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Researcher

Hesselink, M.K.C.

Full professor - Personal chair

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  1. 2019
  2. Published
    Phielix, E., Begovatz, P., Gancheva, S., Bierwagen, A., Kornips, E., Schaart, G., ... Roden, M. (2019). Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion. JCI INSIGHT, 4(21), [127928]. https://doi.org/10.1172/jci.insight.127928
  3. 2018
  4. Published
    Daemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., ... Hesselink, M. K. C. (2018). Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox. Molecular Metabolism, 17, 71-81. https://doi.org/10.1016/j.molmet.2018.08.004
  5. Published
    Zacharewicz, E., Hesselink, M. K. C., & Schrauwen, P. (2018). Exercise counteracts lipotoxicity by improving lipid turnover and lipid droplet quality. Journal of Internal Medicine, 284(5), 505-518. https://doi.org/10.1111/joim.12729
  6. Published
    Stinkens, R., Brouwers, B., Jocken, J. W., Blaak, E. E., Teunissen-Beekman, M. F., Hesselink, M. K., ... Goossens, G. H. (2018). Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity. Journal of Applied Physiology, 125(5), 1585-1593. https://doi.org/10.1152/japplphysiol.00496.2018
  7. Published
    Gemmink, A., Daemen, S., Kuijpers, H. J. H., Schaart, G., Duimel, H., Lopez-Iglesias, C., ... Hesselink, M. K. C. (2018). Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1863(11), 1423-1432. https://doi.org/10.1016/j.bbalip.2018.08.016
  8. Published
    Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., ... Schrauwen, P. (2018). Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 115(30), 7789-7794. https://doi.org/10.1073/pnas.1722295115
  9. Published
    Lancel, S., Hesselink, M. K. C., Woldt, E., Rouille, Y., Dorchies, E., Delhaye, S., ... Sebti, Y. (2018). Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity. JCI INSIGHT, 3(9), 1-13. [e98081]. https://doi.org/10.1172/jci.insight.98081
  10. Published
    Gemmink, A., Daemen, S., Brouwers, B., Huntjens, P. R., Schaart, G., Moonen-Kornips, E., ... Hesselink, M. K. C. (2018). Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5? Journal of Physiology, 596(5), 857-868. https://doi.org/10.1113/JP275182
  11. Published
    Daemen, S., van Polanen, N., & Hesselink, M. K. C. (2018). The effect of diet and exercise on lipid droplet dynamics in human muscle tissue. Journal of Experimental Biology, 221, [167015]. https://doi.org/10.1242/jeb.167015
  12. Published
    Brouwers, B., Schrauwen-Hinderling, V. B., Jelenik, T., Gemmink, A., Sparks, L. M., Havekes, B., ... Schrauwen, P. (2018). Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver. American Journal of Physiology : Endocrinology and Metabolism, 314(2), E165-E173. https://doi.org/10.1152/ajpendo.00266.2017
  13. Published
    Sanders, D., Heijboer, M., Hesselink, M. K. C., Myers, T., & Akubat, I. (2018). Analysing a cycling grand tour: Can we monitor fatigue with intensity or load ratios? Journal of Sports Sciences, 36(12), 1385-1391. https://doi.org/10.1080/02640414.2017.1388669
  14. 2017
  15. Published
    Gemmink, A., Goodpaster, B. H., Schrauwen, P., & Hesselink, M. K. C. (2017). Intramyocellular lipid droplets and insulin sensitivity, the human perspective. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1862(10), 1242-1249. https://doi.org/10.1016/j.bbalip.2017.07.010
  16. Published
    Coleman, R. A., & Hesselink, M. K. (2017). Recent advances in lipid droplet biology. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1862(10), 1129-1130. https://doi.org/10.1016/j.bbalip.2017.08.002
  17. Published
    Dahlmans, D., Houzelle, A., Jorgensen, J. A., Phielix, E., Lindeboom, L., Hesselink, M. K. C., ... Hoeks, J. (2017). Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups. Frontiers in physiology, 8, [711]. https://doi.org/10.3389/fphys.2017.00711
  18. Published
    Hesselink, M. K. C., Daemen, S., van Polanen, N., & Gemmink, A. (2017). What are the benefits of being big? Journal of Physiology, 595(16), 5409-5410. https://doi.org/10.1113/JP274723
  19. Published
    Brouwers, B., Schrauwen-Hinderling, V. B., Jelenik, T., Gemmink, A., Havekes, B., Bruls, Y., ... Schrauwen, P. (2017). Metabolic disturbances of non-alcoholic fatty liver resemble the alterations typical for type 2 diabetes. Clinical Science, 131(15), 1905-1917. https://doi.org/10.1042/CS20170261
  20. Published
