Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial

Harry Bartelink*, Philippe Maingon, Philip Poortmans, Caroline Weltens, Alain Fourquet, Jos Jager, Dominic Schinagl, Bing Oei, Carla Rodenhuis, Jean-Claude Horiot, Henk Struikmans, Erik Van Limbergen, Youlia Kirova, Paula Elkhuizen, Rudolf Bongartz, Raymond Miralbell, David Morgan, Jean-Bernard Dubois, Vincent Remouchamps, Rene-Olivier MirimanoffSandra Collette, Laurence Collette

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

346 Citations (Web of Science)


Background since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 gy on overall survival, local control, and fibrosis for patients with stage i and ii breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results.
Original languageEnglish
Pages (from-to)47-56
JournalLancet oncology
Issue number1
Publication statusPublished - Jan 2015

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