White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Jessica Alber; Suvarna Alladi; Hee-Joon Bae; David A Barton; Laurel A Beckett; Joanne M Bell; Sara E Berman; Geert Jan Biessels; Sandra E Black; Isabelle Bos; Gene L Bowman; Emanuele Brai; Adam M Brickman; Brandy L Callahan; Roderick A Corriveau; Silvia Fossati; Rebecca F Gottesman; Deborah R Gustafson; Vladimir Hachinski; Kathleen M Hayden; Alex M Helman; Timothy M Hughes; Jeremy D Isaacs; Angela L Jefferson; Sterling C Johnson; Alifiya Kapasi; Silke Kern; Jay C Kwon; Juraj Kukolja; Athene Lee; Samuel N Lockhart; Anne Murray; Katie E Osborn; Melinda C Power; Brittani R Price; Hanneke F M Rhodius-Meester; Jacqueline A Rondeau; Allyson C Rosen; Douglas L Rosene; Julie A Schneider; Henrieta Scholtzova; C Elizabeth Shaaban; Narlon C B S Silva; Heather M Snyder; Walter Swardfager; Aron M Troen; Susanne J van Veluw; Prashanthi Vemuri; Anders Wallin; Cheryl Wellington; Donna M Wilcock; Sharon Xiangwen Xie; Atticus H Hainsworth

doi:10.1016/j.trci.2019.02.001

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Jessica Alber
, Suvarna Alladi
, Hee-Joon Bae
, David A Barton
, Laurel A Beckett
, Joanne M Bell
, Sara E Berman
, Geert Jan Biessels
, Sandra E Black
, Isabelle Bos
, Gene L Bowman
, Emanuele Brai
, Adam M Brickman
, Brandy L Callahan
, Roderick A Corriveau
, Silvia Fossati
, Rebecca F Gottesman
, Deborah R Gustafson
, Vladimir Hachinski
, Kathleen M Hayden

Alex M Helman, Timothy M Hughes, Jeremy D Isaacs, Angela L Jefferson, Sterling C Johnson, Alifiya Kapasi, Silke Kern, Jay C Kwon, Juraj Kukolja, Athene Lee, Samuel N Lockhart, Anne Murray, Katie E Osborn, Melinda C Power, Brittani R Price, Hanneke F M Rhodius-Meester, Jacqueline A Rondeau, Allyson C Rosen, Douglas L Rosene, Julie A Schneider, Henrieta Scholtzova, C Elizabeth Shaaban, Narlon C B S Silva, Heather M Snyder, Walter Swardfager, Aron M Troen, Susanne J van Veluw, Prashanthi Vemuri, Anders Wallin, Cheryl Wellington, Donna M Wilcock, Sharon Xiangwen Xie, Atticus H Hainsworth^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.

Original language	English
Pages (from-to)	107-117
Number of pages	11
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.trci.2019.02.001
Publication status	Published - 2019

Keywords

Leukoaraiosis
Small vessel disease
Vascular cognitive impairment
Vascular dementia
White matter lesions
RISK-FACTORS
MRI
ALZHEIMERS-DISEASE
LATE-LIFE
BLOOD-PRESSURE
LESIONS
SMALL-VESSEL DISEASE
UNSELECTED COHORT
BRAIN
PROGRESSION

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Alber, J., Alladi, S., Bae, H.-J., Barton, D. A., Beckett, L. A., Bell, J. M., Berman, S. E., Biessels, G. J., Black, S. E., Bos, I., Bowman, G. L., Brai, E., Brickman, A. M., Callahan, B. L., Corriveau, R. A., Fossati, S., Gottesman, R. F., Gustafson, D. R., Hachinski, V., ... Hainsworth, A. H. (2019). White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5(1), 107-117. https://doi.org/10.1016/j.trci.2019.02.001

@article{3df4c4ccfa3341c5a881c0d291db75a8,

title = "White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities",

abstract = "White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.",

keywords = "Leukoaraiosis, Small vessel disease, Vascular cognitive impairment, Vascular dementia, White matter lesions, RISK-FACTORS, MRI, ALZHEIMERS-DISEASE, LATE-LIFE, BLOOD-PRESSURE, LESIONS, SMALL-VESSEL DISEASE, UNSELECTED COHORT, BRAIN, PROGRESSION",

author = "Jessica Alber and Suvarna Alladi and Hee-Joon Bae and Barton, \{David A\} and Beckett, \{Laurel A\} and Bell, \{Joanne M\} and Berman, \{Sara E\} and Biessels, \{Geert Jan\} and Black, \{Sandra E\} and Isabelle Bos and Bowman, \{Gene L\} and Emanuele Brai and Brickman, \{Adam M\} and Callahan, \{Brandy L\} and Corriveau, \{Roderick A\} and Silvia Fossati and Gottesman, \{Rebecca F\} and Gustafson, \{Deborah R\} and Vladimir Hachinski and Hayden, \{Kathleen M\} and Helman, \{Alex M\} and Hughes, \{Timothy M\} and Isaacs, \{Jeremy D\} and Jefferson, \{Angela L\} and Johnson, \{Sterling C\} and Alifiya Kapasi and Silke Kern and Kwon, \{Jay C\} and Juraj Kukolja and Athene Lee and Lockhart, \{Samuel N\} and Anne Murray and Osborn, \{Katie E\} and Power, \{Melinda C\} and Price, \{Brittani R\} and Rhodius-Meester, \{Hanneke F M\} and Rondeau, \{Jacqueline A\} and Rosen, \{Allyson C\} and Rosene, \{Douglas L\} and Schneider, \{Julie A\} and Henrieta Scholtzova and Shaaban, \{C Elizabeth\} and Silva, \{Narlon C B S\} and Snyder, \{Heather M\} and Walter Swardfager and Troen, \{Aron M\} and \{van Veluw\}, \{Susanne J\} and Prashanthi Vemuri and Anders Wallin and Cheryl Wellington and Wilcock, \{Donna M\} and Xie, \{Sharon Xiangwen\} and Hainsworth, \{Atticus H\}",

year = "2019",

doi = "10.1016/j.trci.2019.02.001",

language = "English",

volume = "5",

pages = "107--117",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

publisher = "Elsevier Inc.",

number = "1",

}

Alber, J, Alladi, S, Bae, H-J, Barton, DA, Beckett, LA, Bell, JM, Berman, SE, Biessels, GJ, Black, SE, Bos, I, Bowman, GL, Brai, E, Brickman, AM, Callahan, BL, Corriveau, RA, Fossati, S, Gottesman, RF, Gustafson, DR, Hachinski, V, Hayden, KM, Helman, AM, Hughes, TM, Isaacs, JD, Jefferson, AL, Johnson, SC, Kapasi, A, Kern, S, Kwon, JC, Kukolja, J, Lee, A, Lockhart, SN, Murray, A, Osborn, KE, Power, MC, Price, BR, Rhodius-Meester, HFM, Rondeau, JA, Rosen, AC, Rosene, DL, Schneider, JA, Scholtzova, H, Shaaban, CE, Silva, NCBS, Snyder, HM, Swardfager, W, Troen, AM, van Veluw, SJ, Vemuri, P, Wallin, A, Wellington, C, Wilcock, DM, Xie, SX & Hainsworth, AH 2019, 'White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 5, no. 1, pp. 107-117. https://doi.org/10.1016/j.trci.2019.02.001

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities. / Alber, Jessica; Alladi, Suvarna; Bae, Hee-Joon et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 5, No. 1, 2019, p. 107-117.

Research output: Contribution to journal › (Systematic) Review article › peer-review

TY - JOUR

T1 - White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID)

T2 - Knowledge gaps and opportunities

AU - Alber, Jessica

AU - Alladi, Suvarna

AU - Bae, Hee-Joon

AU - Barton, David A

AU - Beckett, Laurel A

AU - Bell, Joanne M

AU - Berman, Sara E

AU - Biessels, Geert Jan

AU - Black, Sandra E

AU - Bos, Isabelle

AU - Bowman, Gene L

AU - Brai, Emanuele

AU - Brickman, Adam M

AU - Callahan, Brandy L

AU - Corriveau, Roderick A

AU - Fossati, Silvia

AU - Gottesman, Rebecca F

AU - Gustafson, Deborah R

AU - Hachinski, Vladimir

AU - Hayden, Kathleen M

AU - Helman, Alex M

AU - Hughes, Timothy M

AU - Isaacs, Jeremy D

AU - Jefferson, Angela L

AU - Johnson, Sterling C

AU - Kapasi, Alifiya

AU - Kern, Silke

AU - Kwon, Jay C

AU - Kukolja, Juraj

AU - Lee, Athene

AU - Lockhart, Samuel N

AU - Murray, Anne

AU - Osborn, Katie E

AU - Power, Melinda C

AU - Price, Brittani R

AU - Rhodius-Meester, Hanneke F M

AU - Rondeau, Jacqueline A

AU - Rosen, Allyson C

AU - Rosene, Douglas L

AU - Schneider, Julie A

AU - Scholtzova, Henrieta

AU - Shaaban, C Elizabeth

AU - Silva, Narlon C B S

AU - Snyder, Heather M

AU - Swardfager, Walter

AU - Troen, Aron M

AU - van Veluw, Susanne J

AU - Vemuri, Prashanthi

AU - Wallin, Anders

AU - Wellington, Cheryl

AU - Wilcock, Donna M

AU - Xie, Sharon Xiangwen

AU - Hainsworth, Atticus H

PY - 2019

Y1 - 2019

N2 - White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.

AB - White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.

KW - Leukoaraiosis

KW - Small vessel disease

KW - Vascular cognitive impairment

KW - Vascular dementia

KW - White matter lesions

KW - RISK-FACTORS

KW - MRI

KW - ALZHEIMERS-DISEASE

KW - LATE-LIFE

KW - BLOOD-PRESSURE

KW - LESIONS

KW - SMALL-VESSEL DISEASE

KW - UNSELECTED COHORT

KW - BRAIN

KW - PROGRESSION

U2 - 10.1016/j.trci.2019.02.001

DO - 10.1016/j.trci.2019.02.001

M3 - (Systematic) Review article

C2 - 31011621

VL - 5

SP - 107

EP - 117

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

ER -

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities

Abstract

Keywords

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