%PDF-1.3
%
1 0 obj
<<
/Metadata 2 0 R
/Type /Catalog
/PageLabels 3 0 R
/Pages 4 0 R
>>
endobj
5 0 obj
<<
/Creator (3B2 Total Publishing System 8.07r/W)
/ModDate (D:20210914055512-07'00')
/CreationDate (D:20151001140824+05'30')
/Producer (Adobe LiveCycle PDFG ES; modified using iText 4.2.0 by 1T3XT)
/Subject (Stat Methods Med Res 2015.24:491-493)
/Author (Gerard JP van Breukelen and Math JJM Candel)
/Title (Efficient design and sample size calculation for trials with clustered data)
>>
endobj
2 0 obj
<<
/Length 3404
/Subtype /XML
/Type /Metadata
>>
stream
application/pdfdoi:10.1177/0962280215608718
10.1177/0962280215608718https://doi.org/10.1177/0962280215608718
2015-10-09truejournals.sagepub.com10.1177/0962280215608718
journals.sagepub.comtrue2015-10-0910.1177/0962280215608718
endstream
endobj
3 0 obj
<<
/Nums [0 6 0 R]
>>
endobj
4 0 obj
<<
/Kids [7 0 R 8 0 R 9 0 R 10 0 R]
/Type /Pages
/Count 4
/ITXT (4.2.0)
>>
endobj
6 0 obj
<<
/S /D
>>
endobj
7 0 obj
<<
/Contents 11 0 R
/Type /Page
/Resources <<
/Font <<
/F1 12 0 R
/F2 13 0 R
/F3 14 0 R
/F4 15 0 R
>>
/XObject <<
/Xf1 16 0 R
>>
>>
/Annots [17 0 R 18 0 R 19 0 R]
/Parent 4 0 R
/MediaBox [0 0 595 842]
>>
endobj
8 0 obj
<<
/Contents [20 0 R 21 0 R 22 0 R]
/Type /Page
/Resources <<
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/ExtGState <<
/GS2 23 0 R
/GS3 24 0 R
>>
/Font <<
/F1 25 0 R
/F2 26 0 R
/F3 27 0 R
/F4 28 0 R
/F5 29 0 R
/F6 30 0 R
>>
/XObject <<
/Xi0 31 0 R
/Xi1 32 0 R
>>
/Properties <<
/MC1 33 0 R
/MC2 34 0 R
>>
>>
/Parent 4 0 R
/CropBox [0 0 535.748 697.323]
/Annots [35 0 R]
/Rotate 0
/MediaBox [0 0 535.748 697.323]
>>
endobj
9 0 obj
<<
/Contents 36 0 R
/Type /Page
/Resources 37 0 R
/Parent 4 0 R
/CropBox [0 0 535.748 697.323]
/Rotate 0
/MediaBox [0 0 535.748 697.323]
>>
endobj
10 0 obj
<<
/Contents 38 0 R
/Type /Page
/Resources 39 0 R
/Parent 4 0 R
/CropBox [0 0 535.748 697.323]
/Rotate 0
/MediaBox [0 0 535.748 697.323]
>>
endobj
11 0 obj
<<
/Length 1799
/Filter /FlateDecode
>>
stream
xXoHC%M>Dm*`Nub(_xqa ;M_|rή1넓N
of~3D#*K:YܑlOA{Өh Ss죓.L*]҈fѪ\pS=eҁ1|UfJSDXJƮ{?)J>FfabŌʪxS@tCs.nإXT%S\*,$3]ժ%r8?Y7vs(ѩ2aFk׃%
iH`NDyvNqQ)Ɍ2F>X./}7eM-iZ^V/jnVf]3sCGvN_lBe U1_g
tZXwP@(Q
B|ڳBb7Z'"EEeݸOs94hE:!$.nId+ݐ34JV\$KI gk#9O@(- F=Q!AΓ1o3%MRy&e`)kfx_be626tfڌ
ж6v9 ZvLLGdemIG>+Ӫ:լ19Fb{{69}ׂ1E6? b~ϼE>c(Aj^ʬVq&;EWw6550 B%"K}`.bQ1,~19A#!ɱ~v)\EH!"wh^Pfd3T zi
^
"c lPg%3;g 5H
̠|V
