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Researcher

Prickaerts, J.H.H.J.

Full professor - Specialised remit

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  1. 2019
  2. Published
    van Goethem, N. P., Paes, D., Puzzo, D., Fedele, E., Rebosio, C., Gulisano, W., ... Prickaerts, J. (2019). Antagonizing alpha 7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition. Cellular Signalling, 62, 1-8. [109338]. https://doi.org/10.1016/j.cellsig.2019.06.003
  3. Published
    Tiane, A., Schepers, M., Rombaut, B., Hupperts, R., Prickaerts, J., Hellings, N., ... Vanmierlo, T. (2019). From OPC to Oligodendrocyte: An Epigenetic Journey. Cells, 8(10), [1236]. https://doi.org/10.3390/cells8101236
  4. Published
    Schepers, M., Tiane, A., Paes, D., Sanchez, S., Rombaut, B., Piccart, E., ... Vanmierlo, T. (2019). Targeting Phosphodiesterases-Towards a Tailor-Made Approach in Multiple Sclerosis Treatment. Frontiers in Immunology, 10, 1-17. [1727]. https://doi.org/10.3389/fimmu.2019.01727
  5. Published
    Blokland, A., Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., ... Prickaerts, J. (2019). Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study. Neurobiology of Aging, 77, 37-43. https://doi.org/10.1016/j.neurobiolaging.2019.01.014
  6. Published
    Nelissen, E., van Goethem, N. P., Bonassoli, V. T., Heckman, P. R. A., van Hagen, B. T. J., Suay, D., ... Prickaerts, J. (2019). Validation of the xylazine/ketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats. Neuroscience Letters, 699, 41-46. https://doi.org/10.1016/j.neulet.2019.01.026
  7. Published
    Argyrousi, E. K., de Nijs, L., Lagatta, D. C., Schlütter, A., Weidner, M. T., Zoeller, J., ... Prickaerts, J. (2019). Effects of DNA methyltransferase inhibition on pattern separation performance in mice. Neurobiology of Learning and Memory, 159, 6-15. https://doi.org/10.1016/j.nlm.2019.02.003
  8. Published
    Houben, T., dos Reis, I. M., Oligschlaeger, Y., Steinbusch, H., Gijbels, M. J. J., Hendrikx, T., ... Shiri-Sverdlov, R. (2019). Pneumococcal Immunization Reduces Neurological and Hepatic Symptoms in a Mouse Model for Niemann-Pick Type C1 Disease. Frontiers in Immunology, 9, 1-13. [3089]. https://doi.org/10.3389/fimmu.2018.03089
  9. 2018
  10. Published
    Prickaerts, J. (2018). Neuropsychofarmacologie in Translatie.
  11. Published
    Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M. J., Blankesteijn, W. M., ... Unger, T. (2018). Hypertension-induced cognitive impairment: insights from prolonged angiotensin II infusion in mice. Hypertension Research, 41(10), 817-827. https://doi.org/10.1038/s41440-018-0090-9
  12. Published
    Heckman, P. R. A., Blokland, A., Van Goethem, N. P., Van Hagen, B. T. J., & Prickaerts, J. (2018). The mediating role of phosphodiesterase type 4 in the dopaminergic modulation of motor impulsivity. Behavioural Brain Research, 350, 16-22. https://doi.org/10.1016/j.bbr.2018.05.017
  13. Published
    van Goethem, N. P., van Hagen, B. T. J., & Prickaerts, J. (2018). Assessing spatial pattern separation in rodents using the object pattern separation task. Nature Protocols, 13(8), 1763-1792. https://doi.org/10.1038/s41596-018-0013-x
  14. Published
    Santiago, A., Soares, L. M., Schepers, M., Milani, H., Vanmierlo, T., Prickaerts, J., & de Oliveira, R. M. (2018). Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion. Neuropharmacology, 138, 360-370. https://doi.org/10.1016/j.neuropharm.2018.06.019
  15. Published
    Borghans, L. G. J. M., Sambeth, A., Prickaerts, J., Ramaekers, J. G., & Blokland, A. (2018). The effects of the soluble guanylate cyclase stimulator riociguat on memory performance in healthy volunteers with a biperiden-induced memory impairment. Psychopharmacology, 235(8), 2407-2416. https://doi.org/10.1007/s00213-018-4938-0
  16. Published
    Nelissen, E., Prickaerts, J., & Blokland, A. (2018). Acute stress negatively affects object recognition early memory consolidation and memory retrieval unrelated to state-dependency. Behavioural Brain Research, 345, 9-12. https://doi.org/10.1016/j.bbr.2018.02.027
  17. Published
    Vanmierlo, T., De Vry, J., Nelissen, E., Sierksma, A., Roumans, N., Steinbusch, H. W. M., ... Prickaerts, J. (2018). Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels. Molecular and Cellular Neuroscience, 88, 292-299. https://doi.org/10.1016/j.mcn.2018.02.009
  18. Published
    Heckman, P. R. A., Blokland, A., Bollen, E. P. P., & Prickaerts, J. (2018). Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations. Neuroscience and Biobehavioral Reviews, 87, 233-254. https://doi.org/10.1016/j.neubiorev.2018.02.007
  19. Published
    Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Smit, S., Tsai, M., Lahu, G., ... Prickaerts, J. (2018). Acute administration of roflumilast enhances immediate recall of verbal word memory in healthy young adults. Neuropharmacology, 131, 31-38. https://doi.org/10.1016/j.neuropharm.2017.12.019
  20. Published
    Heckman, P. R. A., Schweimer, J. V., Sharp, T., Prickaerts, J., & Blokland, A. (2018). Phosphodiesterase 4 inhibition affects both the direct and indirect pathway: an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata. Brain Structure & Function, 223(2), 739-748. https://doi.org/10.1007/s00429-017-1518-8
  21. Published
    Heckman, P. R. A., Van Duinen, M. A., Blokland, A., Uz, T., Prickaerts, J., & Sambeth, A. (2018). Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial. Psychopharmacology, 235(1), 301–308. https://doi.org/10.1007/s00213-017-4770-y
  22. 2017
  23. Published
    Prickaerts, J., Van Goethem, N. P., Gulisano, W., Argyrousi, E. K., Palmeri, A., & Puzzo, D. (2017). Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve. European Journal of Pharmacology, 817, 59-70. https://doi.org/10.1016/j.ejphar.2017.05.058
  24. Published
    Borghans, L. G. J. M., Sambeth, A., Prickaerts, J. H. H. J., Ramaekers, J. G., & Blokland, A. (2017). Effects of riociguat and biperiden on memory. S645-S645. Poster session presented at 30th ECNP Congress, Paris, France.
