external validation of predictive models for prevalent and recurrent atrial fibrillation: a protocol for the analysis of the CATCH ME combined dataset. BMC Cardiovascular disorders, 19, [120]. https://doi.org/10.1186/s12872-019-1105-4
  3. Published
    Conte, G., Schotten, U., & Auricchio, A. (2019). The Atrial Phenotype of the Inherited Primary Arrhythmia Syndromes. Arrhythmia & Electrophysiology Review, 8(1), 42-46. https://doi.org/10.15420/aer.2019.4.2
  4. 2018
  5. Published
    Gharaviri, A., Verheule, S., Eckstein, J., Potse, M., Krause, R., Auricchio, A., ... Schotten, U. (2018). Effect of Na+-channel blockade on the three-dimensional substrate of atrial fibrillation in a model of endo-epicardial dissociation and transmural conduction. EP Europace, 20(Suppl. 3), iii69-iii76. https://doi.org/10.1093/europace/euy236
  6. Published
    Pezzuto, S., Gharaviri, A., Schotten, U., Potse, M., Conte, G., Caputo, M. L., ... Auricchio, A. (2018). Beat-to-beat P-wave morphological variability in patients with paroxysmal atrial fibrillation: an in silico study. EP Europace, 20, 26-35. https://doi.org/10.1093/europace/euy227
  7. Published
    Podziemski, P., Zeemering, S., Kuklik, P., van Hunnik, A., Maesen, B., Maessen, J., ... Schotten, U. (2018). Rotors Detected by Phase Analysis of Filtered, Epicardial Atrial Fibrillation Electrograms Colocalize With Regions of Conduction Block. Circulation-Arrhythmia and Electrophysiology, 11(10), [e005858]. https://doi.org/10.1161/CIRCEP.117.005858
  8. Published
    Zhao, J., Schotten, U., Smaill, B., & Verheule, S. (2018). Loss of Side-to-Side Connections Affects the Relative Contributions of the Sodium and Calcium Current to Transverse Propagation Between Strands of Atrial Myocytes. Frontiers in physiology, 9, [1212]. https://doi.org/10.3389/fphys.2018.01212
  9. Published
    Manninger, M., Zweiker, D., van Hunnik, A., Alogna, A., Prassl, A. J., Schipke, J., ... Scherr, D. (2018). Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation. Heart Rhythm, 15(9), 1328-1336. https://doi.org/10.1016/j.hrthm.2018.05.016
  10. Published
    Kirchhof, P., Haeusler, K. G., Blank, B., De Bono, J., Callans, D., Elvan, A., ... Di Biase, L. (2018). Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation. European Heart Journal, 39(32), 2942-2955. https://doi.org/10.1093/eurheartj/ehy176
  11. Published
    van Hunnik, A., Zeemering, S., Podziemski, P., Simons, J., Gatta, G., Hannink, L., ... Schotten, U. (2018). Stationary Atrial Fibrillation Properties in the Goat Do Not Entail Stable or Recurrent Conduction Patterns. Frontiers in physiology, 9, [947]. https://doi.org/10.3389/fphys.2018.00947
  12. Published
    Zeemering, S., Lankveld, T. A. R., Bonizzi, P., Limantoro, I., Bekkers, S. C. A. M., Crijns, H. J. G. M., & Schotten, U. (2018). The electrocardiogram as a predictor of successful pharmacological cardioversion and progression of atrial fibrillation. EP Europace, 20(7), E96-E104. https://doi.org/10.1093/europace/eux234
  13. Published
    Erkuner, O., Rienstra, M., Van Gelder, I. C., Schotten, U., Crijns, H. J. G. M., & Luermans, J. G. L. M. (2018). Stroke risk in patients with device-detected atrial high-rate episodes. Netherlands Heart Journal, 26(4), 177-181. https://doi.org/10.1007/s12471-017-1047-3
  14. Published
    Kotecha, D., Breithardt, G., Camm, A. J., Lip, G. Y. H., Schotten, U., Ahlsson, A., ... Kirchhof, P. (2018). Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. EP Europace, 20(3), 395-407. https://doi.org/10.1093/europace/eux318
  15. Published
    Zink, M. D., Marx, N., Crijns, H. J. G. M., & Schotten, U. (2018). Opportunities and challenges of large-scale screening for atrial fibrillation. Herzschrittmachertherapie und Elektrophysiologie, 29(1), 57-61. https://doi.org/10.1007/s00399-017-0550-y
  16. Published
    Conte, G., Caputo, M. L., Volders, P. G. A., Luca, A., Mainardi, L., Schotten, U., ... Auricchio, A. (2018). Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation. International Journal of Cardiology, 253, 66-70. https://doi.org/10.1016/j.ijcard.2017.09.214
  17. Published
    European Society Cardiology ESC; CATCH ME Consortium; EHRA, Kotecha, D., Chua, W. W. L., Fabritz, L., Hendriks, J., Casadei, B., ... Kirchhof, P. (2018). European Society of Cardiology smartphone and tablet applications for patients with atrial fibrillation and their health care providers. EP Europace, 20(2), 225-233. https://doi.org/10.1093/europace/eux299
