"You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology

A. Bast; J.C. Hanekamp

doi:10.2203/dose-response.13-032.Hanekamp

"You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology

A. Bast, J.C. Hanekamp^*

^*Corresponding author for this work

Farmacologie en Toxicologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.

Original language	English
Pages (from-to)	664-672
Number of pages	9
Journal	Dose-Response
Volume	12
Issue number	4
DOIs	https://doi.org/10.2203/dose-response.13-032.Hanekamp
Publication status	Published - 1 Jan 2014

Keywords

Golden Ratio
LNT
adaption
reification fallacy
SUPEROXIDE-DISMUTASE
DIETARY NITRATE

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abstract = "Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.",

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AB - Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.

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KW - LNT

KW - adaption

KW - reification fallacy

KW - SUPEROXIDE-DISMUTASE

KW - DIETARY NITRATE

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DO - 10.2203/dose-response.13-032.Hanekamp

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EP - 672

JO - Dose-Response

JF - Dose-Response

IS - 4

ER -

"You Can't Always Get What You Want" - Linearity as the Golden Ratio of Toxicology

Abstract

Keywords

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