
Researcher
Hesselink, M.K.C.
Full professor - Personal chair
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- 2019
- PublishedPhielix, E., Begovatz, P., Gancheva, S., Bierwagen, A., Kornips, E., Schaart, G., ... Roden, M. (2019). Athletes feature greater rates of muscle glucose transport and glycogen synthesis during lipid infusion. JCI INSIGHT, 4(21), [127928]. https://doi.org/10.1172/jci.insight.127928
- 2018
- PublishedDaemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., ... Hesselink, M. K. C. (2018). Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox. Molecular Metabolism, 17, 71-81. https://doi.org/10.1016/j.molmet.2018.08.004
- Published
- PublishedStinkens, R., Brouwers, B., Jocken, J. W., Blaak, E. E., Teunissen-Beekman, M. F., Hesselink, M. K., ... Goossens, G. H. (2018). Exercise training-induced effects on the abdominal subcutaneous adipose tissue phenotype in humans with obesity. Journal of Applied Physiology, 125(5), 1585-1593. https://doi.org/10.1152/japplphysiol.00496.2018
- PublishedGemmink, A., Daemen, S., Kuijpers, H. J. H., Schaart, G., Duimel, H., Lopez-Iglesias, C., ... Hesselink, M. K. C. (2018). Super-resolution microscopy localizes perilipin 5 at lipid droplet-mitochondria interaction sites and at lipid droplets juxtaposing to perilipin 2. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1863(11), 1423-1432. https://doi.org/10.1016/j.bbalip.2018.08.016
- PublishedWefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., ... Schrauwen, P. (2018). Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 115(30), 7789-7794. https://doi.org/10.1073/pnas.1722295115
- PublishedLancel, S., Hesselink, M. K. C., Woldt, E., Rouille, Y., Dorchies, E., Delhaye, S., ... Sebti, Y. (2018). Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity. JCI INSIGHT, 3(9), 1-13. [e98081]. https://doi.org/10.1172/jci.insight.98081
- PublishedGemmink, A., Daemen, S., Brouwers, B., Huntjens, P. R., Schaart, G., Moonen-Kornips, E., ... Hesselink, M. K. C. (2018). Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5? Journal of Physiology, 596(5), 857-868. https://doi.org/10.1113/JP275182
- Published
- PublishedBrouwers, B., Schrauwen-Hinderling, V. B., Jelenik, T., Gemmink, A., Sparks, L. M., Havekes, B., ... Schrauwen, P. (2018). Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver. American Journal of Physiology : Endocrinology and Metabolism, 314(2), E165-E173. https://doi.org/10.1152/ajpendo.00266.2017
- PublishedSanders, D., Heijboer, M., Hesselink, M. K. C., Myers, T., & Akubat, I. (2018). Analysing a cycling grand tour: Can we monitor fatigue with intensity or load ratios? Journal of Sports Sciences, 36(12), 1385-1391. https://doi.org/10.1080/02640414.2017.1388669
- 2017
- Published
- PublishedColeman, R. A., & Hesselink, M. K. (2017). Recent advances in lipid droplet biology. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1862(10), 1129-1130. https://doi.org/10.1016/j.bbalip.2017.08.002
- PublishedDahlmans, D., Houzelle, A., Jorgensen, J. A., Phielix, E., Lindeboom, L., Hesselink, M. K. C., ... Hoeks, J. (2017). Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups. Frontiers in physiology, 8, [711]. https://doi.org/10.3389/fphys.2017.00711
- PublishedHesselink, M. K. C., Daemen, S., van Polanen, N., & Gemmink, A. (2017). What are the benefits of being big? Journal of Physiology, 595(16), 5409-5410. https://doi.org/10.1113/JP274723
- Published
- PublishedDuvivier, B. M. F. M., Schaper, N. C., Koster, A., van Kan, L., Peters, H. P. F., Adam, J. J., ... Savelberg, H. H. C. M. (2017). Benefits of Substitution Sitting with Standing and Walking in Free-living Conditions for Cardiometabolic Risk Markers, cognition and Mood in Overweight Adults. Frontiers in physiology, 8, [353]. https://doi.org/10.3389/fphys.2017.00353
- PublishedSanders, D., Abt, G., Hesselink, M. K. C., Myers, T., & Akubat, I. (2017). Methods of Monitoring Training Load and Their Relationships to Changes in Fitness and Performance in Competitive Road Cyclists. International Journal of Sports Physiology and Performance, 12(5), 668-675. https://doi.org/10.1123/ijspp.2016-0454
