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THR0MB0SIS RESEARCH 37: 295-307, '19850049-3848/85 $3.00 + .00 Printed in the USA.Copyright (c) '1985 Pergamon Press Ltd. A1l rights reserved.
COMPARISON BETWEEN THE EFFECT OF PENTOS?IN POLYSULPTIATEHEPARIN AND ANTITHRO}4BIN III INJEETIONSIN ANTITHROMBIN III DEFICIENT PATIENTSA.M. Fischerl, M.D. Dautzenbergl, M.H. Aurousg"^u2,S. B6guinl, J. Goudemandr and H.C. Heftker$.1. cHu Necker-Enfants Malades, 75730 Parls e6dex 15.2. H6pital Jean Verdier, 93140 Bondy. 3. eHR de L111e,France. 4. Department of Biochemistfy, I"imburg UnLvetsLty,62OO MD, Maastficht, The Netherlande.(Recqived 22.4.1984; Accepted in revlsed forni 24,70,1984by Editor C.A. Bouvlef)ABSTRACT
Pentosan polysulphate is an heparin ahalogue which actsvia an antithrombin ItI (AT IIl) independent pathway. Wecompared the effect of this drug to that of heparin andAT IIf infusions in AT III def,icient patients. Fourpatients with AT III congenital deficiency received onthree different occasions : (i) an infuslon of human ATrrr concentrate (2o u/kg or 40 'J/kTl r (ii) afl intramus-cular i-njection of pentosan polysulphate (2 ng/kgl ' (iii)a subcutaneous calcj-um heparin injection (1OO U/kg). arIII -infusion inhibits the excessive thrombin qeneration(46 Z of inhibition) observed in the plasma of AT IIIdeficient patients during at least 12 hours, but does notmodify the factor Xa formation. On the contrary, pentosanpotysulphate has a marked effect on both thrombin (62 Zof inhibition) and factor Xa generation (57 Z of inhibi-tion) still present 8 hours after injection. Heparininjection has the same effect, more prolonged, as pento-san polysulphate on thrombin generation but is not soeffective on impairing factor Xa generation (27 Z ofinhibition). The marked effect of pentosan polysulphateon thrombin and factor Xa generation in these patientsis due to its AT III independent mechanism of action.
INTRODUCTION
Patientsgeneral tendency
Key words :
TII concentrate,III deficiency.
with a congenital AT III deficiency show ato thrombo-embolism (1). To prevent accidents,
ATAT
heparin, pentosan polysulphate,295
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