Floor Moenen

2024

Peri-operative desmopressin combined with pharmacokinetic-guided factor VIII concentrate in non-severe haemophilia A patients

Romano, L. G. R., Schutte, L. M., van Hest, R. M., Meijer, K., Laros-van Gorkom, B. A. P., Nieuwenhuizen, L., Eikenboom, J., Heubel-Moenen, F. C. J. I., Uitslager, N., Coppens, M., Fijnvandraat, K., Driessens, M. H. E., Polinder, S., Cnossen, M. H., Leebeek, F. W. G., Mathot, R. A. A., Kruip, M. J. H. A. & DAVID SYMPHONY Consortium, Mar 2024, In: Haemophilia. 30, 2, p. 355-366 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Predictive performance of pharmacokinetic-guided prophylactic dosing of factor concentrates in hemophilia A and B

Goedhart, T. M. H. J., Bukkems, L. H., Zwagemaker, A. F., Coppens, M., Fijnvandraat, K., Schols, S. E. M., Schutgens, R. E. G., Eikenboom, J., Heubel-Moenen, F. C. J. I., Ypma, P. F., Nieuwenhuizen, L., Meijer, K., Leebeek, F. W. G., Mathôt, R. A. A., Cnossen, M. H. & OPTI-CLOT study group and SYMPHONY consortium, 1 Mar 2024, In: Research and practice in thrombosis and haemostasis. 8, 3, 102397.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Restraining of glycoprotein VI- and integrin a2ß1-dependent thrombus formation by platelet PECAM1

Jooss, N. J., Diender, M. G., Fernandez, D. I., Huang, J., Heubel-Moenen, F. C. J., van der Veer, A., Kuijpers, M. J. E., Poulter, N. S., Henskens, Y. M. C., te Loo, M. & Heemskerk, J. W. M., 1 Dec 2024, In: Cellular and Molecular Life Sciences. 81, 1, 14 p., 44.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Standardisation of Definition and Management for Bleeding Disorder of Unknown Cause: Communication from the SSC of the ISTH

Baker, R. I., Choi, P., Curry, N., Gebhart, J., Gomez, K., Henskens, Y., Heubel-Moenen, F., James, P., Abdul Kadir, R., Kouides, P., Lavin, M., Lordkipanidze, M., Lowe, G., Mumford, A., Mutch, N., Nagler, M., Othman, M., Pabinger, I., Sidonio, R., Thomas, W., & 2 othersO'Donnell, J. S. & ISTH SSC Von Willebrand Factor, Platelet Physiology and Women’s Health Issues in Thrombosis and Haemostasis., 20 Mar 2024, (E-pub ahead of print) In: Journal of Thrombosis and Haemostasis.

Research output: Contribution to journal › Article › Academic › peer-review

Type 1 VWD classification revisited - novel insights from combined analysis of the LoVIC and WiN studies

Atiq, F., Blok, R., van Kwawegen, C., Doherty, D., Lavin, M., van der Bom, J. G., O'Connell, N. M., de Meris, J., Ryan, K., Schols, S. E. M., Byrne, M. B., Heubel-Moenen, F. C. J. I., van Galen, K. P. M., Preston, R. J. S., Cnossen, M. H., Fijnvandraat, K., Baker, R. I., Meijer, K., James, P. D., Di Paola, J., & 3 othersEikenboom, J. C. J., Leebeek, F. W. G. & O'Donnell, J. S., 4 Apr 2024, In: Blood. 143, 14, p. 1414-1424 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

2023

Colorectal cancer screening in patients with inherited bleeding disorders: high cancer detection rate in hemophilia patients

Kempers, E. K., van Kwawegen, C. B., de Meris, J., Spaander, M. C. W., Schols, S. E. M., Ypma, P. F., Heubel-Moenen, F. C. J. I., van Vulpen, L. F. D., Coppens, M., van der Bom, J. G., Fijnvandraat, K., Meijer, K., Eikenboom, J., Gouw, S. C., Leebeek, F. W. G. & Kruip, M. J. H. A., May 2023, In: Journal of Thrombosis and Haemostasis. 21, 5, p. 1177-1188 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Desmopressin in nonsevere hemophilia A: patient perspectives on use and efficacy