    Duvivier, B. M. F. M., Schaper, N. C., Koster, A., van Kan, L., Peters, H. P. F., Adam, J. J., ... Savelberg, H. H. C. M. (2017). Benefits of Substitution Sitting with Standing and Walking in Free-living Conditions for Cardiometabolic Risk Markers, cognition and Mood in Overweight Adults. Frontiers in physiology, 8, [353]. https://doi.org/10.3389/fphys.2017.00353
  21. Published
    Sanders, D., Abt, G., Hesselink, M. K. C., Myers, T., & Akubat, I. (2017). Methods of Monitoring Training Load and Their Relationships to Changes in Fitness and Performance in Competitive Road Cyclists. International Journal of Sports Physiology and Performance, 12(5), 668-675. https://doi.org/10.1123/ijspp.2016-0454
  22. Published
    Duvivier, B. M. F. M., Schaper, N. C., Hesselink, M. K. C., van Kan, L., Stienen, N., Winkens, B., ... Savelberg, H. H. C. M. (2017). Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes. Diabetologia, 60(3), 490-498. https://doi.org/10.1007/s00125-016-4161-7
  23. Published
    Gosens, W., van't Hul, A. J., Oomen, J. M., Hesselink, M. K. C., & Borghouts, L. B. (2017). Mechanical Efficiency in Chronic Obstructive Pulmonary Disease. Journal of Cardiopulmonary Rehabilitation and Prevention, 37(2), 146-153. https://doi.org/10.1097/HCR.0000000000000241
  24. Published
    Sanders, D., Heijboer, M., Akubat, I., Meijer, K., & Hesselink, M. K. (2017). Predicting High-Power Performance in Professional Cyclists. International Journal of Sports Physiology and Performance, 12(3), 410-413. https://doi.org/10.1123/ijspp.2016-0134
  25. Published
    Gemmink, A., Bakker, L. E. H., Guigas, B., Kornips, E., Schaart, G., Meinders, A. E., ... Hesselink, M. K. C. (2017). Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians. Scientific Reports, 7, [42393]. https://doi.org/10.1038/srep42393
  26. Published
    Lindeboom, L., Bruls, Y. M. H., van Ewijk, P. A., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2017). Longitudinal relaxation time editing for acetylcarnitine detection with H-MRS. Magnetic Resonance in Medicine, 77(2), 505–510. https://doi.org/10.1002/mrm.26149
  27. 2016
  28. Published
    Timmers, S., de Ligt, M., Phielix, E., van de Weijer, T., Hansen, J., Moonen-Kornips, E., ... Schrauwen, P. (2016). Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care, 39(12), 2211-2217. https://doi.org/10.2337/dc16-0499
  29. Published
    Hesselink, M. K. C., Schrauwen-Hinderling, V., & Schrauwen, P. (2016). Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus. Nature Reviews Endocrinology, 12(11), 633-645. https://doi.org/10.1038/nrendo.2016.104
  30. Published
    Hansen, J., Timmers, S., Moonen-Kornips, E., Duez, H., Staels, B., Hesselink, M. K. C., & Schrauwen, P. (2016). Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes. Scientific Reports, 6, [35047]. https://doi.org/10.1038/srep35047
  31. Published
    Brouwers, B., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2016). Effects of exercise training on intrahepatic lipid content in humans. Diabetologia, 59(10), 2068-2079. https://doi.org/10.1007/s00125-016-4037-x
  32. Published
    Lindeboom, L., de Graaf, R. A., Nabuurs, C. I., van Ewijk, E., Hesselink, M. K. C., Wildberger, J. E., ... Schrauwen-Hinderling, V. B. (2016). Quantum coherence spectroscopy to measure dietary fat retention in the liver. JCI INSIGHT, 1(13), [e84671]. https://doi.org/10.1172/jci.insight.84671
  33. Published
    van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jorgensen, J. A., Hoeks, J., ... Schrauwen, P. (2016). Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Molecular Metabolism, 5(8), 635-645. https://doi.org/10.1016/j.molmet.2016.06.012
  34. Published
    van Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., ... Hesselink, M. K. C. (2016). A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats. Scientific Reports, 6, [22854]. https://doi.org/10.1038/srep22854
  35. Published
    Daemen, S., van Zandvoort, M. A. M. J., Parekh, S. H., & Hesselink, M. K. C. (2016). Microscopy tools for the investigation of intracellular lipid storage and dynamics. Molecular Metabolism, 5(3), 153-163. https://doi.org/10.1016/j.molmet.2015.12.005
  36. 2015
  37. Published
    Sarzynski, M. A., Davidsen, P. K., Sung, Y. J., Hesselink, M., Schrauwen, P., Rice, T. K., ... Bouchard, C. (2015). Genomic and transcriptomic predictors of triglyceride response to regular exercise. British Journal of Sports Medicine, 49(23), 1524-1531. https://doi.org/10.1136/bjsports-2015-095179
  38. Published
    Gnaiger, E., Boushel, R., Sondergaard, H., Munch-Andersen, T., Damsgaard, R., Hagen, C., ... Saltin, B. (2015). Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter. Scandinavian Journal of Medicine & Science in Sports, 25(Suppl 4), 126-134. https://doi.org/10.1111/sms.12612
