
Researcher
Bast, A.
Full professor - Key domain chair
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- 2019
- Published
- PublishedBast, A. (2019). Biomarkers of adaptive responses in human health. Toxicology Letters, 314, S26-S26.
- Publishedvan der Lugt, T., Weseler, A. R., Vrolijk, M. F., Opperhuizen, A., & Bast, A. (2019). Dietary advanced glycation endproducts and glucocorticoid resistance, are the two linked? Toxicology Letters, 314, S179-S179.
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- PublishedZoubek, M. E., Woitok, M. M., Sydor, S., Nelson, L. J., Bechmann, L. P., Lucena, M. I., ... Cubero, F. J. (2019). Protective role of c-Jun N-terminal kinase-2 (JNK2) in ibuprofen-induced acute liver injury. Journal of Pathology, 247(1), 110-122. https://doi.org/10.1002/path.5174
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- 2018
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- Publishedvan Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E., & Sagis, L. M. C. (2018). Lipase diffusion in oil-filled, alginate micro- and macrobeads. Food Hydrocolloids, 85, 242-247. https://doi.org/10.1016/j.foodhyd.2018.07.028
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- PublishedLeak, R. K., Calabrese, E. J., Kozumbo, W. J., Gidday, J. M., Johnson, T. E., Mitchell, J. R., ... Andersen, M. E. (2018). Enhancing and Extending Biological Performance and Resilience. Dose-Response, 16(3), [1559325818784501]. https://doi.org/10.1177/1559325818784501
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- PublishedDecroix, L., Tonoli, C., Lespagnol, E., Balestra, C., Descat, A., Drittij-Reijnders, M. J., ... Heyman, E. (2018). One-week cocoa flavanol intake increases prefrontal cortex oxygenation at rest and during moderate-intensity exercise in normoxia and hypoxia. Journal of Applied Physiology, 125(1), 8-18. https://doi.org/10.1152/japplphysiol.00055.2018
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- PublishedZanoni, T. B., Pedrosa, T. N., Catarino, C. M., Spiekstra, S. W., de Oliveira, D. P., Den Hartog, G., ... Maria-Engler, S. S. (2018). Allergens of permanent hair dyes induces epidermal damage, skin barrier loss and IL-1 alpha increase in epidermal in vitro model. Food and Chemical Toxicology, 112, 265-272. https://doi.org/10.1016/j.fct.2017.12.033
- 2017
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- Publishedvan Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E., & Sagis, L. M. C. (2017). Permeation of probe molecules into alginate microbeads: Effect of salt and processing. Food Hydrocolloids, 73, 255-261. https://doi.org/10.1016/j.foodhyd.2017.06.028
- PublishedBaumgartner, S., Mensink, R. P., Haenen, G. R., Bast, A., Binder, C. J., Bekers, O., ... Plat, J. (2017). The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial. Scientific Reports, 7, [15288]. https://doi.org/10.1038/s41598-017-15615-y
- PublishedVrolijk, M. F., Opperhuizen, A., Jansen, E. H. J. M., Hageman, G. J., Bast, A., & Haenen, G. R. M. M. (2017). The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function. Toxicology in Vitro, 44, 206-212. https://doi.org/10.1016/j.tiv.2017.07.009
