@article{38fef9544d254d4faf7d61d49e306628,
title = "When to withhold oral anticoagulation in atrial fibrillation - an overview of frequent clinical discussion topics",
abstract = "Stroke prevention with oral anticoagulants in patients with atrial fibrillation predisposes for bleeding. As a result, in select patient groups anticoagulation is withheld because of a perceived unfavorable risk-benefit ratio. Reasons for withholding anticoagulation can vary greatly between clinicians, often leading to discussion in daily clinical practice on the best approach. To guide clinical decision-making, we have reviewed available evidence on the most frequently reported reasons for withholding anticoagulation: previous bleeding, frailty and age, and an overall high bleeding risk.",
keywords = "hemorrhage, frail elderly, age, anticoagulants, atrial fibrillation, INTRACRANIAL HEMORRHAGE, BLEEDING RISK, ANTITHROMBOTIC THERAPY, PREDICTING STROKE, ELDERLY-PATIENTS, WARFARIN, OUTCOMES, DABIGATRAN, SCORE, ASSOCIATION",
author = "Jaap Seelig and Ron Pisters and Hemels, {Martin E.} and Huisman, {Menno V.} and {ten Cate}, Hugo and Marco Alings",
note = "Funding Information: J Seelig receives funding from the Netherlands Federation of Anticoagulation clinics. ME Hemels discloses speaker fees from Bayer, Bristol-Myers Squibb, Pfizer, Boehringer Ingelheim, Daiichi Sankyo, Roche and received a research grant from Netherlands Federation of Anticoagulation clinics. M.V. Huisman reports research grants from Dutch Healthcare Fund, Bayer, Bristol-Myers Squibb, Pfizer, Boehringer Ingelheim, and Daiichi Sankyo. H ten Cate received research grants from Bayer and Pfizer; advisory boards for Bayer, Pfizer, Leo; consultancy for Alveron. H ten Cate is an unpaid chairman of the board of the Netherlands Federation of Anticoagulation clinics. M Alings discloses speaker fees from Bayer, Bristol-Myers Squibb, Boehringer Ingelheim, Pfizer, Daiichi Sankyo, and Milestone Pharmaceuticals. The authors report no other conflicts of interest in this work. Publisher Copyright: {\textcopyright} 2019 Seelig et al.",
year = "2019",
doi = "10.2147/VHRM.S187656",
language = "English",
volume = "15",
pages = "399--408",
journal = "Vascular health and risk management",
issn = "1176-6344",
publisher = "Dove Medical Press Ltd.",
}