  25. Published
    Van Duinen, M. A., Sambeth, A., Heckman, P. R. A., Tsai, M., Lahu, G., Uz, T., ... Prickaerts, J. (2017). The PDE4-inhibitor roflumilast improves memory: findings from a translational perspective. European Neuropsychopharmacology, 27(Suppl 4), S1024-S1025. https://doi.org/10.1016/S0924-977X(17)31794-7
  26. Published
    Prickaerts, J., Heckman, P. R. A., & Blokland, A. (2017). Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease. Expert Opinion on Investigational Drugs, 26(9), 1033-1048 . https://doi.org/10.1080/13543784.2017.1364360
  27. Published
    Nelissen, E., De Vry, J., Antonides, A., Paes, D., Schepers, M., van der Staay, F. J., ... Vanmierlo, T. (2017). Early-postnatal iron deficiency impacts plasticity in the dorsal and ventral hippocampus in piglets. International Journal of Developmental Neuroscience, 59, 47-51. https://doi.org/10.1016/j.ijdevneu.2017.03.006
  28. Published
    Ricciarelli, R., Brullo, C., Prickaerts, J., Arancio, O., Villa, C., Rebosio, C., ... Fedele, E. (2017). Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease. Scientific Reports, 7, [46320]. https://doi.org/10.1038/srep46320
  29. Published
    Soares, L. M., Meyer, E., Milani, H., Steinbusch, H. W. M., Prickaerts, J., & de Oliveira, R. M. W. (2017). The phosphodiesterase type 2 inhibitor BAY 60-7550 reverses functional impairments induced by brain ischemia by decreasing hippocampal neurodegeneration and enhancing hippocampal neuronal plasticity. European Journal of Neuroscience, 45(4), 510-520. https://doi.org/10.1111/ejn.13461
  30. Published
    Heckman, P., Blokland, A., & Prickaerts, J. (2017). From age-related cognitive decline to Alzheimer’s disease: a translational overview of the potential role for phosphodiesterases. In H-T. Zhang, Y. Xu, & J. M. O'Donnell (Eds.), Phosphodiesterases: CNS Functions and Diseases. (pp. 217-221). (Advances in Neurobiology; Vol. 17). Berlin: Springer Verlag.
  31. Published
    Heckman, P. R. A., Blokland, A., & Prickaerts, J. (2017). From Age-Related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential Role for Phosphodiesterases. In H-T. Zhang, Y. Xu, & J. M. O'Donnell (Eds.), Phosphodiesterases: CNS Functions and Diseases (pp. 135-168). (Advances in Neurobiology; Vol. 17). Springer. https://doi.org/10.1007/978-3-319-58811-7_6
  32. 2016
  33. Published
    Brullo, C., Ricciarelli, R., Prickaerts, J., Arancio, O., Massa, M., Rotolo, C., ... Bruno, O. (2016). New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment. European Journal of Medicinal Chemistry, 124, 82-102. https://doi.org/10.1016/j.ejmech.2016.08.018
  34. Published
    Heckman, P. R. A., van Duinen, M. A., Bollen, E. P. P., Nishi, A., Wennogle, L. P., Blokland, A., & Prickaerts, J. (2016). Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications. International Journal of Neuropsychopharmacology, 19(10), [pyw030]. https://doi.org/10.1093/ijnp/pyw030
  35. Published
    Blokland, A., Sambeth, A., Prickaerts, J., & Riedel, W. J. (2016). Why an M1 Antagonist Could Be a More Selective Model for Memory Impairment than Scopolamine. Frontiers in Neurology, 7, [167]. https://doi.org/10.3389/fneur.2016.00167
  36. Published
    Snyder, G. L., Prickaerts, J., Wadenberg, M-L., Zhang, L., Zheng, H., Yao, W., ... Wennogle, L. P. (2016). Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats. Psychopharmacology, 233(17), 3113-3124. https://doi.org/10.1007/s00213-016-4346-2
  37. Published
    de Bruin, N. M. W. J., van Loevezijn, A., Wicke, K. M., de Haan, M., Venhorst, J., Lange, J. H. M., ... Kruse, C. G. (2016). The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment. Neurobiology of Learning and Memory, 133, 100-117. https://doi.org/10.1016/j.nlm.2016.06.020
  38. Published
    Yahyanejad, S., King, H., Iglesias, V. S., Granton, P. V., Barbeau, L. M. O., van Hoof, S. J., ... Vooijs, M. (2016). NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma. Oncotarget, 7(27), 41251-41264. https://doi.org/10.18632/oncotarget.9275
  39. Published
    Soares, L. M., De Vry, J., Steinbusch, H. W. M., Milani, H., Prickaerts, J., & Weffort De Oliveira, R. M. (2016). ROLIPRAM IMPROVES COGNITION, REDUCES ANXIETY- AND DESPAIR-LIKE BEHAVIORS AND IMPACTS HIPPOCAMPAL NEUROPLASTICITY AFTER TRANSIENT GLOBAL CEREBRAL ISCHEMIA. Neuroscience, 326, 69-83. https://doi.org/10.1016/j.neuroscience.2016.03.062
  40. Published
    Vanmierlo, T., Creemers, P., Akkerman, S., van Duinen, M., Sambeth, A., De Vry, J., ... Prickaerts, J. (2016). The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses. Behavioural Brain Research, 303, 26-33. https://doi.org/10.1016/j.bbr.2016.01.031
  41. Published
    Akkerman, S., Blokland, A., & Prickaerts, J. (2016). Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach. Learning & Memory, 23(1), 29-37. https://doi.org/10.1101/lm.040162.115
  42. Published
    De Vry, J., Vanmierlo, T., Martinez-Martinez, P., Losen, M., Temel, Y., Boere, J., ... Prickaerts, J. (2016). TrkB in the hippocampus and nucleus accumbens differentially modulates depression-like behavior in mice. Behavioural Brain Research, 296, 15-25. https://doi.org/10.1016/j.bbr.2015.08.027
  43. Published
    Sierksma, A. S. R., de Nijs, L., Hoogland, G., Vanmierlo, T., van Leeuwen, F. W., Rutten, B. P. F., ... van den Hove, D. L. A. (2016). Fluoxetine Treatment Induces Seizure Behavior and Premature Death in APPswe/PS1dE9 Mice. Journal of Alzheimer's Disease, 51(3), 677-682. https://doi.org/10.3233/JAD-151066
  44. 2015
  45. Published
    Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., ... Rutten, B. P. F. (2015). Defeat stress in rodents: From behavior to molecules. Neuroscience and Biobehavioral Reviews, 59, 111-40. https://doi.org/10.1016/j.neubiorev.2015.10.006
  46. Published
    Akkerman, S., Blokland, A., van Goethem, N. P., Cremers, P., Shaffer, C. L., Osgood, S. M., ... Prickaerts, J. (2015). PDE5 inhibition improves acquisition processes after learning via a central mechanism. Neuropharmacology, 97, 233-239. https://doi.org/10.1016/j.neuropharm.2015.04.019
  47. Published
