
Researcher
Jacobs, H.I.L.
Assistant Professor
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- 2011
- PublishedEchavarri, C., Aalten, P., Uylings, H. B. M., Jacobs, H. I. L., Visser, P. J., Gronenschild, E. H. B. M., ... Burgmans, S. (2011). Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer's disease. Brain Structure & Function, 215(3-4), 265-271. https://doi.org/10.1007/s00429-010-0283-8
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Uylings, H. B. M., Gronenschild, E. H. B., Verhey, F. R., & Jolles, J. (2011). Atrophy of the parietal lobe in preclinical dementia. Brain and Cognition, 75(2), 154-163. https://doi.org/10.1016/j.bandc.2010.11.003
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., van der Elst, W., Burgmans, S., Smeets, F. G. B., Gronenschild, E. H. B. M., ... Jolles, J. (2011). Increasing the diagnostic accuracy of medial temporal lobe atrophy in Alzheimer's disease. Journal of Alzheimer's Disease, 25(3), 477-490. https://doi.org/10.3233/JAD-2011-102043
- PublishedJacobs, H. I. L. (2011). Parietal matters in early Alzheimer's disease : evidence from structural and functional MRI. Maastricht: NeuroPsych Publishers.
- PublishedBurgmans, S., van Boxtel, M. P. J., Berg, K. E. M., Gronenschild, E. H. B. M., Jacobs, H. I. L., Jolles, J., & Uylings, H. B. M. (2011). The posterior parahippocampal gyrus is preferentially affected in age-related memory decline. Neurobiology of Aging, 32(9), 1572-1578. https://doi.org/10.1016/j.neurobiolaging.2009.09.008
- 2012
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Heinecke, A., Gronenschild, E. H. B. M., Backes, W. H., Ramakers, I. H. G. B., ... Verhey, F. R. J. (2012). Functional integration of parietal lobe activity in early Alzheimer disease. Neurology, 78(5), 352-360. https://doi.org/10.1212/WNL.0b013e318245287d
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Jolles, J., Verhey, F. R. J., & Uylings, H. B. M. (2012). Parietal cortex matters in alzheimer's disease: An overview of structural, functional and metabolic findings. Neuroscience and Biobehavioral Reviews, 36(1), 297-309. https://doi.org/10.1016/j.neubiorev.2011.06.009
- PublishedJacobs, H. I. L., Visser, P. J., van Boxtel, M. P. J., Frisoni, G. B., Tsolaki, M., Papapostolou, P., ... Verhey, F. R. J. (2012). The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent. Neurobiology of Aging, 33(1), 201.e1-201.e8. [ARTN 201.e1]. https://doi.org/10.1016/j.neurobiolaging.2010.07.015
- PublishedGronenschild, E. H. B. M., Habets, P., Jacobs, H. I. L., Mengelers, R., Rozendaal, N., van Os, J., & Marcelis, M. (2012). The Effects of FreeSurfer Version, Workstation Type, and Macintosh Operating System Version on Anatomical Volume and Cortical Thickness Measurements. PLOS ONE, 7(6), [e38234]. https://doi.org/10.1371/journal.pone.0038234
- PublishedBeral, V., Bull, D., Pirie, K., Reeves, G., Peto, R., Skegg, D., ... Fukao, A. (2012). Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet oncology, 13(11), 1141-1151. https://doi.org/10.1016/S1470-2045(12)70425-4
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Williams, V. J., Burgmans, S., Uylings, H. B. M., ... Verhey, F. R. J. (2012). Patterns of Gray and White Matter Changes in Individuals at Risk for Alzheimer's Disease. Current Alzheimer Research, 9(9), 1097-1105. https://doi.org/10.2174/156720512803568993
- 2013
