Whole-liver diffusion-weighted MRI histogram analysis: effect of the presence of colorectal hepatic metastases on the remaining liver parenchyma

Doenja M. J. Lambregts, Milou H. Martens, Raymond C. W. Quah, Katerina Nikiforaki, Luc A. Heijnen, Cornelis H.C. Dejong, Geerard L. Beets, Kostas Marias, Nickolas Papanikolaou, Regina G. H. Beets-Tan*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


OBJECTIVES: To explore whether whole-liver diffusion-weighted MRI analysis (of the apparently normal liver parenchyma) can help differentiate between patients with colorectal liver metastasis and controls without liver disease. MATERIALS AND METHODS: Ten patients with colorectal liver metastasis and 10 controls with no focal/diffuse liver disease underwent liver MRI at 1.5 T including diffusion-weighted imaging (DWI; b-values 0, 50, 100, 500, 750, 1000). Apparent diffusion coefficient (ADC) maps were calculated from the DWI images to carry out quantitative diffusion analyses. An experienced reader performed segmentation of the apparently nondiseased liver (excluding metastases/focal liver lesions) on the ADC maps. Histogram ADC parameters were calculated and compared between the patients and the controls. RESULTS: The mean liver ADC was 0.95x10 mm/s for the patients versus 1.03x10 mm/s for the controls (P=0.42). The fifth percentile of the ADC was significantly lower for the patients compared with the controls (0.45 vs. 0.69 10 mm/s, P=0.01). The SD was significantly higher in the patient group (0.30 vs. 0.22, P<0.001). Median, skewness, kurtosis, and 30th-95th percentile were not significantly different between the two groups. Areas under the receiver operator characteristics curves to differentiate patients with metastatic liver involvement from healthy controls without liver disease were 0.79 for the fifth percentile and 0.95 for the SD. CONCLUSION: Whole-liver diffusion-weighted MRI histogram analysis showed a significant shift towards lower fifth percentile ADC values and higher SD in patients with colorectal liver metastasis compared with controls without liver disease.
Original languageEnglish
Pages (from-to)399-404
JournalEuropean Journal of Gastroenterology & Hepatology
Issue number4
Publication statusPublished - Apr 2015


  • apparent diffusion coefficient
  • colorectal liver metastases
  • diffusion-weighted magnetic resonance imaging
  • histogram analysis


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