    Biallosterski, B. T., Prickaerts, J., Rahnama'i, M. S., de Wachter, S., van Koeveringe, G. A., & Meriaux, C. (2015). Changes in voiding behavior in a mouse model of Alzheimer's disease. Frontiers in Aging Neuroscience, 7, [160]. https://doi.org/10.3389/fnagi.2015.00160
  48. Published
    Blokland, A., Prickaerts, J., van Duinen, M., & Sambeth, A. (2015). The use of EEG parameters as predictors of drug effects on cognition. European Journal of Pharmacology, 759, 163-168. https://doi.org/10.1016/j.ejphar.2015.03.031
  49. Published
    van Goethem, N. P., Prickaerts, J., Welty, D., Flood, D. G., & Koenig, G. (2015). Continuous infusion of the alpha 7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study. Behavioural Pharmacology, 26(4), 403-406. https://doi.org/10.1097/FBP.0000000000000134
  50. Published
    van Hagen, B. T. J., van Goethem, N. P., Lagatta, D. C., & Prickaerts, J. (2015). The object pattern separation (OPS) task: A behavioral paradigm derived from the object recognition task. Behavioural Brain Research, 285, 44-52. https://doi.org/10.1016/j.bbr.2014.10.041
  51. Published
    Bus, B. A. A., Molendijk, M. L., Tendolkar, I., Penninx, B. W. J. H., Prickaerts, J., Elzinga, B. M., & Voshaar, R. C. O. (2015). Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time. Molecular Psychiatry, 20(5), 602-608. https://doi.org/10.1038/mp.2014.83
  52. Published
    van Goethem, N. P., Schreiber, R., Newman-Tancredi, A., Varney, M., & Prickaerts, J. (2015). Divergent effects of the 'biased' 5-HT1A receptor agonists F15599 and F13714 in a novel object pattern separation task. British Journal of Pharmacology, 172(10), 2532-2543. https://doi.org/10.1111/bph.13071
  53. Published
    Bollen, E., Akkerman, S., Puzzo, D., Gulisano, W., Palmeri, A., D'Hooge, R., ... Prickaerts, J. (2015). Object memory enhancement by combining sub-efficacious doses of specific phosphodiesterase inhibitors. Neuropharmacology, 95, 361-366. https://doi.org/10.1016/j.neuropharm.2015.04.008
  54. Published
    Lim, L. W., Prickaerts, J., Huguet, G., Kadar, E., Hartung, H., Sharp, T., & Temel, Y. (2015). Electrical stimulation alleviates depressive-like behaviors of rats: investigation of brain targets and potential mechanisms. Translational Psychiatry, 5, [e535]. https://doi.org/10.1038/tp.2015.24
  55. Published
    Heckman, P., Blokland, A., Ramaekers, J., & Prickaerts, J. (2015). PDE and cognitive processing : beyond the memory domain. Neurobiology of Learning and Memory, 119, 108-122. https://doi.org/10.1016/j.nlm.2014.10.011
  56. Published
    Heckman, P. R. A., Van Duinen, M., Blokland, A., Ramaekers, J., & Prickaerts, J. (2015). Phosphodiesterase 2A inhibition and impulsivity. S31-S31. Abstract from ECNP Workshop for Junior Scientists in Europe, NIce, France.
  57. Published
    Theunissen, E. L., Heckman, P., de Sousa Fernandes Perna, E. B., Kuypers, K. P. C., Sambeth, A., Blokland, A., ... Ramaekers, J. G. (2015). Rivastigmine but not vardenafil reverses cannabis-induced impairment of verbal memory in healthy humans. Psychopharmacology, 232(2), 343-353. https://doi.org/10.1007/s00213-014-3667-2
  58. Published
    van Duinen, M., Reneerkens, O. A. H., Lambrecht, L., Sambeth, A., Rutten, B. P. F., van Os, J., ... Prickaerts, J. (2015). Treatment of cognitive impairment in schizophrenia: potential value of phosphodiesterase inhibitors in prefrontal dysfunction. Current Pharmaceutical Design, 21(26), 3813-3828. https://doi.org/10.2174/1381612821666150605110941
  59. Published
    Hammels, C., Prickaerts, J., Kenis, G., Vanmierlo, T., Fischer, M., Steinbusch, H. W. M., ... Rutten, B. P. F. (2015). Differential susceptibility to chronic social defeat stress relates to the number of Dnmt3a-immunoreactive neurons in the hippocampal dentate gyrus. Psychoneuroendocrinology, 51, 547-556. https://doi.org/10.1016/j.psyneuen.2014.09.021
  60. Published
    Berkers, R., van Goethem, N., Rutten, K., Blokland, A., & Prickaerts, J. (2015). Episodic memory and the medial temporal lobe: towards a unifying framework of recognition and recall. In K. Edison (Ed.), Episodic Memory: Formation, Clinical Disorders and Role of Aging. (pp. 85-134). New York: Nova Science Publishers.
  61. Published
    Soares, L. M., Prickaerts, J., Milani, H., Del Bel, E., Steinbusch, H. W. M., & Weffort de Oliveira, R. M. (2015). Phosphodiesterase Inhibition as a Therapeutic Target for Brain Ischemia. Cns & Neurological Disorders-Drug Targets, 14(8), 1012-1023. https://doi.org/10.2174/1871527314666150909114249
  62. Published
    Prickaerts, J. (2015). Phosphodiesterase Inhibitors. In Encyclopedia of Psychopharmacology
  63. Published
    Heckman, P. R. A., Wouters, C., & Prickaerts, J. (2015). Phosphodiesterase Inhibitors as a Target for Cognition Enhancement in Aging and Alzheimer's Disease: A Translational Overview. Current Pharmaceutical Design, 21(3), 317-331. https://doi.org/10.2174/1381612820666140826114601
  64. Published
    de Vry, J., Boulle, F., Rutten, B., van den Hove, D., & Prickaerts, J. (2015). The Impact of Fluoxetine Treatment on BDNF Signaling and Cellular Plasticity in the Brain. In Fluoxetine: Pharmacology, Mechanisms of Action and Potential Side Effects
  65. 2014
  66. Published
    Karamihalev, S., Prickaerts, J., & van Goethem, N. P. (2014). Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse modet of cognitive impairment in schizophrenia. Behavioural Brain Research, 272, 248-251. https://doi.org/10.1016/j.bbr.2014.07.017
  67. Published
    Bruno, O., Ricciarelli, R., Prickaerts, J., Parker, L., & Fedele, E. (2014). PDE4D inhibitors: A potential strategy for the treatment of memory impairment? Neuropharmacology, 85, 290-292. https://doi.org/10.1016/j.neuropharm.2014.05.038
  68. Published
    Bus, B. A. A., Molendijk, M. L., Penninx, B. W. J. H., Buitelaar, J. K., Prickaerts, J., Elzinga, B. M., & Voshaar, R. C. O. (2014). Low serum BDNF levels in depressed patients cannot be attributed to individual depressive symptoms or symptom cluster. World Journal of Biological Psychiatry, 15(7), 561-569. https://doi.org/10.3109/15622975.2013.841994
  69. Published
    Bollen, E., Puzzo, D., Rutten, K., Privitera, L., De Vry, J., Vanmierlo, T., ... Prickaerts, J. (2014). Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling. Neuropsychopharmacology, 39, 2497-2505. https://doi.org/10.1038/npp.2014.106
