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Researcher

Losen, M.R.

Assistant Professor

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  1. 2019
  2. Published
    Mane-Damas, M., Hoffmann, C., Zong, S., Tan, A., Molenaar, P. C., Losen, M., & Martinez-Martinez, P. (2019). Autoimmunity in psychotic disorders. Where we stand, challenges and opportunities. Autoimmunity Reviews, 18(9), 1-14. [102348]. https://doi.org/10.1016/j.autrev.2019.102348
  3. Published
    Takata, K., Stathopoulos, P., Cao, M., Mane-Damas, M., Fichtner, M. L., Benotti, E. S., ... O'Connor, K. C. (2019). Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients. JCI INSIGHT, 4(12), [127167]. https://doi.org/10.1172/jci.insight.127167
  4. Published
    Chteinberg, E., Klufah, F., Rennspiess, D., Mannheims, M. F., Abdul-Hamid, M. A., Losen, M., ... zur Hausen, A. (2019). Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors. Thoracic Cancer, 10(3), 445-451. https://doi.org/10.1111/1759-7714.12953
  5. Published
    Koneczny, I., Rennspiess, D., Marcuse, F., Dankerlui, N., Hamid, M. A., Mane-Damas, M., ... Martinez-Martinez, P. (2019). Characterization of the thymus in Lrp4 myasthenia gravis: Four cases. Autoimmunity Reviews, 18(1), 50-55. https://doi.org/10.1016/j.autrev.2018.07.011
  6. 2018
  7. Published
    Hoffmann, C., Stevens, J., Zong, S., van Kruining, D., Saxena, A., Kucukali, C. I., ... Martinez-Martinez, P. (2018). Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder. PLOS ONE, 13(12), [e0208412]. https://doi.org/10.1371/journal.pone.0208412
  8. Published
    Iglesias, V. S., Theys, J., Groot, A. J., Barbeau, L. M. O., Lemmens, A., Yaromina, A., ... Vooijs, M. (2018). Synergistic Effects of NOTCH/gamma-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells. Frontiers in Oncology, 8, [460]. https://doi.org/10.3389/fonc.2018.00460
  9. Published
    Antibodies Editorial Off (2018). Addendum: Hoffmann, C.; et al. Autoantibodies in Neuropsychiatric Disorders. Antibodies 2016, 5, 9. ANTIBODIES, 7(3), [33]. https://doi.org/10.3390/antib7030033
  10. Published
    Meesters, A., Den Bosch-Meevissen, Y. M. C. I., Weijzen, C. A. H., Buurman, W. A., Losen, M., Schepers, J., ... Peters, M. L. (2018). The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study. Journal of Behavioral Medicine, 41(3), 385-397. https://doi.org/10.1007/s10865-017-9901-8
  11. Published
    Verschuuren, J. J. G. M., Plomp, J. J., Burden, S. J., Zhang, W., Fillie-Grijpma, Y. E., Stienstra-van Es, I. E., ... Huijbers, M. G. (2018). Passive transfer models of myasthenia gravis with muscle-specific kinase antibodies. Annals of the New York Academy of Sciences, 1413(1), 111-118. https://doi.org/10.1111/nyas.13543
  12. 2017
  13. Published
    Saxena, A., Stevens, J., Cetin, H., Koneczny, I., Webster, R., Lazaridis, K., ... Martinez-Martinez, P. (2017). Characterization of an anti-fetal AChR monoclonal antibody isolated from a myasthenia gravis patient. Scientific Reports, 7, [14426]. https://doi.org/10.1038/s41598-017-14350-8
  14. Published
    Zong, S., Hoffmann, C., Mane-Damas, M., Molenaar, P., Losen, M., & Martinez-Martinez, P. (2017). Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There implications for Depression? Frontiers in Immunology, 8, [752]. https://doi.org/10.3389/fimmu.2017.00752
  15. Published
    Dirks, M. L., Tieland, M., Verdijk, L. B., Losen, M., Nilwik, R., Mensink, M., ... van Loon, L. J. C. (2017). Protein Supplementation Augments Muscle Fiber Hypertrophy but Does Not Modulate Satellite Cell Content During Prolonged Resistance-Type Exercise Training in Frail Elderly. Journal of the American Medical Directors Association, 18(7), 608-615. https://doi.org/10.1016/j.jamda.2017.02.006
