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Researcher

Schols, A.M.W.J.

Full professor - Personal chair

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  1. 2019
  2. Published
    Leermakers, P. A., Kneppers, A. E. M., Schols, A. M. W. J., Kelders, M. C. J. M., de Theije, C. C., Verdijk, L. B., ... Gosker, H. R. (2019). Skeletal muscle unloading results in increased mitophagy and decreased mitochondrial biogenesis regulation. Muscle & Nerve, 60(6), 769-778. https://doi.org/10.1002/mus.26702
  3. Published
    de Jong, E. E. C., Sanders, K. J. C., Deist, T. M., van Elmpt, W., Jochems, A., van Timmeren, J. E., ... Lambin, P. (2019). Can radiomics help to predict skeletal muscle response to chemotherapy in stage IV non-small cell lung cancer? European Journal of Cancer, 120, 107-113. https://doi.org/10.1016/j.ejca.2019.07.023
  4. Published
    Bauer, J., Morley, J. E., Schols, A. M. W. J., Ferrucci, L., Cruz-Jentoft, A. J., Dent, E., ... Anker, S. D. (2019). Sarcopenia: A Time for Action. An SCWD Position Paper. Journal of cachexia, sarcopenia and muscle, 10(5), 956-961. https://doi.org/10.1002/jcsm.12483
  5. Published
    Jonker, R., Deutz, N. E. P., Schols, A. M. W. J., Veley, E. A., Harrykissoon, R., Zachria, A. J., & Engelen, M. P. K. J. (2019). Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clinical Nutrition, 38(4), 1684-1691. https://doi.org/10.1016/j.clnu.2018.08.006
  6. Published
    Gosker, H. R., Clarke, G., de Theije, C. C., Cryan, J. E., & Schols, A. M. W. J. (2019). Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease. Journal of Clinical Medicine, 8(7), [915]. https://doi.org/10.3390/jcm8070915
  7. Published
    Degens, J. H. R. J., Sanders, K. J. C., de Jong, E. E. C., Groen, H. J. M., Smit, E. F., Aerts, J. G., ... Dingemans, A-M. C. (2019). The prognostic value of early onset, CT derived loss of muscle and adipose tissue during chemotherapy in metastatic non-small cell lung cancer. Lung Cancer, 133, 130-135. https://doi.org/10.1016/j.lungcan.2019.05.021
  8. Published
    Mount, S., Ferrucci, L., Wesselius, A., Zeegers, M. P., & Schols, A. M. W. J. (2019). Measuring successful aging: an exploratory factor analysis of the InCHIANTI study into different health domains. Aging, 11(10), 3023-3040. https://doi.org/10.18632/aging.101957
  9. Published
    Kneppers, A. E. M., Haast, R. A. M., Langen, R. C. J., Verdijk, L. B., Leermakers, P. A., Gosker, H. R., ... Schols, A. M. W. J. (2019). Distinct skeletal muscle molecular responses to pulmonary rehabilitation in chronic obstructive pulmonary disease: a cluster analysis. Journal of cachexia, sarcopenia and muscle, 10(2), 311-322. https://doi.org/10.1002/jcsm.12370
  10. Published
    Sanders, K. J. C., Klooster, K., Vanfleteren, L. E. G. W., Slebos, D-J., & Schols, A. M. W. J. (2019). CT-derived muscle remodelling after bronchoscopic lung volume reduction in advanced emphysema. Thorax, 74(2), 206-207. https://doi.org/10.1136/thoraxjnl-2018-211931
  11. Published
    Pelgrim, C. E., Peterson, J. D., Gosker, H. R., Schols, A. M. W. J., van Helvoort, A., Garssen, J., ... Kraneveld, A. D. (2019). Psychological co-morbidities in COPD: Targeting systemic inflammation, a benefit for both? European Journal of Pharmacology, 842, 99-110. https://doi.org/10.1016/j.ejphar.2018.10.001
  12. Published
    Kneppers, A., Leermakers, P., Pansters, N., Backx, E., Gosker, H., van Loon, L., ... Verdijk, L. (2019). Coordinated regulation of skeletal muscle mass and metabolic plasticity during recovery from disuse. Faseb Journal, 33(1), 1288-1298. https://doi.org/10.1096/fj.201701403RRR
  13. Published
    Sanders, K. J. C., Degens, J. H. R. J., Dingemans, A-M. C., & Schols, A. M. W. J. (2019). Cross-sectional and longitudinal assessment of muscle from regular chest computed tomography scans: L1 and pectoralis muscle compared to L3 as reference in non-small cell lung cancer. International journal of chronic obstructive pulmonary disease, 14, 781-789. https://doi.org/10.2147/COPD.S194003