Romano, L. G. R., van Vulpen, L. F. D., den Exter, P. L., Heubel-Moenen, F. C. J. I., Hooijmeijer, H. L., Coppens, M., Fijnvandraat, K., Schols, S. E. M., Ypma, P. F., Smit, C., Driessens, M. H. E., Md, F. R. R., van der Bom, J. G., Gouw, S. C. & Kruip, M. J. H. A., 1 Jul 2023, In: Research and practice in thrombosis and haemostasis. 7, 5, 8 p., 100281.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Effectiveness and costs of a stepwise versus an all-in-one approach to diagnose mild bleeding disorders

Heubel-Moenen, F. C. J. I., Ansems, L. E. M., Verhezen, P. W. M., Wetzels, R. J. H., van Oerle, R. G. M., Straat, R. J. M. H. E., Megy, K., Downes, K., Henskens, Y. M. C., Beckers, E. A. M. & Joore, M. A., Mar 2023, In: British Journal of Haematology. 200, 6, p. 792-801 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Nationwide study of eculizumab in paroxysmal nocturnal hemoglobinuria: Evaluation of treatment indications and outcomes

Schaap, C. C. M., Heubel-Moenen, F. C. J. I., Nur, E., Bartels, M., van der Heijden, O. W. H., de Jonge, E., Preijers, F. W. M. B., Blijlevens, N. M. A., Langemeijer, S. M. C. & Dutch PNH Working Group, Jun 2023, In: European Journal of Haematology. 110, 6, p. 648-658 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Sensitive Measurement of Clinically Relevant Factor VIII Levels in Thrombin Generation Assays Requires Presence of Factor XIa

Van de Berg, T. W., Beckers, E. A. M., Heubel-Moenen, F. C. J. I., Henskens, Y. M. C., Thomassen, M. C. L. G. D. & Hackeng, T. M., Nov 2023, In: Thrombosis and Haemostasis. 123, 11, p. 1034-1041 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Transition readiness among adolescents and young adults with haemophilia in the Netherlands: Nationwide questionnaire study

Brands, M. R., Janssen, E. A. M., Cnossen, M. H., Smit, C., van Vulpen, L. F. D., van der Valk, P. R., Eikenboom, J., Heubel-Moenen, F. C. J. I., Hooimeijer, L., Ypma, P., Nieuwenhuizen, L., Coppens, M., Schols, S. E. M., Laros-van Gorkom, B. A. P., Leebeek, F. W. G., Driessens, M. H. E., Rosendaal, F. R., van der Bom, J. G., Fijnvandraat, K. & Gouw, S. C., Sept 2023, In: Haemophilia. 29, 5, p. 1191-1201 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2022

Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study

Post, D. S., van der Veer, A., Schijns, O. E. M. G., Klinkenberg, S., Rijkers, K., Wagner, G. L., van Kranen-Mastenbroek, V. H. J. M., Willems, P. C. P. H., Verhezen, P. W. M., Beckers, E. A. M., Heubel-Moenen, F. C. J. I. & Henskens, Y. M. C., 25 Feb 2022, In: PLOS ONE. 17, 2, 16 p., e0264351.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Design of a Prospective Study on Pharmacokinetic-Guided Dosing of Prophylactic Factor Replacement in Hemophilia A and B (OPTI-CLOT TARGET Study)

Goedhart, T. M. H. J., Bukkems, L. H., Coppens, M., Fijnvandraat, K. J., Schols, S. E. M., Schutgens, R. E. G., Eikenboom, J., Heubel-Moenen, F. C. J. I., Ypma, P. F., Nieuwenhuizen, L., Meijer, K., Leebeek, F. W. G., Mathôt, R. A. A. & Cnossen, M. H., Jan 2022, In: TH open : companion journal to thrombosis and haemostasis. 6, 1, p. e60-e69

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Diagnostics and mechanisms of hemostasis: In patients with mild bleeding disorders and thrombocytopenia

Heubel-Moenen, F. C. J. I., 2022, Maastricht: ProefschriftMaken. 249 p.

