
Researcher
Lumens, J.E.
Associate Professor
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- 2019
- PublishedGorcsan, J., Anderson, C. P., Tayal, B., Sugahara, M., Walmsley, J., Starling, R. C., & Lumens, J. (2019). Systolic Stretch Characterizes the Electromechanical Substrate Responsive to Cardiac Resynchronization Therapy. JACC-Cardiovascular Imaging, 12(9), 1741-1752. https://doi.org/10.1016/j.jcmg.2018.07.013
- PublishedHeusinkveld, M. H. G., Delhaas, ET., Lumens, J., Huberts, W., Spronck, B., Hughes, A. D., & Reesink, K. D. (2019). Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model. Journal of Applied Physiology, 127(2), 491-500. https://doi.org/10.1152/japplphysiol.00769.2018
- PublishedHeusinkveld, M. H. G., Huberts, W., Lumens, J., Arts, T., Delhaas, T., & Reesink, K. D. (2019). Large vessels as a tree of transmission lines incorporated in the CircAdapt whole-heart model: A computational tool to examine heart-vessel interaction. PLoS Computational Biology, 15(7), [1007173]. https://doi.org/10.1371/journal.pcbi.1007173
- Published
- PublishedRech, M., Kuhn, A. R., Lumens, J., Carai, P., van Leeuwen, R., Verhesen, W., ... Schroen, B. (2019). AntagomiR-103 and-107 Treatment Affects Cardiac Function and Metabolism. Molecular Therapy - Nucleic Acids, 14, 424-437. https://doi.org/10.1016/j.omtn.2018.12.010
- PublishedMast, T. P., Taha, K., Cramer, M. J., Lumens, J., van der Heijden, J. F., Bouma, B. J., ... Teske, A. J. (2019). The Prognostic Value of Right Ventricular Deformation Imaging in Early Arrhythmogenic Right Ventricular Cardiomyopathy. JACC-Cardiovascular Imaging, 12(3), 446-455. https://doi.org/10.1016/j.jcmg.2018.01.012
- PublishedWillemen, E., Schreurs, R., Huntjens, P. R., Strik, M., Plank, G., Vigmond, E., ... Lumens, J. (2019). The Left and Right Ventricles Respond Differently to Variation of Pacing Delays in Cardiac Resynchronization Therapy: A Combined Experimental- Computational Approach. Frontiers in physiology, 10, 1-13. [17]. https://doi.org/10.3389/fphys.2019.00017
- PublishedNiederer, S. A., Lumens, J., & Trayanova, N. A. (2019). Computational models in cardiology. Nature Reviews Cardiology, 16(2), 100-111. https://doi.org/10.1038/s41569-018-0104-y
- PublishedLumens, J., Fan, C-P. S., Walmsley, J., Yim, D., Manlhiot, C., Dragulescu, A., ... Friedberg, M. K. (2019). Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot. Journal of the American Heart Association, 8(2), [010903]. https://doi.org/10.1161/JAHA.118.010903
- PublishedNoordegraaf, A. V., Chin, K. M., Haddad, F., Hassoun, P. M., Hemnes, A. R., Hopkins, S. R., ... Naeije, R. (2019). Pathophysiology of the right ventricle and of the pulmonary circulation in pulmonary hypertension: an update. European Respiratory Journal, 53(1), [1801900]. https://doi.org/10.1183/13993003.01900-2018
- Publishedvan Mourik, M. J. W., Zaar, D. V. J., Smulders, M. W., Heijman, J., Lumens, J., Dokter, J. E., ... Bekkers, S. C. A. M. (2019). Adding Speckle-Tracking Echocardiography to Visual Assessment of Systolic Wall Motion Abnormalities Improves the Detection of Myocardial Infarction. Journal of the American Society of Echocardiography, 32(1), 65-73. https://doi.org/10.1016/j.echo.2018.09.007
- 2018
- Published
- Published
