%PDF-1.7
%
1 0 obj
<<
/PageMode /UseOutlines
/Names 2 0 R
/Outlines 3 0 R
/Metadata 4 0 R
/Pages 5 0 R
/PageLayout /SinglePage
/OpenAction [6 0 R /FitH 810]
/Threads [7 0 R]
/StructTreeRoot 8 0 R
/Type /Catalog
/PageLabels 9 0 R
>>
endobj
10 0 obj
<<
/CrossMarkDomains#5B2#5D (elsevier.com)
/CrossmarkMajorVersionDate (2010-04-23)
/CreationDate (D:20180130052116+05'30')
/Subject (European Journal of Cancer, 91 \(2018\) 92-98. doi:10.1016/j.ejca.2017.12.011)
/Author (Mart Schiefer)
/Creator (Elsevier)
/Producer (Acrobat Distiller 8.1.0 \(Windows\))
/ElsevierWebPDFSpecifications (6.5)
/CrossmarkDomainExclusive (true)
/robots (noindex)
/ModDate (D:20180130052148+05'30')
/doi (10.1016/j.ejca.2017.12.011)
/CrossMarkDomains#5B1#5D (sciencedirect.com)
/Title (Current perspective: Osimertinib-induced QT prolongation: new drugs with new side-effects need careful patient monitoring)
>>
endobj
2 0 obj
<<
/Dests 11 0 R
>>
endobj
3 0 obj
<<
/First 12 0 R
/Count 9
/Last 12 0 R
>>
endobj
4 0 obj
<<
/Length 7154
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
doi:10.1016/j.ejca.2017.12.011
Current perspective: Osimertinib-induced QT prolongation: new drugs with new side-effects need careful patient monitoring
Mart Schiefer
Lizza E.L. Hendriks
Trang Dinh
Ulrich Lalji
Anne-Marie C. Dingemans
Non-small cell lung cancer
Tyrosine kinase inhibitor
QT interval
Disease flare
Drug monitoring
European Journal of Cancer, 91 (2018) 92-98. doi:10.1016/j.ejca.2017.12.011
Elsevier Ltd
journal
European Journal of Cancer
© 2017 Elsevier Ltd. All rights reserved.
0959-8049
91
March 2018
92-98
92
98
10.1016/j.ejca.2017.12.011
https://doi.org/10.1016/j.ejca.2017.12.011
2010-04-23
true
10.1016/j.ejca.2017.12.011
elsevier.com
sciencedirect.com
VoR
10.1016/j.ejca.2017.12.011
noindex
2010-04-23
true
sciencedirect.com
elsevier.com
Elsevier
2018-01-30T05:21:16+05:30
2018-01-30T05:21:48+05:30
2018-01-30T05:21:48+05:30
True
Acrobat Distiller 8.1.0 (Windows)
uuid:ddb58df9-2cef-43d2-b849-401c58a1381f
uuid:d17863f2-0ec9-40e1-af57-43a9dbf701f3
endstream
endobj
5 0 obj
<<
/Count 8
/Type /Pages
/Kids [13 0 R 6 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R]
>>
endobj
6 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R
30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R
40 0 R 41 0 R 42 0 R]
/Parent 5 0 R
/B [43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R]
/StructParents 1
/Contents [52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R]
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 60 0 R
/Type /Page
>>
endobj
7 0 obj
<<
/F 43 0 R
/I 61 0 R
>>
endobj
8 0 obj
<<
/K [62 0 R 63 0 R 64 0 R 65 0 R]
/ParentTree 66 0 R
/ParentTreeNextKey 4
/Type /StructTreeRoot
>>
endobj
9 0 obj
<<
/Nums [0 67 0 R]
>>
endobj
11 0 obj
<<
/Kids [68 0 R]
>>
endobj
12 0 obj
<<
/First 69 0 R
/Parent 3 0 R
/Dest
/Count 8
/Last 70 0 R
/Title
>>
endobj
13 0 obj
<<
/Contents 71 0 R
/Type /Page
/Resources <<
/Font <<
/F1 72 0 R
/F2 73 0 R
/F3 74 0 R
/F4 75 0 R
>>
/XObject <<
/Xf1 76 0 R
>>
>>
/Annots [77 0 R 78 0 R 79 0 R]
/Parent 5 0 R
/MediaBox [0 0 595 842]
>>
endobj
14 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [80 0 R 81 0 R 82 0 R 83 0 R 84 0 R]
/Parent 5 0 R
/B [85 0 R 86 0 R 87 0 R]
/StructParents 2
/Contents 88 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 89 0 R
/Type /Page
>>
endobj
15 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [90 0 R 91 0 R 92 0 R 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R 98 0 R 99 0 R
100 0 R 101 0 R]
/Parent 5 0 R
/B [102 0 R 103 0 R]
/StructParents 3
/Contents 104 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 105 0 R
/Type /Page
>>
endobj
16 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R
116 0 R 117 0 R 118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R 124 0 R 125 0 R
126 0 R 127 0 R 128 0 R 129 0 R 130 0 R 131 0 R 132 0 R 133 0 R 134 0 R 135 0 R
136 0 R 137 0 R]
/Parent 5 0 R
/B [138 0 R]
/Contents 139 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 140 0 R
/Type /Page
>>
endobj
17 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R
151 0 R 152 0 R 153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R
161 0 R 162 0 R 163 0 R 164 0 R 165 0 R]
/Parent 5 0 R
/Contents 166 0 R
/Rotate 90
/MediaBox [0 0 595.276 793.701]
/Resources 167 0 R
/Type /Page
>>
endobj
18 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R
178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R 187 0 R
188 0 R 189 0 R 190 0 R 191 0 R 192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R
198 0 R 199 0 R 200 0 R 201 0 R 202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R
