Wnt signaling plays an essential role during development, but is also activated in diseases as diverse as neurodegeneration, osteoporosis, and cancer. Accumulating evidence demonstrates that Wnt signaling is also activated during cardiac remodeling and heart failure. In this chapter, we will provide a brief overview of Wnt signaling in all its complexity. Then we will discuss the evidence for its involvement in the development of cardiac hypertrophy, the wound healing after myocardial infarction (MI) and heart failure. Finally, we will provide an overview of the drugs that are available to target Wnt signaling at different levels of the signaling cascade and the results of these pharmacological interventions in cardiac disease.
|Title of host publication||Heart Failure|
|Editors||Johann Bauersachs, Javed Butler, Peter Sandner|
|Number of pages||23|
|Publication status||Published - 2017|
|Series||Handbook of Experimental Pharmacology|
Stylianidis, V., Hermans, K. C. M., & Blankesteijn, W. M. (2017). Wnt Signaling in Cardiac Remodeling and Heart Failure. In J. Bauersachs, J. Butler, & P. Sandner (Eds.), Heart Failure (pp. 371-393). Springer. Handbook of Experimental Pharmacology, Vol.. 243 https://doi.org/10.1007/164_2016_56