  70. Published
    Prickaerts, J., Gieling, E. T., Bruder, A. K., van der Staay, F. J., & Vanmierlo, T. (2014). Long-term effects of prenatal allopurinol treatment on brain plasticity markers in low and normal birth weight piglets. International Journal of Developmental Neuroscience, 33, 29-32. https://doi.org/10.1016/j.ijdevneu.2013.11.001
  71. Published
    Van den Hove, D. L. A., Leibold, N. K., Strackx, E., Martinez-Claros, M., Lesch, K. P., Steinbusch, H. W. M., ... Prickaerts, J. (2014). Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. European Neuropsychopharmacology, 24(4), 595-607. https://doi.org/10.1016/j.euroneuro.2013.09.006
  72. Published
    Sierksma, A. S. R., van den Hove, D. L. A., Pfau, F., Philippens, M., Bruno, O., Fedele, E., ... Prickaerts, J. (2014). Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology, 77, 120-130. https://doi.org/10.1016/j.neuropharm.2013.09.015
  73. Published
    Akkerman, S., Blokland, A., & Prickaerts, J. (2014). Mind the gap: Delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors. Neurobiology of Learning and Memory, 109, 139-143. https://doi.org/10.1016/j.nlm.2014.01.006
  74. Published
    Akkerman, S., Prickaerts, J., Bruder, A. K., Wolfs, K. H. M., De Vry, J., Vanmierlo, T., & Blokland, A. (2014). PDE5 inhibition improves object memory in standard housed rats but not in rats housed in an enriched environment : implications for memory models? PLOS ONE, 9(11), [e111692]. https://doi.org/10.1371/journal.pone.0111692
  75. Published
    Duster, R., Prickaerts, J., & Blokland, A. (2014). Purinergic signaling and hippocampal long-term potentiation. Current Neuropharmacology, 12(1), 37-43. https://doi.org/10.2174/1570159X113119990045
  76. Published
    Blokland, A., van Goethem, N., Heckman, P., Schreiber, R., & Prickaerts, J. (2014). Translational issues with the development of cognition enhancing drugs. Frontiers in Neurology, 5, [190]. https://doi.org/10.3389/fneur.2014.00190
  77. Published
    De Vry, J., Vanmierlo, T., Martínez-Martínez, P., Losen, M., Temel, Y., Steinbusch, H., ... Prickaerts, J. (2014). Delivery of DNA into the central nervous system via electroporation. In Methods in molecular biology (Vol. 1121, pp. 157-63) https://doi.org/10.1007/978-1-4614-9632-8_14
  78. Published
    Foecking, M., Opstelten, R., Prickaerts, J., Steinbusch, H. W. M., Dunn, M. J., van den Hove, D. L. A., & Cotter, D. R. (2014). Proteomic Investigation of the Hippocampus in Prenatally Stressed Mice Implicates Changes in Membrane Trafficking, Cytoskeletal, and Metabolic Function. Developmental Neuroscience, 36(5), 432-442. https://doi.org/10.1159/000365327
  79. 2013
  80. Published
    Bollen, E., Vanmierlo, T., Akkerman, S., Wouters, C., Steinbusch, H. M. W., & Prickaerts, J. (2013). 7,8-Dihydroxyflavone improves memory consolidation processes in rats and mice. Behavioural Brain Research, 257, 8-12. https://doi.org/10.1016/j.bbr.2013.09.029
  81. Published
    Van den Hove, D. L. A., Kenis, G., Brass, A., Opstelten, R., Rutten, B. P. F., Bruschettini, M., ... Prickaerts, J. (2013). Vulnerability versus resilience to prenatal stress in male and female rats; Implications from gene expression profiles in the hippocampus and frontal cortex. European Neuropsychopharmacology, 23(10), 1226-1246. https://doi.org/10.1016/j.euroneuro.2012.09.011
  82. Published
    Reneerkens, O. A. H., Sambeth, A., Blokland, A., & Prickaerts, J. (2013). PDE2 and PDE10, but not PDE5, inhibition affect basic auditory information processing in rats. Behavioural Brain Research, 250, 251-256. https://doi.org/10.1016/j.bbr.2013.05.014
  83. Published
    van Donkelaar, E. L., Prickaerts, J., Akkerman, S., Rutten, K., Steinbusch, H., & Blokland, A. (2013). No effect of acute tryptophan depletion on phosphodiesterase inhibition-related improvements of short-term object memory in male Wistar rats. Acta Psychiatrica Scandinavica, 128(2), 107-113. https://doi.org/10.1111/acps.12166
  84. Published
    Martinez-Claros, M., Steinbusch, H. W. M., van Selm, A., van den Hove, D. L. A., Prickaerts, J., & Pawluski, J. L. (2013). Adrenalectomy and corticosterone replacement differentially alter CA3 dendritic morphology and new cell survival in the adult rat hippocampus. Journal of Chemical Neuroanatomy, 48-49, 23-28. https://doi.org/10.1016/j.jchemneu.2013.01.001
  85. Published
    Hescham, S., Lim, L. W., Jahanshahi, A., Steinbusch, H. W. M., Prickaerts, J., Blokland, A., & Temel, Y. (2013). Deep brain stimulation of the forniceal area enhances memory functions in experimental dementia: The role of stimulation parameters. Brain stimulation, 6(1), 72-77. https://doi.org/10.1016/j.brs.2012.01.008
  86. Published
    Reneerkens, O. A. H., Rutten, K., Bollen, E., Hage, T., Blokland, A., Steinbusch, H. W. M., & Prickaerts, J. (2013). Inhibition of phoshodiesterase type 2 or type 10 reverses object memory deficits induced by scopolamine or MK-801. Behavioural Brain Research, 236, 16-22. https://doi.org/10.1016/j.bbr.2012.08.019
  87. Published
    Reneerkens, O. A. H., Sambeth, A., van Duinen, M. A., Blokland, A., Steinbusch, H. W. M., & Prickaerts, J. (2013). The PDE5 inhibitor vardenafil does not affect auditory sensory gating in rats and humans. Psychopharmacology, 225(2), 303-312. https://doi.org/10.1007/s00213-012-2817-7
  88. Published
    Sierksma, A. S. R., Prickaerts, J., Chouliaras, L., Rostamian, S., Delbroek, L., Rutten, B. P. F., ... van den Hove, D. L. A. (2013). Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice. Neurobiology of Aging, 34(1), 319-337. https://doi.org/10.1016/j.neurobiolaging.2012.05.012
  89. Published
    Sierksma, A. S. R., Rutten, K., Sydlik, S., Rostamian, S., Steinbusch, H. W. M., van den Hove, D. L. A., & Prickaerts, J. (2013). Chronic phosphodiesterase type 2 inhibition improves memory in the APPswe/PS1dE9 mouse model of Alzheimer's disease. Neuropharmacology, 64, 124-136. https://doi.org/10.1016/j.neuropharm.2012.06.048
  90. 2012
  91. Published
    Bollen, E., & Prickaerts, J. (2012). Phosphodiesterases in neurodegenerative disorders. Iubmb Life, 64(12), 965-970. https://doi.org/10.1002/iub.1104
  92. Published
    Molendijk, M. L., Haffmans, J. P. M., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Prickaerts, J., ... Elzinga, B. M. (2012). Serum BDNF Concentrations Show Strong Seasonal Variation and Correlations with the Amount of Ambient Sunlight. PLOS ONE, 7(11), [e48046]. https://doi.org/10.1371/journal.pone.0048046
  93. Published
    Sierksma, A. S. R., Vanmierlo, T., De Vry, J., Raijmakers, M. E. A., Steinbusch, H. W. M., van den Hove, D. L. A., & Prickaerts, J. (2012). Effects of prenatal stress exposure on soluble A beta and brain-derived neurotrophic factor signaling in male and female APPswe/PS1dE9 mice. Neurochemistry International, 61(5), 697-701. https://doi.org/10.1016/j.neuint.2012.06.022
  94. Published
    Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Prickaerts, J., Voshaar, R. C. O., & Elzinga, B. M. (2012). Gender specific associations of serum levels of brain-derived neurotrophic factor in anxiety. World Journal of Biological Psychiatry, 13(7), 535-543. https://doi.org/10.3109/15622975.2011.587892
  95. Published
    Prickaerts, J., De Vry, J., Boere, J., Kenis, G., Quinton, M. S., Engel, S., ... Schreiber, R. (2012). Differential BDNF Responses of Triple Versus Dual Reuptake Inhibition in Neuronal and Astrocytoma Cells as well as in Rat Hippocampus and Prefrontal Cortex. Journal of Molecular Neuroscience, 48(1), 167-175. https://doi.org/10.1007/s12031-012-9802-9
  96. Published
    De Vry, J., Prickaerts, J., Jetten, M., Hulst, M., Steinbusch, H. W. M., van den Hove, D. L. A., ... van der Staay, F. J. (2012). Recurrent long-lasting tethering reduces BDNF protein levels in the dorsal hippocampus and frontal cortex in pigs. Hormones and Behavior, 62(1), 10-17. https://doi.org/10.1016/j.yhbeh.2012.04.019
  97. Published
    Hosseini-Sharifabad, A., Ghahremani, M. H., Sabzevari, O., Naghdi, N., Abdollahi, M., Beyer, C., ... Sharifzadeh, M. (2012). Effects of protein kinase A and G inhibitors on hippocampal cholinergic markers expressions in rolipram- and sildenafil-induced spatial memory improvement. Pharmacology, Biochemistry and Behavior, 101(3), 311-319. https://doi.org/10.1016/j.pbb.2012.01.017
  98. Published
    Reneerkens, O. A. H., Rutten, K., Akkerman, S., Blokland, A., Shaffer, C. L., Menniti, F. S., ... Prickaerts, J. (2012). Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: Indications for central and peripheral mechanisms. Neurobiology of Learning and Memory, 97(4), 370-379. https://doi.org/10.1016/j.nlm.2012.02.008
  99. Published
    Blokland, A., Menniti, F. S., & Prickaerts, J. (2012). PDE Inhibition and cognition enhancement. Expert Opinion on Therapeutic Patents, 22(4), 349-354. https://doi.org/10.1517/13543776.2012.674514
  100. Published
    Zeef, D. H., van Goethem, N. P., Vlamings, R., Schaper, F., Jahanshahi, A., Hescham, S., ... Temel, Y. (2012). Memory deficits in the transgenic rat model of Huntington's disease. Behavioural Brain Research, 227(1), 194-198. https://doi.org/10.1016/j.bbr.2011.11.009
  101. Published
    Prickaerts, J., van Goethem, N. P., Chesworth, R., Shapiro, G., Boess, F. G., Methfessel, C., ... Koenig, G. (2012). EVP-6124, a novel and selective alpha 7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha 7 nicotinic acetylcholine receptors. Neuropharmacology, 62(2), 1099-1110. https://doi.org/10.1016/j.neuropharm.2011.10.024
  102. Published
    Zeef, D. H., Vlamings, R., Lim, L. W., Tan, S., Janssen, M. L. F., Jahanshahi, A., ... Temel, Y. (2012). Motor and non-motor behaviour in experimental Huntington's disease. Behavioural Brain Research, 226(2), 435-439. https://doi.org/10.1016/j.bbr.2011.09.041
  103. Published
    Akkerman, S., Blokland, A., Reneerkens, O., Goethem, N. P., Bollen, E., Gijselaers, H. J. M., ... Prickaerts, J. (2012). Object recognition testing: methodological considerations on exploration and discrimination measures. Behavioural Brain Research, 232(2), 335-347. https://doi.org/10.1016/j.bbr.2012.03.022
  104. Published
    van Goethem, M., Rutten, K., van der Staay, F. J., Jans, L. A. W., Akkerman, S., Steinbusch, H. W. M., ... Prickaerts, J. (2012). Object recognition testing: Rodent species, strains, housing conditions, and estrous cycle. Behavioural Brain Research, 232(2), 323-334. https://doi.org/10.1016/j.bbr.2012.03.023
  105. Published
    Akkerman, S., Prickaerts, J. H. H. J., Steinbusch, H. W. M., & Blokland, A. (2012). Object recognition testing: statistical considerations. Behavioural Brain Research, 232(2), 317-322. https://doi.org/10.1016/j.bbr.2012.03.024
  106. Published
    Bus, B. A. A., Arias-Vasquez, A., Franke, B., Prickaerts, J., de Graaf, J., & Voshaar, R. C. O. (2012). Increase in Serum Brain-Derived Neurotrophic Factor in Met Allele Carriers of the BDNF Val66Met Polymorphism Is Specific to Males. Neuropsychobiology, 65(4), 183-187. https://doi.org/10.1159/000336997
  107. 2011
  108. Published
    Bruno, O., Fedele, E., Prickaerts, J., Parker, L. A., Canepa, E., Brullo, C., ... Ricciarelli, R. (2011). GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. British Journal of Pharmacology, 164(8), 2054-2063. https://doi.org/10.1111/j.1476-5381.2011.01524.x
  109. Published
    Molendijk, M. L., Bus, B. A. A., Spinhoven, P., Penninx, B. W. J. H., Kenis, G., Prickaerts, J., ... Elzinga, B. M. (2011). Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Molecular Psychiatry, 16(11), 1088-1095. https://doi.org/10.1038/mp.2010.98
  110. Published
    Rayen, I., van den Hove, D. L., Prickaerts, J., Steinbusch, H. W., & Pawluski, J. L. (2011). Fluoxetine during Development Reverses the Effects of Prenatal Stress on Depressive-Like Behavior and Hippocampal Neurogenesis in Adolescence. PLOS ONE, 6(9), 9. https://doi.org/10.1371/journal.pone.0024003
  111. Published
    de Bruin, N. M. W. J., Prickaerts, J., van Loevezijn, A., Venhorst, J., de Groote, L., Houba, P., ... Kruse, C. G. (2011). Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats. Neurobiology of Learning and Memory, 96(2), 392-402. https://doi.org/10.1016/j.nlm.2011.06.015
  112. Published
    Van den Hove, D., Jakob, S. B., Schraut, K-G., Kenis, G., Schmitt, A. G., Kneitz, S., ... Lesch, K-P. (2011). Differential Effects of Prenatal Stress in 5-Htt Deficient Mice: Towards Molecular Mechanisms of Gene x Environment Interactions. PLOS ONE, 6(8), 16. https://doi.org/10.1371/journal.pone.0022715
