Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

Ruben Coronel; Mark Potse; Michel Haïssaguerre; Nicolas Derval; Mathilde R Rivaud; Veronique M F Meijborg; Matthijs Cluitmans; Mélèze Hocini; Bastiaan J Boukens

doi:10.3389/fphys.2021.648396

Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

Ruben Coronel
, Mark Potse
, Michel Haïssaguerre
, Nicolas Derval
, Mathilde R Rivaud
, Veronique M F Meijborg
, Matthijs Cluitmans
, Mélèze Hocini
, Bastiaan J Boukens^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.

Original language	English
Article number	648396
Number of pages	6
Journal	Frontiers in physiology
Volume	12
DOIs	https://doi.org/10.3389/fphys.2021.648396
Publication status	Published - 23 Mar 2021
Externally published	Yes

Keywords

Purkinje
ablation
arrhythmias
early repolarization syndrome
electrophysiology
idiopathic ventricular fibrillation

Access to Document

10.3389/fphys.2021.648396Licence: CC BY

Cite this

@article{bbe90586927249bfbcb76be96d2f8785,

title = "Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis",

abstract = "Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.",

keywords = "Purkinje, ablation, arrhythmias, early repolarization syndrome, electrophysiology, idiopathic ventricular fibrillation",

author = "Ruben Coronel and Mark Potse and Michel Ha{\"i}ssaguerre and Nicolas Derval and Rivaud, \{Mathilde R\} and Meijborg, \{Veronique M F\} and Matthijs Cluitmans and M{\'e}l{\`e}ze Hocini and Boukens, \{Bastiaan J\}",

note = "Copyright {\textcopyright} 2021 Coronel, Potse, Ha{\"i}ssaguerre, Derval, Rivaud, Meijborg, Cluitmans, Hocini and Boukens.",

year = "2021",

month = mar,

day = "23",

doi = "10.3389/fphys.2021.648396",

language = "English",

volume = "12",

journal = "Frontiers in physiology",

issn = "1664-042X",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic

T2 - The Interplay Between Fast Activation and Arrhythmogenesis

AU - Coronel, Ruben

AU - Potse, Mark

AU - Haïssaguerre, Michel

AU - Derval, Nicolas

AU - Rivaud, Mathilde R

AU - Meijborg, Veronique M F

AU - Cluitmans, Matthijs

AU - Hocini, Mélèze

AU - Boukens, Bastiaan J

PY - 2021/3/23

Y1 - 2021/3/23

N2 - Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.

AB - Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.

KW - Purkinje

KW - ablation

KW - arrhythmias

KW - early repolarization syndrome

KW - electrophysiology

KW - idiopathic ventricular fibrillation

U2 - 10.3389/fphys.2021.648396

DO - 10.3389/fphys.2021.648396

M3 - Article

C2 - 33833689

SN - 1664-042X

VL - 12

JO - Frontiers in physiology

JF - Frontiers in physiology

M1 - 648396

ER -

Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

Abstract

Keywords

Access to Document

Fingerprint

Cite this