- PublishedDuvivier, B. M. F. M., Schaper, N. C., Hesselink, M. K. C., van Kan, L., Stienen, N., Winkens, B., ... Savelberg, H. H. C. M. (2017). Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes. Diabetologia, 60(3), 490-498. https://doi.org/10.1007/s00125-016-4161-7
- PublishedGosens, W., van't Hul, A. J., Oomen, J. M., Hesselink, M. K. C., & Borghouts, L. B. (2017). Mechanical Efficiency in Chronic Obstructive Pulmonary Disease. Journal of Cardiopulmonary Rehabilitation and Prevention, 37(2), 146-153. https://doi.org/10.1097/HCR.0000000000000241
- PublishedSanders, D., Heijboer, M., Akubat, I., Meijer, K., & Hesselink, M. K. (2017). Predicting High-Power Performance in Professional Cyclists. International Journal of Sports Physiology and Performance, 12(3), 410-413. https://doi.org/10.1123/ijspp.2016-0134
- PublishedGemmink, A., Bakker, L. E. H., Guigas, B., Kornips, E., Schaart, G., Meinders, A. E., ... Hesselink, M. K. C. (2017). Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians. Scientific Reports, 7, [42393]. https://doi.org/10.1038/srep42393
- PublishedLindeboom, L., Bruls, Y. M. H., van Ewijk, P. A., Hesselink, M. K. C., Wildberger, J. E., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2017). Longitudinal relaxation time editing for acetylcarnitine detection with H-MRS. Magnetic Resonance in Medicine, 77(2), 505–510. https://doi.org/10.1002/mrm.26149
- 2016
- PublishedTimmers, S., de Ligt, M., Phielix, E., van de Weijer, T., Hansen, J., Moonen-Kornips, E., ... Schrauwen, P. (2016). Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care, 39(12), 2211-2217. https://doi.org/10.2337/dc16-0499
- Published
- PublishedHansen, J., Timmers, S., Moonen-Kornips, E., Duez, H., Staels, B., Hesselink, M. K. C., & Schrauwen, P. (2016). Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes. Scientific Reports, 6, [35047]. https://doi.org/10.1038/srep35047
- Published
- PublishedLindeboom, L., de Graaf, R. A., Nabuurs, C. I., van Ewijk, E., Hesselink, M. K. C., Wildberger, J. E., ... Schrauwen-Hinderling, V. B. (2016). Quantum coherence spectroscopy to measure dietary fat retention in the liver. JCI INSIGHT, 1(13), [e84671]. https://doi.org/10.1172/jci.insight.84671
- Publishedvan Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jorgensen, J. A., Hoeks, J., ... Schrauwen, P. (2016). Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Molecular Metabolism, 5(8), 635-645. https://doi.org/10.1016/j.molmet.2016.06.012
- Publishedvan Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., ... Hesselink, M. K. C. (2016). A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats. Scientific Reports, 6, [22854]. https://doi.org/10.1038/srep22854
- PublishedDaemen, S., van Zandvoort, M. A. M. J., Parekh, S. H., & Hesselink, M. K. C. (2016). Microscopy tools for the investigation of intracellular lipid storage and dynamics. Molecular Metabolism, 5(3), 153-163. https://doi.org/10.1016/j.molmet.2015.12.005
- 2015
- PublishedSarzynski, M. A., Davidsen, P. K., Sung, Y. J., Hesselink, M., Schrauwen, P., Rice, T. K., ... Bouchard, C. (2015). Genomic and transcriptomic predictors of triglyceride response to regular exercise. British Journal of Sports Medicine, 49(23), 1524-1531. https://doi.org/10.1136/bjsports-2015-095179
- PublishedGnaiger, E., Boushel, R., Sondergaard, H., Munch-Andersen, T., Damsgaard, R., Hagen, C., ... Saltin, B. (2015). Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter. Scandinavian Journal of Medicine & Science in Sports, 25(Suppl 4), 126-134. https://doi.org/10.1111/sms.12612
- PublishedDijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M., ... Kersten, S. (2015). ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure. Elife, 4, [e08428]. https://doi.org/10.7554/eLife.08428
- PublishedHanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., ... Schrauwen, P. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21(8), 863-865. https://doi.org/10.1038/nm.3891
