TY - JOUR
T1 - Whole-breast irradiation with or without a boost for patients treated with breast-conserving surgery for early breast cancer: 20-year follow-up of a randomised phase 3 trial
AU - Bartelink, Harry
AU - Maingon, Philippe
AU - Poortmans, Philip
AU - Weltens, Caroline
AU - Fourquet, Alain
AU - Jager, Jos
AU - Schinagl, Dominic
AU - Oei, Bing
AU - Rodenhuis, Carla
AU - Horiot, Jean-Claude
AU - Struikmans, Henk
AU - Van Limbergen, Erik
AU - Kirova, Youlia
AU - Elkhuizen, Paula
AU - Bongartz, Rudolf
AU - Miralbell, Raymond
AU - Morgan, David
AU - Dubois, Jean-Bernard
AU - Remouchamps, Vincent
AU - Mirimanoff, Rene-Olivier
AU - Collette, Sandra
AU - Collette, Laurence
PY - 2015/1
Y1 - 2015/1
N2 - Background since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 gy on overall survival, local control, and fibrosis for patients with stage i and ii breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results.
AB - Background since the introduction of breast-conserving treatment, various radiation doses after lumpectomy have been used. In a phase 3 randomised controlled trial, we investigated the effect of a radiation boost of 16 gy on overall survival, local control, and fibrosis for patients with stage i and ii breast cancer who underwent breast-conserving treatment compared with patients who received no boost. Here, we present the 20-year follow-up results.
U2 - 10.1016/S1470-2045(14)71156-8
DO - 10.1016/S1470-2045(14)71156-8
M3 - Article
SN - 1470-2045
VL - 16
SP - 47
EP - 56
JO - Lancet oncology
JF - Lancet oncology
IS - 1
ER -