  16. Published
    Losen, M., Labrijn, A. F., van Kranen-Mastenbroek, V. H., Janmaat, M. L., Haanstra, K. G., Beurskens, F. J., ... Parren, P. W. H. I. (2017). Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys. Scientific Reports, 7, [992]. https://doi.org/10.1038/s41598-017-01019-5
  17. Published
    Koneczny, I., Stevens, J. A. A., De Rosa, A., Huda, S., Huijbers, M. G., Saxena, A., ... Losen, M. (2017). IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients. Journal of Autoimmunity, 77, 104-115. https://doi.org/10.1016/j.jaut.2016.11.005
  18. Published
    Crivelli, S. M., Paulus, A., Markus, J., Bauwens, M., Berkes, D., De Vries, H. E., ... Martinez-Martinez, P. (2017). Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications. Journal of Alzheimer's Disease, 60(3), 783-794. https://doi.org/10.3233/JAD-161231
  19. 2016
  20. Published
    Gomez, A. M., Stevens, J. A. A., Mane-Damas, M., Molenaar, P., Duimel, H., Verheyen, F., ... Martinez-Martinez, P. (2016). Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to Passive Transfer Myasthenia Gravis. American Journal of Pathology, 186(10), 2559-2568. https://doi.org/10.1016/j.ajpath.2016.05.025
  21. Published
    Hoffmann, C., Zong, S., Mane-Damas, M., Molenaar, P., Losen, M., & Martinez-Martinez, P. (2016). Autoantibodies in Neuropsychiatric Disorders. ANTIBODIES, 5(2), [9]. https://doi.org/10.3390/antib5020009
  22. Published
    Kohler, S., Losen, M., Alexander, T., Hiepe, F., & Meisel, A. (2016). Myasthenia gravis: subgroup classifications. Lancet Neurology, 15(4), 356-357. https://doi.org/10.1016/S1474-4422(16)00033-8
  23. Published
    Stergiou, C., Lazaridis, K., Zouvelou, V., Tzartos, J., Mantegazza, R., Antozzi, C., ... Tzartos, S. J. (2016). Titin antibodies in "seronegative" myasthenia gravis - A new role for an old antigen. Journal of Neuroimmunology, 292, 108-115. https://doi.org/10.1016/j.jneuroim.2016.01.018
  24. Published
    Panth, K. M., van den Beucken, T., Biemans, R., Lieuwes, N. G., Weber, M., Losen, M., ... Lambin, P. (2016). In vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity. Scientific Reports, 6, [22198]. https://doi.org/10.1038/srep22198
  25. Published
    De Vry, J., Vanmierlo, T., Martinez-Martinez, P., Losen, M., Temel, Y., Boere, J., ... Prickaerts, J. (2016). TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice. Behavioural Brain Research, 296, 15-25. https://doi.org/10.1016/j.bbr.2015.08.027
  26. 2015
  27. Published
    Rekers, N. H., Zegers, C. M. L., Yaromina, A., Lieuwes, N. G., Biemans, R., Senden-Gijsbers, B. L. M. G., ... Lambin, P. (2015). Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model. Radiotherapy and Oncology, 116(3), 438-442. https://doi.org/10.1016/j.radonc.2015.06.019
  28. Published
    Phillips, W. D., Christadoss, P., Losen, M., Punga, A. R., Shigemoto, K., Verschuuren, J., & Vincent, A. (2015). Guidelines for pre-clinical animal and cellular models of MuSK-myasthenia gravis. Experimental Neurology, 270, 29-40. https://doi.org/10.1016/j.expneurol.2014.12.013
  29. Published
    Kusner, L. L., Losen, M., Vincent, A., Lindstrom, J., Tzartos, S., Lazaridis, K., & Martinez-Martinez, P. (2015). Guidelines for pre-clinical assessment of the acetylcholine receptor-specific passive transfer myasthenia gravis model-Recommendations for methods and experimental designs. Experimental Neurology, 270, 3-10. https://doi.org/10.1016/j.expneurol.2015.02.025
