White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?

Elaine Schepers; Richel Lousberg; Sinan Guloksuz; Lotta-Katrin Pries; Philippe Delespaul; Gunter Kenis; Jurjen J. Luykx; Bochao D. Lin; Alexander L. Richards; Berna Akdede; Tolga Binbay; Vesile Altinyazar; Berna Yalincetin; Guvem Gumus-Akay; Burcin Cihan; Haldun Soygur; Halis Ulas; Eylem Sahin Cankurtaran; Semra Ulusoy Kaymak; Marina M. Mihaljevic; Sanja Andric Petrovic; Tijana Mirjanic; Miguel Bernardo; Bibiana Cabrera; Julio Bobes; Pilar A. Saiz; Maria Paz Garcia-Portilla; Julio Sanjuan; Eduardo J. Aguilar; Jose Luis Santos; Estela Jimenez-Lopez; Manuel Arrojo; Angel Carracedo; Gonzalo Lopez; Javier Gonzalez-Penas; Mara Parellada; Nadja P. Maric; Cem Atbasoglu; Alp Ucok; Koksal Alptekin; Meram Can Saka; Celso Arango; Bart P. F. Rutten; Jim van Os

doi:10.3389/fpsyt.2019.00676

White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?

Elaine Schepers^*, Richel Lousberg, Sinan Guloksuz, Lotta-Katrin Pries, Philippe Delespaul, Gunter Kenis, Jurjen J. Luykx, Bochao D. Lin, Alexander L. Richards, Berna Akdede, Tolga Binbay, Vesile Altinyazar, Berna Yalincetin, Guvem Gumus-Akay, Burcin Cihan, Haldun Soygur, Halis Ulas, Eylem Sahin Cankurtaran, Semra Ulusoy Kaymak, Marina M. MihaljevicSanja Andric Petrovic, Tijana Mirjanic, Miguel Bernardo, Bibiana Cabrera, Julio Bobes, Pilar A. Saiz, Maria Paz Garcia-Portilla, Julio Sanjuan, Eduardo J. Aguilar, Jose Luis Santos, Estela Jimenez-Lopez, Manuel Arrojo, Angel Carracedo, Gonzalo Lopez, Javier Gonzalez-Penas, Mara Parellada, Nadja P. Maric, Cem Atbasoglu, Alp Ucok, Koksal Alptekin, Meram Can Saka, Celso Arango, Bart P. F. Rutten, Jim van Os

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: White noise speech illusions index liability for psychotic disorder in case-control comparisons. In the current study, we examined i) the rate of white noise speech illusions in siblings of patients with psychotic disorder and ii) to what degree this rate would be contingent on exposure to known environmental risk factors (childhood adversity and recent life events) and level of known endophenotypic dimensions of psychotic disorder [psychotic experiences assessed with the Community Assessment of Psychic Experiences (CAPE) scale and cognitive ability].

Methods: The white noise task was used as an experimental paradigm to elicit and measure speech illusions in 1,014 patients with psychotic disorders, 1,157 siblings, and 1,507 healthy participants. We examined associations between speech illusions and increasing familial risk (control -> sibling -> patient), modeled as both a linear and a categorical effect, and associations between speech illusions and level of childhood adversities and life events as well as with CAPE scores and cognitive ability scores.

Results: While a positive association was found between white noise speech illusions across hypothesized increasing levels of familial risk (controls -> siblings -> patients) [odds ratio (OR) linear 1.11, 95% confidence interval (CI) 1.02-1.21, p = 0.019], there was no evidence for a categorical association with sibling status (OR 0.93, 95% CI 0.79-1.09, p = 0.360). The association between speech illusions and linear familial risk was greater if scores on the CAPE positive scale were higher (p interaction = 0.003; ORlow (CAPE positive sale )0.96, 95% CI 0.85-1.07; ORhigh CAPE positive (scale) 1.26, 95% CI 1.09-1.46); cognitive ability was lower (p(interaction) <0.001; ORhigh cognitive (ability) 0.94, 95% CI 0.84-1.05; ORhigh cognitive abilty 1.43, 95% CI 1.23-1.68); and exposure to childhood adversity was higher (p interaction <0.001; ORlow (adversity) 0.92, 95% CI 0.82-1.04; ORhigh (adversity) 1.31, 95% CI 1.13-1.52). A similar, although less marked, pattern was seen for categorical patient-control and sibling-control comparisons. Exposure to recent life events did not modify the association between white noise and familial risk (p interaction = 0.232).

Conclusion: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity. Therefore, speech illusions may represent a trait-dependent risk marker.