  113. Published
    van Donkelaar, E. L., Blokland, A., Ferrington, L., Kelly, P. A., Steinbusch, H. W. M., & Prickaerts, J. (2011). Mechanism of acute tryptophan depletion: is it only serotonin? Molecular Psychiatry, 16(7), 695-713. https://doi.org/10.1038/mp.2011.9
  114. Published
    Vanmierlo, T., Rutten, K., van Vark - van der Zee, L. C., Friedrichs, S., Bloks, V. W., Blokland, A., ... Mulder, M. (2011). Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. Plant Foods for Human Nutrition, 66(2), 149-156. https://doi.org/10.1007/s11130-011-0219-3
  115. Published
    Pawluski, J. L., van den Hove, D. L. A., Rayen, I., Prickaerts, J., & Steinbusch, H. W. M. (2011). Stress and the pregnant female: Impact on hippocampal cell proliferation, but not affective-like behaviors. Hormones and Behavior, 59(4), 572-580. https://doi.org/10.1016/j.yhbeh.2011.02.012
  116. Published
    Elzinga, B. M., Molendijk, M. L., Voshaar, R. C. O., Bus, B. A. A., Prickaerts, J., Spinhoven, P., & Penninx, B. W. J. H. (2011). The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val(66)Met. Psychopharmacology, 214(1), 319-328. https://doi.org/10.1007/s00213-010-1961-1
  117. Published
    Bus, B. A. A., Molendijk, M. L., Penninx, B. W. J. H., Buitelaar, J. K., Kenis, G., Prickaerts, J., ... Voshaar, R. C. O. (2011). Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinology, 36(2), 228-239. https://doi.org/10.1016/j.psyneuen.2010.07.013
  118. Published
    Berbee, J. F., Vanmierlo, T., Abildayeva, K., Blokland, A., Jansen, P. J., Lütjohann, D., ... Mulder, M. (2011). Apolipoprotein CI knock-out mice display impaired memory functions. Journal of Alzheimer's Disease, 23(4), 737-747. https://doi.org/10.3233/JAD-2010-100576
  119. Published
    Kenis, G. R. L., Prickaerts, J. H. H. J., van Os, J. J., Koek, G. H., Robaeys, G., Steinbusch, H. W. M., & Wichers, M. C. (2011). Depressive symptoms following interferon-a therapy: mediated by immune-induced reductions in brain-derived neurotrophic factor? International Journal of Neuropsychopharmacology, 14(2), 247-253. https://doi.org/10.1017/S1461145710000830
  120. Published
    Rutten, K., Wallace, T. L., Works, M., Prickaerts, J., Blokland, A., Novak, T. J., ... Misner, D. L. (2011). Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B-/-) mice. Neuropharmacology, 61(1-2), 138-147. https://doi.org/10.1016/j.neuropharm.2011.03.020
  121. Published
    Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V. W., Vark-van der Zee, L. C., Kuipers, F., ... Mulder, M. (2011). Liver X receptor activation restores memory in aged AD mice without reducing amyloid. Neurobiology of Aging, 32(7), 1262-1272. https://doi.org/10.1016/j.neurobiolaging.2009.07.005
  122. Published
    Behan, A. T., Van den Hove, D. L. A., Mueller, L., Jetten, M. J. A., Steinbusch, H. W. M., Cotter, D. R., & Prickaerts, J. (2011). Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress. European Neuropsychopharmacology, 21(1), 71-79. https://doi.org/10.1016/j.euroneuro.2010.07.004
  123. 2010
  124. Published
    De Vry, J., Martinez-Martinez, P., Losen, M., Temel, Y., Steckler, T., Steinbusch, H. W. M., ... Prickaerts, J. (2010). In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery. Progress in Neurobiology, 92(3), 227-244. https://doi.org/10.1016/j.pneurobio.2010.10.001
  125. Published
    De Vry, J., Martinez-Martinez, P., Losen, M., Bode, G. H., Temel, Y., Steckler, T., ... Prickaerts, J. (2010). Low Current-driven Micro-electroporation Allows Efficient In Vivo Delivery of Nonviral DNA into the Adult Mouse Brain. Molecular Therapy, 18(6), 1183-1191. https://doi.org/10.1038/mt.2010.62
  126. Published
    van Donkelaar, E. L., Kelly, P. A., Dawson, N., Blokland, A., Prickaerts, J., Steinbusch, H. W. M., & Ferrington, L. (2010). Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats. Journal of Neuroscience Research, 88(7), 1557-1568. https://doi.org/10.1002/jnr.22308
  127. Published
    van der Staay, F. J., Schuurman, T., Hulst, M., Smits, M., Prickaerts, J., Kenis, G., & Korte, S. M. (2010). Effects of chronic stress: A comparison between tethered and loose sows. Physiology & Behavior, 100(2), 154-164. https://doi.org/10.1016/j.physbeh.2010.02.020
  128. Published
    de Bruin, N. M. W. J., Prickaerts, J., Lange, J. H. M., Akkerman, S., Andriambeloson, E., de Haan, M., ... Kruse, C. G. (2010). SLV330, a cannabinoid CB1 receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents. Neurobiology of Learning and Memory, 93(4), 522-531. https://doi.org/10.1016/j.nlm.2010.01.010
  129. Published
    Strackx, E., Van den Hove, D. L. A., Prickaerts, J., Zimmermann, L., Steinbusch, H. W. M., Blanco, C. E., ... Vles, J. S. H. (2010). Fetal asphyctic preconditioning protects against perinatal asphyxia-induced behavioral consequences in adulthood. Behavioural Brain Research, 208(2), 343-351. https://doi.org/10.1016/j.bbr.2009.11.040
  130. Published
    Sierksma, A. S. R., van den Hove, D. L. A., Steinbusch, H. W. M., & Prickaerts, J. (2010). Major depression, cognitive dysfunction and Alzheimer's disease: Is there a link? European Journal of Pharmacology, 626(1), 72-82. https://doi.org/10.1016/j.ejphar.2009.10.021
  131. Published
    Balanza-Martinez, V., Selva, G., Martinez-Aran, A., Prickaerts, J., Salazar, J., Gonzalez-Pinto, A., ... Tabares-Seisdedos, R. (2010). Neurocognition in bipolar disorders-A closer look at comorbidities and medications. European Journal of Pharmacology, 626(1), 87-96. https://doi.org/10.1016/j.ejphar.2009.10.018
  132. Published
    van Donkelaar, E. L., Blokland, A., Lieben, C. K. J., Kenis, G. R. L., Ferrington, L., Kelly, P. A., ... Prickaerts, J. (2010). Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes. Neurochemistry International, 56(1), 21-34. https://doi.org/10.1016/j.neuint.2009.08.010
  133. Published
    van den Hove, D. L. A., Kenis, G., Steinbusch, H. W. M., Blanco, C. E., & Prickaerts, J. (2010). Maternal stress-induced reduction in birth weight as a marker for adult affective state. Frontiers in Bioscience, Elite edition, 2, 43-6.