s=(~sF-)>M=@37(Pٕ
)g3^&6F*wD2?$<&-A,)b)H
1RrwZh`g3Py(֍[/^QN/鉱8OpHXG@3$`~j\sI$lݝK-eB{dc
jCQjq|IHE\Б[zZpLJ9O8Ǣ]+s1ɳDlLɮ)5`D3&z윮2$CBhItq:1KJinƻ+6L>qFW(.yê3MBm<-i<륆A-&"){MѮH
"lycMIS6'z&o9sFwtr۩4㍃%nRZkN1^
;ee/6}72Zt#&:E!7
}}T$g_b:bVuEŴ&:kU:&νk7$9; Pm֞~?UncܲK+\}hZE赜yݸmwwP!Yא{qqYD}ŚfM
endstream
endobj
12 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Bold
/Encoding /WinAnsiEncoding
>>
endobj
13 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica
/Encoding /WinAnsiEncoding
>>
endobj
14 0 obj
<<
/Subtype /Type0
/Type /Font
/BaseFont /PQJHXM+LiberationSans
/Encoding /Identity-H
/DescendantFonts [40 0 R]
/ToUnicode 41 0 R
>>
endobj
15 0 obj
<<
/Subtype /Type1
/Type /Font
/BaseFont /Helvetica-Oblique
/Encoding /WinAnsiEncoding
>>
endobj
16 0 obj
<<
/Length 273
/Subtype /Form
/Filter /FlateDecode
/Type /XObject
/Matrix [1 0 0 1 0 0]
/FormType 1
/Resources <<
/ExtGState <<
/GS7 42 0 R
/GS8 43 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/Font <<
/F1 44 0 R
>>
/XObject <<
/Image9 45 0 R
>>
>>
/BBox [0 0 595.32 841.92]
>>
stream
x=k0w;$C!IB %!8[iG;j8};U,wNܹ,)scn>fed
߽?.u_d2!NR"ʃ$|cKAJbC _z`NtdfefS(ڶ(HE+J7=[l=μ]L遹Gg¿%Tw\YYDH-݁o;_dB\OM|ͯy
endstream
endobj
17 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1177/0962280215608718)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [85 618 276.25 628]
>>
endobj
18 0 obj
<<
/A <<
/S /URI
/URI (https://doi.org/10.1177/0962280215608718)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [85 508 212.88 518]
>>
endobj
19 0 obj
<<
/A <<
/S /URI
/URI (https://cris.maastrichtuniversity.nl/en/publications/62ffe0e0-6b28-4c4f-b07b-873250b2d894)
>>
/Subtype /Link
/C [0 0 1]
/Border [0 0 0]
/Rect [85 304 165.04 314]
>>
endobj
20 0 obj
<<
/Length 10
/Filter /FlateDecode
>>
stream
x+ |
endstream
endobj
21 0 obj
<<
/Length 10573
/Filter /FlateDecode
>>
stream
hޔ{]G%rߪ/$2k֖=xl,Kzջ\}{'bzAo77xe趫|wapٟ_~_}_Wn]\CFTnCqKWba]^K //2Шb}H'rT/eH83X__ׂev^:ʩu4:z%`e7hO&iC5W!K"!b{5@K]Ls9eB1ezrU~ϠH2kT\`uI1Tű>X@!.ƆL/I1ћn2kΕ-T z,84f\A+FP%T16~(,T""y
9dGVs?NdTF[eμB%:`3Xe)~ >$g4f|. 0H;_}5{Dg:4Mz*{r$Чhґ'4'7PajCYGHѵ)tM9R ÅebGpٞRW+2
0yUn
q2/L
Bd~Qm%xk,(
(DȆT~L
J@
.*iYhPCTN;.{$D(,>B
?ߋPS,I'7~ OIH =.b7L[UZ-` "Dd}%s>EY3"Dtp. H"aiOHXnIVr!JcH",80QlBd.H*i8wHS#DD(A!(
5N]֖S##
q/ƂL['PrN~!c*un47ɡ`nL0%F`,эf&GoęJ%&sE,@7}X%F &m d#*^qOsO˱.i%*2P*K6d)*i<(lkeHJE]B#kVP:(|rp5Di5Rĝ{e P^
JQ#%jk(j۷WZS}v.z⇨F!G@T1bp+k,XJd9i@&