Original language	English
Article number	676
Pages (from-to)	1-10
Number of pages	10
Journal	Frontiers in Psychiatry
Volume	10
Issue number	SEP
DOIs	https://doi.org/10.3389/fpsyt.2019.00676
Publication status	Published - 25 Sept 2019

Keywords

white noise speech illusions
psychotic disorder
Community Assessment of Psychic Experiences
cognitive ability
childhood adversity
life events
CHILDHOOD TRAUMA
THREATENING EXPERIENCES
SHORT-FORM
HALLUCINATIONS
SCHIZOPHRENIA
RELIABILITY
ENVIRONMENT
SYMPTOMS
VALIDITY
QUESTIONNAIRE

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Schepers, E., Lousberg, R., Guloksuz, S., Pries, L.-K., Delespaul, P., Kenis, G., Luykx, J. J., Lin, B. D., Richards, A. L., Akdede, B., Binbay, T., Altinyazar, V., Yalincetin, B., Gumus-Akay, G., Cihan, B., Soygur, H., Ulas, H., Cankurtaran, E. S., Kaymak, S. U., ... van Os, J. (2019). White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder? Frontiers in Psychiatry, 10(SEP), 1-10. Article 676. https://doi.org/10.3389/fpsyt.2019.00676

@article{bb8a331f13764744b0c32a380a83cca0,

title = "White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?",

abstract = "Introduction: White noise speech illusions index liability for psychotic disorder in case-control comparisons. In the current study, we examined i) the rate of white noise speech illusions in siblings of patients with psychotic disorder and ii) to what degree this rate would be contingent on exposure to known environmental risk factors (childhood adversity and recent life events) and level of known endophenotypic dimensions of psychotic disorder [psychotic experiences assessed with the Community Assessment of Psychic Experiences (CAPE) scale and cognitive ability].Methods: The white noise task was used as an experimental paradigm to elicit and measure speech illusions in 1,014 patients with psychotic disorders, 1,157 siblings, and 1,507 healthy participants. We examined associations between speech illusions and increasing familial risk (control -> sibling -> patient), modeled as both a linear and a categorical effect, and associations between speech illusions and level of childhood adversities and life events as well as with CAPE scores and cognitive ability scores.Results: While a positive association was found between white noise speech illusions across hypothesized increasing levels of familial risk (controls -> siblings -> patients) [odds ratio (OR) linear 1.11, 95% confidence interval (CI) 1.02-1.21, p = 0.019], there was no evidence for a categorical association with sibling status (OR 0.93, 95% CI 0.79-1.09, p = 0.360). The association between speech illusions and linear familial risk was greater if scores on the CAPE positive scale were higher (p interaction = 0.003; ORlow (CAPE positive sale )0.96, 95% CI 0.85-1.07; ORhigh CAPE positive (scale) 1.26, 95% CI 1.09-1.46); cognitive ability was lower (p(interaction) <0.001; ORhigh cognitive (ability) 0.94, 95% CI 0.84-1.05; ORhigh cognitive abilty 1.43, 95% CI 1.23-1.68); and exposure to childhood adversity was higher (p interaction <0.001; ORlow (adversity) 0.92, 95% CI 0.82-1.04; ORhigh (adversity) 1.31, 95% CI 1.13-1.52). A similar, although less marked, pattern was seen for categorical patient-control and sibling-control comparisons. Exposure to recent life events did not modify the association between white noise and familial risk (p interaction = 0.232).Conclusion: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity. Therefore, speech illusions may represent a trait-dependent risk marker.",

keywords = "white noise speech illusions, psychotic disorder, Community Assessment of Psychic Experiences, cognitive ability, childhood adversity, life events, CHILDHOOD TRAUMA, THREATENING EXPERIENCES, SHORT-FORM, HALLUCINATIONS, SCHIZOPHRENIA, RELIABILITY, ENVIRONMENT, SYMPTOMS, VALIDITY, QUESTIONNAIRE",

