@article{d93543025af34642afcdbfee41e2f38f,
title = "Zebrafish models of impulsivity and impulse control disorders",
abstract = "Impulse control disorders (ICDs) are characterized by generalized difficulty controlling emotions and behaviors. ICDs are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional-defiant disorder, antisocial personality disorder, kleptomania, pyromania and other illnesses. Although they all share a common feature (aberrant impulsivity), their pathobiology is complex and poorly understood. There are also currently no ICD-specific therapies to treat these illnesses. Animal models are a valuable tool for studying ICD pathobiology and potential therapies. The zebrafish (Danio rerio) has become a useful model organism to study CNS disorders due to high genetic and physiological homology to mammals, and sensitivity to various pharmacological and genetic manipulations. Here, we summarize experimental models of impulsivity and ICD in zebrafish and highlight their growing translational significance. We also emphasize the need for further development of zebrafish ICD models to improve our understanding of their pathogenesis and to search for novel therapeutic treatments.",
keywords = "AGGRESSIVE-BEHAVIOR, ANIMAL-MODELS, CONDUCT DISORDER, DEFICIT HYPERACTIVITY DISORDER, ENVIRONMENTAL ENRICHMENT, INTERMITTENT EXPLOSIVE DISORDER, NATIONAL COMORBIDITY, NEURAL BASIS, OPPOSITIONAL DEFIANT DISORDER, REACTION-TIME-TASK, aggressive-behavior, aggressiveness, animal models, animal-models, behavior, central nervous system, conduct disorder, deficit hyperactivity disorder, environmental enrichment, genetic models, intermittent explosive disorder, national comorbidity, neural basis, oppositional defiant disorder, reaction-time-task, ADULT ZEBRAFISH",
author = "{de Abreu}, M.S. and A.C.V.V. Giacomini and R. Genario and B.D. Fontana and M.O. Parker and L. Marcon and N. Scolari and B. Bueno and K.A. Demin and D. Galstyan and T.O. Kolesnikova and T.G. Amstislavskaya and K.N. Zabegalov and T. Strekalova and A.V. Kalueff",
note = "Funding Information: AVK is supported by the Southwest University Zebrafish Platform Funds (Chongqing, China). He is the Chair of the International Zebrafish Neuroscience Consortium (ZNRC) that coordinated this collaborative study. ACVVG is supported by the Funda??o de Amparo ? Pesquisa do Estado do Rio Grande do Sul (FAPERGS) research fellowships 17/2551-0001-269-0. KAD is supported by the President of Russia Graduate Fellowship and the Special Rector's Productivity Fellowship for SPSU PhD Students. The laboratory is supported by St. Petersburg State University state budgetary research fund project 51130521. Their zebrafish research project is supported by the Russian Science Foundation (RSF) grant 19-15-00053. TGA's research is supported by the budgetary funding for basic research from the Scientific Research Institute of Physiology and Basic Medicine (program AAAA-A16-116021010228-0, Novosibirsk, Russia). BDF receives funding from CAPES Foundation (Brazil). MOP currently receives funding from the Foundation for Liver Research (UK) and Alzheimer's Research UK. The funders had no role in the design, analyses and interpretation of the submitted study, or decision to publish. The authors thank Mrs Lyudmyla. Funding Information: AVK is supported by the Southwest University Zebrafish Platform Funds (Chongqing, China). He is the Chair of the International Zebrafish Neuroscience Consortium (ZNRC) that coordinated this collaborative study. ACVVG is supported by the Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa do Estado do Rio Grande do Sul (FAPERGS) research fellowships 17/2551‐0001‐269‐0. KAD is supported by the President of Russia Graduate Fellowship and the Special Rector's Productivity Fellowship for SPSU PhD Students. The laboratory is supported by St. Petersburg State University state budgetary research fund project 51130521. Their zebrafish research project is supported by the Russian Science Foundation (RSF) grant 19‐15‐00053. TGA's research is supported by the budgetary funding for basic research from the Scientific Research Institute of Physiology and Basic Medicine (program AAAA‐A16‐116021010228‐0, Novosibirsk, Russia). BDF receives funding from CAPES Foundation (Brazil). MOP currently receives funding from the Foundation for Liver Research (UK) and Alzheimer's Research UK. The funders had no role in the design, analyses and interpretation of the submitted study, or decision to publish. The authors thank Mrs Lyudmyla. Publisher Copyright: {\textcopyright} 2020 Federation of European Neuroscience Societies and John Wiley & Sons Ltd",
year = "2020",
month = nov,
day = "1",
doi = "10.1111/ejn.14893",
language = "English",
volume = "52",
pages = "4233--4248",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "John Wiley & Sons Inc.",
number = "10",
}