
Researcher
Schols, A.M.W.J.
Full professor - Personal chair
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- 2019
- PublishedLeermakers, P. A., Kneppers, A. E. M., Schols, A. M. W. J., Kelders, M. C. J. M., de Theije, C. C., Verdijk, L. B., ... Gosker, H. R. (2019). Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation. Muscle & Nerve, 60(6), 769-778. https://doi.org/10.1002/mus.26702
- Publishedde Jong, E. E. C., Sanders, K. J. C., Deist, T. M., van Elmpt, W., Jochems, A., van Timmeren, J. E., ... Lambin, P. (2019). Can radiomics help to predict skeletal muscle response to chemotherapy in stage IV non-small cell lung cancer? European Journal of Cancer, 120, 107-113. https://doi.org/10.1016/j.ejca.2019.07.023
- PublishedBauer, J., Morley, J. E., Schols, A. M. W. J., Ferrucci, L., Cruz-Jentoft, A. J., Dent, E., ... Anker, S. D. (2019). Sarcopenia: A Time for Action. An SCWD Position Paper. Journal of cachexia, sarcopenia and muscle, 10(5), 956-961. https://doi.org/10.1002/jcsm.12483
- PublishedJonker, R., Deutz, N. E. P., Schols, A. M. W. J., Veley, E. A., Harrykissoon, R., Zachria, A. J., & Engelen, M. P. K. J. (2019). Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clinical Nutrition, 38(4), 1684-1691. https://doi.org/10.1016/j.clnu.2018.08.006
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- PublishedDegens, J. H. R. J., Sanders, K. J. C., de Jong, E. E. C., Groen, H. J. M., Smit, E. F., Aerts, J. G., ... Dingemans, A-M. C. (2019). The prognostic value of early onset, CT derived loss of muscle and adipose tissue during chemotherapy in metastatic non-small cell lung cancer. Lung Cancer, 133, 130-135. https://doi.org/10.1016/j.lungcan.2019.05.021
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- PublishedKneppers, A. E. M., Haast, R. A. M., Langen, R. C. J., Verdijk, L. B., Leermakers, P. A., Gosker, H. R., ... Schols, A. M. W. J. (2019). Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis. Journal of cachexia, sarcopenia and muscle, 10(2), 311-322. https://doi.org/10.1002/jcsm.12370
- PublishedSanders, K. J. C., Klooster, K., Vanfleteren, L. E. G. W., Slebos, D-J., & Schols, A. M. W. J. (2019). CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema. Thorax, 74(2), 206-207. https://doi.org/10.1136/thoraxjnl-2018-211931
- PublishedPelgrim, C. E., Peterson, J. D., Gosker, H. R., Schols, A. M. W. J., van Helvoort, A., Garssen, J., ... Kraneveld, A. D. (2019). Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both? European Journal of Pharmacology, 842, 99-110. https://doi.org/10.1016/j.ejphar.2018.10.001
- PublishedKneppers, A., Leermakers, P., Pansters, N., Backx, E., Gosker, H., van Loon, L., ... Verdijk, L. (2019). Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse. Faseb Journal, 33(1), 1288-1298. https://doi.org/10.1096/fj.201701403RRR
- PublishedSanders, K. J. C., Degens, J. H. R. J., Dingemans, A-M. C., & Schols, A. M. W. J. (2019). Cross-sectional and longitudinal assessment of muscle from regular chest computed tomography scans: L1 and pectoralis muscle compared to L3 as reference in non-small cell lung cancer. International journal of chronic obstructive pulmonary disease, 14, 781-789. https://doi.org/10.2147/COPD.S194003
- 2018
- Publishedvan Beers, M., Janssen, D. J. A., Gosker, H. R., & Schols, A. M. W. J. (2018). Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions. Expert Review of Respiratory Medicine, 12(12), 1061-1074. https://doi.org/10.1080/17476348.2018.1533405
- PublishedBeijers, R. J. H. C. G., Huysmans, S. M. D., van de Bool, C., Kingma, B. R. M., Verdijk, L. B., van Loon, L. J. C., ... Schols, A. M. W. J. (2018). The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease. Clinical Nutrition, 37(6), 1852-1861. https://doi.org/10.1016/j.clnu.2017.10.011
- PublishedSPRINTT Consortium, Marzetti, E., Cesari, M., Calvani, R., Msihid, J., Tosato, M., ... Landi, F. (2018). The "Sarcopenia and Physical fRailty IN older people multi-componenT Treatment strategies" (SPRINTT): Case finding, screening and characteristics of eligible participants. Experimental Gerontology, 113, 48-57. https://doi.org/10.1016/j.exger.2018.09.017
