%PDF-1.7
%
1 0 obj
<<
/MarkInfo <<
/Marked true
>>
/Metadata 2 0 R
/Names 3 0 R
/OpenAction [4 0 R /FitH 910]
/Outlines 5 0 R
/PageLabels 6 0 R
/PageLayout /SinglePage
/PageMode /UseOutlines
/Pages 7 0 R
/StructTreeRoot 8 0 R
/Threads [9 0 R]
/Type /Catalog
>>
endobj
10 0 obj
<<
/Author (Justine L. Kuiper)
/CreationDate (D:20150806111945Z)
/Creator (Elsevier)
/CrossMarkDomains#5B1#5D (sciencedirect.com)
/CrossMarkDomains#5B2#5D (elsevier.com)
/CrossmarkDomainExclusive (true)
/CrossmarkMajorVersionDate (2010-04-23)
/ElsevierWebPDFSpecifications (6.4)
/Keywords ()
/ModDate (D:20150806210553+05'30')
/Producer (Acrobat Distiller 10.0.0 \(Windows\))
/Subject (Lung Cancer, 89 \(2015\) 255-261. doi:10.1016/j.lungcan.2015.05.023)
/Title (Treatment and survival of patients with EGFR-mutated non-small cell lung cancer and leptomeningeal metastasis: A retrospective cohort analysis)
/doi (10.1016/j.lungcan.2015.05.023)
/robots (noindex)
>>
endobj
2 0 obj
<<
/Length 7458
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
10.1016/j.lungcan.2015.05.023
Treatment and survival of patients with EGFR-mutated non-small cell lung cancer and leptomeningeal metastasis: A retrospective cohort analysis
Justine L. Kuiper
Lizza E. Hendriks
Anthonie J. van der Wekken
Adrianus J. de Langen
Idris Bahce
Erik Thunnissen
Daniëlle A.M. Heideman
Yvonne Berk
Ed J.M. Buijs
Ernst-Jan M. Speel
Frans H. Krouwels
Hans J.M. Smit
Harry J.M. Groen
Anne-Marie C. Dingemans
Egbert F. Smit
NSCLC
EGFR
Leptomeningeal metastasis
TKI
Lung Cancer, 89 (2015) 255-261. doi:10.1016/j.lungcan.2015.05.023
Elsevier Ireland Ltd
journal
Lung Cancer
© 2015 Elsevier Ireland Ltd. All rights reserved.
0169-5002
89
3
September 2015
2015-09
255-261
255
261
10.1016/j.lungcan.2015.05.023
http://dx.doi.org/10.1016/j.lungcan.2015.05.023
2010-04-23
true
10.1016/j.lungcan.2015.05.023
elsevier.com
sciencedirect.com
10.1016/j.lungcan.2015.05.023
noindex
2010-04-23
true
sciencedirect.com
elsevier.com
Elsevier
2015-08-06T11:19:45Z
2015-08-06T21:05:53+05:30
True
Acrobat Distiller 10.0.0 (Windows)
uuid:5057eb19-3829-4a0e-abcd-f2ca387ab753
uuid:7515b78d-1489-43dc-b1d5-16d94e1912f0
endstream
endobj
3 0 obj
<<
/Dests 11 0 R
>>
endobj
4 0 obj
<<
/Annots [12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R
22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R
32 0 R 33 0 R 34 0 R 35 0 R 36 0 R]
/B [37 0 R 38 0 R]
/BleedBox [33.4 38 645.7 848.7]
/Contents [39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R]
/CropBox [41.9 46.5 637.2 840.2]
/MediaBox [33.4 38 645.7 848.7]
/Parent 7 0 R
/Resources 47 0 R
/Rotate 0
/StructParents 1
/Tabs /S
/TrimBox [41.9 46.5 637.2 840.2]
/Type /Page
>>
endobj
5 0 obj
<<
/Count 14
/First 48 0 R
/Last 48 0 R
>>
endobj
6 0 obj
<<
/Nums [0 49 0 R]
>>
endobj
7 0 obj
<<
/Count 8
/Kids [50 0 R 4 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R]
/Type /Pages
>>
endobj
8 0 obj
<<
/K [57 0 R 58 0 R 59 0 R 60 0 R]
/ParentTree 61 0 R
/ParentTreeNextKey 4
/Type /StructTreeRoot
>>
endobj
9 0 obj
<<
/F 37 0 R
/I <<
/Title (PDFThreading)
>>
>>
endobj
11 0 obj
<<
/Kids [62 0 R 63 0 R]
>>
endobj
12 0 obj
<<
/A <<
/S /URI
/URI (dx.doi.org/10.1016/j.lungcan.2015.05.023)
>>
/Border [0 0 0]
/Rect [296.579 798.113 393.731 803.137]
/Subtype /Link
/Type /Annot
>>
endobj
13 0 obj
<<
/A <<
/S /URI
/URI (http://www.sciencedirect.com/science/journal/01695002)
>>
/Border [0 0 0]
/Rect [370.2 771.114 421.416 777.012]
/Subtype /Link
/Type /Annot
>>
endobj
14 0 obj
<<
/A <<
/S /URI
/URI (http://www.elsevier.com/locate/lungcan)
>>
/Border [0 0 0]
/Rect [314.573 715.423 471.561 721.178]
/Subtype /Link
/Type /Annot
>>
endobj
