Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial

Parvin Tajik; Linda van Wyk; Kim E. Boers; Saskia le Cessie; Mohammad Hadi Zafarmand; Frans Roumen; Joris A. M. van der Post; Martina Porath; Maria G. van Pampus; Marc E. A. Spaanderdami; Anneke Kwee; Johannes J. Duvekot; Henk A. Bremer; Friso M. C. Delemarre; Kitty W. M. Bloemenkamp; Christianne J. M. de Groot; Christine Willekes; Jan M. M. van Lith; Patrick M. Bossuyt; Ben W. J. Mol; Sicco A. Scherjon

doi:10.1016/j.ejogrb.2013.10.014

Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial

Parvin Tajik^*
, Linda van Wyk
, Kim E. Boers
, Saskia le Cessie
, Mohammad Hadi Zafarmand
, Frans Roumen
, Joris A. M. van der Post
, Martina Porath
, Maria G. van Pampus
, Marc E. A. Spaanderdami
, Anneke Kwee
, Johannes J. Duvekot
, Henk A. Bremer
, Friso M. C. Delemarre
, Kitty W. M. Bloemenkamp
, Christianne J. M. de Groot
, Christine Willekes
, Jan M. M. van Lith
, Patrick M. Bossuyt
, Ben W. J. Mol

Sicco A. Scherjon

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective: The Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT trial) showed that in women with suspected intrauterine growth restriction (IUGR) at term, there were no substantial outcome differences between induction of labour and expectant monitoring. The objective of the present analysis is to evaluate whether maternal or fetal markers could identify IUGR fetuses who would benefit from early labour induction. Study design: The DIGITAT trial was a multicenter, parallel and open-label randomised controlled trial in women who had a singleton pregnancy beyond 36 + 0 weeks' gestation with suspected IUGR (n = 650). Women had been randomly allocated to either labour induction or expectant monitoring. The primary outcome was a composite measure of adverse neonatal outcome, defined as neonatal death before hospital discharge, Apgar score

Original language	English
Pages (from-to)	20-25
Number of pages	6
Journal	European Journal of Obstetrics & Gynecology and Reproductive Biology
Volume	172
Issue number	1
DOIs	https://doi.org/10.1016/j.ejogrb.2013.10.014
Publication status	Published - Jan 2014

Keywords

Intrauterine growth restriction (IUGR)
Labour induction
Expectant monitoring
Treatment selection markers

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Tajik, P., van Wyk, L., Boers, K. E., le Cessie, S., Zafarmand, M. H., Roumen, F., van der Post, J. A. M., Porath, M., van Pampus, M. G., Spaanderdami, M. E. A., Kwee, A., Duvekot, J. J., Bremer, H. A., Delemarre, F. M. C., Bloemenkamp, K. W. M., de Groot, C. J. M., Willekes, C., van Lith, J. M. M., Bossuyt, P. M., ... Scherjon, S. A. (2014). Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial. European Journal of Obstetrics & Gynecology and Reproductive Biology, 172(1), 20-25. https://doi.org/10.1016/j.ejogrb.2013.10.014

@article{1cbf751d26364d92bbb38f1cfd08c24a,

title = "Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial",

abstract = "Objective: The Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT trial) showed that in women with suspected intrauterine growth restriction (IUGR) at term, there were no substantial outcome differences between induction of labour and expectant monitoring. The objective of the present analysis is to evaluate whether maternal or fetal markers could identify IUGR fetuses who would benefit from early labour induction. Study design: The DIGITAT trial was a multicenter, parallel and open-label randomised controlled trial in women who had a singleton pregnancy beyond 36 + 0 weeks' gestation with suspected IUGR (n = 650). Women had been randomly allocated to either labour induction or expectant monitoring. The primary outcome was a composite measure of adverse neonatal outcome, defined as neonatal death before hospital discharge, Apgar score ",

keywords = "Intrauterine growth restriction (IUGR), Labour induction, Expectant monitoring, Treatment selection markers",

author = "Parvin Tajik and \{van Wyk\}, Linda and Boers, \{Kim E.\} and \{le Cessie\}, Saskia and Zafarmand, \{Mohammad Hadi\} and Frans Roumen and \{van der Post\}, \{Joris A. M.\} and Martina Porath and \{van Pampus\}, \{Maria G.\} and Spaanderdami, \{Marc E. A.\} and Anneke Kwee and Duvekot, \{Johannes J.\} and Bremer, \{Henk A.\} and Delemarre, \{Friso M. C.\} and Bloemenkamp, \{Kitty W. M.\} and \{de Groot\}, \{Christianne J. M.\} and Christine Willekes and \{van Lith\}, \{Jan M. M.\} and Bossuyt, \{Patrick M.\} and Mol, \{Ben W. J.\} and Scherjon, \{Sicco A.\}",

