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Researcher

Hebels, D.G.A.J.

Project Leader

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1 - 26 out of 26Page size: 50
  1. 2019
  2. Published
    Espin-Perez, A., Hebels, D. G. A. J., Kiviranta, H., Rantakokko, P., Georgiadis, P., Botsivali, M., ... de Kok, T. M. C. M. (2019). Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs). Scientific Reports, 9, 1-12. [746]. https://doi.org/10.1038/s41598-018-37449-y
  3. 2017
  4. Published
    Hebels, D. G. A. J., Carlier, A., Coonen, M. L. J., Theunissen, D. H., & de Boer, J. (2017). cBiT: A transcriptomics database for innovative biomaterial engineering. Biomaterials, 149, 88-97. https://doi.org/10.1016/j.biomaterials.2017.10.008
  5. Published
    Plusquin, M., Guida, F., Polidoro, S., Vermeulen, R., Raaschou-Nielsen, O., Campanella, G., ... Chadeau-Hyam, M. (2017). DNA methylation and exposure to ambient air pollution in two prospective cohorts. Environment International, 108, 127-136. https://doi.org/10.1016/j.envint.2017.08.006
  6. Published
    Georgiadis, P., Liampa, I., Hebels, D. G., Krauskopf, J., Chatziioannou, A., Valavanis, I., ... EnviroGenomarkers Consortium (2017). Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis. BMC Genomics, 18, [728]. https://doi.org/10.1186/s12864-017-4117-4
  7. Published
    Krauskopf, J., de Kok, T. M., Hebels, D. G., Bergdahl, I. A., Johansson, A., Spaeth, F., ... Kleinjans, J. C. (2017). MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery. Scientific Reports, 7, [9262]. https://doi.org/10.1038/s41598-017-10167-7
  8. Published
    Mostafavi, N., Vlaanderen, J., Portengen, L., Chadeau-Hyam, M., Modig, L., Palli, D., ... Vermeulen, R. (2017). Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides. Epidemiology, 28(3), 320-328. https://doi.org/10.1097/EDE.0000000000000628
  9. Published
    Vlaanderen, J., Leenders, M., Chadeau-Hyam, M., Portengen, L., Kyrtopoulos, S. A., Bergdahl, I. A., ... Vermeulen, R. C. H. (2017). Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage. BMC Genomics, 18, [239]. https://doi.org/10.1186/s12864-017-3627-4
  10. Published
    Groen, N., Yuan, H., Hebels, D. G. A. J., Kocer, G., Mbuyi, F., LaPointe, V., ... de Boer, J. (2017). Linking the Transcriptional Landscape of Bone Induction to Biomaterial Design Parameters. Advanced Materials, 29(10), [1603259]. https://doi.org/10.1002/adma.201603259
  11. Published
    Chatziioannou, A., Georgiadis, P., Hebels, D. G., Liampa, I., Valavanis, I., Bergdahl, I. A., ... EnviroGenomarkers Project Consorti (2017). Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases. Scientific Reports, 7, [42870]. https://doi.org/10.1038/srep42870
  12. Published
    Kelly, R. S., Kiviranta, H., Bergdahl, I. A., Palli, D., Johansson, A-S., Botsivali, M., ... Chadeau-Hyam, M. (2017). Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study. Environmental Health, 16, [9]. https://doi.org/10.1186/s12940-017-0214-8
  13. 2016
  14. Published
    Hardt, C., Beber, M. E., Rasche, A., Kamburov, A., Hebels, D. G., Kleinjans, J. C., & Herwig, R. (2016). ToxDB: pathway-level interpretation of drug-treatment data. Database-The Journal of Biological Databases and Curation, 2016, [baw052]. https://doi.org/10.1093/database/baw052
  15. Published
    Georgiadis, P., Hebels, D. G., Valavanis, I., Liampa, I., Bergdahl, I. A., Johansson, A., ... Kyrtopoulos, S. A. (2016). Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking. Scientific Reports, 6, [20544]. https://doi.org/10.1038/srep20544
  16. Published
    Hebels, D., Rasche, A., Herwig, R., van Westen, G. J. P., Jennen, D., & Kleinjans, J. (2016). A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure. In E. Benfenati (Ed.), In Silico Methods for Predicting Drug Toxicity (1 ed., Vol. 1425, pp. 339-359). (Methods in Molecular Biology). Humana Press. https://doi.org/10.1007/978-1-4939-3609-0
