"You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology

A. Bast, J.C. Hanekamp

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.
Original languageEnglish
Pages (from-to)664-672
Number of pages9
JournalDose-Response
Volume12
Issue number4
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Golden Ratio
  • LNT
  • adaption
  • reification fallacy
  • SUPEROXIDE-DISMUTASE
  • DIETARY NITRATE

Cite this

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"You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology. / Bast, A.; Hanekamp, J.C.

In: Dose-Response, Vol. 12, No. 4, 01.01.2014, p. 664-672.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - "You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology

AU - Bast, A.

AU - Hanekamp, J.C.

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N2 - Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.

AB - Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.

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KW - LNT

KW - adaption

KW - reification fallacy

KW - SUPEROXIDE-DISMUTASE

KW - DIETARY NITRATE

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DO - 10.2203/dose-response.13-032.Hanekamp

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JO - Dose-Response

JF - Dose-Response

SN - 1559-3258

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