- PublishedBilet, L., Brouwers, B., van Ewijk, P. A., Hesselink, M. K., Kooi, M. E., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2015). Acute exercise does not decrease liver fat in men with overweight or NAFLD. Scientific Reports, 5, [9709]. https://doi.org/10.1038/srep09709
- Publishedvan de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., ... Schrauwen, P. (2015). Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans. Diabetes, 64(4), 1193-1201. https://doi.org/10.2337/db14-0667
- PublishedBillecke, N., Bosma, M., Rock, W., Fleissner, F., Best, G., Schrauwen, P., ... Parekh, S. H. (2015). Perilipin 5 mediated lipid droplet remodelling revealed by coherent Raman imaging. Integrative Biology, 7(4), 467-476. https://doi.org/10.1039/c4ib00271g
- Publishedvan Ewijk, P. A., Paglialunga, S. A., Kooi, M. E., Nunes, P. M., Gemmink, A., Slenter, J., ... Schrauwen-Hinderling, V. B. (2015). Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring. Obesity, 23(11), 2242-2250. https://doi.org/10.1002/oby.21235
- PublishedLindeboom, L., Nabuurs, C. I., Hesselink, M. K., Wildberger, J. E., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2015). Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein. American Journal of Clinical Nutrition, 101(1), 65-71. https://doi.org/10.3945/ajcn.114.094730
- 2014
- PublishedNabben, M., van Bree, B. W., Lenaers, E., Hoeks, J., Hesselink, M. K., Schaart, G., ... Schrauwen, P. (2014). Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic Research in Cardiology, 109(6), [447]. https://doi.org/10.1007/s00395-014-0447-4
- PublishedLindeboom, L., Nabuurs, C. I., Hoeks, J., Brouwers, B., Phielix, E., Kooi, M. E., ... Schrauwen-Hinderling, V. B. (2014). Long-echo time MR spectroscopy for skeletal muscle acetylcarnitine detection. Journal of Clinical Investigation, 124(11), 4915-4925. https://doi.org/10.1172/JCI74830
- PublishedSparks, L. M., Bosma, M., Brouwers, B., van de Weijer, T., Bilet, L., Schaart, G., ... Schrauwen, P. (2014). Reduced incorporation of Fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes. Diabetes, 63(5), 1583-1593. https://doi.org/10.2337/db13-1123
- PublishedCatoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers - van Gogh, I., Schaart, G., ... Kersten, S. (2014). Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Proceedings of the National Academy of Sciences of the United States of America, 111(11), E1043-E1052. https://doi.org/10.1073/pnas.1400889111
- PublishedBillecke, N., Rago, G., Bosma, M., Eijkel, G., Gemmink, A., Leproux, P., ... Parekh, S. H. (2014). Chemical imaging of lipid droplets in muscle tissues using hyperspectral coherent Raman microscopy. Histochemistry and Cell Biology, 141(3), 263-273. https://doi.org/10.1007/s00418-013-1161-2
- 2013
- PublishedSparks, L. M., Johannsen, N. M., Church, T. S., Earnest, C. P., Moonen-Kornips, E., Moro, C., ... Schrauwen, P. (2013). Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes. Journal of Clinical Endocrinology & Metabolism, 98(4), 1694-1702. https://doi.org/10.1210/jc.2012-3874
- PublishedBosma, M., Sparks, L. M., Hooiveld, G., Jorgensen, J., Houten, S. M., Schrauwen, P., ... Hesselink, M. K. C. (2013). Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1831(4), 844-852. https://doi.org/10.1016/j.bbalip.2013.01.007
- PublishedSchrauwen, P., Timmers, S., & Hesselink, M. K. C. (2013). Blocking the entrance to open the gate. Diabetes, 62(3), 703-705. https://doi.org/10.2337/db12-1663
- PublishedRoy, C., Paglialunga, S., Schaart, G., Moonen-Kornips, E., Meex, R. C., Phielix, E., ... Schrauwen, P. (2013). Relationship of C5L2 receptor to skeletal muscle substrate utilization. PLOS ONE, 8(2), [57494]. https://doi.org/10.1371/journal.pone.0057494
- Publishedvan de Weijer, T., Sparks, L. M., Phielix, E., Meex, R. C., van Herpen, N. A., Hesselink, M. K., ... Schrauwen-Hinderling, V. B. (2013). Relationships between mitochondrial function and metabolic flexibility in type 2 diabetes mellitus. PLOS ONE, 8(2), [51648]. https://doi.org/10.1371/journal.pone.0051648