Research output: Thesis › Doctoral Thesis › Internal

Open Access

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1093 Downloads (Pure)

GPVI expression is linked to platelet size, age, and reactivity

Veninga, A., Handtke, S., Aurich, K., Tullemans, B., Brouns, S., Schwarz, S. L., Heubel-Moenen, F. C., Greinacher, A., Heemskerk, J. W. M., van der Meijden, P. & Thiele, T., 26 Jul 2022, In: Blood advances. 6, 14, p. 4162-4173 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Multiparameter platelet function analysis of bleeding patients with a prolonged platelet function analyser closure time

Heubel-Moenen, F. C. J. I., Brouns, S. L. N., Herfs, L., Boerenkamp, L. S., Jooss, N. J., Wetzels, R. J. H., Verhezen, P. W. M., Machiels, P., Megy, K., Downes, K., Heemskerk, J. W. M., Beckers, E. A. M. & Henskens, Y. M. C., Mar 2022, In: British Journal of Haematology. 196, 6, p. 1388-1400 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2021

Multiparameter microfluidics assay of thrombus formation reveals increased sensitivity to contraction and antiplatelet agents at physiological temperature

Herfs, L., Swieringa, F., Jooss, N., Kozlowski, M., Heubel-Moenen, F. C. J., van Oerle, R., Machiels, P., Henskens, Y. & Heemskerk, J. W. M., Jul 2021, In: Thrombosis Research. 203, p. 46-56 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation

Perrella, G., Huang, J., Provenzale, I., Swieringa, F., Heubel-Moenen, F. C. J., Farndale, R. W., Roest, M., van der Meijden, P. E. J., Thomas, M., Ariens, R. A. S., Jandrot-Perrus, M., Watson, S. P. & Heemskerk, J. W. M., Feb 2021, In: Arteriosclerosis Thrombosis and Vascular Biology. 41, 2, p. E97-E111 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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44 Downloads (Pure)

2020

Donor fecal microbiota transplantation ameliorates intestinal graft-versus-host disease in allogeneic hematopoietic cell transplant recipients

van Lier, Y. F., Davids, M., Haverkate, N. J. E., de Groot, P. F., Donker, M. L., Meijer, E., Heubel-Moenen, F. C. J. I., Nur, E., Zeerleder, S. S., Nieuwdorp, M., Blom, B. & Hazenberg, M. D., 12 Aug 2020, In: Science Translational Medicine. 12, 556, 12 p., 8926.

Research output: Contribution to journal › Article › Academic › peer-review

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

Thaventhiran, J. E. D., Allen, H. L., Burren, O. S., Rae, W., Greene, D., Staples, E., Zhang, Z., Farmery, J. H. R., Simeoni, I., Rivers, E., Maimaris, J., Penkett, C. J., Stephens, J., Deevi, S. V. V., Sanchis-Juan, A., Gleadall, N. S., Thomas, M. J., Sargur, R. B., Gordins, P., Baxendale, H. E., & 36 othersBrown, M., Tuijnenburg, P., Worth, A., Hanson, S., Linger, R. J., Buckland, M. S., Rayner-Matthews, P. J., Gilmour, K. C., Samarghitean, C., Seneviratne, S. L., Sansom, D. M., Lynch, A. G., Megy, K., Ellinghaus, E., Ellinghaus, D., Jorgensen, S. F., Karlsen, T. H., Stirrups, K. E., Cutler, A. J., Kumararatne, D. S., Chandra, A., Edgar, J. D. M., Herwadkar, A., Cooper, N., Grigoriadou, S., Huissoon, A. P., Goddard, S., Jolles, S., Schuetz, C., Boschann, F., Primary Immunodeficiency Consortium for the NIHR Bioresource, Heemskerk, J., Henskens, Y., Moenen, F., Vries, M. & Smith, K. G. C., 2 Jul 2020, In: Nature. 583, 7814, p. 90-95 24 p.

Research output: Contribution to journal › Article › Academic › peer-review

2019

Fibrinolysis in patients with chemotherapy-induced thrombocytopenia and the effect of platelet transfusion

Heubel-Moenen, F. C. J. I., Henskens, Y. M. C., Verhezen, P. W. M., Wetzels, R. J. H., Schouten, H. C. & Beckers, E. A. M., Jul 2019, In: Journal of Thrombosis and Haemostasis. 17, 7, p. 1073-1084 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

Screening for platelet function disorders with Multiplate and platelet function analyzer

Moenen, F. C. J., Vries, M. J. A., Nelemans, P. J., van Rooy, K. J. M., Vranken, J. R. R. A., Verhezen, P. W. M., Wetzels, R. J. H., ten Cate, H., Schouten, H. C., Beckers, E. A. M. & Henskens, Y. M. C., 2 Jan 2019, In: Platelets. 30, 1, p. 81-87 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

2018