  18. Published
    van Hunnik, A., Nasrallah, H., Lau, D. H., Kuiper, M., Verheule, S., & Schotten, U. (2018). Vernakalant does not alter early repolarization or contractility in normal and electrically remodelled atria. EP Europace, 20(1), 140-148. https://doi.org/10.1093/europace/eux025
  19. 2017
  20. Published
    Bonizzi, P., Zeemering, S., Karel, J., azman, M. H., Lankveld, T. A. R., Schotten, U., ... Meste, O. (2017). Noninvasive Characterisation of Short-and Long-Term Recurrence of Atrial Signals During Persistent Atrial Fibrillation. In Computing in Cardiology Rennes, France.
  21. Published
    Hohl, M., Lau, D. H., Mueller, A., Elliott, A. D., Linz, B., Mahajan, R., ... Linz, D. (2017). Concomitant Obesity and Metabolic Syndrome Add to the Atrial Arrhythmogenic Phenotype in Male Hypertensive Rats. Journal of the American Heart Association, 6(9), [006717]. https://doi.org/10.1161/JAHA.117.006717
  22. Published
    Lau, D. H., Linz, D., Schotten, U., Mahajan, R., Sanders, P., & Kalman, J. M. (2017). Pathophysiology of Paroxysmal and Persistent Atrial Fibrillation: Rotors, Foci and Fibrosis. Heart Lung and Circulation, 26(9), 887-893. https://doi.org/10.1016/j.hlc.2017.05.119
  23. Published
    Gharaviri, A., Verheule, S., Eckstein, J., Potse, M., Kuklik, P., Kuijpers, N. H. L., & Schotten, U. (2017). How disruption of endo-epicardial electrical connections enhances endo-epicardial conduction during atrial fibrillation. EP Europace, 19(2), 308-318. https://doi.org/10.1093/europace/euv445
  24. Published
    Kuklik, P., Zeemering, S., van Hunnik, A., Maesen, B., Pison, L., Lau, D. H., ... Schotten, U. (2017). Identification of Rotors during Human Atrial Fibrillation Using Contact Mapping and Phase Singularity Detection: Technical Considerations. Ieee Transactions on Biomedical Engineering, 64(2), 310-318. https://doi.org/10.1109/TBME.2016.2554660
  25. Published
    Spronk, H. M. H., De Jong, A. M., Verheule, S., De Boer, H. C., Maass, A. H., Lau, D. H., ... Schotten, U. (2017). Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation. European Heart Journal, 38(1), 38-50. https://doi.org/10.1093/eurheartj/ehw119
  26. Published
    Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., ... European Stroke Org (2017). Guía ESC 2016 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración con la EACTS. Revista Espanola de Cardiologia, 70(1), 50.E1-50.E84. https://doi.org/10.1016/j.recesp.2016.11.014
  27. Published
    Di Biase, L., Callans, D., Haeusler, K. G., Hindricks, G., Al-Khalidi, H., Mont, L., ... Kirchhof, P. (2017). Rationale and design of AXAFA-AFNET 5: an investigator-initiated, randomized, open, blinded outcome assessment, multi-centre trial to comparing continuous apixaban to vitamin K antagonists in patients undergoing atrial fibrillation catheter ablation. EP Europace, 19(1), 132-138. https://doi.org/10.1093/europace/euw368
  28. 2016
  29. Published
    Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., ... Zeppenfeld, K. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. EP Europace, 18(11), 1609-1678. https://doi.org/10.1093/europace/euw295
  30. Published
    Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., ... Vardas, P. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Journal of Cardio-Thoracic Surgery, 50(5), E1-E88. https://doi.org/10.1093/ejcts/ezw313
  31. Published
    Kuklik, P., Schaeffer, B., Hoffmann, B. A., Ganesan, A. N., Schreiber, D., Moser, J. M., ... Willems, S. (2016). Local Electrical Dyssynchrony during Atrial Fibrillation: Theoretical Considerations and Initial Catheter Ablation Results. PLOS ONE, 11(10), [e0164236]. https://doi.org/10.1371/journal.pone.0164236
  32. Published
    Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., ... Vardas, P. (2016). 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal, 37(38), 2893-2962. https://doi.org/10.1093/eurheartj/ehw210
  33. Published
    Meste, O., Zeemering, S., Karel, J., Lankveld, T. A. R., Schotten, U., Crijns, H., ... Bonizzi, P. (2016). Noninvasive Recurrence Quanti cation Analysis Predicts Atrial Fibrillation Recurrence in Persistent Patients Undergoing Electrical Cardioversion. In Computing in Cardiology Vancouver, Canada.