- PublishedSthijns, M. M. J. P. E., den Hartog, G. J. M., Scasso, C., Haenen, J. P., Bast, A., & Haenen, G. R. M. M. (2017). Activation versus inhibition of microsomal glutathione S-transferase activity by acrolein. Dependence on the concentration and time of acrolein exposure. Chemico-Biological Interactions, 275, 116-120. https://doi.org/10.1016/j.cbi.2017.08.001
- PublishedDecroix, L., Tonoli, C., Soares, D. D., Descat, A., Drittij-Reijnders, M-J., Weseler, A. R., ... Meeusen, R. (2017). Acute cocoa Flavanols intake has minimal effects on exercise-induced oxidative stress and nitric oxide production in healthy cyclists: a randomized controlled trial. Journal of the International Society of Sports Nutrition, 14, [28]. https://doi.org/10.1186/s12970-017-0186-7
- PublishedSthijns, M. M. J. P. E., Schiffers, P. M., Janssen, G. M., Lemmens, K. J. A., Ides, B., Vangrieken, P., ... Haenen, G. R. M. M. (2017). Rutin protects against H2O2-triggered impaired relaxation of placental arterioles and induces Nrf2-mediated adaptation in Human Umbilical Vein Endothelial Cells exposed to oxidative stress. Biochimica et Biophysica Acta-general Subjects, 1861(5), 1177-1189. https://doi.org/10.1016/j.bbagen.2017.03.004
- PublishedSthijns, M. M. J. P. E., Thongkam, W., Albrecht, C., Hellack, B., Bast, A., Haenen, G. R. M. M., & Schins, R. P. F. (2017). Silver nanoparticles induce hormesis in A549 human epithelial cells. Toxicology in Vitro, 40, 223-233. https://doi.org/10.1016/j.tiv.2017.01.010
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- 2016
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- PublishedBaumgartner, S., Mensink, R. P., Haenen, G., Bast, A., Binder, C., Bekers, O., ... Plat, J. (2016). EFFECTS OF VITAMIN E OR LIPOIC ACID SUPPLEMENTATION ON FASTING OXYPHYTOSTEROL CONCENTRATIONS IN SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE OR TYPE II DIABETES. Atherosclerosis, 252, E89-E89. https://doi.org/10.1016/j.atherosclerosis.2016.07.529
- Publishedvan Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E., & Sagis, L. M. C. (2016). Structure engineering of filled protein microbeads to tailor release of oil droplets in gastric digestion. Food & Function, 7(8), 3539-3547. https://doi.org/10.1039/c6fo00405a
- PublishedHeyninck, K., Sabbe, L., Chirumamilla, C. S., Szic, K. S. V., Veken, P. V., Lemmens, K. J. A., ... Berghe, W. V. (2016). Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway. Biochemical Pharmacology, 109, 48-61. https://doi.org/10.1016/j.bcp.2016.03.026
- Publishedvan Leusden, P., den Hartog, G. J. M., Bast, A., Postema, M., van der Linden, E., & Sagis, L. M. C. (2016). Strength of microbeads for the encapsulation of heat sensitive, hydrophobic components. Food Hydrocolloids, 56, 318-324. https://doi.org/10.1016/j.foodhyd.2015.12.017
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- PublishedDrent, M., Bast, A., Bootsma, H-P., & Deneer, V. (2016). REPOSITIONING 'OLD' DRUGS TO TREAT RARE DISEASES: ARGUING FROM THE MECHANISM OF ACTION. Sarcoidosis Vasculitis and Diffuse Lung Diseases, 33(2), 191-194.