- PublishedDupuis, L. J., Lumens, J., Arts, T., & Delhaas, T. (2018). High tension in sarcomeres hinders myocardial relaxation: A computational study. PLOS ONE, 13(10), [e0204642]. https://doi.org/10.1371/journal.pone.0204642
- Published
- PublishedPrinzen, F. W., Dagres, N., Bollmann, A., Arnar, D. O., Bove, S., Camm, J., ... Hindricks, G. (2018). Innovation in cardiovascular disease in Europe with focus on arrhythmias: current status, opportunities, roadblocks, and the role of multiple stakeholders. EP Europace, 20(5), 733-738. https://doi.org/10.1093/europace/eux095
- Published
- PublishedHuntjens, P. R., Ploux, S., Strik, M., Walmsley, J., Ritter, P., Haissaguerre, M., ... Bordachar, P. (2018). Electrical Substrates Driving Response to Cardiac Resynchronization Therapy: A Combined Clinical–Computational Evaluation. Circulation-Arrhythmia and Electrophysiology, 11(4), [e005647]. https://doi.org/10.1161/CIRCEP.117.005647
- 2017
- PublishedWalmsley, J., van Everdingen, W., Cramer, M. J., Prinzen, F. W., Delhaas, T., & Lumens, J. (2017). Combining computer modelling and cardiac imaging to understand right ventricular pump function. Cardiovascular Research, 113(12), 1486-1498. https://doi.org/10.1093/cvr/cvx154
- Publishedvan Everdingen, W. M., Walmsley, J., Cramer, M. J., van Hagen, I., De Boeck, B. W. L., Meine, M., ... Leenders, G. E. (2017). Echocardiographic Prediction of Cardiac Resynchronization Therapy Response Requires Analysis of Both Mechanical Dyssynchrony and Right Ventricular Function: A Combined Analysis of Patient Data and Computer Simulations. Journal of the American Society of Echocardiography, 30(10), 1012-1020. https://doi.org/10.1016/j.echo.2017.06.004
- PublishedGorcsan, J., & Lumens, J. (2017). Rocking and Flashing With RV Pacing Implications for Resynchronization Therapy. JACC-Cardiovascular Imaging, 10(10), 1100-1102. https://doi.org/10.1016/j.jcmg.2016.09.020
- PublishedJanousek, J., Kovanda, J., Lozek, M., Tomek, V., Vojtovic, P., Gebauer, R., ... Prinzen, F. (2017). Pulmonary Right Ventricular Resynchronization in Congenital Heart Disease Acute Improvement in Right Ventricular Mechanics and Contraction Efficiency. Circulation-Cardiovascular Imaging, 10(9), [006424]. https://doi.org/10.1161/CIRCIMAGING.117.006424
- PublishedJones, S., Lumens, J., Sohaib, S. M. A., Finegold, J. A., Kanagaratnam, P., Tanner, M., ... BRAVO Investigators (2017). Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function. EP Europace, 19(7), 1178-1186. https://doi.org/10.1093/europace/euw136
- PublishedDerval, N., Duchateau, J., Mahida, S., Eschalier, R., Sacher, F., Lumens, J., ... Bordachar, P. (2017). Distinctive Left Ventricular Activations Associated With ECG Pattern in Heart Failure Patients. Circulation-Arrhythmia and Electrophysiology, 10(6), [e005073]. https://doi.org/10.1161/CIRCEP.117.005073
- PublishedPalau-Caballero, G., Walmsley, J., Van Empel, V., Lumens, J., & Delhaas, T. (2017). Why septal motion is a marker of right ventricular failure in pulmonary arterial hypertension: mechanistic analysis using a computer model. American Journal of Physiology-heart and Circulatory Physiology, 312(4), H691-H700. https://doi.org/10.1152/ajpheart.00596.2016
- 2016
- PublishedPluijmert, M., Bovendeerd, P. H. M., Lumens, J., Vernooy, K., Prinzen, F., & Delhaas, T. (2016). New insights from a computational model on the relation between pacing site and CRT response. EP Europace, 18(Suppl_4), iv94–iv103. https://doi.org/10.1093/europace/euw355
