What is the impact of impaired left ventricular ejection fraction in COPD after adjusting for confounders?

Rafael Barreto de Mesquita*, Frits M. E. Franssen, Sarah Houben-Wilke, Nicole Lencer, Lowie E. G. W. Vanfleteren, Yvonne M. J. Goertz, Fabio Pitta, Emiel F. M. Wouters, Martijn Spruit

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Web of Science)


Background: It remains unknown whether and to what extent impaired left ventricular ejection fraction (LVEF) affects physical and psychological status in COPD. We aimed to compare health outcome measures between COPD patients with and without impaired LVEF after adjusting for age, sex, BMI and FEV1. Methods: Impaired LVEF was defined as values 0.05). Conclusions: Impaired LVEF has a clear impact on physical and psychological status in patients with COPD, even after adjusting for confounders. This reinforces the importance of assessing and treating cardiac problems in COPD.
Original languageEnglish
Pages (from-to)365-370
JournalInternational Journal of Cardiology
Publication statusPublished - 15 Dec 2016


  • Chronic obstructive pulmonary disease
  • Comorbidity
  • Chronic heart failure
  • Outcome assessment (health care)

Cite this