- PublishedBruner, E., & Jacobs, H. I. L. (2013). Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe? Journal of Alzheimer's Disease, 35(2), 227-240. https://doi.org/10.3233/JAD-122299
- PublishedJacobs, H. I. L., Leritz, E. C., Williams, V. J., van Boxtel, M. P. J., van der Elst, W., Jolles, J., ... Salat, D. H. (2013). Association between white matter microstructure, executive functions, and processing speed in older adults: The impact of vascular health. Human Brain Mapping, 34(1), 77-95. https://doi.org/10.1002/hbm.21412
- PublishedJacobs, H. I. L., van Boxtel, M. P. J., Gronenschild, E. H. B. M., Uylings, H. B. M., Jolles, J., & Verhey, F. R. J. (2013). Decreased gray matter diffusivity: a potential early Alzheimer's disease biomarker? Alzheimer's & Dementia, 9(1), 93-97. https://doi.org/10.1016/j.jalz.2011.11.004
- PublishedMills, J. D., Nalpathamkalam, T., Jacobs, H. I. L., Janitz, C., Merico, D., Hu, P., & Janitz, M. (2013). RNA-Seq analysis of the parietal cortex in Alzheimer's disease reveals alternatively spliced isoforms related to lipid metabolism. Neuroscience Letters, 536, 90-95. https://doi.org/10.1016/j.neulet.2012.12.042
- Published
- PublishedClerx, L., Jacobs, H. I. L., Burgmans, S., Gronenschild, E. H. B. M., Uylings, H. B. M., Echavarri, C., ... Aalten, P. (2013). Sensitivity of Different MRI-Techniques to Assess Gray Matter Atrophy Patterns in Alzheimer's Disease is Region-Specific. Current Alzheimer Research, 10(9), 940-951. https://doi.org/10.2174/15672050113109990158
- 2014
- PublishedJacobs, H. I. L., Clerx, L., Gronenschild, E. H. B. M., Aalten, P., & Verhey, F. R. J. (2014). White Matter Hyperintensities are Positively Associated with Cortical Thickness in Alzheimer's Disease. Journal of Alzheimer's Disease, 39(2), 409-422. https://doi.org/10.3233/JAD-131232
- Published
- PublishedBruner, E., Rangel de Lazaro, G., Manuel de la Cuetara, J., Martin-Loeches, M., Colom, R., & Jacobs, H. I. L. (2014). Midsagittal brain variation and MRI shape analysis of the precuneus in adult individuals. Journal of Anatomy, 224(4), 367-376. https://doi.org/10.1111/joa.12155
- 2015
- PublishedClerx, L., Gronenschild, E. H. B. M., Echavarri, C., Verhey, F., Aalten, P., & Jacobs, H. I. L. (2015). Can FreeSurfer Compete with Manual Volumetric Measurements in Alzheimer's Disease? Current Alzheimer Research, 12(4), 358-367. https://doi.org/10.2174/1567205012666150324174813
- PublishedJacobs, H. I. L., Wiese, S., van de Ven, V., Gronenschild, E. H. B. M., Verhey, F. R. J., & Matthews, P. M. (2015). Relevance of parahippocampal-locus coeruleus connectivity to memory in early dementia. Neurobiology of Aging, 36(2), 618-626. https://doi.org/10.1016/j.neurobiolaging.2014.10.041
- PublishedJacobs, H. I. L., Gronenschild, E. H. B. M., Evers, E. A. T., Ramakers, I. H. G. B., Hofman, P. A. M., Backes, W. H., ... van Boxtel, M. P. J. (2015). Visuospatial processing in early Alzheimer's disease: a multimodal neuroimaging study. Cortex, 64, 394-406. https://doi.org/10.1016/j.cortex.2012.01.005
- PublishedJacobs, H. I. L., Dillen, K. N. H., Risius, O., Goereci, Y., Onur, O. A., Fink, G. R., & Kukolja, J. (2015). Consolidation in older adults depends upon competition between resting-state networks. Frontiers in Aging Neuroscience, 6, [344]. https://doi.org/10.3389/fnagi.2014.00344
- PublishedJacobs, H. I. L., Riphagen, J. M., Razat, C. M., Wiese, S., & Sack, A. T. (2015). Transcutaneous vagus nerve stimulation boosts associative memory in older individuals. Neurobiology of Aging, 36(5), 1860-1867. https://doi.org/10.1016/j.neurobiolaging.2015.02.023