- PublishedMast, T. P., Teske, A. J., Walmsley, J., van der Heijden, J. F., van Es, R., Prinzen, F. W., ... Lumens, J. (2016). Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy. Journal of the American College of Cardiology, 68(20), 2185-2197. https://doi.org/10.1016/j.jacc.2016.08.061
- PublishedPalau-Caballero, G., Walmsley, J., Gorcsan, J. III., Lumens, J., & Delhaas, T. (2016). Abnormal Ventricular and Aortic Wall Properties Can Cause Inconsistencies in Grading Aortic Regurgitation Severity: A Computer Simulation Study. Journal of the American Society of Echocardiography, 29(11), 1122-1130.e4. https://doi.org/10.1016/j.echo.2016.07.015
- Published
- PublishedWalmsley, J., Huntjens, P. R., Prinzen, F. W., Delhaas, T., & Lumens, J. (2016). Septal flash and septal rebound stretch have different underlying mechanisms. American Journal of Physiology-heart and Circulatory Physiology, 310(3), H394-H403. https://doi.org/10.1152/ajpheart.00639.2015
- PublishedPrinzen, F., Vernooy, K., Lumens, J., & Auricchio, A. (2016). Physiology of Cardiac Pacing and Resynchronization. In Clinical Cardiac Pacing, Defibrillation and Resynchronization Therapy (5 ed., pp. 213-248). Elsevier Canada.
- 2015
- Published
- PublishedLumens, J., Tayal, B., Walmsley, J., Delgado-Montero, A., Huntjens, P. R., Schwartzman, D., ... Gorcsan, J. (2015). Differentiating Electromechanical From Non-Electrical Substrates of Mechanical Discoordination to Identify Responders to Cardiac Resynchronization Therapy. Circulation-Cardiovascular Imaging, 8(9), [e003744]. https://doi.org/10.1161/CIRCIMAGING.115.003744
- PublishedWalmsley, J., Arts, T., Derval, N., Bordachar, P., Cochet, H., Ploux, S., ... Lumens, J. (2015). Fast Simulation of Mechanical Heterogeneity in the Electrically Asynchronous Heart Using the MultiPatch Module. PLoS Computational Biology, 11(7), [e1004284]. https://doi.org/10.1371/journal.pcbi.1004284
- PublishedKroon, W., Lumens, J., Potse, M., Suerder, D., Klersy, C., Regoli, F., ... Auricchio, A. (2015). In vivo electromechanical assessment of heart failure patients with prolonged QRS duration. Heart Rhythm, 12(6), 1259-1267. https://doi.org/10.1016/j.hrthm.2015.03.006
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- PublishedPloux, S., Eschalier, R., Whinnett, Z. I., Lumens, J., Derval, N., Sacher, F., ... Bordachar, P. (2015). Electrical dyssynchrony induced by biventricular pacing: Implications for patient selection and therapy improvement. Heart Rhythm, 12(4), 782-791. https://doi.org/10.1016/j.hrthm.2014.12.031
- PublishedEschalier, R., Ploux, S., Lumens, J., Whinnett, Z., Varma, N., Meillet, V., ... Bordachar, P. (2015). Detailed analysis of ventricular activation sequences during right ventricular apical pacing and left bundle branch block and the potential implications for cardiac resynchronization therapy. Heart Rhythm, 12(1), 137-143. https://doi.org/10.1016/j.hrthm.2014.09.059
- PublishedHuntjens, P. R., Walmsley, J., Wu, V., Delhaas, T., Axel, L., & Lumens, J. (2015). Assessment of septal motion abnormalities in left bundle branch block patients using computer simulations. In Functional Imaging and Modeling of the Heart 2015 (pp. 40-47). Berlin Heidelberg: Springer Verlag.