  14. 2018
  15. Published
    van Beers, M., Janssen, D. J. A., Gosker, H. R., & Schols, A. M. W. J. (2018). Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions. Expert Review of Respiratory Medicine, 12(12), 1061-1074. https://doi.org/10.1080/17476348.2018.1533405
  16. Published
    Beijers, R. J. H. C. G., Huysmans, S. M. D., van de Bool, C., Kingma, B. R. M., Verdijk, L. B., van Loon, L. J. C., ... Schols, A. M. W. J. (2018). The effect of acute and 7-days dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with chronic obstructive pulmonary disease. Clinical Nutrition, 37(6), 1852-1861. https://doi.org/10.1016/j.clnu.2017.10.011
  17. Published
    SPRINTT Consortium, Marzetti, E., Cesari, M., Calvani, R., Msihid, J., Tosato, M., ... Landi, F. (2018). The "Sarcopenia and Physical fRailty IN older people multi-componenT Treatment strategies" (SPRINTT): Case finding, screening and characteristics of eligible participants. Experimental Gerontology, 113, 48-57. https://doi.org/10.1016/j.exger.2018.09.017
  18. Published
    Leermakers, P. A., Schols, A. M. W. J., Kneppers, A. E. M., Kelders, M. C. J. M., de Theije, C. C., Lainscak, M., & Gosker, H. R. (2018). Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD). Scientific Reports, 8, [15007]. https://doi.org/10.1038/s41598-018-33471-2
  19. Published
    Ten Hoor, G. A., Rutten, G. M., Van Breukelen, G. J. P., Kok, G., Ruiter, R. A. C., Meijer, K., ... Plasqui, G. (2018). Strength exercises during physical education classes in secondary schools improve body composition: a cluster randomized controlled trial. International Journal of Behavioral Nutrition and Physical Activity, 15(1), [92]. https://doi.org/10.1186/s12966-018-0727-8
  20. Published
    Kneppers, A., Haast, R., Langen, R., Verdijk, L., Leermakers, P., Gosker, H., ... Schols, A. (2018). Unbiased analysis of skeletal muscle molecular responses upon pulmonary rehabilitation in advanced COPD. European Respiratory Journal, 52(S62), [OA1622]. https://doi.org/10.1183/13993003.congress-2018.OA1622
  21. Published
    de Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Neumann, D., Kohler, S. E., & Langen, R. C. J. (2018). Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy. PLOS ONE, 13(9), [0203630]. https://doi.org/10.1371/journal.pone.0203630
  22. Published
    Theeuwes, W. F., Gosker, H. R., Langen, R. C. J., Pansters, N. A. M., Schols, A. M. W. J., & Remels, A. H. V. (2018). Inactivation of glycogen synthase kinase 3 beta (GSK-3 beta) enhances mitochondrial biogenesis during myogenesis. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1864(9), 2913-2926. https://doi.org/10.1016/j.bbadis.2018.06.002
  23. Published
    Ceelen, J. J. M., Schols, A. M. W. J., Kneppers, A. E. M., Rosenbrand, R. P. H. A., Drozdz, M. M., van Hoof, S. J., ... Langen, R. C. J. (2018). Altered protein turnover signaling and myogenesis during impaired recovery of inflammation-induced muscle atrophy in emphysematous mice. Scientific Reports, 8, [10761]. https://doi.org/10.1038/s41598-018-28579-4
  24. Published
    Ceelen, J. J. M., Schols, A. M. W. J., Thielen, N. G. M., Haegens, A., Gray, D. A., Kelders, M. C. J. M., ... Langen, R. C. J. (2018). Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation. Respiratory Research, 19, [80]. https://doi.org/10.1186/s12931-018-0753-8
  25. Published
    Stewart, K. F. J., Wesselius, A., Schols, A. M. W. J., & Zeegers, M. P. (2018). Stages of behavioural change after direct-to-consumer disease risk profiling: study protocol of two integrated controlled pragmatic trials. Trials, 19, [240]. https://doi.org/10.1186/s13063-018-2630-7
  26. Published
    Ten Hoor, G. A., Plasqui, G., Schols, A. M. W. J., & Kok, G. (2018). A Benefit of Being Heavier Is Being Strong: a Cross-Sectional Study in Young Adults. Sports medicine - open, 4, [12]. https://doi.org/10.1186/s40798-018-0125-4
  27. Published
    Beijers, R. J. H. C. G., Gosker, H. R., & Schols, A. M. W. J. (2018). Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? Current Opinion in Clinical Nutrition and Metabolic Care, 21(2), 138-144. https://doi.org/10.1097/MCO.0000000000000444