  17. 2015
  18. Published
    Hendrickx, D., Aerts, H., Caiment, F., Clark, D., Ebbels, T. M., Evelo, C. T., ... Kleinjans, J. C. (2015). diXa: a data infrastructure for chemical safety assessment. Bioinformatics, 31(9), 1505-1507. https://doi.org/10.1093/bioinformatics/btu827
  19. 2014
  20. Published
    Hebels, D. G. A. J., van Herwijnen, M. H. M., Brauers, K. J. J., de Kok, T. M. C. M., Chalkiadaki, G., Kyrtopoulos, S. A., & Kleinjans, J. C. S. (2014). Elimination of Heparin Interference During Microarray Processing of Fresh and Biobank-Archived Blood Samples. Environmental and Molecular Mutagenesis, 55(6), 482-491. https://doi.org/10.1002/em.21869
  21. Published
    Chadeau-Hyam, M., Vermeulen, R. C. H., Hebels, D. G. A. J., Castagne, R., Campanella, G., Portengen, L., ... Kyrtopoulos, S. A. (2014). Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis. Annals of Oncology, 25(5), 1065-1072. https://doi.org/10.1093/annonc/mdu056
  22. Published
    Hebels, D. G. A., Jetten, M. J. A., Aerts, H. J. W., Herwig, R., Theunissen, D. H. J., Gaj, S., ... Kleinjans, J. C. S. (2014). Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity. Biomarkers in Medicine, 8(2), 185-200. https://doi.org/10.2217/bmm.13.154
  23. 2013
  24. Published
    Hebels, D. G. A. J., Georgiadis, P., Keun, H. C., Athersuch, T. J., Vineis, P., Vermeulen, R., ... Kyrtopoulos, S. A. (2013). Performance in Omics Analyses of Blood Samples in Long-Term Storage: Opportunities for the Exploitation of Existing Biobanks in Environmental Health Research. Environmental Health Perspectives, 121(4), 480-487. https://doi.org/10.1289/ehp.1205657
  25. 2012
  26. Published
    Hebels, D., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., ... de Kok, T. M. (2012). Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon. Food and Chemical Toxicology, 50(2), 95-103. https://doi.org/10.1016/j.fct.2011.10.038
  27. 2011
  28. Published
    Hebels, D. G. A. J., Brauers, K. J. J., van Herwijnen, M. H. M., Georgiadis, P. A., Kyrtopoulos, S. A., Kleinjans, J. C. S., & de Kok, T. M. C. M. (2011). Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells. Toxicology Letters, 207(3), 232-241. https://doi.org/10.1016/j.toxlet.2011.09.012
  29. Published
    Hebels, D. G. A. J., Jennen, D. G. J., van Herwijnen, M. H. M., Moonen, E. J. C., Pedersen, M., Knudsen, L. E., ... de Kok, T. M. C. M. (2011). Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells. Mutagenesis, 26(6), 753-761. https://doi.org/10.1093/mutage/ger043
  30. Published
    Hebels, D. G., Sveje, K. M., de Kok, M. C., van Herwijnen, M. H., Kuhnle, G. G., Engels, L. G. B., ... de Kok, T. M. (2011). N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer. Cancer Letters, 309(1), 1-10. https://doi.org/10.1016/j.canlet.2011.05.007
  31. 2010
  32. Published
    Hebels, D. G. A. J., Briedé, J. J., Khampang, R., Kleinjans, J. C. S., & de Kok, T. M. C. M. (2010). Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells. Toxicological Sciences, 116(1), 194-205. https://doi.org/10.1093/toxsci/kfq121
  33. Published
    Hebels, D. G. (2010). Toxicogenomic responses to N-Nitroso compound exposure in relation to human colorectal cancer risk. Maastricht: Datawyse / Universitaire Pers Maastricht.
  34. 2009
  35. Published
    Hebels, D. G., Jennen, D. G., Kleinjans, J. C., & de Kok, T. M. (2009). Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis. Toxicological Sciences, 108(2), 290-300. https://doi.org/10.1093/toxsci/kfp035
  36. 2007
  37. Published
    Staal, Y. C., Hebels, D. G., van Herwijnen, M. H., Gottschalk, R. W., van Schooten, F. J., & van Delft, J. H. (2007). Binary PAH-mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation. Carcinogenesis, 28(12), 2632-2640. https://doi.org/10.1093/carcin/bgm182

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