- PublishedPluijmert, M., Lumens, J., Potse, M., Delhaas, T., Auricchio, A., & Prinzen, F. W. (2015). Computer modelling for better diagnosis and therapy of patients by cardiac resynchronisation therapy. Arrhythmia & Electrophysiology Review, 4(1), 62-67. https://doi.org/10.15420/aer.2015.4.1.62
- PublishedPalau Caballero, G., Walmsley, J., Rudenick, P., Evangelista, A., Lumens, J., & Delhaas, T. (2015). Hemodynamics in aortic regurgitation simulated using a computational cardiovascular system model. In Functional Imaging and Modeling of the Heart 2015 (pp. 364-372 ). Berlin Heidelberg: Springer Verlag.
- 2014
- PublishedHuntjens, P. R., Walmsley, J., Ploux, S., Bordachar, P., Prinzen, F. W., Delhaas, T., & Lumens, J. (2014). Influence of left ventricular lead position relative to scar location on response to cardiac resynchronization therapy: a model study. EP Europace, 16 Suppl 4, iv62-iv68. https://doi.org/10.1093/europace/euu231
- PublishedKuijpers, N. H. L., Hermeling, E., Lumens, J., ten Eikelder, H. M. M., Delhaas, T., & Prinzen, F. W. (2014). Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT. American Journal of Physiology-heart and Circulatory Physiology, 306(12), H1644-H1659. https://doi.org/10.1152/ajpheart.00689.2013
- PublishedAuricchio, A., Lumens, J., & Prinzen, F. W. (2014). Does Cardiac Resynchronization Therapy Benefit Patients With Right Bundle Branch Block Cardiac Resynchronization Therapy Has a Role in Patients With Right Bundle Branch Block. Circulation-Arrhythmia and Electrophysiology, 7(3), 532-542. https://doi.org/10.1161/CIRCEP.113.000628
- PublishedBordachar, P., Eschalier, R., Lumens, J., & Ploux, S. (2014). Optimal Strategies on Avoiding CRT Nonresponse. Current treatment options in cardiovascular medicine, 16(5), [299]. https://doi.org/10.1007/s11936-014-0299-0
- PublishedLumens, J. (2014). Creating your own virtual patient with CircAdapt Simulator. European Heart Journal, 35(6), 335-337.
- 2013
- PublishedLumens, J., Ploux, S., Strik, M., Gorcsan, J. III., Cochet, H., Derval, N., ... Bordachar, P. (2013). Comparative Electromechanical and Hemodynamic Effects of Left Ventricular and Biventricular Pacing in Dyssynchronous Heart Failure Electrical Resynchronization Versus Left-Right Ventricular Interaction. Journal of the American College of Cardiology, 62(25), 2395-2403. https://doi.org/10.1016/j.jacc.2013.08.715
- PublishedVonk-Noordegraaf, A., Haddad, F., Chin, K. M., Forfia, P. R., Kawut, S. M., Lumens, J., ... Hassoun, P. M. (2013). Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. Journal of the American College of Cardiology, 62(25 Suppl), D22-33. https://doi.org/10.1016/j.jacc.2013.10.027
- PublishedPloux, S., Lumens, J., Whinnett, Z., Montaudon, M., Strom, M., Ramanathan, C., ... Bordachar, P. (2013). Noninvasive Electrocardiographic Mapping to Improve Patient Selection for Cardiac Resynchronization Therapy Beyond QRS Duration and Left Bundle Branch Block Morphology. Journal of the American College of Cardiology, 61(24), 2435-2443. https://doi.org/10.1016/j.jacc.2013.01.093
- PublishedCochet, H., Denis, A., Ploux, S., Lumens, J., Amraoui, S., Derval, N., ... Bordachar, P. (2013). Pre- and Intra-Procedural Predictors of Reverse Remodeling After Cardiac Resynchronization Therapy: An MRI Study. Journal of Cardiovascular Electrophysiology, 24(6), 682-691. https://doi.org/10.1111/jce.12101