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Haemostasis ,Managing Editor: H.C, Hemker, Maastricht
ReprintPublisher: S.KargerAG, BaselPrintd in Switzerland
Haemostasis I3: 192-197 (1983)
@ 1983 S. KargerAG, Basel030 l-0 147183/0 I 334t92$2.7 5 /O
Evaluation of a Coagulation Assay Determining the
Activity State of Factor VII in Plasma
W.A. van Deijk", M.C.E. van Dam-Mierasb, A.D. Mullerb, H.C. HemkerbaDepartment of Internal Medicine, University Hospital Annadal, and bDepartment of Biochemistry,University of Limburg, Maastricht, The Netherlands
Key Words. Factor VIIa . Factor VII ' Factor Vll-deficient plasma . Cold-promotedactivation . Factor VIla assavAbstract. A coagulation assay is described that allows the measurement of the degree ofactivation of factor VII in circulating blood. The test is based on the use of both bovine andhuman brain thromboplastin, together with an artificial factor Vll-deficient plasma. Thelatter can be prepared on a relatively large scale which makes it possible to measure factor VIIactivation in large series ofpatients.The determination of factor VII activation during incubation at 4"C of plasma of womenusing oral contraceptives shows that the test described adequately measures factor VII acti-yation. Differences in the time course of factor VII activation during this incubation in glassand plastic containers are found and implicate that rigorous standardization of blood sam-pling and test conditions is necessary. A possible mechanism that causes this critical depen-dence upon the test conditions is discussed.
IntroductionIn the preliminary phase of an epidemio-logical investigation of the activation of coag-ulation enzymes in the circulating blood ofcancer patients we critically assessed the fac-tor VII activation test describedby Hemkeret al. [6]. The test system described allows themeasurement of the degree of activation offactor VII in plasma and is based on the useof both bovine and human brain thrombo-plastin, together with an artifrcial factor VII-deficient reagent. The latter can be preparedon a relatively large scale which makes it pos-
sible to measure factor VII activation in alarge series of patients. This may be of im-portance because of the possible epidemio-logic use of this estimation [2, 9].The usefulness of the test was assessed bythe measurement of factor VII activationduring incubation at 4'C of pooled plasmaof women using oral contraceptive agents(OCAs) [4]. Because differences in the timecourse of activation of factor VII in plasmaduring incubation in the cold in glass andplastic containers have been reported in theliterature 14, 5, l2l we also investigated thisaspect.
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