  134. 2009
  135. Published
    van Donkelaar, E. L., Ferrington, L., Blokland, A., Steinbusch, H. W. M., Prickaerts, J. H. H. J., & Kelly, P. A. (2009). Acute tryptophan depletion in rats alters the relationship between cerebral blood flow and glucose metabolism independent of central serotonin. Neuroscience, 163(2), 683-694. https://doi.org/10.1016/j.neuroscience.2009.06.063
  136. Published
    Rutten, K., van Donkelaar, E. L., Ferrington, L., Blokland, A., Bollen, E., Steinbusch, H. W. M., ... Prickaerts, J. H. H. J. (2009). Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology, 34(8), 1914-1925. https://doi.org/10.1038/npp.2009.24
  137. Published
    Reneerkens, O. A. H., Rutten, K., Steinbusch, H. W. M., Blokland, A., & Prickaerts, J. H. H. J. (2009). Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology, 202(1-3), 419-443. https://doi.org/10.1007/s00213-008-1273-x
  138. Published
    van Donkelaar, E. L., van den Hove, D. L. A., Blokland, A., Steinbusch, H. W. M., & Prickaerts, J. H. H. J. (2009). Stress-mediated decreases in brain-derived neurotrophic factor as potential confounding factor for acute tryptophan depletion-induced neurochemical effects. European Neuropsychopharmacology, 19(11), 812-821. https://doi.org/10.1016/j.euroneuro.2009.06.012
  139. 2008
  140. Published
    van Gerven, P. W. M., Meijer, W. A., Prickaerts, J. H. H. J., & van der Veen, F. M. (2008). Aging and focus switching in working memory: Excluding the potential role of memory load. Experimental Aging Research, 34(4), 367-378. https://doi.org/10.1080/03610730802274165
  141. Published
    Rutten, K., Reneerkens, O. A. H., Hamers, H., Sik, A., McGregor, I. S., Prickaerts, J. H. H. J., & Blokland, A. (2008). Automated scoring of novel object recognition in rats. Journal of Neuroscience Methods, 171(1), 72-77. https://doi.org/10.1016/j.jneumeth.2008.02.006
  142. Published
    van Donkelaar, E. L., Rutten, K., Blokland, A., Akkerman, S., Steinbusch, H. P., & Prickaerts, J. H. H. J. (2008). Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion. European Journal of Pharmacology, 600(1-3), 98-104. https://doi.org/10.1016/j.ejphar.2008.10.027
  143. Published
    van den Hove, D. L., Blanco, C. E., Scheepens, A., Desbonnet, L., Myint, A. M., Leonard, B. E., ... Steinbusch, H. W. M. (2008). Prenatal maternal paroxetine treatment and neonatal mortality in the rat: a preliminary study. Neonatology, 93(1), 52-55. https://doi.org/10.1159/000106433
  144. Published
    Rutten, K., Basile, J. L., Prickaerts, J. H. H. J., Blokland, A., & Vivian, J. (2008). Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques. Psychopharmacology, 196(4), 643-648. https://doi.org/10.1007/s00213-007-0999-1
  145. Published
    Rutten, K., Prickaerts, J. H. H. J., Schaenzle, G., Rosenbrock, H., & Blokland, A. (2008). Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats. Neurobiology of Learning and Memory, 90(3), 569-575. https://doi.org/10.1016/j.nlm.2008.04.016
  146. Published
    Michelsen, K. A. P., Prickaerts, J. H. H. J., & Steinbusch, H. P. J. (2008). The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease. Progress in Brain Research, 172, 233-264. https://doi.org/10.1016/S0079-6123(08)00912-6
  147. Published
    van der Staay, F. J., Rutten, K., Barfacker, L., Devry, J., Erb, C., Heckroth, H., ... Hendrix, M. (2008). The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents. Neuropharmacology, 55(5), 908-918. https://doi.org/10.1016/j.neuropharm.2008.07.005
  148. 2007
  149. Published
    Mulder, M. T., Koopmans, G., Wassink, G., Al Mansouri, G., Simard, M. L., Havekes, L. M., ... Blokland, A. (2007). LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus. Neuroscience Research, 59(3). https://doi.org/10.1016/j.neures.2007.07.004
  150. Published
    Michelsen, K. A., van den Hove, D. L., Schmitz, C., Segers, O., Prickaerts, J. H. H. J., & Steinbusch, H. W. M. (2007). Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex. BMC Neuroscience, 8(1), 107-107. https://doi.org/10.1186/1471-2202-8-107
  151. Published
    Rutten, K., Prickaerts, J. H. H. J., Hendrix, M., van der Staay, F. J., Sik, A., & Blokland, A. (2007). Time-dependent involvement of cAMP and cGMP in consolidation of object memory: Studies using selective phosphodiesterase type 2, 4 and 5 inhibitors. European Journal of Pharmacology, 558(1-3), 107-112. https://doi.org/10.1016/j.ejphar.2006.11.041
  152. 2006
  153. Published
    Blokland, A., Rutten, K., & Prickaerts, J. H. H. J. (2006). Analysis of spatial orientation strategies of male and female Wistar rats in a Morris water escape task. Behavioural Brain Research, 171, 216-224. https://doi.org/10.1016/j.bbr.2006.03.033
  154. Published
    Prickaerts, J. H. H. J., van den Hove, D. L. A., Fierens, F. L., Kia, H. K., Lenaerts, I., & Steckler, T. (2006). Chronic corticosterone manipulations in mice affect brain cell proliferation rates, but only partly affect BDNF protein levels. Neuroscience Letters, 396, 12-2007. https://doi.org/10.1016/j.neulet.2005.11.002
  155. Published
    Bruschettini, M., van den Hove, D. L. A., Timmers, S., Welling, M., Steinbusch, H. P. J., Prickaerts, J. H. H. J., ... Steinbusch, H. W. M. (2006). Cognition- and anxiety-related behavior, synaptophysin and MAP2 immunoreactivity in the adult rat treated with a single course of antenatal betamethasone. Pediatric Research, 60(1), 50-54. https://doi.org/10.1203/01.pdr.0000220349.41675.92
  156. Published
    Scholtissen, B., Verhey, F. R. J., Adam, J. J. M. E., Prickaerts, J. H. H. J., & Leentjens, A. F. G. (2006). Effects of acute tryptophan depletion on cognition, memory and motor performance in Parkinson's disease. Journal of the Neurological Sciences, 248(1-2), 259-265. https://doi.org/10.1016/j.jns.2006.05.029
  157. Published
    Scholtissen, B., Deumens, R., Leentjens, A. F. G., Schmitz, C., Blokland, A., Steinbusch, H. W. M., & Prickaerts, J. H. H. J. (2006). Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats. Pharmacology, Biochemistry and Behavior, 83, 175-85. https://doi.org/10.1016/j.pbb.2006.01.003
  158. Published
    Blokland, A., Schreiber, R., & Prickaerts, J. H. H. J. (2006). Improving memory: a role for phosphodiesterases. Current Pharmaceutical Design, 12, 2511-2523. https://doi.org/10.2174/138161206777698855
  159. Published
    Warnock, G., Prickaerts, J. H. H. J., & Steckler, T. (2006). Interactions between CRF and acetylcholine in the modulation of cognitive behaviour. EXS, 98, 41-63.