- 2016
- PublishedDillen, K. N. H., Jacobs, H. I. L., Kukolja, J., von Reutern, B., Richter, N., Onur, O. A., ... Fink, G. R. (2016). Aberrant functional connectivity differentiates retrosplenial cortex from posterior cingulate cortex in prodromal Alzheimer's disease. Neurobiology of Aging, 44, 114-126. https://doi.org/10.1016/j.neurobiolaging.2016.04.010
- 2017
- PublishedDillen, K. N. H., Jacobs, H. I. L., Kukolja, J., Richter, N., von Reutern, B., Onur, O. A., ... Fink, G. R. (2017). Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's Disease. Journal of Alzheimer's Disease, 59(1), 169-187. https://doi.org/10.3233/JAD-161120
- PublishedCleutjens, F. A. H. M., Ponds, R. W. H. M., Spruit, M. A., Burgmans, S., Jacobs, H. I. L., Gronenschild, E. H. B. M., ... Janssen, D. J. A. (2017). The Relationship between Cerebral Small Vessel Disease, Hippocampal Volume and Cognitive Functioning in Patients with COPD: An MRI Study. Frontiers in Aging Neuroscience, 9, [88]. https://doi.org/10.3389/fnagi.2017.00088
- PublishedDekhtyar, M., Papp, K. V., Buckley, R., Jacobs, H. I. L., Schultz, A. P., Johnson, K. A., ... Rentz, D. M. (2017). Neuroimaging markers associated with maintenance of optimal memory performance in late-life. Neuropsychologia, 100, 164-170. https://doi.org/10.1016/j.neuropsychologia.2017.04.037
- PublishedFreeze, W. M., Schnerr, R. S., Palm, W. M., Jansen, J. F., Jacobs, H. I., Hoff, E. I., ... Backes, W. H. (2017). Pericortical Enhancement on Delayed Postgadolinium Fluid-Attenuated Inversion Recovery Images in Normal Aging, Mild Cognitive Impairment, and Alzheimer Disease. American Journal of Neuroradiology, 38(9), 1742-1747. https://doi.org/10.3174/ajnr.A5273
- PublishedFreeze, W. M., Jacobs, H. I. L., Gronenschild, E. H., Jansen, J. F. A., Burgmans, S., Aalten, P., ... LeARN Project (2017). White Matter Hyperintensities Potentiate Hippocampal Volume Reduction in Non-Demented Older Individuals with Abnormal Amyloid-beta. Journal of Alzheimer's Disease, 55(1), 333-342. https://doi.org/10.3233/JAD-160474
- PublishedJacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2017). CORRIGENDUM: The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline (awx194, 2017). Brain, 140, E77-E77. https://doi.org/10.1093/brain/awx257
- PublishedBos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., ... Vos, S. J. B. (2017). Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimer's Research & Therapy, 9, [101]. https://doi.org/10.1186/s13195-017-0328-9
- 2018
- PublishedAlzheimers Dis Neuroimaging Initia, Muller-Ehrenberg, L., Riphagen, J. M., Verhey, F. R. J., Sack, A. T., & Jacobs, H. I. L. (2018). Alzheimer's Disease Biomarkers Have Distinct Associations with Specific Hippocampal Subfield Volumes. Journal of Alzheimer's Disease, 66(2), 811-823. https://doi.org/10.3233/JAD-180676
- PublishedLee, C. M., Jacobs, H. I. L., Marquie, M., Becker, J. A., Andrea, N. V., Jin, D. S., ... Johnson, K. A. (2018). 18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal. Journal of Alzheimer's Disease, 62(4), 1691-1702. https://doi.org/10.3233/JAD-170840
- PublishedJacobs, H. I. L., Hopkins, D. A., Mayrhofer, H. C., Bruner, E., van Leeuwen, F. W., Raaijmakers, W., & Schmahmann, J. D. (2018). The cerebellum in Alzheimer's disease: evaluating its role in cognitive decline. Brain, 141, 37-47. https://doi.org/10.1093/brain/awx194