author = "Elaine Schepers and Richel Lousberg and Sinan Guloksuz and Lotta-Katrin Pries and Philippe Delespaul and Gunter Kenis and Luykx, {Jurjen J.} and Lin, {Bochao D.} and Richards, {Alexander L.} and Berna Akdede and Tolga Binbay and Vesile Altinyazar and Berna Yalincetin and Guvem Gumus-Akay and Burcin Cihan and Haldun Soygur and Halis Ulas and Cankurtaran, {Eylem Sahin} and Kaymak, {Semra Ulusoy} and Mihaljevic, {Marina M.} and Petrovic, {Sanja Andric} and Tijana Mirjanic and Miguel Bernardo and Bibiana Cabrera and Julio Bobes and Saiz, {Pilar A.} and {Paz Garcia-Portilla}, Maria and Julio Sanjuan and Aguilar, {Eduardo J.} and {Luis Santos}, Jose and Estela Jimenez-Lopez and Manuel Arrojo and Angel Carracedo and Gonzalo Lopez and Javier Gonzalez-Penas and Mara Parellada and Maric, {Nadja P.} and Cem Atbasoglu and Alp Ucok and Koksal Alptekin and Saka, {Meram Can} and Celso Arango and Rutten, {Bart P. F.} and {van Os}, Jim",

year = "2019",

month = sep,

day = "25",

doi = "10.3389/fpsyt.2019.00676",

language = "English",

volume = "10",

pages = "1--10",

journal = "Frontiers in Psychiatry",

issn = "1664-0640",

publisher = "Frontiers Media S.A.",

number = "SEP",

}

Schepers, E, Lousberg, R , Guloksuz, S, Pries, L-K, Delespaul, P , Kenis, G, Luykx, JJ, Lin, BD, Richards, AL, Akdede, B, Binbay, T, Altinyazar, V, Yalincetin, B, Gumus-Akay, G, Cihan, B, Soygur, H, Ulas, H, Cankurtaran, ES, Kaymak, SU, Mihaljevic, MM, Petrovic, SA, Mirjanic, T, Bernardo, M, Cabrera, B, Bobes, J, Saiz, PA, Paz Garcia-Portilla, M, Sanjuan, J, Aguilar, EJ, Luis Santos, J, Jimenez-Lopez, E, Arrojo, M, Carracedo, A, Lopez, G, Gonzalez-Penas, J, Parellada, M, Maric, NP, Atbasoglu, C, Ucok, A, Alptekin, K, Saka, MC, Arango, C, Rutten, BPF & van Os, J 2019, 'White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?', Frontiers in Psychiatry, vol. 10, no. SEP, 676, pp. 1-10. https://doi.org/10.3389/fpsyt.2019.00676

TY - JOUR

T1 - White Noise Speech Illusions

T2 - A Trait-Dependent Risk Marker for Psychotic Disorder?

AU - Schepers, Elaine

AU - Lousberg, Richel

AU - Guloksuz, Sinan

AU - Pries, Lotta-Katrin

AU - Delespaul, Philippe

AU - Kenis, Gunter

AU - Luykx, Jurjen J.

AU - Lin, Bochao D.

AU - Richards, Alexander L.

AU - Akdede, Berna

AU - Binbay, Tolga

AU - Altinyazar, Vesile

AU - Yalincetin, Berna

AU - Gumus-Akay, Guvem

AU - Cihan, Burcin

AU - Soygur, Haldun

AU - Ulas, Halis

AU - Cankurtaran, Eylem Sahin

AU - Kaymak, Semra Ulusoy

AU - Mihaljevic, Marina M.

AU - Petrovic, Sanja Andric

AU - Mirjanic, Tijana

AU - Bernardo, Miguel

AU - Cabrera, Bibiana

AU - Bobes, Julio

AU - Saiz, Pilar A.

AU - Paz Garcia-Portilla, Maria

AU - Sanjuan, Julio

AU - Aguilar, Eduardo J.

AU - Luis Santos, Jose

AU - Jimenez-Lopez, Estela

AU - Arrojo, Manuel

AU - Carracedo, Angel

AU - Lopez, Gonzalo

AU - Gonzalez-Penas, Javier

AU - Parellada, Mara

AU - Maric, Nadja P.

AU - Atbasoglu, Cem

AU - Ucok, Alp

AU - Alptekin, Koksal

AU - Saka, Meram Can

AU - Arango, Celso

AU - Rutten, Bart P. F.