  160. Published
    Prickaerts, J. H. H. J., van den Hove, D. L. A., Fierens, F. L. P., Kia, H. K., Lenaerts, I., & Steckler, T. (2006). Plasma corticosterone manipulations in mice affect brain cell proliferation, but only partly affect BDNF protein levels. Neuroscience Letters, 396, 1-2016.
  161. Published
    van den Hove, D. L. A., Steinbusch, H. W. M., Scheepens, A., van de Berg, W. D. J., Kooiman, L. A. M., Boosten, B. J. G., ... Blanco, C. E. (2006). Prenatal stress and neonatal rat brain development. Neuroscience, 137(1), 145-155. https://doi.org/10.1016/j.neuroscience.2005.08.060
  162. Published
    van den Hove, D. L., Lauder, J. M., Scheepens, A., Prickaerts, J. H. H. J., Blanco, C. E., & Steinbusch, H. W. M. (2006). Prenatal stress in the rat alters 5-HT1A receptor binding in the ventral hippocampus. Brain Research, 1090(1), 29-34. https://doi.org/10.1016/j.brainres.2006.03.057
  163. Published
    van den Hove, D. L., Steinbusch, H. W. M., Bruschettini, M., Gazzolo, D., Frulio, R., Scheepens, A., ... Blanco, C. E. (2006). Prenatal stress reduces S100B in the neonatal rat hippocampus. Neuroreport, 17(10), 1077-1080. https://doi.org/10.1097/01.wnr.0000223391.74575.c9
  164. Published
    Rutten, K., Prickaerts, J. H. H. J., & Blokland, A. (2006). Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action. Neurobiology of Learning and Memory, 85(2), 132-138. https://doi.org/10.1016/j.nlm.2005.09.002
  165. Published
    Prickaerts, J. H. H. J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., ... Steckler, T. (2006). Transgenic mice overexpressing glycogen synthase kinase 3beta: a putative model of hyperactivity and mania. Journal of Neuroscience, 26, 9022-9. https://doi.org/10.1523/JNEUROSCI.5216-05.2006
  166. 2005
  167. Published
    Prickaerts, J. H. H. J., Sik, A., van der Staay, F. J., de Vente, J., & Blokland, A. (2005). Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation. Psychopharmacology, 177, 381-90. https://doi.org/10.1007/s00213-004-1967-7
  168. Published
    Prickaerts, J. H. H. J., & Steckler, T. (2005). Effects of glucocorticoids on emotion and memory processes in animals. In T. Steckler, & N. H. Kalin (Eds.), Handbook of Stress and the Brain, Part 1: The Neurobiology of Stress (pp. 359-386). (Techniques in the behavioral and neural sciences; No. 15). Amsterdam [etc.]: Elsevier.
  169. Published
    Steckler, T., Lavreysen, H., Oliveira, A. M., Aerts, N., van Craenendonck, H., Prickaerts, J. H. H. J., ... Lesage, A. S. (2005). Effects of mGlu1 receptor blockade on anxiety-related behaviour in the rat lick suppression test. Psychopharmacology, 179, 198-206. https://doi.org/10.1007/s00213-004-2056-7
  170. Published
    Steckler, T., Oliveira, A. F., van Dyck, C., van Craenendonck, H., Mateus, A. M., Langlois, X., ... Prickaerts, J. H. H. J. (2005). Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task. Behavioural Brain Research, 164, 52-60. https://doi.org/10.1016/j.bbr.2005.05.010
  171. Published
    van den Hove, D. L. A., Blanco, C. E., Aendekerk, B., Desbonnet, L., Bruschettini, M., Steinbusch, H. P. J., ... Steinbusch, H. W. M. (2005). Prenatal restraint stress and long-term affective consequences. Developmental Neuroscience, 27(5), 313-320. https://doi.org/10.1159/000086711
  172. Published
    Rutten, K., Vente, J. D., Sik, A., van Markerink, M., Prickaerts, J. H. H. J., & Blokland, A. (2005). The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices. Behavioural Brain Research, 164(1), 11-6. https://doi.org/10.1016/j.bbr.2005.04.021
  173. 2004
  174. Published
    Steckler, T., & Prickaerts, J. (2004). Depressed neurogenesis and its role in the genesis of depression. Commentary on Fuchs et al., examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews. Behavioural Pharmacology, 15(5-6), 365-368. https://doi.org/10.1097/00008877-200409000-00008
  175. Published
    Boess, F. G., Hendrix, M., van der Staay, F. J., Erb, C., Schreiber, R., van Staveren, W. C. G., ... Koenig, G. (2004). Inhibition of phosphodiesterase 2 increases nuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology, 47(7), 1081-1092. https://doi.org/10.1016/j.neuropharm.2004.07.040
  176. Published
    Prickaerts, J., Koopmans, G., Blokland, A., & Scheepens, A. (2004). Learning and adult neurogenesis: survival with or without proliferation? Neurobiology of Learning and Memory, 81(1), 1-11. https://doi.org/10.1016/j.nlm.2003.09.001
  177. 2002
  178. Published
    Dijkstra, J. B., Strik, J. J. M. H., Lousberg, R., Prickaerts, J. H. H. J., Riedel, W. J., Jolles, J., ... Honig, A. (2002). Atypical cognitive profile in patients with depression after myocardial infarction. Journal of Affective Disorders, 20, 181-190. https://doi.org/10.1016/S0165-0327(01)00348-2
  179. Published
    Prickaerts, J. H. H. J., van Staveren, W. C. G., Sik, A., van Markerink, M., Niewohner, U., van der Staay, F. J., ... de Vente, J. (2002). Effects of inhibition of phosphodieserase type 5 on object recognition and hippocampal cyclic GMP levels. Neuroscience, 13, 351-361.
  180. 1998
  181. Published
    Prickaerts, J. H. H. J. (1998). Memory formation, neurodegeneration and drugs : behavioral, neurochemical and neuroanatomical investigations in the rat. Maastricht: NeuroPsych Publishers.

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