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<<
/Length 2651
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stream
"/
MED RAZGL 1990;29:SLJPPL 1:95- 110DETERMINATION OF HEPARIN IN BLOODC. H. Hemket nnd S. Bdguin
Haemctas's and Thrombosis
1990, Edited by D Kebcr. Mediciroki rogledi, Ljublim 1990'
INTRODUCTIONProbably the mostimportant antithrombotic drug in-use atthe moment is heparin (1-10)'Actuaflf the annual iale in the Netherlands is 6.1010 U, that is 2000 U per head of thepoprrlato.r. Its administration by injection and the fact that the prescribing doctors arewell aware of the inherent risk of bleeding (11) make that it is not likely to be usedinJvertently. The consumption in the Netherlands is probably the minimum that canbe used in any medical community that takes the prevention and treatrnent of thrombosisseriously because especialty in this country the use of the only serious alternative - i'e'oral unticougulatio.- is',reiy well organized and hence very common (12'L3).In recent years we have witnessed the advent of low molecular weight heparins(LlvMH), [h"." u." indications that they may be more convenient drugs then unfrac-tionatedheparin (uFH) is Ga-23).This piomises that heparin usage will still increase- Infact the discussion that is going o., o., iMWH ulready seems to bring about a rise in theuse of UFH.This situation makes that the question of how to determine heparin in the plasma of apatient becomes more and moie urgent. Logically another question should precede thequestionof kozo todetermineheparin,and thatis zolry to determine heparin' Is itnecessaryto determine heparin levels (or a related parameter) or will giving standard doses do thejob? That fundamental question can be answered only from controlled-clinical trials andfo. su.h trials an adeq,rate heparin test must be available. This is a circular argument'Therefore the question of what makes a good heparin test may well be the one to startwith.CURRENT TYPES OF HEPARIN TESTSAll current determinations of heparin are based on its influence on the blood coagulationprocess i.e. its enhancing effeit on the inactivation of activated clotting factors byantithrombin III (AT III). ierreral other actions of heparin have been described however'It binds to the vessel wall(u-27),influence.s fibrinolysis (2s-32), causes the release oflipoprotein lipase (33-38) etc. we keep thinking that its main therapeutic action is onUiooa coag,rtition for a simple reason: vitamin K antagonists also have a large sPectrumof actions apart from that on coagulation. Yet coagulation is the only one that it has incommon with heparin. It seems more likely then not that it is indeed this commondenominator that has the antithrombotic effect. Until proof of the contrary we therefore
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