year = "2014",

month = jan,

doi = "10.1016/j.ejogrb.2013.10.014",

language = "English",

volume = "172",

pages = "20--25",

journal = "European Journal of Obstetrics \& Gynecology and Reproductive Biology",

issn = "0301-2115",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Tajik, P, van Wyk, L, Boers, KE, le Cessie, S, Zafarmand, MH, Roumen, F, van der Post, JAM, Porath, M, van Pampus, MG, Spaanderdami, MEA, Kwee, A, Duvekot, JJ, Bremer, HA, Delemarre, FMC, Bloemenkamp, KWM, de Groot, CJM, Willekes, C, van Lith, JMM, Bossuyt, PM, Mol, BWJ & Scherjon, SA 2014, 'Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial', European Journal of Obstetrics & Gynecology and Reproductive Biology, vol. 172, no. 1, pp. 20-25. https://doi.org/10.1016/j.ejogrb.2013.10.014

Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial. / Tajik, Parvin; van Wyk, Linda; Boers, Kim E. et al.
In: European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 172, No. 1, 01.2014, p. 20-25.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial

AU - Tajik, Parvin

AU - van Wyk, Linda

AU - Boers, Kim E.

AU - le Cessie, Saskia

AU - Zafarmand, Mohammad Hadi

AU - Roumen, Frans

AU - van der Post, Joris A. M.

AU - Porath, Martina

AU - van Pampus, Maria G.

AU - Spaanderdami, Marc E. A.

AU - Kwee, Anneke

AU - Duvekot, Johannes J.

AU - Bremer, Henk A.

AU - Delemarre, Friso M. C.

AU - Bloemenkamp, Kitty W. M.

AU - de Groot, Christianne J. M.

AU - Willekes, Christine

AU - van Lith, Jan M. M.

AU - Bossuyt, Patrick M.

AU - Mol, Ben W. J.

AU - Scherjon, Sicco A.

PY - 2014/1

Y1 - 2014/1

N2 - Objective: The Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT trial) showed that in women with suspected intrauterine growth restriction (IUGR) at term, there were no substantial outcome differences between induction of labour and expectant monitoring. The objective of the present analysis is to evaluate whether maternal or fetal markers could identify IUGR fetuses who would benefit from early labour induction. Study design: The DIGITAT trial was a multicenter, parallel and open-label randomised controlled trial in women who had a singleton pregnancy beyond 36 + 0 weeks' gestation with suspected IUGR (n = 650). Women had been randomly allocated to either labour induction or expectant monitoring. The primary outcome was a composite measure of adverse neonatal outcome, defined as neonatal death before hospital discharge, Apgar score

AB - Objective: The Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT trial) showed that in women with suspected intrauterine growth restriction (IUGR) at term, there were no substantial outcome differences between induction of labour and expectant monitoring. The objective of the present analysis is to evaluate whether maternal or fetal markers could identify IUGR fetuses who would benefit from early labour induction. Study design: The DIGITAT trial was a multicenter, parallel and open-label randomised controlled trial in women who had a singleton pregnancy beyond 36 + 0 weeks' gestation with suspected IUGR (n = 650). Women had been randomly allocated to either labour induction or expectant monitoring. The primary outcome was a composite measure of adverse neonatal outcome, defined as neonatal death before hospital discharge, Apgar score

KW - Intrauterine growth restriction (IUGR)

KW - Labour induction

KW - Expectant monitoring

KW - Treatment selection markers

U2 - 10.1016/j.ejogrb.2013.10.014

DO - 10.1016/j.ejogrb.2013.10.014

M3 - Article

C2 - 24192662

SN - 0301-2115

VL - 172

SP - 20

EP - 25

JO - European Journal of Obstetrics & Gynecology and Reproductive Biology

JF - European Journal of Obstetrics & Gynecology and Reproductive Biology

IS - 1

ER -

Which intrauterine growth restricted fetuses at term benefit from early labour induction? A secondary analysis of the DIGITAT randomised trial

Abstract

Keywords

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