  34. Published
    Linz, D., Hohl, M., Dhein, S., Ruf, S., Reil, J-C., Kabiri, M., ... Schotten, U. (2016). Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats. Cardiovascular Research, 110(3), 371-380. https://doi.org/10.1093/cvr/cvw071
  35. Published
    Reilly, S. N., Liu, X., Carnicer, R., Recalde, A., Muszkiewicz, A., Jayaram, R., ... Casadei, B. (2016). Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase. Science Translational Medicine, 8(340), [340ra74]. https://doi.org/10.1126/scitranslmed.aac4296
  36. Published
    Lau, D. H., Schotten, U., Mahajan, R., Antic, N. A., Hatem, S. N., Pathak, R. K., ... Sanders, P. (2016). Novel mechanisms in the pathogenesis of atrial fibrillation: practical applications. European Heart Journal, 37(20), 1573-+. https://doi.org/10.1093/eurheartj/ehv375
  37. Published
    Schotten, U., Dobrev, D., Platonov, P. G., Kottkamp, H., & Hindricks, G. (2016). Current controversies in determining the main mechanisms of atrial fibrillation. Journal of Internal Medicine, 279(5), 428-438. https://doi.org/10.1111/joim.12492
  38. Published
    Lankveld, T., de Vos, C. B., Limantoro, I., Zeemering, S., Dudink, E., Crijns, H. J., & Schotten, U. (2016). Systematic analysis of ECG predictors of sinus rhythm maintenance after electrical cardioversion for persistent atrial fibrillation. Heart Rhythm, 13(5), 1020-1027. https://doi.org/10.1016/j.hrthm.2016.01.004
  39. Published
    Van Gelder, I. C., Hobbelt, A. H., Marcos, E. G., Schotten, U., Cappato, R., Lewalter, T., ... Boriani, G. (2016). Tailored treatment strategies: a new approach for modern management of atrial fibrillation. Journal of Internal Medicine, 279(5), 457-466. https://doi.org/10.1111/joim.12489
  40. Published
    Opacic, D., van Bragt, K. A., Nasrallah, H. M., Schotten, U., & Verheule, S. (2016). Atrial metabolism and tissue perfusion as determinants of electrical and structural remodelling in atrial fibrillation. Cardiovascular Research, 109(4), 527-541. https://doi.org/10.1093/cvr/cvw007
  41. Published
    Kirchhof, P., Goette, A., Naebauer, M., & Schotten, U. (2016). 12 Jahre AFNET. Vom Forschungsnetzwerk zur Academic Research Organisation. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz, 59(4), 514-522. https://doi.org/10.1007/s00103-016-2323-x
  42. Published
    van Hunnik, A., Lau, D. H., Zeemering, S., Kuiper, M., Verheule, S., & Schotten, U. (2016). Antiarrhythmic effect of vernakalant in electrically remodeled goat atria is caused by slowing of conduction and prolongation of postrepolarization refractoriness. Heart Rhythm, 13(4), 964-972. https://doi.org/10.1016/j.hrthm.2015.12.009
  43. Published
    Fabritz, L., Guasch, E., Antoniades, C., Bardinet, I., Benninger, G., Betts, T. R., ... Kirchhof, P. (2016). Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment. Nature Reviews Cardiology, 13(4), 230-237. https://doi.org/10.1038/nrcardio.2015.194
  44. Published
