Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study

Katherine M. Livingstone; Carlos Celis-Morales; Ulrich Hoeller; Christina P. Lambrinou; George Moschonis; