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  1. 2019
  2. E-pub ahead of print
    van der Kolk, B. W., Kalafati, M., Adriaens, M., van Greevenbroek, M. M. J., Vogelzangs, N., Saris, W. H. M., ... Blaak, E. E. (2019). Subcutaneous Adipose Tissue and Systemic Inflammation are Associated with Peripheral But Not Hepatic Insulin Resistance in Humans. Diabetes. https://doi.org/10.2337/db19-0560
  3. Published
    Keenan, S. N., Meex, R. C., Lo, J. C. Y., Ryan, A., Nie, S., Montgomery, M. K., & Watt, M. J. (2019). Perilipin 5 Deletion in Hepatocytes Remodels Lipid Metabolism and Causes Hepatic Insulin Resistance in Mice. Diabetes, 68(3), 543-555. https://doi.org/10.2337/db18-0670
  4. 2018
  5. Published
    Stehouwer, C. D. A. (2018). Microvascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences. Diabetes, 67(9), 1729-1741. https://doi.org/10.2337/dbi17-0044
  6. 2017
  7. Published
    Hanssen, N. M. J., Scheijen, J. L. J. M., Jorsal, A., Parving, H-H., Tarnow, L., Rossing, P., ... Schalkwijk, C. G. (2017). Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study. Diabetes, 66(8), 2278-2283. https://doi.org/10.2337/db16-1578
  8. Published
    Liu, Y., Steinbusch, L. K. M., Nabben, M., Kapsokalyvas, D., van Zandvoort, M., Schonleitner, P., ... Luiken, J. J. F. P. (2017). Palmitate-Induced Vacuolar-Type H(+)-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction. Diabetes, 66(6), 1521-1534. https://doi.org/10.2337/db16-0727
  9. Published
    van Bussel, F. C. G., Backes, W. H., van Veenendaal, T. M., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., ... Jansen, J. F. A. (2017). Erratum: Functional Brain Networks Are Altered in Type 2 Diabetes and Prediabetes: Signs for Compensation of Cognitive Decrements? The Maastricht Study (vol 65, pg 2404, 2016). Diabetes, 66(2), 560. https://doi.org/10.2337/db17-er02a
  10. 2016
  11. Published
    Arredouani, A., Stocchero, M., Culeddu, N., Moustafa, J. E-S., Tichet, J., Balkau, B., ... Falchi, M. (2016). Metabolomic Profile of Low-Copy Number Carriers at the Salivary alpha-Amylase Gene Suggests a Metabolic Shift Toward Lipid-Based Energy Production. Diabetes, 65(11), 3362-3368. https://doi.org/10.2337/db16-0315
  12. Published
    Dirks, M. L., Wall, B. T., van de Valk, B., Holloway, T. M., Holloway, G. P., Chabowski, A., ... van Loon, L. (2016). One Week of Bed Rest Leads to Substantial Muscle Atrophy and Induces Whole-Body Insulin Resistance in the Absence of Skeletal Muscle Lipid Accumulation. Diabetes, 65(10), 2862-2875. https://doi.org/10.2337/db15-1661
  13. Published
    van Bussel, F. C. G., Backes, W. H., van Veenendaal, T. M., Hofman, P. A. M., van Boxtel, M. P. J., Schram, M. T., ... Jansen, J. (2016). Functional brain networks are altered in type 2 diabetes and pre-diabetes signs for compensation of cognitive decrements? - The Maastricht Study: signs for compensation of cognitive decrements? - The Maastricht Study. Diabetes, 65(8), 2404-2413. https://doi.org/10.2337/db16-0128
  14. Published
    Maessen, D. E., Brouwers, O., Gaens, K. H., Wouters, K., Cleutjens, J. P., Janssen, B. J., ... Schalkwijk, C. G. (2016). Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet-Induced Obese Mice. Diabetes, 65(4), 956-966. https://doi.org/10.2337/db15-1390
  15. 2015
  16. Published
    van de Weijer, T., Phielix, E., Bilet, L., Williams, E. G., Ropelle, E. R., Bierwagen, A., ... Schrauwen, P. (2015). Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans. Diabetes, 64(4), 1193-1201. https://doi.org/10.2337/db14-0667
  17. Published
    Stephens, F. B., Chee, C., Wall, B. T., Murton, A. J., Shannon, C. E., van Loon, L. J., & Tsintzas, K. (2015). Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino Acid ingestion in healthy young men. Diabetes, 64(5), 1615-1620. https://doi.org/10.2337/db14-0961
  18. Published
    Hanssen, N. M. J., Beulens, J. W. J., van Dieren, S., Scheijen, J. L. J. M., van der A, D. L., Spijkerman, A. M. W., ... Schalkwijk, C. G. (2015). Plasma Advanced Glycation End Products Are Associated With Incident Cardiovascular Events in Individuals With Type 2 Diabetes: A Case-Cohort Study With a Median Follow-up of 10 Years (EPIC-NL). Diabetes, 64(1), 257-265. https://doi.org/10.2337/db13-1864
  19. 2014
  20. Published
    Jain, S. S., Paglialunga, S., Vigna, C., Ludzki, A., Herbst, E. A., Lally, J. S., ... Holloway, G. P. (2014). High-Fat Diet-Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII. Diabetes, 63(6), 1907-1913. https://doi.org/10.2337/db13-0816
  21. Published
    Sparks, L. M., Bosma, M., Brouwers, B., van de Weijer, T., Bilet, L., Schaart, G., ... Schrauwen, P. (2014). Reduced incorporation of Fatty acids into triacylglycerol in myotubes from obese individuals with type 2 diabetes. Diabetes, 63(5), 1583-1593. https://doi.org/10.2337/db13-1123
  22. 2013
  23. Published
    Schrauwen, P., Timmers, S., & Hesselink, M. K. C. (2013). Blocking the entrance to open the gate. Diabetes, 62(3), 703-705. https://doi.org/10.2337/db12-1663
  24. 2012
  25. Published
    Vosselman, M. J., van der Lans, A. A., Brans, B., Wierts, R., van Baak, M. A., Schrauwen, P., & van Marken Lichtenbelt, W. D. (2012). Systemic ß-Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans. Diabetes, 61(12), 3106-3113. https://doi.org/10.2337/db12-0288
  26. Published
    Bosma, M., Hesselink, M. K. C., Sparks, L. M., Timmers, S., Ferraz, M. J., Mattijssen, F., ... Schrauwen, P. (2012). Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels. Diabetes, 61(11), 2679-2690. https://doi.org/10.2337/db11-1402
  27. Published
    Phielix, E., Meex, R., Ouwens, DM., Sparks, L. M., Hoeks, J., Schaart, G., ... Schrauwen, P. (2012). High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance. Diabetes, 61(10), 2472-2478. https://doi.org/10.2337/db11-1832
  28. 2011
  29. Published
    Lamprianou, S., Immonen, R., Nabuurs, C. I., Gjinovci, A., Vinet, L., Montet, X. C., ... Meda, P. (2011). High-resolution magnetic resonance imaging quantitatively detects individual pancreatic islets. Diabetes, 60(11), 2853-2860. https://doi.org/10.2337/db11-0726
  30. 2010
  31. Published
    Hoeks, J., van Herpen, N. A., Mensink, M. R., Kornips, C. F. P., Van Beurden, D., Hesselink, M. K. C., & Schrauwen, P. (2010). Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance. Diabetes, 59(9), 2117-2125. https://doi.org/10.2337/db10-0519
  32. Published
    Nin, J. W., Jorsal, A., Ferreira, I., Schalkwijk, C. G., Prins, M. H., Parving, H. H., ... Stehouwer, C. D. (2010). Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study. incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-yr follow-up study. Diabetes, 59(8), 2027-2032. https://doi.org/10.2337/db09-1509
  33. Published
    Kars, M., Yang, L., Gregor, M. F., Mohammed, B. S., Pietka, T. A., Finck, B. N., ... Klein, S. (2010). Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women. Diabetes, 59(8), 1899-1905. https://doi.org/10.2337/db10-0308
  34. Published
    Meex, R. C., Schrauwen-Hinderling, V. B., Kornips, E., Schaart, G., Mensink, M., Phielix, E., ... Hesselink, M. K. (2010). Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes, 59(3), 572-579. https://doi.org/10.2337/db09-1322
  35. 2009
  36. Published
    Yi, C. X., Serlie, M. J., Ackermans, M. T., Foppen, E., Buijs, R. M., Sauerwein, H. P., ... Kalsbeek, A. (2009). A major role for perifornical orexin neurons in the control of glucose metabolism in rats. Diabetes, 58(9), 1998-2005. https://doi.org/10.2337/db09-0385
  37. 2008
  38. Published
    Gruden, G., Bruno, G., Cahturvedi, N., Burt, D., Schalkwijk, C. G., Pinach, S., ... Cavallo Perin, P. (2008). EURODIAB Prospective Complications Study Group Serum HSP27 and diabetes complications in the Eurodiab Prospective Complications Study: a novel circulating marker for diabetic neuropathy. Diabetes, 57, 1966-70. https://doi.org/10.2337/db08-0009
  39. Published