15 0 obj
<<
/A <<
/S /URI
/URI (http://crossmark.crossref.org/dialog/?doi=10.1016/j.lungcan.2015.05.023&domain=pdf)
>>
/Border [0 0 0]
/Rect [547.276 650.193 606.276 675.193]
/Subtype /Link
/Type /Annot
>>
endobj
16 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0005)
/Rect [168.015 609.835 186.834 616.689]
/Subtype /Link
/Type /Annot
>>
endobj
17 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865COR0005)
/Rect [174.934 609.835 193.753 616.689]
/Subtype /Link
/Type /Annot
>>
endobj
18 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0010)
/Rect [271.662 609.835 290.482 616.689]
/Subtype /Link
/Type /Annot
>>
endobj
19 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0015)
/Rect [423.894 609.835 442.713 616.689]
/Subtype /Link
/Type /Annot
>>
endobj
20 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0005)
/Rect [194.046 596.884 212.866 603.738]
/Subtype /Link
/Type /Annot
>>
endobj
21 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0020)
/Rect [200.966 596.884 219.785 603.738]
/Subtype /Link
/Type /Annot
>>
endobj
22 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0005)
/Rect [268.151 596.884 286.971 603.738]
/Subtype /Link
/Type /Annot
>>
endobj
23 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0020)
/Rect [275.07 596.884 293.89 603.738]
/Subtype /Link
/Type /Annot
>>
endobj
24 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0025)
/Rect [367.919 596.884 386.739 603.738]
/Subtype /Link
/Type /Annot
>>
endobj
25 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0025)
/Rect [501.073 596.884 519.893 603.738]
/Subtype /Link
/Type /Annot
>>
endobj
26 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0030)
/Rect [149.681 583.932 168.501 590.787]
/Subtype /Link
/Type /Annot
>>
endobj
27 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0005)
/Rect [221.302 583.932 240.122 590.787]
/Subtype /Link
/Type /Annot
>>
endobj
28 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0035)
/Rect [324.638 583.932 343.457 590.787]
/Subtype /Link
/Type /Annot
>>
endobj
29 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0040)
/Rect [427.46 583.932 446.28 590.787]
/Subtype /Link
/Type /Annot
>>
endobj
30 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0045)
/Rect [512.448 583.932 531.268 590.787]
/Subtype /Link
/Type /Annot
>>
endobj
31 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0015)
/Rect [169.979 570.981 188.798 577.835]
/Subtype /Link
/Type /Annot
>>
endobj
32 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0010)
/Rect [312.898 570.981 331.718 577.835]
/Subtype /Link
/Type /Annot
>>
endobj
33 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0005)
/Rect [394.457 570.981 413.277 577.835]
/Subtype /Link
/Type /Annot
>>
endobj
34 0 obj
<<
/Border [0 0 0]
/Dest (LUNG4865AFF0050)
/Rect [401.376 570.981 420.196 577.835]
/Subtype /Link
/Type /Annot
>>
endobj
35 0 obj
<<
/A <<
/S /URI
/URI (mailto:jl.kuiper@vumc.nl)
>>
/Border [0 0 0]
/Rect [143.677 132.908 198.728 137.932]
/Subtype /Link
/Type /Annot
>>
endobj
36 0 obj
<<
/A <<
/S /URI
/URI (dx.doi.org/10.1016/j.lungcan.2015.05.023)
>>
/Border [0 0 0]
/Rect [84.632 114.753 231.269 119.777]
/Subtype /Link
/Type /Annot
>>
endobj
37 0 obj
<<
/N 38 0 R
/P 4 0 R
/R [85 243 606 813]
/T 9 0 R
/V 64 0 R
>>
endobj
38 0 obj
<<
/N 65 0 R
/P 4 0 R
/R [85 225 606 232]
/T 9 0 R
/V 37 0 R
>>
endobj
39 0 obj
<<
/Length 857
/Filter /FlateDecode
>>
stream
HT[81)KYawVxdȥ$i+xs;vժU9uww@vm. W@$_E#0xȍRǚhSqB4S ?liظSO37R
f`lD7Fn3>@r|'Ƃ*I*.51Wr|t^dL5SDIWP@Mw|;45Jr
4(F "'괬V]J8,v1͋KaY<~fOi8ܢ1
Z.=Fb0y|Fd(cWXv~E؛7V{
%0ZQ%Ubo'4@7>>4UZE}]}&@#Kt:Q[ۆfu(,@YZ͒HDRQ%\ӕGދxA?|>&6bF,e,nvUgEb3'<.:Gg)z"