- 2015
- PublishedZanoni, T. B., Hudari, F., Munnia, A., Peluso, M., Godschalk, R. W., Zanoni, M. V., ... de Oliveira, D. P. (2015). The oxidation of p-phenylenediamine, an ingredient used for permanent hair dyeing purposes, leads to the formation of hydroxyl radicals: Oxidative stress and DNA damage in human immortalized keratinocytes. Toxicology Letters, 239(3), 194-204. https://doi.org/10.1016/j.toxlet.2015.09.026
- Publishedvan de Wier, B., Balk, J. M., Bast, A., Koek, G. H., & Haenen, G. R. (2015). Chemical characteristics for optimizing CYP2E1 inhibition. Chemico-Biological Interactions, 242, 139-144. https://doi.org/10.1016/j.cbi.2015.09.024
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- Publishedde Boer, A., van Hunsel, F., & Bast, A. (2015). Adverse food-drug interactions. Regulatory Toxicology and Pharmacology, 73(3), 859-865. https://doi.org/10.1016/j.yrtph.2015.10.009
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- PublishedLemmens, K. J., Herst, P. M., Housmans, B. A., Moalin, M., van der Vijgh, W. J., Bast, A., & Haenen, G. R. (2015). The contribution of the major metabolite 4'-O-methylmonoHER to the antioxidant activity of the flavonoid monoHER. Chemico-Biological Interactions, 239, 146-152. https://doi.org/10.1016/j.cbi.2015.07.004
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- PublishedVrolijk, M. F., Haenen, G. R., Opperhuizen, A., Jansen, E. H., Schiffers, P. M., & Bast, A. (2015). The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation. European Journal of Pharmacology, 746, 132-137. https://doi.org/10.1016/j.ejphar.2014.11.006
- PublishedHanekamp, J. C., & Bast, A. (2015). Antibiotics exposure and health risks: Chloramphenicol. Environmental Toxicology and Pharmacology, 39(1), 213-220. https://doi.org/10.1016/j.etap.2014.11.016
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- PublishedBoesten, D. M. P. H. J., den Hartog, G. J. M., de Cock, P., Bosscher, D., Bonnema, A., & Bast, A. (2015). Health effects of erythritol. Nutrafoods, 14, 3-9. https://doi.org/10.1007/s13749-014-0067-5
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- PublishedBalk, J. M., Haenen, G. R. M., Koc, O. M., Peters, R., Bast, A., van der Vijgh, W. J. F., & Koek, G. H. (2015). Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial. Pharmacogenomics and personalized medicine, 8, 137-144. https://doi.org/10.2147/pgpm.s82782
- PublishedBoesten, D. M., von Ungern-Sternberg, S. N., den Hartog, G. J., & Bast, A. (2015). Protective Pleiotropic Effect of Flavonoids on NAD(+) Levels in Endothelial Cells Exposed to High Glucose. Oxidative Medicine and Cellular Longevity, 2015, [894597]. https://doi.org/10.1155/2015/894597
- PublishedLemmens, K., van de Wier, B., Koek, G. H., Köhler, E. S., Drittij, M. J., van der Vijgh, W., ... Haenen, G. R. (2015). The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD. Biochemical and Biophysical Research Communications, 456(1), 179-182. https://doi.org/10.1016/j.bbrc.2014.11.055
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- PublishedRezk, B., van der Vijgh, W. J. F., Bast, A., & Haenen, G. R. (2015). Toxicity of Antioxidants. Toxicology and Forensic Medicine, 1(1), [1000TFMOJ1e002].
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- PublishedBast, A., & Haenen, G. (2015). Nutritional Antioxidants: It Is Time to Categorise. In M. Lamprecht (Ed.), Antioxidants in Sport Nutrition (pp. 17-38). Boca Raton: CRC Press, Taylor & Frances Group.
- PublishedRezk, B. M., van der Vijgh, W., Bast, A., & Haenen, G. (2015). Toxicity of the anti-oxidants. Toxicology and Forensic Medicine, 1(1), e3-e4. https://doi.org/10.17140/TFMOJ-1-e002
- 2014
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- Publishedvan Berlo, D., Wilhelmi, V., Boots, A. W., Hullmann, M., Kuhlbusch, T. A., Bast, A., ... Albrecht, C. (2014). Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung. Archives of Toxicology, 88(9), 1725-1737. https://doi.org/10.1007/s00204-014-1220-z
- PublishedLemmens, K. J., van de Wier, B., Vaes, N., Ghosh, M., van Zandvoort, M. A., van der Vijgh, W., ... Haenen, G. R. (2014). The flavonoid 7-mono-O-(beta-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect. Toxicology in Vitro, 28(4), 538-543. https://doi.org/10.1016/j.tiv.2013.12.019