- Published
- PublishedJacobs, H. I. L., Hedden, T., Schultz, A. P., Sepulcre, J., Perea, R. D., Amariglio, R. E., ... Johnson, K. A. (2018). Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience, 21(3), 424–431 . https://doi.org/10.1038/s41593-018-0070-z
- PublishedBos, I., Verhey, F. R., Ramakers, I. H. G. B., Jacobs, H. I. L., Soininen, H., Freund-Levi, Y., ... Vos, S. J. B. (2018). Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline (vol 9, 101, 2017). Alzheimer's Research & Therapy, 10, [56]. https://doi.org/10.1186/s13195-018-0391-x
- PublishedRiphagen, J. M., Gronenschild, E. H. B. M., Salat, D. H., Freeze, W. M., Ivanov, D., Clerx, L., ... Jacobs, H. I. L. (2018). Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia. Neurobiology of Aging, 68, 48-58. https://doi.org/10.1016/j.neurobiolaging.2018.03.029
- PublishedAlzheimer's Dis Neuroimaging Initi, Van Hooren, R. W. E., Riphagen, J. M., & Jacobs, H. I. L. (2018). Inter-network connectivity and amyloid-beta linked to cognitive decline in preclinical Alzheimer's disease: a longitudinal cohort study. Alzheimer's Research & Therapy, 10(88), 1-12. [88]. https://doi.org/10.1186/s13195-018-0420-9
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- PublishedRosenberg, J., Jacobs, H. I. L., Maximov, I. I., Reske, M., & Shah, N. J. (2018). Chronotype differences in cortical thickness: grey matter reflects when you go to bed. Brain Structure & Function, 223(7), 3411-3421. https://doi.org/10.1007/s00429-018-1697-y
- PublishedCollaborators Alzheimer's Dis Neur; Australian Imaging Biomarker Lifes; Harvard Aging Brain Study, Buckley, R. F., Mormino, E. C., Amariglio, R. E., Properzi, M. J., Rabin, J. S., ... Sperling, R. A. (2018). Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimer's & Dementia, 14(9), 1193-1203. https://doi.org/10.1016/j.jalz.2018.04.010
- PublishedBachmann, C., Jacobs, H. I. L., Mana, P. P., Dillen, K., Richter, N., von Reutern, B., ... Morrison, A. (2018). On the Extraction and Analysis of Graphs From Resting-State fMRI to Support a Correct and Robust Diagnostic Tool for Alzheimer's Disease. Frontiers in Neuroscience, 12, [528]. https://doi.org/10.3389/fnins.2018.00528
- PublishedJacobs, H. I. L., & Buckley, R. F. (2018). Where do white matter alterations dovetail with the cascade model of Alzheimer's disease? Brain, 141, 2830-2833. https://doi.org/10.1093/brain/awy243
- PublishedAlzheimers Dis Neuroimaging Initia; Harvard Aging Brain Study, Hanseeuw, B. J., Betensky, R. A., Mormino, E. C., Schultz, A. P., Sepulcre, J., ... Johnson, K. A. (2018). PET staging of amyloidosis using striatum. Alzheimer's & Dementia, 14(10), 1281-1292. https://doi.org/10.1016/j.jalz.2018.04.011
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- PublishedFreeze, W. M., Jacobs, H. I. L., Schreuder, F. H. B. M., van Oostenbrugge, R. J., Backes, W. H., Verhey, F. R., & Klijn, C. J. M. (2018). Blood-Brain Barrier Dysfunction in Small Vessel Disease Related Intracerebral Hemorrhage. Frontiers in Neurology, 9, [926]. https://doi.org/10.3389/fneur.2018.00926
- PublishedUquillas, F. DO., Jacobs, H. I. L., Biddle, K. D., Properzi, M., Hanseeuw, B., Schultz, A. P., ... Donovan, N. J. (2018). Regional tau pathology and loneliness in cognitively normal older adults. Translational Psychiatry, 8, [282]. https://doi.org/10.1038/s41398-018-0345-x