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THROMBOSIS RESEARCH Volme 10, Pages 495-fr7. Pergamon Press, L977. Printed in ct. Britain.
A NEII 1m?HOD FOR THE PREPARATfON OF ARTIFfCIAL FACTOR TfREAGENTS FROM NORMAL HUMAN AND BOVINE PI,ASMAC. Vermeer, E.A.M. Soute and H.C. HemkerDepartnrent of Bioctremistny, State UniversityLimburg, Maastricht, Ttre Netherl"ands.
(Received 28.6.L976. Accepted by Editor F. Josso.Received by Executive Editorial Offiee 28.L,L977)
ABSTRAOTAn artificiaL factor II reagent is composed by supplemen-ting BaSO4 adsorbed plasma with a concentrated so1-utiontcontaining factors VII and X. Ttrese factors are preparedby the addition of Echis Carinatus venom to p1asmae rrlo-va1 of the clot wtrich has formed within'l hourr adsorptionof ttre factors VII and X to DEAE Sephadex, followed by astep eJ-ution and subsequent diaLysis of the factors. Thereagent contains no detectable Echis Carinatus venomtfactor If or thrombin. The adwantagbs of tl-is reagentover ttre conventional" ones are discussed.
TNTRODUCTION
For the deterrrination of coagulation factor II generally tr^/o procedures areus ed:a. The one-stage assay in which factor II deficient plasna and thromboplastinconstitute a medium in which all factors except prothrombin are present inexcess.The prothrombin content of the sample added is rate lirniting. Theclotting tine upon recalcification thus indicates Lhe prothrombin level(t).b. The trrro-stage assay in tvliich first the prothrombin present in the sampleis converted into thrombin. In a second stage the thrombin content is+95
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