  39. Published
    Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M., ... Kersten, S. (2015). ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure. Elife, 4, [e08428]. https://doi.org/10.7554/eLife.08428
  40. Published
    Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., ... Schrauwen, P. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21(8), 863-865. https://doi.org/10.1038/nm.3891
  41. Published
    Bilet, L., Brouwers, B., van Ewijk, P. A., Hesselink, M. K., Kooi, M. E., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2015). Acute exercise does not decrease liver fat in men with overweight or NAFLD. Scientific Reports, 5, [9709]. https://doi.org/10.1038/srep09709
  42. Published
    van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., ... Schrauwen, P. (2015). Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans. Diabetes, 64(4), 1193-1201. https://doi.org/10.2337/db14-0667
  43. Published
    Billecke, N., Bosma, M., Rock, W., Fleissner, F., Best, G., Schrauwen, P., ... Parekh, S. H. (2015). Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging. Integrative Biology, 7(4), 467-476. https://doi.org/10.1039/c4ib00271g
  44. Published
    van Ewijk, P. A., Paglialunga, S. A., Kooi, M. E., Nunes, P. M., Gemmink, A., Slenter, J., ... Schrauwen-Hinderling, V. B. (2015). Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring. Obesity, 23(11), 2242-2250. https://doi.org/10.1002/oby.21235
  45. Published
    Lindeboom, L., Nabuurs, C. I., Hesselink, M. K., Wildberger, J. E., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2015). Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein. American Journal of Clinical Nutrition, 101(1), 65-71. https://doi.org/10.3945/ajcn.114.094730
  46. 2014
  47. Published
    Nabben, M., van Bree, B. W., Lenaers, E., Hoeks, J., Hesselink, M. K., Schaart, G., ... Schrauwen, P. (2014). Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic Research in Cardiology, 109(6), [447]. https://doi.org/10.1007/s00395-014-0447-4
  48. Published
    Lindeboom, L., Nabuurs, C. I., Hoeks, J., Brouwers, B., Phielix, E., Kooi, M. E., ... Schrauwen-Hinderling, V. B. (2014). Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. Journal of Clinical Investigation, 124(11), 4915-4925. https://doi.org/10.1172/JCI74830
  49. Published
    Sparks, L. M., Bosma, M., Brouwers, B., van de Weijer, T., Bilet, L., Schaart, G., ... Schrauwen, P. (2014). Reduced incorporation of Fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes. Diabetes, 63(5), 1583-1593. https://doi.org/10.2337/db13-1123
  50. Published
    Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers - van Gogh, I., Schaart, G., ... Kersten, S. (2014). Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Proceedings of the National Academy of Sciences of the United States of America, 111(11), E1043-E1052. https://doi.org/10.1073/pnas.1400889111
  51. Published
    Billecke, N., Rago, G., Bosma, M., Eijkel, G., Gemmink, A., Leproux, P., ... Parekh, S. H. (2014). Chemical imaging of lipid droplets in muscle tissues using hyperspectral coherent Raman microscopy. Histochemistry and Cell Biology, 141(3), 263-273. https://doi.org/10.1007/s00418-013-1161-2
  52. 2013
  53. Published
    Sparks, L. M., Johannsen, N. M., Church, T. S., Earnest, C. P., Moonen-Kornips, E., Moro, C., ... Schrauwen, P. (2013). Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes. Journal of Clinical Endocrinology & Metabolism, 98(4), 1694-1702. https://doi.org/10.1210/jc.2012-3874
  54. Published
    Bosma, M., Sparks, L. M., Hooiveld, G., Jorgensen, J., Houten, S. M., Schrauwen, P., ... Hesselink, M. K. C. (2013). Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1831(4), 844-852. https://doi.org/10.1016/j.bbalip.2013.01.007
  55. Published
    Schrauwen, P., Timmers, S., & Hesselink, M. K. C. (2013). Blocking the entrance to open the gate. Diabetes, 62(3), 703-705. https://doi.org/10.2337/db12-1663
  56. Published
    Roy, C., Paglialunga, S., Schaart, G., Moonen-Kornips, E., Meex, R. C., Phielix, E., ... Schrauwen, P. (2013). Relationship of C5L2 receptor to skeletal muscle substrate utilization. PLOS ONE, 8(2), [57494]. https://doi.org/10.1371/journal.pone.0057494
  57. Published
    van de Weijer, T., Sparks, L. M., Phielix, E., Meex, R. C., van Herpen, N. A., Hesselink, M. K., ... Schrauwen-Hinderling, V. B. (2013). Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus. PLOS ONE, 8(2), [51648]. https://doi.org/10.1371/journal.pone.0051648
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