  28. Published
    Kneppers, A., Verdijk, L., de Theije, C., Corten, M., Gielen, E., van Loon, L., ... Langen, R. (2018). A novel in vitro model for the assessment of postnatal myonuclear accretion. Skeletal Muscle, 8, [4]. https://doi.org/10.1186/s13395-018-0151-4
  29. Published
    Brzeszczynska, J., Meyer, A., McGregor, R., Schilb, A., Degen, S., Tadini, V., ... Jacobi, C. (2018). Alterations in the in vitro and in vivo regulation of muscle regeneration in healthy ageing and the influence of sarcopenia. Journal of cachexia, sarcopenia and muscle, 9(1), 93-105. https://doi.org/10.1002/jcsm.12252
  30. Published
    Sanders, K. J. C., Ash, S. Y., Washko, G. R., Mottaghy, F. M., & Schols, A. M. W. J. (2018). Imaging approaches to understand disease complexity: chronic obstructive pulmonary disease as a clinical model. Journal of Applied Physiology, 124(2), 512-520. https://doi.org/10.1152/japplphysiol.00143.2017
  31. Published
    Calder, P. C., Laviano, A., Lonnqvist, F., Muscaritoli, M., Ohlander, M., & Schols, A. (2018). Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: a randomized, controlled trial. Journal of cachexia, sarcopenia and muscle, 9(1), 28-40. https://doi.org/10.1002/jcsm.12228
  32. Published
    Stewart, K. F. J., Wesselius, A., Schreurs, M. A. C., Schols, A. M. W. J., & Zeegers, M. P. (2018). Behavioural changes, sharing behaviour and psychological responses after receiving direct-to-consumer genetic test results: a systematic review and meta-analysis. Journal of Community Genetics, 9(1), 1-18. https://doi.org/10.1007/s12687-017-0310-z
  33. Published
    Stewart, K. F. J., Kokole, D., Wesselius, A., Schols, A. M. W. J., Zeegers, M. P., de Vries, H., & van Osch, L. A. D. M. (2018). Factors Associated with Acceptability, Consideration and Intention of Uptake of Direct-To-Consumer Genetic Testing: A Survey Study. Public Health Genomics, 21(1-2), 45-52. https://doi.org/10.1159/000492960
  34. Published
    Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Ceelen, J. J. M., van Gorp, R. H., Hermans, J. J. R., ... Langen, R. C. J. (2018). Glucocorticoid Receptor Signaling Impairs Protein Turnover Regulation in Hypoxia-Induced Muscle Atrophy in Male Mice. Endocrinology, 159(1), 519-534. https://doi.org/10.1210/en.2017-00603
  35. Published
    Schrauwen-Hinderling, V. B., & Schols, A. M. W. J. (2018). Imaging in metabolic research: challenges and opportunities. Journal of Applied Physiology, 124(1), 160-161. https://doi.org/10.1152/japplphysiol.00906.2017
  36. 2017
  37. Published
    Ten Hoor, G. A., Plasqui, G., Schols, A. M. W. J., & Kok, G. (2017). Development, Implementation, and Evaluation of an Interdisciplinary Theory- and Evidence-Based Intervention to Prevent Childhood Obesity: Theoretical and Methodological Lessons Learned. Frontiers in Public Health, 5, 352. [352]. https://doi.org/10.3389/fpubh.2017.00352
  38. Published
    Theeuwes, W. F., Gosker, H. R., Langen, R. C. J., Verhees, K. J. P., Pansters, N. A. M., Schols, A. M. W. J., & Remels, A. H. V. (2017). Inactivation of glycogen synthase kinase-3 beta (GSK-3 beta) enhances skeletal muscle oxidative metabolism. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1863(12), 3075-3086. https://doi.org/10.1016/j.bbadis.2017.09.018
  39. Published
    van de Bool, C., Rutten, E. P. A., van Helvoort, A., Franssen, F. M. E., Wouters, E. F. M., & Schols, A. M. W. J. (2017). A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD. Journal of cachexia, sarcopenia and muscle, 8(5), 748-758. https://doi.org/10.1002/jcsm.12219
  40. Published
    Ten Hoor, G. A., Kok, G., Peters, G-J. Y., Frissen, T., Schols, A. M. W. J., & Plasqui, G. (2017). The psychological effects of strength exercises in people who are overweight or obese: a systematic review. Sports Medicine, 47(10), 2069–2081. https://doi.org/10.1007/s40279-017-0748-5
  41. Published