- PublishedLeermakers, P. A., Schols, A. M. W. J., Kneppers, A. E. M., Kelders, M. C. J. M., de Theije, C. C., Lainscak, M., & Gosker, H. R. (2018). Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD). Scientific Reports, 8, [15007]. https://doi.org/10.1038/s41598-018-33471-2
- PublishedTen Hoor, G. A., Rutten, G. M., Van Breukelen, G. J. P., Kok, G., Ruiter, R. A. C., Meijer, K., ... Plasqui, G. (2018). Strength exercises during physical education classes in secondary schools improve body composition: a cluster randomized controlled trial. International Journal of Behavioral Nutrition and Physical Activity, 15(1), [92]. https://doi.org/10.1186/s12966-018-0727-8
- PublishedKneppers, A., Haast, R., Langen, R., Verdijk, L., Leermakers, P., Gosker, H., ... Schols, A. (2018). Unbiased analysis of skeletal muscle molecular responses upon pulmonary rehabilitation in advanced COPD. European Respiratory Journal, 52(S62), [OA1622]. https://doi.org/10.1183/13993003.congress-2018.OA1622
- Publishedde Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Neumann, D., Kohler, S. E., & Langen, R. C. J. (2018). Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy. PLOS ONE, 13(9), [0203630]. https://doi.org/10.1371/journal.pone.0203630
- PublishedTheeuwes, W. F., Gosker, H. R., Langen, R. C. J., Pansters, N. A. M., Schols, A. M. W. J., & Remels, A. H. V. (2018). Inactivation of glycogen synthase kinase 3 beta (GSK-3 beta) enhances mitochondrial biogenesis during myogenesis. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(9), 2913-2926. https://doi.org/10.1016/j.bbadis.2018.06.002
- PublishedCeelen, J. J. M., Schols, A. M. W. J., Kneppers, A. E. M., Rosenbrand, R. P. H. A., Drozdz, M. M., van Hoof, S. J., ... Langen, R. C. J. (2018). Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice. Scientific Reports, 8, [10761]. https://doi.org/10.1038/s41598-018-28579-4
- PublishedCeelen, J. J. M., Schols, A. M. W. J., Thielen, N. G. M., Haegens, A., Gray, D. A., Kelders, M. C. J. M., ... Langen, R. C. J. (2018). Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation. Respiratory Research, 19, [80]. https://doi.org/10.1186/s12931-018-0753-8
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- PublishedBrzeszczynska, J., Meyer, A., McGregor, R., Schilb, A., Degen, S., Tadini, V., ... Jacobi, C. (2018). Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia. Journal of cachexia, sarcopenia and muscle, 9(1), 93-105. https://doi.org/10.1002/jcsm.12252
- PublishedSanders, K. J. C., Ash, S. Y., Washko, G. R., Mottaghy, F. M., & Schols, A. M. W. J. (2018). Imaging approaches to understand disease complexity: chronic obstructive pulmonary disease as a clinical model. Journal of Applied Physiology, 124(2), 512-520. https://doi.org/10.1152/japplphysiol.00143.2017
- PublishedCalder, P. C., Laviano, A., Lonnqvist, F., Muscaritoli, M., Ohlander, M., & Schols, A. (2018). Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: a randomized, controlled trial. Journal of cachexia, sarcopenia and muscle, 9(1), 28-40. https://doi.org/10.1002/jcsm.12228
- PublishedStewart, K. F. J., Wesselius, A., Schreurs, M. A. C., Schols, A. M. W. J., & Zeegers, M. P. (2018). Behavioural changes, sharing behaviour and psychological responses after receiving direct-to-consumer genetic test results: a systematic review and meta-analysis. Journal of Community Genetics, 9(1), 1-18. https://doi.org/10.1007/s12687-017-0310-z
- PublishedStewart, K. F. J., Kokole, D., Wesselius, A., Schols, A. M. W. J., Zeegers, M. P., de Vries, H., & van Osch, L. A. D. M. (2018). Factors Associated with Acceptability, Consideration and Intention of Uptake of Direct-To-Consumer Genetic Testing: A Survey Study. Public Health Genomics, 21(1-2), 45-52. https://doi.org/10.1159/000492960
- PublishedTheije, C. C., Schols, A. M. W. J., Lamers, W. H., Ceelen, J. J. M., van Gorp, R. H., Hermans, J. J. R., ... Langen, R. C. J. (2018). Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice. Endocrinology, 159(1), 519-534. https://doi.org/10.1210/en.2017-00603
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- 2017
