Women's Experience with Non-Invasive Prenatal Testing and Emotional Well-being and Satisfaction after Test-Results

Rachel V. van Schendel, G. C. M. Lieve Page-Christiaens, Lean Beulen, Caterina M. Bilardo, Marjon A. de Boer, Audrey B. C. Coumans, Brigitte H. W. Faas, Irene M. van Langen, Klaske D. Lichtenbelt, Merel C. van Maarle, Merryn V. E. Macville, Dick Oepkes, Eva Pajkrt, Lidewij Henneman*, Dutch NIPT Consortium

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Increasingly, high-risk pregnant women opt for non-invasive prenatal testing (NIPT) instead of invasive diagnostic testing. Since NIPT is less accurate than invasive testing, a normal NIPT result might leave women less reassured. A questionnaire study was performed among pregnant women with elevated risk for fetal aneuploidy based on first-trimester combined test (risk >= 1:200) or medical history, who were offered NIPT in the nationwide Dutch TRIDENT study. Pre- and post-test questionnaires (n = 682) included measures on: experiences with NIPT procedure, feelings of reassurance, anxiety (State-Trait Anxiety Inventory, STAI), child-related anxiety (PRAQ-R), and satisfaction. The majority (96.1%) were glad to have been offered NIPT. Most (68.5%) perceived the waiting time for NIPT results (mean: 15 days, range 5-32) as (much) too long. Most women with a normal NIPT result felt reassured (80.9%) or somewhat reassured (15.7%). Levels of anxiety and child-related anxiety were significantly lower after receiving a normal NIPT result as compared to the moment of intake (p <0.001). Women with inadequate health literacy or a medical history (e.g. previous child with trisomy) experienced significantly higher post-test-result anxiety (Mean (M) STAI = 31.6 and 30.0, respectively) compared to those with adequate health literacy (M = 28.6) and no medical history (M = 28.6), indicating these women might benefit from extra information and/or guidance when communicating NIPT test-results. Introducing NIPT as an alternative to invasive testing, led to an offer that satisfied and largely reassured high-risk pregnant women.

Original languageEnglish
Pages (from-to)1348-1356
Number of pages9
JournalJournal of Genetic Counseling
Issue number6
Publication statusPublished - Dec 2017


  • Prenatal Screening
  • NIPT
  • Non-invasive Prenatal Testing
  • Anxiety
  • Reassurance
  • Satisfaction
  • AGE

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