    Lankveld, T., Zeemering, S., Scherr, D., Kuklik, P., Hoffmann, B. A., Willems, S., ... Schotten, U. (2016). Atrial Fibrillation Complexity Parameters Derived From Surface ECGs Predict Procedural Outcome and Long-Term Follow-Up of Stepwise Catheter Ablation for Atrial Fibrillation. Circulation-Arrhythmia and Electrophysiology, 9(2), [e003354]. https://doi.org/10.1161/CIRCEP.115.003354
  45. Published
    Kirchhof, P., Breithardt, G., Bax, J., Benninger, G., Blomstrom-Lundqvist, C., Boriani, G., ... Camm, A. J. (2016). A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference. EP Europace, 18(1), 37-50. https://doi.org/10.1093/europace/euv304
  46. Published
    Potse, M., Lankveld, T. A. R., Zeemering, S., Dagnelie, P. C., Stehouwer, C. D. A., Henry, R. M., ... Schotten, U. (2016). P-wave complexity in normal subjects and computer models. Journal of Electrocardiology, 49(4), 545-553. https://doi.org/10.1016/j.jelectrocard.2016.05.005
  47. 2015
  48. Published
    Schotten, U., Hatem, S., Ravens, U., Jais, P., Mueller, F-U., Goette, A., ... Camm, A. J. (2015). The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. EP Europace, 17(10), 1457-1466. https://doi.org/10.1093/europace/euv252
  49. Published
    Zeemering, S., Podziemski, P., van Hunnik, A., Maesen, B., Bonizzi, P., & Schotten, U. (2015). Electrogram Coupling as a Measure of Local Conduction during Atrial Fibrillation. In Computing in Cardiology Nice, France.
  50. Published
    Podziemski, P., Kuklik, P., van Hunnik, A., Zeemering, S., Maesen, B., & Schotten, U. (2015). Far-field effect in unipolar electrograms revisited: High-density mapping of atrial fibrillation in humans. IEEE Engineering in Medicine and Biology Society, 2015, 5680-3. https://doi.org/10.1109/EMBC.2015.7319681
  51. Published
    Lau, D. H., Maesen, B., Zeemering, S., Kuklik, P., van Hunnik, A., Lankveld, T. A. R., ... Schotten, U. (2015). Indices of bipolar complex fractionated atrial electrograms correlate poorly with each other and atrial fibrillation substrate complexity. Heart Rhythm, 12(7), 1415-1423. https://doi.org/10.1016/j.hrthm.2015.03.017
  52. Published
    Lau, D. H., Volders, P. G. A., Kohl, P., Prinzen, F. W., Zaza, A., Kaeaeb, S., ... Schotten, U. (2015). Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula. EP Europace, 17(5), 825-833. https://doi.org/10.1093/europace/euu301
  53. Published
    van Bragt, K. A., Nasrallah, H. M., Kuiper, M., van Hunnik, A., Kuijpers, N. H. L., Schotten, U., & Verheule, S. (2015). Dynamic regulation of atrial coronary blood flow in healthy adult pigs. Heart Rhythm, 12(5), 991-1000. https://doi.org/10.1016/j.hrthm.2015.01.016
  54. Published
    Pluteanu, F., Hess, J., Plackic, J., Nikonova, Y., Preisenberger, J., Bukowska, A., ... Kockskaemper, J. (2015). Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats. Cardiovascular Research, 106(1), 87-97. https://doi.org/10.1093/cvr/cvv045
  55. Published
    Linz, D., van Hunnik, A., Hohl, M., Mahfoud, F., Wolf, M., Neuberger, H-R., ... Schotten, U. (2015). Catheter-Based Renal Denervation Reduces Atrial Nerve Sprouting and Complexity of Atrial Fibrillation in Goats. Circulation-Arrhythmia and Electrophysiology, 8(2), 466-U294. https://doi.org/10.1161/CIRCEP.114.002453
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