  30. Published
    Losen, M., Martinez-Martinez, P., Molenaar, P. C., Lazaridis, K., Tzartos, S., Brenner, T., ... Kusner, L. (2015). Standardization of the experimental autoimmune myasthenia gravis (EAMG) model by immunization of rats with Torpedo californica acetylcholine receptors - Recommendations for methods and experimental designs. Experimental Neurology, 270, 18-28. https://doi.org/10.1016/j.expneurol.2015.03.010
  31. Published
    Tsonis, A. I., Zisimopoulou, P., Lazaridis, K., Tzartos, J., Matsigkou, E., Zouvelou, V., ... Tzartos, S. J. (2015). MuSK autoantibodies in myasthenia gravis detected by cell based assay - A multinational study. Journal of Neuroimmunology, 284, 10-17. https://doi.org/10.1016/j.jneuroim.2015.04.015
  32. Published
    Nogales-Gadea, G., Saxena, A., Hoffmann, C., Hounjet, J., Coenen, D., Molenaar, P., ... Martinez-Martinez, P. (2015). Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells. Journal of visualized experiment, (100), [e52830]. https://doi.org/10.3791/52830
  33. Published
    Bode, G. H., Pickl, K. E., Sanchez-Purra, M., Albaiges, B., Borros, S., Poetgens, A. J. G., ... Martinez-Martinez, P. (2015). Detection of Peptide-Based Nanoparticles in Blood Plasma by ELISA. PLOS ONE, 10(5), [e0126136]. https://doi.org/10.1371/journal.pone.0126136
  34. Published
    Schaffert, H., Pelz, A., Saxena, A., Losen, M., Meisel, A., Thiel, A., & Kohler, S. (2015). IL-17-producing CD4(+) T cells contribute to the loss of B-cell tolerance in experimental autoimmune myasthenia gravis. European Journal of Immunology, 45(5), 1339-1347. https://doi.org/10.1002/eji.201445064
  35. Published
    Martinez Martinez, P., Molenaar, P., Losen, M., Hoffmann, C., Stevens, J., de Witte, L. D., ... Rutten, B. (2015). Auto-immuunaandoeningen als mogelijke oorzaak van neuropsychiatrische syndromen. Tijdschrift voor Psychiatrie.
  36. 2014
  37. Published
    de Jong, S., van Middendorp, L. B., Hermans, R. H. A., de Bakker, J. M. T., Bierhuizen, M. F. A., Prinzen, F. W., ... van Zandvoort, M. A. M. J. (2014). Ex Vivo and In Vivo Administration of Fluorescent CNA35 Specifically Marks Cardiac Fibrosis. Molecular Imaging, 13. https://doi.org/10.2310/7290.2014.00036
  38. Published
    Gomez, A. M., Willcox, N., Vrolix, K., Hummel, J., Nogales-Gadea, G., Saxena, A., ... Losen, M. (2014). Proteasome Inhibition with Bortezomib Depletes Plasma Cells and Specific Autoantibody Production in Primary Thymic Cell Cultures from Early-Onset Myasthenia Gravis Patients. Journal of Immunology, 193(3), 1055-1063. https://doi.org/10.4049/jimmunol.1301555
  39. Published
    Zisimopoulou, P., Evangelakou, P., Tzartos, J., Lazaridis, K., Zouvelou, V., Mantegazza, R., ... Tzartos, S. J. (2014). A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis. Journal of Autoimmunity, 52, 139-145. https://doi.org/10.1016/j.jaut.2013.12.004
  40. Published
    Vrolix, K., Fraussen, J., Losen, M., Stevens, J., Lazaridis, K., Molenaar, P. C., ... Martinez-Martinez, P. (2014). Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor. Journal of Autoimmunity, 52, 101-112. https://doi.org/10.1016/j.jaut.2013.12.008
  41. Published
    Martinez-Martinez, P., Molenaar, P. C., Losen, M., & de Baets, M. H. (2014). Glycine receptor antibodies in PERM: a new channelopathy. Brain, 137, 2115-2116. https://doi.org/10.1093/brain/awu153
  42. Published