- PublishedMilenkovic, D., Vanden Berghe, W., Boby, C., Leroux, C., Declerck, K., Szarc Vel Szic, K., ... Weseler, A. R. (2014). Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State. PLOS ONE, 9(4), [e95527]. https://doi.org/10.1371/journal.pone.0095527
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- PublishedYelisyeyeva, O. P., Semen, K. O., Ostrovska, G. V., Kaminskyy, D. V., Sirota, T. V., Zarkovic, N., ... Bast, A. (2014). The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress. Food Chemistry, 147, 152-159. https://doi.org/10.1016/j.foodchem.2013.09.119
- Publishedden Hartog, G. J., Qi, S., van Tilburg, J. H., Koek, G. H., & Bast, A. (2014). Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: A new target in liver fibrosis. European Journal of Pharmacology, 724(5 February), 140-144. https://doi.org/10.1016/j.ejphar.2013.12.033
- PublishedBast, A., & Hanekamp, J. C. (2014). "You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology. Dose-Response, 12(4), 664-672. https://doi.org/10.2203/dose-response.13-032.Hanekamp
- PublishedSthijns, M. M., Randall, M. J., Bast, A., & Haenen, G. R. (2014). Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept. Biochemical and Biophysical Research Communications, 446(4), 1029-1034. https://doi.org/10.1016/j.bbrc.2014.03.081
- PublishedZanoni, T. B., Tiago, M., Faiao-Flores, F., Moraes de Barros, S. B., Bast, A., Hageman, G., ... Maria-Engler, S. S. (2014). Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3D skin model using human keratinocytes (HaCaT). Toxicology Letters, 227(2), 139-149. https://doi.org/10.1016/j.toxlet.2014.03.007
- PublishedPijls, K. E., de Vries, H., Nikkessen, S., Bast, A., Wodzig, W. K. W. H., & Koek, G. H. (2014). Critical appraisal of (13) C breath tests for microsomal liver function: aminopyrine revisited. Liver International, 34(4), 487-494. https://doi.org/10.1111/liv.12451
- PublishedBoesten, D. M. P. H. J., Elie, A. G. I. M., Dritty-Reijnders, M. J. H. J., den Hartog, G. J. M., & Bast, A. (2014). Effect of NÉ›-carboxymethyllysine on oxidative stress and the glutathione system in beta cells. Toxicology Reports, 1, 973-980. https://doi.org/10.1016/j.toxrep.2014.06.003
- PublishedWeseler, A. R., & Bast, A. (2014). Nutritional components: How they enhance the ability to adapt. In S. I. S. Rattan, & E. Le Bourg (Eds.), Hormesis in health and disease (pp. 45-78). Boca Raton: CRC Press, Taylor & Frances Group.
- PublishedDrent, M., Bast, A., & Bootsma, H. P. (2014). 'Oude' medicijnen kans voor zeldzame ziekten. Medisch Contact, 5 juni(6), 1153-1155.
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- PublishedLemmens, K. J., Vrolijk, M. F., Bouwman, F. G., van der Vijgh, W. J., Bast, A., & Haenen, G. R. (2014). The Minor Structural Difference between the Antioxidants Quercetin and 4'O-Methylquercetin Has a Major Impact on Their Selective Thiol. International Journal of Molecular Sciences, 15(5), 7475-7484. https://doi.org/10.3390/ijms15057475
- 2013
- PublishedRuijters, E. J. B., Weseler, A. R., Kicken, C., Haenen, G. R. M. M., & Bast, A. (2013). The flavanol (-)-epicatechin and its metabolites protect against oxidative stress in primary endothelial cells via a direct antioxidant effect. European Journal of Pharmacology, 715(1-3), 147-153. https://doi.org/10.1016/j.ejphar.2013.05.029
- PublishedCremers, J. P., Drent, M., Bast, A., Shigemitsu, H., Baughman, R. P., Valeyre, D., ... Jansen, T. L. (2013). Multinational evidence-based World Association of Sarcoidosis and Other Granulomatous Disorders recommendations for the use of methotrexate in sarcoidosis: integrating systematic literature research and expert opinion of sarcoidologists worldwide. Current Opinion in Pulmonary Medicine, 19(5), 545-561. https://doi.org/10.1097/MCP.0b013e3283642a7a
- Publishedvan de Wier, B., Balk, J. M., Haenen, G. R. M. M., Giamouridis, D., Bakker, J. A., Bast, B. C., ... Bast, A. (2013). Elevated citrate levels in non-alcoholic fatty liver disease: The potential of citrate to promote radical production. Febs Letters, 587(15), 2461-2466. https://doi.org/10.1016/j.febslet.2013.06.019
- PublishedBast, A., den Hartog, G. J., & Boesten, D. M. (2013). Zoet in de strijd tegen suiker. Dagblad de Limburger - Limburgs Dagblad.