- PublishedTen Hoor, G. A., Plasqui, G., Schols, A. M. W. J., & Kok, G. (2017). Development, Implementation, and Evaluation of an Interdisciplinary Theory- and Evidence-Based Intervention to Prevent Childhood Obesity: Theoretical and Methodological Lessons Learned. Frontiers in Public Health, 5, 352. [352]. https://doi.org/10.3389/fpubh.2017.00352
- PublishedTheeuwes, W. F., Gosker, H. R., Langen, R. C. J., Verhees, K. J. P., Pansters, N. A. M., Schols, A. M. W. J., & Remels, A. H. V. (2017). Inactivation of glycogen synthase kinase-3 beta (GSK-3 beta) enhances skeletal muscle oxidative metabolism. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1863(12), 3075-3086. https://doi.org/10.1016/j.bbadis.2017.09.018
- Publishedvan de Bool, C., Rutten, E. P. A., van Helvoort, A., Franssen, F. M. E., Wouters, E. F. M., & Schols, A. M. W. J. (2017). A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD. Journal of cachexia, sarcopenia and muscle, 8(5), 748-758. https://doi.org/10.1002/jcsm.12219
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- PublishedLaville, M., Segrestin, B., Alligier, M., Ruano-Rodriguez, C., Serra-Majem, L., Hiesmayr, M., ... Gluud, C. (2017). Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with? Trials, 18, [425]. https://doi.org/10.1186/s13063-017-2160-8
- PublishedKneppers, A. E. M., Langen, R. C. J., Gosker, H. R., Verdijk, L. B., Lipovec, N. C., Leermakers, P. A., ... Schols, A. M. W. J. (2017). Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia. Journal of the American Medical Directors Association, 18(7), 637.e1-637.e11. https://doi.org/10.1016/j.jamda.2017.04.016
- PublishedBeijers, R. J. H. C. G., van de Bool, C., van den Borst, B., Franssen, F. M. E., Wouters, E. F. M., & Schols, A. M. W. J. (2017). Normal Weight but Low Muscle Mass and Abdominally Obese: Implications for the Cardiometabolic Risk Profile in Chronic Obstructive Pulmonary Disease. Journal of the American Medical Directors Association, 18(6), 533-538. https://doi.org/10.1016/j.jamda.2016.12.081
- PublishedZinad, K., Schols, A. M. W. J., & Schols, J. G. J. H. (2017). Messungen der Compliance und Bestimmungsfaktoren für einen Therapieerfolg mit herausnehmbaren funktionskieferorthopädischen Apparaturen. Informationen aus Orthodontie & Kieferorthopädie, 49(2), 133-139. https://doi.org/10.1055/s-0043-111785
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- 2016
- PublishedMount, S., Lara, J., Schols, A. M. W. J., & Mathers, J. C. (2016). Towards a multidimensional healthy ageing phenotype. Current Opinion in Clinical Nutrition and Metabolic Care, 19(6), 418-426. https://doi.org/10.1097/MCO.0000000000000318
- Publisheddos Santos, C., Hussain, S. N. A., Mathur, S., Picard, M., Herridge, M., Correa, J., ... Batt, J. (2016). Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. American Journal of Respiratory and Critical Care Medicine, 194(7), 821-830. https://doi.org/10.1164/rccm.201512-2344OC
- PublishedCebron Lipovec, N., Schols, A. M. W. J., van den Borst, B., Beijers, R. J. H. C. G., Kosten, T., Omersa, D., & Lainscak, M. (2016). Sarcopenia in Advanced COPD Affects Cardiometabolic Risk Reduction by Short-Term High-intensity Pulmonary Rehabilitation. Journal of the American Medical Directors Association, 17(9), 814-820. https://doi.org/10.1016/j.jamda.2016.05.002
- PublishedZinad, K., Schols, A. M. W. J., & Schols, J. G. J. H. (2016). Another way of looking at treatment stability. Angle Orthodontist, 86(5), 721-726. https://doi.org/10.2319/101515-697.1
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- PublishedBrzeszczynska, J., Johns, N., Schilb, A., Degen, S., Degen, M., Langen, R., ... Ross, J. A. (2016). Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly. Aging, 8(8), 1690-1702. https://doi.org/10.18632/aging.101006
- PublishedTen Hoor, G. A., Kok, G., Rutten, G. M., Ruiter, R. A. C., Kremers, S. P. J., Schols, A., & Plasqui, G. (2016). The Dutch 'Focus on Strength' intervention study protocol: programme design and production, implementation and evaluation plan. BMC Public Health, 16(1), [496]. https://doi.org/10.1186/s12889-016-3150-6