    Bode, G. H., Losen, M., Buurman, W. A., Veerhuis, R., Molenaar, P. C., Steinbusch, H. W. M., ... Martinez-Martinez, P. (2014). Complement Activation by Ceramide Transporter Proteins. Journal of Immunology, 192(3), 1154-1161. https://doi.org/10.4049/jimmunol.1301673
  43. Published
    De Vry, J., Vanmierlo, T., Martínez-Martínez, P., Losen, M., Temel, Y., Steinbusch, H., ... Prickaerts, J. (2014). Delivery of DNA into the central nervous system via electroporation. In Methods in molecular biology (Vol. 1121, pp. 157-63) https://doi.org/10.1007/978-1-4614-9632-8_14
  44. 2013
  45. Published
    Fraussen, J., Vrolix, K., Claes, N., Martinez-Martinez, P., Losen, M., Hupperts, R., ... Somers, V. (2013). Autoantigen induced clonal expansion in immortalized B cells from the peripheral blood of multiple sclerosis patients. Journal of Neuroimmunology, 261(1-2), 98-107. https://doi.org/10.1016/j.jneuroim.2013.05.002
  46. Published
    Gomez, A. M., Vanheel, A., Losen, M., Molenaar, P. C., De Baets, M. H., Noben, J-P., ... Martinez-Martinez, P. (2013). Proteomic analysis of rat tibialis anterior muscles at different stages of experimental autoimmune myasthenia gravis. Journal of Neuroimmunology, 261(1-2), 141-145. https://doi.org/10.1016/j.jneuroim.2013.05.008
  47. Published
    Verschuuren, J. J. G. M., Huijbers, M. G., Plomp, J. J., Niks, E. H., Molenaar, P. C., Martinez-Martinez, P., ... Losen, M. (2013). Pathophysiology of myasthenia gravis with antibodies to the acetylcholine receptor, muscle-specific kinase and low-density lipoprotein receptor-related protein 4. Autoimmunity Reviews, 12(9), 918-923. https://doi.org/10.1016/j.autrev.2013.03.001
  48. 2012
  49. Published
    Basta, I., Nikolic, A., Losen, M., Martinez-Martinez, P., Stojanovic, V., Lavrnic, S., ... Lavrnic, D. (2012). MuSK myasthenia gravis and Lambert-Eaton myasthenic syndrome in the same patient. Clinical Neurology and Neurosurgery, 114(6), 795-797. https://doi.org/10.1016/j.clineuro.2011.12.044
  50. Published
    Mencarelli, C., Bode, G. H., Losen, M., Kulharia, M., Molenaar, P. C., Veerhuis, R., ... Martinez-Martinez, P. (2012). Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques. Journal of Biological Chemistry, 287(18), 14897-14911. https://doi.org/10.1074/jbc.M111.299545
  51. Published
    Klooster, R., Plomp, J. J., Huijbers, M. G., Niks, E. H., Straasheijm, K. R., Detmers, F. J., ... Verschuuren, J. J. (2012). Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice. Brain, 135, 1081-1101. https://doi.org/10.1093/brain/aws025
  52. Published
    Bosma, M., Minnaard, R., Sparks, L. M., Schaart, G., Losen, M. R., de Baets, M. H. V., ... Hesselink, M. K. C. (2012). The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Histochemistry and Cell Biology, 137(2), 205-216. https://doi.org/10.1007/s00418-011-0888-x
  53. Published
    Mencarelli, C., Bode, G. H., Vlamings, R., Janssen, M. L. F., Losen, M., De Baets, M. H., ... Martinez-Martinez, P. (2012). Unchanged expression of the ceramide transfer protein in the acute 6-OHDA neurodegenerative model. Neuroscience Letters, 506(1), 39-43. https://doi.org/10.1016/j.neulet.2011.10.044
  54. Published
    Gomez, A. M., Willcox, N., Molenaar, P. C., Buurman, W. A., Martinez-Martinez, P., De Baets, M. H., & Losen, M. (2012). Targeting plasma cells with proteasome inhibitors: possible roles in treating myasthenia gravis? Annals of the New York Academy of Sciences, 1274, 48-59. https://doi.org/10.1111/j.1749-6632.2012.06824.x
  55. 2011
  56. Published
