Within patient horizontal gene transfer dynamics of a blaNDM-7 plasmid among four different bacterial species

O. Van Katwijk; M. Mulder; L. Van Alphen; F. Landman; A. Hendrickx; A. Verkerk; L. Sligman; R. Schnabel; W. Van Der Zwet; E. Smeets; Jamc. Dirks; C. Jamin

doi:10.1007/s10096-025-05327-x

Within patient horizontal gene transfer dynamics of a bla_NDM-7 plasmid among four different bacterial species

O. Van Katwijk^*
, M. Mulder
, L. Van Alphen
, F. Landman
, A. Hendrickx
, A. Verkerk
, L. Sligman
, R. Schnabel
, W. Van Der Zwet
, E. Smeets
, Jamc. Dirks
, C. Jamin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PurposeWe describe the case of a 73-year old male who was found to be a carrier of an blaNDM -producing Citrobacter freundii shortly after admission. During his admission, he developed abdominal abscesses and received multiple courses of piperacillin-tazobactam. In the following months, he was found to carry three other carbapenemase-positive species: Klebsiella oxytoca, Raoultella planticola and Serratia marscescens. ResultsTwo of these strains had clustering carbapenem-sensitive isolates cultured before. The species all carried an blaNDM-7 encoding incX3 plasmid, which demonstrated horizontal gene transfer within this patient.ConclusionThis case report underlines the importance of mobile genetic elements in infection control, as they serve as transmission vehicles for antimicrobial resistance beyond the spread of identical bacterial strains.

Original language	English
Number of pages	5
Journal	European Journal of Clinical Microbiology & Infectious Diseases
DOIs	https://doi.org/10.1007/s10096-025-05327-x
Publication status	E-pub ahead of print - 1 Oct 2025

Keywords

Horizontal gene transfer
Carbapenemase-producing
blaNDM7
IncX3
Antimicrobial resistance
Infection control

Access to Document

10.1007/s10096-025-05327-xLicence: CC BY

Cite this

Van Katwijk, O., Mulder, M., Van Alphen, L., Landman, F., Hendrickx, A., Verkerk, A., Sligman, L., Schnabel, R., Van Der Zwet, W., Smeets, E., Dirks, J., & Jamin, C. (2025). Within patient horizontal gene transfer dynamics of a bla_NDM-7 plasmid among four different bacterial species. European Journal of Clinical Microbiology & Infectious Diseases. Advance online publication. https://doi.org/10.1007/s10096-025-05327-x

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title = "Within patient horizontal gene transfer dynamics of a blaNDM-7 plasmid among four different bacterial species",

abstract = "PurposeWe describe the case of a 73-year old male who was found to be a carrier of an blaNDM -producing Citrobacter freundii shortly after admission. During his admission, he developed abdominal abscesses and received multiple courses of piperacillin-tazobactam. In the following months, he was found to carry three other carbapenemase-positive species: Klebsiella oxytoca, Raoultella planticola and Serratia marscescens. ResultsTwo of these strains had clustering carbapenem-sensitive isolates cultured before. The species all carried an blaNDM-7 encoding incX3 plasmid, which demonstrated horizontal gene transfer within this patient.ConclusionThis case report underlines the importance of mobile genetic elements in infection control, as they serve as transmission vehicles for antimicrobial resistance beyond the spread of identical bacterial strains.",

keywords = "Horizontal gene transfer, Carbapenemase-producing, blaNDM7, IncX3, Antimicrobial resistance, Infection control",

author = "\{Van Katwijk\}, O. and M. Mulder and \{Van Alphen\}, L. and F. Landman and A. Hendrickx and A. Verkerk and L. Sligman and R. Schnabel and \{Van Der Zwet\}, W. and E. Smeets and Jamc. Dirks and C. Jamin",

year = "2025",

month = oct,

day = "1",

doi = "10.1007/s10096-025-05327-x",

language = "English",

journal = "European Journal of Clinical Microbiology \& Infectious Diseases",

issn = "0934-9723",

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Van Katwijk, O , Mulder, M , Van Alphen, L, Landman, F, Hendrickx, A, Verkerk, A , Sligman, L , Schnabel, R , Van Der Zwet, W, Smeets, E, Dirks, J & Jamin, C 2025, 'Within patient horizontal gene transfer dynamics of a bla_NDM-7 plasmid among four different bacterial species', European Journal of Clinical Microbiology & Infectious Diseases. https://doi.org/10.1007/s10096-025-05327-x

TY - JOUR

T1 - Within patient horizontal gene transfer dynamics of a blaNDM-7 plasmid among four different bacterial species

AU - Van Katwijk, O.

AU - Mulder, M.

AU - Van Alphen, L.

AU - Landman, F.

AU - Hendrickx, A.

AU - Verkerk, A.

AU - Sligman, L.

AU - Schnabel, R.

AU - Van Der Zwet, W.

AU - Smeets, E.

AU - Dirks, Jamc.

AU - Jamin, C.

PY - 2025/10/1

Y1 - 2025/10/1

N2 - PurposeWe describe the case of a 73-year old male who was found to be a carrier of an blaNDM -producing Citrobacter freundii shortly after admission. During his admission, he developed abdominal abscesses and received multiple courses of piperacillin-tazobactam. In the following months, he was found to carry three other carbapenemase-positive species: Klebsiella oxytoca, Raoultella planticola and Serratia marscescens. ResultsTwo of these strains had clustering carbapenem-sensitive isolates cultured before. The species all carried an blaNDM-7 encoding incX3 plasmid, which demonstrated horizontal gene transfer within this patient.ConclusionThis case report underlines the importance of mobile genetic elements in infection control, as they serve as transmission vehicles for antimicrobial resistance beyond the spread of identical bacterial strains.

AB - PurposeWe describe the case of a 73-year old male who was found to be a carrier of an blaNDM -producing Citrobacter freundii shortly after admission. During his admission, he developed abdominal abscesses and received multiple courses of piperacillin-tazobactam. In the following months, he was found to carry three other carbapenemase-positive species: Klebsiella oxytoca, Raoultella planticola and Serratia marscescens. ResultsTwo of these strains had clustering carbapenem-sensitive isolates cultured before. The species all carried an blaNDM-7 encoding incX3 plasmid, which demonstrated horizontal gene transfer within this patient.ConclusionThis case report underlines the importance of mobile genetic elements in infection control, as they serve as transmission vehicles for antimicrobial resistance beyond the spread of identical bacterial strains.

KW - Horizontal gene transfer

KW - Carbapenemase-producing

KW - blaNDM7

KW - IncX3

KW - Antimicrobial resistance

KW - Infection control

U2 - 10.1007/s10096-025-05327-x

DO - 10.1007/s10096-025-05327-x

M3 - Article

SN - 0934-9723

JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

ER -