    Jocken, J. W., Roepstorff, C., Goossens, G. H., van der Baan, P., van Baak, M., Saris, W. H., ... Blaak, E. E. (2008). Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation. Diabetes, 57(7), 1834-1841. https://doi.org/10.2337/db07-0857
  40. Published
    Phielix, E., Schrauwen-Hinderling, V., Mensink, M., Lenaers, E., Meex, R. C., Hoeks, J., ... Schrauwen, P. (2008). Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. Diabetes, 57(11), 2943-2949. https://doi.org/10.2337/db08-0391
  41. Published
    Bakker, W., Sipkema, P., Stehouwer, C. D. A., Serne, E. H., Smulders, Y. M., van Hinsbergh, V. W. M., & Eringa, E. C. (2008). Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries. Diabetes, 57, 706-13. https://doi.org/10.2337/db07-0792
  42. 2007
  43. Published
    Bickerton, A. S., Roberts, R., Fielding, B. A., Hodson, L., Blaak, E. E., Wagenmakers, A. J., ... Frayn, K. N. (2007). Preferential uptake of dietary Fatty acids in adipose tissue and muscle in the postprandial period. Diabetes, 56(1), 168-176. https://doi.org/10.2337/db06-0822
  44. 2006
  45. Published
    Shiri-Sverdlov, R., Custers, A., van Vliet-Ostaptchouk, J. V., van Gorp, P. J. J., Lindsey, P. J., van Tilburg, J. H. O., ... Wijmenga, C. (2006). Identification of TUB as a novel candidate gene influencing body weight in humans. Diabetes, 55(2), 385-389. https://doi.org/10.2337/diabetes.55.02.06.db05-0997
  46. 2004
  47. Published
    de Jongh, R. T., Serné, E. H., Ijzerman, R. G., de Vries, G., & Stehouwer, C. D. A. (2004). Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes, 53(11), 2873-2882. https://doi.org/10.2337/diabetes.53.11.2873
  48. Published
    Schrauwen, P., & Hesselink, M. K. (2004). Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes, 53(6), 1412-7. https://doi.org/10.2337/diabetes.53.6.1412
  49. 2002
  50. Published
    Schrauwen, P., van Leijssen - Aggel, D. P. C., Hul, G. B. J., Wagenmakers, A. J. M., Vidal, H., Saris, W. H. M., & van Baak, M. A. (2002). The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression. Diabetes, 51(7), 2220-2226. https://doi.org/10.2337/diabetes.51.7.2220
  51. Published
    Blaak, E. E., & Wagenmakers, A. J. M. (2002). The fate of [U-(13)C]palmitate extracted by skeletal muscle in subjects with type 2 diabetes and control subjects. Diabetes, 51(3), 784-789. https://doi.org/10.2337/diabetes.51.3.784
  52. 2001
  53. Published
    Mensink, M. R., Blaak, E. E., van Baak, M. A., Wagenmakers, A. J. M., & Saris, W. H. M. (2001). Plasma free Fatty Acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes. Diabetes, 50, 2548-2554. https://doi.org/10.2337/diabetes.50.11.2548
  54. Published
    Schrauwen, P., Hesselink, M. K. C., Blaak, E. E., Borghouts, L., Schaart, G., Saris, W. H. M., & Keizer, H. A. (2001). Uncoupling protein 3 content is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes, 50, 2870-2873. https://doi.org/10.2337/diabetes.50.12.2870
  55. 2000
  56. Published
    Blaak, E. E., van Leijssen - Aggel, D. P. C., Wagenmakers, A. J. M., Saris, W. H. M., & van Baak, M. A. (2000). Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise. Diabetes, 49, 2102-7. https://doi.org/10.2337/diabetes.49.12.2102
  57. Published
    Schrauwen, P., Wagenmakers, A. J. M., van Marken Lichtenbelt, W. D., Saris, W. H. M., & Westerterp, K. R. (2000). Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation. Diabetes, 49(4), 640-646. https://doi.org/10.2337/diabetes.49.4.640
  58. 1999
  59. Published
    Huvers, F. C., de Leeuw, P. W., Houben, A. J. H. M., de Haan, C. H. A., Hamulyak, K., Schouten, H. J. A., ... Wyse, D. G. (1999). Endothelium-dependent vasodilatation, plasma markers of endothelial function, and adrenergic vasoconstrictor responses in type 1 diabetes under near-normoglycemic conditions. Diabetes, 48(6), 1300-1307. https://doi.org/10.2337/diabetes.48.6.1300
  60. Published
    Schrauwen, P., Xia, J., Bogardus, C., Pratley, R. E., & Ravussin, E. (1999). Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. Diabetes, 48(1), 146-149. https://doi.org/10.2337/diabetes.48.1.146

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