Abstract
BACKGROUND: Diet-induced weight loss is accompanied by adaptive ie, a disproportional or greater than expected reduction of resting rate (RMR). OBJECTIVE: The aim of this study was to investigate whether thermogenesis is sustained during weight maintenance after weight loss. Subjects were 22 men and 69 women [mean +/- SD age: 40 +/- 9 y; body (BMI; in kg/m2): 31.9 +/- 3.0]. They followed a very-low-energy diet for followed by a 44-wk period of weight maintenance. Body composition was with a 3-compartment model based on body weight, total body water dilution), and body volume. RMR was measured (RMRm) with a ventilated addition, RMR was predicted (RMRp) on the basis of the measured body RMRp (MJ/d) = 0.024 x fat mass (kg) + 0.102 x fat-free mass (kg) + 0.85. Measurements took place before the diet and 8, 20, and 52 wk after the the diet. RESULTS: The ratio of RMRm to RMRp decreased from 1.004 +/- before the diet to 0.963 +/- 0.073 after the diet (P < 0.001), and the was sustained after 20 wk (0.983 +/- 0.063; P < 0.01) and 52 wk (0.984 P < 0.01). RMRm/RMRp was correlated with the weight loss after 8 wk (P < 20 wk (P < 0.05), and 52 wk (P < 0.05). CONCLUSION: Weight loss results adaptive thermogenesis, and there is no indication for a change in thermogenesis up to 1 y, when weight loss is maintained. This trial was registered at clinicaltrials.gov as NCT01015508.
Original language | English |
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Pages (from-to) | 990-994 |
Number of pages | 5 |
Journal | American Journal of Clinical Nutrition |
Volume | 97 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2013 |
Keywords
- RESTING METABOLIC-RATE
- BODY-WEIGHT
- ENERGY-EXPENDITURE
- PHYSICAL-ACTIVITY
- OBESE SUBJECTS
- LEPTIN
- REDUCTION
- HUMANS
- SYSTEM
- FAT