    Jaken, R. J., Van Gorp, S., Joosten, E. A., Losen, M., Martinez-Martinez, P., De Baets, M., ... Deumens, R. (2011). Neuropathy-Induced Spinal GAP-43 Expression Is Not a Main Player in the Onset of Mechanical Pain Hypersensitivity. Journal of Neurotrauma, 28(12), 2463-2473. https://doi.org/10.1089/neu.2011.1833
  57. Published
    Vrolix, K., Niks, E. H., Le Panse, R., van Ostaijen-ten Dam, M. M., Muris, A-H., Jol-van der Zijde, C. M., ... Martinez-Martinez, P. (2011). Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis. Journal of Neuroimmunology, 232(1-2), 158-165. https://doi.org/10.1016/j.jneuroim.2010.10.024
  58. Published
    Gomez, A. M., Vrolix, K., Martinez-Martinez, P., Molenaar, P. C., Phernambucq, M., van der Esch, E., ... Losen, M. (2011). Proteasome Inhibition with Bortezomib Depletes Plasma Cells and Autoantibodies in Experimental Autoimmune Myasthenia Gravis. Journal of Immunology, 186(4), 2503-2513. https://doi.org/10.4049/jimmunol.1002539
  59. Published
    Timmers, S., de Vogel-van den Bosch, J., Hesselink, M. K. C., Van Beurden, D., Schaart, G., Ferraz, M. J., ... Schrauwen, P. (2011). Paradoxical Increase in TAG and DAG Content Parallel the Insulin Sensitizing Effect of Unilateral DGAT1 Overexpression in Rat Skeletal Muscle. PLOS ONE, 6(1), [14503]. https://doi.org/10.1371/journal.pone.0014503
  60. 2010
  61. Published
    De Vry, J., Martinez-Martinez, P., Losen, M., Temel, Y., Steckler, T., Steinbusch, H. W. M., ... Prickaerts, J. (2010). In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery. Progress in Neurobiology, 92(3), 227-244. https://doi.org/10.1016/j.pneurobio.2010.10.001
  62. Published
    Fraussen, J., Vrolix, K., Martinez-Martinez, P., Losen, M., Meulemans, E., De Baets, M. H., ... Somers, V. (2010). A novel method for making human monoclonal antibodies. Journal of Autoimmunity, 35(2), 130-134. https://doi.org/10.1016/j.jaut.2010.05.001
  63. Published
    De Vry, J., Martinez-Martinez, P., Losen, M., Bode, G. H., Temel, Y., Steckler, T., ... Prickaerts, J. (2010). Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain. Molecular Therapy, 18(6), 1183-1191. https://doi.org/10.1038/mt.2010.62
  64. Published
    Mencarelli, C., Losen, M. R., Hammels, C., De Vry, J., Hesselink, M. K. C., Steinbusch, H. W. M., ... Perez Martinez, P. (2010). The ceramide transporter and the Goodpasture antigen binding protein: one protein - one function? Journal of Neurochemistry, 113(6), 1369-1386. https://doi.org/10.1111/j.1471-4159.2010.06673.x
  65. Published
    Gomez, A. M., Van den Broeck, J., Vrolix, K., Janssen, S. P., Lemmens, M. A. M., van der Esch, E., ... Losen, M. (2010). Antibody effector mechanisms in myasthenia gravis-Pathogenesis at the neuromuscular junction. Autoimmunity, 43(5-6), 353-370. https://doi.org/10.3109/08916930903555943
  66. Published
    Vrolix, K., Fraussen, J., Molenaar, P. C., Losen, M., Somers, V., Stinissen, P., ... Martinez-Martinez, P. (2010). The auto-antigen repertoire in myasthenia gravis. Autoimmunity, 43(5-6), 380-400. https://doi.org/10.3109/08916930903518073
  67. 2006
  68. Published
    Losen, M. R. (2006). Therapeutic approaches for the protection of neurological synapses in autoimmunity. Maastricht: Universiteit Maastricht.
  69. 2005
  70. Published
    Roorda, B. D., Hesselink, M. K. C., Schaart, G., Moonen-Kornips, E., Martinez-Martinez, P., Losen, M., ... Schrauwen, P. (2005). DGAT1 overexpression in muscle by in vivo DNA electroporation increases intramyocellular lipid content. Journal of Lipid Research, 46(2), 230-236. https://doi.org/10.1194/jlr.M400416-JLR200

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