- PublishedBoesten, D. M., Berger, A., de Cock, P., Dong, H., Hammock, B. D., den Hartog, G. J. M., & Bast, A. (2013). Multi-targeted mechanisms underlying the endothelial protective effects of the diabetic-safe sweetener erythritol. PLOS ONE, 8(6), [e65741]. https://doi.org/10.1371/journal.pone.0065741
- PublishedRes, P. T., Cermak, N. M., Stinkens, R. E., Tollakson, T. J., Haenen, G. R. M. M., Bast, A., & van Loon, L. J. C. (2013). Astaxanthin supplementation does not augment fat use or improve endurance performance. Medicine and Science in Sports and Exercise, 45(6), 1158-1165. https://doi.org/10.1249/MSS.0b013e31827fddc4
- PublishedWijnen, P. A. H. M., Verschakelen, J. A., Bast, A., Bekers, O., & Drent, M. (2013). Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger? Lung, 191(1), 53-59. https://doi.org/10.1007/s00408-012-9436-2
- PublishedBoesten, D. M., de Vos-Houben, J. M., Timmermans, L., den Hartog, G. J., Bast, A., & Hageman, G. J. (2013). Accelerated aging during chronic oxidative stress: a role for PARP-1. Oxidative Medicine and Cellular Longevity, 2013, [680414]. https://doi.org/10.1155/2013/680414
- PublishedKlinkenberg, L. J., Res, P. T., Haenen, G. R., Bast, A., van Loon, L. J., van Dieijen-Visser, M. P., & Meex, S. J. (2013). Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial. PLOS ONE, 8(11), [e79280]. https://doi.org/10.1371/journal.pone.0079280
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- PublishedSemen, K. O., den Hartog, G. J. M., Kaminsky, D. V., Sirota, T. V., Maij, N. G. A. A., Yelisyeyeva, O. P., & Bast, A. (2013). Redox Modulation by Amaranth Oil in Human Lung Fibroblasts. Natural Products Chemistry & Research, December(2013). https://doi.org/10.4172/2329-6836.1000122
- PublishedBast, A., Briggs, W., Calabrese, E., Fenech, M., Hanekamp, J. C., Heaney, R., ... Verhoeven, P. (2013). Scientism, Legalism and Precaution - Contending with Regulating Nutrition and Health Claims in Europe. European Food and Feed Law Review, 6(2013), 401-409.
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- PublishedBieghs, V., Hendrikx, T., van Gorp, P. J. J., Verheyen, F., Guichot, Y. D., Walenbergh, S. M., ... Shiri-Sverdlov, R. (2013). The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Gastroenterology, 144(1), 167-178.e1. https://doi.org/10.1053/j.gastro.2012.09.062
- PublishedMartens, M. H., van Roozendaal, L. M., Schouten, L. J., Hermans, J. J. R. M., Bast, A., Weijenberg, M. P., & Smidt, M. L. (2013). The use of complementary and alternative medicine by breast cancer patients. Nederlands Tijdschrift voor Geneeskunde.
- PublishedBast, A., & Hanekamp, J. C. (2013). CHEMICALS AND HEALTH - THOUGHT FOR FOOD. Dose-Response, 11(3), 295-300. https://doi.org/10.2203/dose-response.12-031.Hanekamp
- 2012
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