AU - van Os, Jim

PY - 2019/9/25

Y1 - 2019/9/25

N2 - Introduction: White noise speech illusions index liability for psychotic disorder in case-control comparisons. In the current study, we examined i) the rate of white noise speech illusions in siblings of patients with psychotic disorder and ii) to what degree this rate would be contingent on exposure to known environmental risk factors (childhood adversity and recent life events) and level of known endophenotypic dimensions of psychotic disorder [psychotic experiences assessed with the Community Assessment of Psychic Experiences (CAPE) scale and cognitive ability].Methods: The white noise task was used as an experimental paradigm to elicit and measure speech illusions in 1,014 patients with psychotic disorders, 1,157 siblings, and 1,507 healthy participants. We examined associations between speech illusions and increasing familial risk (control -> sibling -> patient), modeled as both a linear and a categorical effect, and associations between speech illusions and level of childhood adversities and life events as well as with CAPE scores and cognitive ability scores.Results: While a positive association was found between white noise speech illusions across hypothesized increasing levels of familial risk (controls -> siblings -> patients) [odds ratio (OR) linear 1.11, 95% confidence interval (CI) 1.02-1.21, p = 0.019], there was no evidence for a categorical association with sibling status (OR 0.93, 95% CI 0.79-1.09, p = 0.360). The association between speech illusions and linear familial risk was greater if scores on the CAPE positive scale were higher (p interaction = 0.003; ORlow (CAPE positive sale )0.96, 95% CI 0.85-1.07; ORhigh CAPE positive (scale) 1.26, 95% CI 1.09-1.46); cognitive ability was lower (p(interaction) <0.001; ORhigh cognitive (ability) 0.94, 95% CI 0.84-1.05; ORhigh cognitive abilty 1.43, 95% CI 1.23-1.68); and exposure to childhood adversity was higher (p interaction <0.001; ORlow (adversity) 0.92, 95% CI 0.82-1.04; ORhigh (adversity) 1.31, 95% CI 1.13-1.52). A similar, although less marked, pattern was seen for categorical patient-control and sibling-control comparisons. Exposure to recent life events did not modify the association between white noise and familial risk (p interaction = 0.232).Conclusion: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity. Therefore, speech illusions may represent a trait-dependent risk marker.

AB - Introduction: White noise speech illusions index liability for psychotic disorder in case-control comparisons. In the current study, we examined i) the rate of white noise speech illusions in siblings of patients with psychotic disorder and ii) to what degree this rate would be contingent on exposure to known environmental risk factors (childhood adversity and recent life events) and level of known endophenotypic dimensions of psychotic disorder [psychotic experiences assessed with the Community Assessment of Psychic Experiences (CAPE) scale and cognitive ability].Methods: The white noise task was used as an experimental paradigm to elicit and measure speech illusions in 1,014 patients with psychotic disorders, 1,157 siblings, and 1,507 healthy participants. We examined associations between speech illusions and increasing familial risk (control -> sibling -> patient), modeled as both a linear and a categorical effect, and associations between speech illusions and level of childhood adversities and life events as well as with CAPE scores and cognitive ability scores.Results: While a positive association was found between white noise speech illusions across hypothesized increasing levels of familial risk (controls -> siblings -> patients) [odds ratio (OR) linear 1.11, 95% confidence interval (CI) 1.02-1.21, p = 0.019], there was no evidence for a categorical association with sibling status (OR 0.93, 95% CI 0.79-1.09, p = 0.360). The association between speech illusions and linear familial risk was greater if scores on the CAPE positive scale were higher (p interaction = 0.003; ORlow (CAPE positive sale )0.96, 95% CI 0.85-1.07; ORhigh CAPE positive (scale) 1.26, 95% CI 1.09-1.46); cognitive ability was lower (p(interaction) <0.001; ORhigh cognitive (ability) 0.94, 95% CI 0.84-1.05; ORhigh cognitive abilty 1.43, 95% CI 1.23-1.68); and exposure to childhood adversity was higher (p interaction <0.001; ORlow (adversity) 0.92, 95% CI 0.82-1.04; ORhigh (adversity) 1.31, 95% CI 1.13-1.52). A similar, although less marked, pattern was seen for categorical patient-control and sibling-control comparisons. Exposure to recent life events did not modify the association between white noise and familial risk (p interaction = 0.232).Conclusion: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity. Therefore, speech illusions may represent a trait-dependent risk marker.

KW - white noise speech illusions

KW - psychotic disorder

KW - Community Assessment of Psychic Experiences

KW - cognitive ability

KW - childhood adversity

KW - life events

KW - CHILDHOOD TRAUMA

KW - THREATENING EXPERIENCES

KW - SHORT-FORM

KW - HALLUCINATIONS

KW - SCHIZOPHRENIA

KW - RELIABILITY

KW - ENVIRONMENT

KW - SYMPTOMS

KW - VALIDITY

KW - QUESTIONNAIRE

U2 - 10.3389/fpsyt.2019.00676

DO - 10.3389/fpsyt.2019.00676

M3 - Article

SN - 1664-0640

VL - 10

SP - 1

EP - 10

JO - Frontiers in Psychiatry

JF - Frontiers in Psychiatry

IS - SEP

M1 - 676

ER -

White Noise Speech Illusions: A Trait-Dependent Risk Marker for Psychotic Disorder?

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