    Laville, M., Segrestin, B., Alligier, M., Ruano-Rodriguez, C., Serra-Majem, L., Hiesmayr, M., ... Gluud, C. (2017). Evidence-based practice within nutrition: what are the barriers for improving the evidence and how can they be dealt with? Trials, 18, [425]. https://doi.org/10.1186/s13063-017-2160-8
  42. Published
    Kneppers, A. E. M., Langen, R. C. J., Gosker, H. R., Verdijk, L. B., Lipovec, N. C., Leermakers, P. A., ... Schols, A. M. W. J. (2017). Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia. Journal of the American Medical Directors Association, 18(7), 637.e1-637.e11. https://doi.org/10.1016/j.jamda.2017.04.016
  43. Published
    Beijers, R. J. H. C. G., van de Bool, C., van den Borst, B., Franssen, F. M. E., Wouters, E. F. M., & Schols, A. M. W. J. (2017). Normal Weight but Low Muscle Mass and Abdominally Obese: Implications for the Cardiometabolic Risk Profile in Chronic Obstructive Pulmonary Disease. Journal of the American Medical Directors Association, 18(6), 533-538. https://doi.org/10.1016/j.jamda.2016.12.081
  44. Published
    Zinad, K., Schols, A. M. W. J., & Schols, J. G. J. H. (2017). Messungen der Compliance und Bestimmungsfaktoren für einen Therapieerfolg mit herausnehmbaren funktionskieferorthopädischen Apparaturen. Informationen aus Orthodontie & Kieferorthopädie, 49(2), 133-139. https://doi.org/10.1055/s-0043-111785
  45. Published
    Ceelen, J. J. M., Schols, A. M. W. J., van Hoof, S. J., de Theije, C. C., Verhaegen, F., & Langen, R. C. J. (2017). Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation. Respiratory Research, 18, [75]. https://doi.org/10.1186/s12931-017-0531-z
  46. 2016
  47. Published
    Mount, S., Lara, J., Schols, A. M. W. J., & Mathers, J. C. (2016). Towards a multidimensional healthy ageing phenotype. Current Opinion in Clinical Nutrition and Metabolic Care, 19(6), 418-426. https://doi.org/10.1097/MCO.0000000000000318
  48. Published
    dos Santos, C., Hussain, S. N. A., Mathur, S., Picard, M., Herridge, M., Correa, J., ... Batt, J. (2016). Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. American Journal of Respiratory and Critical Care Medicine, 194(7), 821-830. https://doi.org/10.1164/rccm.201512-2344OC
  49. Published
    Cebron Lipovec, N., Schols, A. M. W. J., van den Borst, B., Beijers, R. J. H. C. G., Kosten, T., Omersa, D., & Lainscak, M. (2016). Sarcopenia in Advanced COPD Affects Cardiometabolic Risk Reduction by Short-Term High-intensity Pulmonary Rehabilitation. Journal of the American Medical Directors Association, 17(9), 814-820. https://doi.org/10.1016/j.jamda.2016.05.002
  50. Published
    Zinad, K., Schols, A. M. W. J., & Schols, J. G. J. H. (2016). Another way of looking at treatment stability. Angle Orthodontist, 86(5), 721-726. https://doi.org/10.2319/101515-697.1
  51. Published
    Al-Zalabani, A. H., Stewart, K. F. J., Wesselius, A., Schols, A. M. W. J., & Zeegers, M. P. (2016). Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses. European Journal of Epidemiology, 31(9), 811-851. https://doi.org/10.1007/s10654-016-0138-6
  52. Published
    Horstman, A. M. H., Olde Damink, S., Schols, A. M. W. J., & van Loon, L. (2016). Is Cancer Cachexia Attributed to Impairments in Basal or Postprandial Muscle Protein Metabolism? Nutrients, 8(8), e499. https://doi.org/10.3390/nu8080499
  53. Published
    Brzeszczynska, J., Johns, N., Schilb, A., Degen, S., Degen, M., Langen, R., ... Ross, J. A. (2016). Loss of oxidative defense and potential blockade of satellite cell maturation in the skeletal muscle of patients with cancer but not in the healthy elderly. Aging, 8(8), 1690-1702. https://doi.org/10.18632/aging.101006
  54. Published
    Ten Hoor, G. A., Kok, G., Rutten, G. M., Ruiter, R. A. C., Kremers, S. P. J., Schols, A., & Plasqui, G. (2016). The Dutch 'Focus on Strength' intervention study protocol: programme design and production, implementation and evaluation plan. BMC Public Health, 16(1), [496]. https://doi.org/10.1186/s12889-016-3150-6
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