208 0 R 209 0 R 210 0 R 211 0 R 212 0 R 213 0 R 214 0 R 215 0 R 216 0 R 217 0 R
218 0 R 219 0 R 220 0 R 221 0 R 222 0 R 223 0 R 224 0 R 225 0 R]
/Parent 5 0 R
/B [226 0 R 227 0 R]
/Contents 228 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 229 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0 0 595.276 793.701]
/Annots [230 0 R 231 0 R 232 0 R 233 0 R 234 0 R 235 0 R 236 0 R 237 0 R 238 0 R 239 0 R
240 0 R 241 0 R 242 0 R 243 0 R 244 0 R 245 0 R 246 0 R 247 0 R 248 0 R 249 0 R
250 0 R 251 0 R 252 0 R 253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R
260 0 R 261 0 R 262 0 R 263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R
270 0 R 271 0 R 272 0 R 273 0 R 274 0 R]
/Parent 5 0 R
/B [275 0 R 276 0 R]
/Contents 277 0 R
/Rotate 0
/MediaBox [0 0 595.276 793.701]
/Resources 278 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/Rect [53.802 513.468 53.802 516.019]
/Subtype /Link
/A 279 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
21 0 obj
<<
/Rect [134.419 517.266 139.294 530.192]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
22 0 obj
<<
/Rect [147.118 513.468 147.118 516.019]
/Subtype /Link
/A 280 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
23 0 obj
<<
/Rect [264.813 517.266 270.198 530.192]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
24 0 obj
<<
/Rect [272.806 512.391 279.269 525.373]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
25 0 obj
<<
/Rect [287.093 513.468 287.093 516.019]
/Subtype /Link
/A 281 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
26 0 obj
<<
/Rect [357.222 517.266 361.474 530.192]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
27 0 obj
<<
/Rect [369.298 513.468 369.298 516.019]
/Subtype /Link
/A 282 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
28 0 obj
<<
/Rect [438.349 517.266 443.679 530.192]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
29 0 obj
<<
/Rect [53.802 498.501 53.802 501.109]
/Subtype /Link
/A 283 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
30 0 obj
<<
/Rect [209.31 502.299 214.639 515.282]
/Subtype /Link
/Border [0 0 0]
/Dest
/Type /Annot
>>
endobj
31 0 obj
<<
/Rect [125.745 101.934 212.031 109.928]
/Subtype /Link
/A 284 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
32 0 obj
<<
/Rect [263.509 101.934 345.487 109.928]
/Subtype /Link
/A 285 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
33 0 obj
<<
/Rect [413.348 101.934 484.441 109.928]
/Subtype /Link
/A 286 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
34 0 obj
<<
/Rect [524.012 101.934 549.921 109.928]
/Subtype /Link
/A 287 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
35 0 obj
<<
/Rect [53.802 92.013 82.942 99.95]
/Subtype /Link
/A 288 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
36 0 obj
<<
/Rect [121.89 92.013 199.842 99.95]
/Subtype /Link
/A 289 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
37 0 obj
<<
/Rect [479.225 577.077 507.572 605.424]
/Subtype /Link
/A 290 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
38 0 obj
<<
/Rect [53.802 70.639 192.132 78.633]
/Subtype /Link
/A 291 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
39 0 obj
<<
/Rect [294.576 727.257 387.496 736.214]
/Subtype /Link
/A 292 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
40 0 obj
<<
/Rect [304.554 661.209 389.99 669.203]
/Subtype /Link
/A 293 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
41 0 obj
<<
/Rect [53.802 751.975 199.786 759.912]
/Subtype /Link
/A 294 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
42 0 obj
<<
/Rect [205.739 751.975 213.676 759.912]
/Subtype /Link
/A 295 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
43 0 obj
<<
/N 44 0 R
/P 6 0 R
/R [51 734 296 739]
/T 7 0 R
/V 276 0 R
>>
endobj
44 0 obj
<<
/N 45 0 R
/P 6 0 R
/R [51 620 553 641]
/T 7 0 R
/V 43 0 R
>>
endobj
45 0 obj
<<
/N 46 0 R
/P 6 0 R
/R [51 545 472 614]
/T 7 0 R
/V 44 0 R
>>
endobj
46 0 obj
<<
/N 47 0 R
/P 6 0 R
/R [51 494 472 533]
/T 7 0 R
/V 45 0 R
>>
endobj
47 0 obj
<<
/N 48 0 R
/P 6 0 R
/R [51 409 472 477]
/T 7 0 R
/V 46 0 R
>>
endobj
48 0 obj
<<
/N 49 0 R
/P 6 0 R
/R [51 380 553 408]
/T 7 0 R
/V 47 0 R
>>
endobj
49 0 obj
<<
/N 50 0 R
/P 6 0 R
/R [51 335 296 364]
/T 7 0 R
/V 48 0 R
>>
endobj
50 0 obj
<<
/N 51 0 R
/P 6 0 R
/R [51 229 164 340]
/T 7 0 R
/V 49 0 R
>>
endobj
51 0 obj
<<
/N 85 0 R
/P 6 0 R
/R [188 131 553 335]
/T 7 0 R
/V 50 0 R
>>
endobj
52 0 obj
<<
/Length 1258
/Filter /FlateDecode
>>
stream
HV]S7}_G9}k}
@H΄f-M5]/P;=v
n1d`@t={
o;^2_gFK"fHԚ>eQ&"lnaBN'N&8 `2D)ǴZƃeLά*^lcf~N_d3VH9l6 'D&LV1RaJd#*.u|UWѧɛLCeurٯjDpGW~
z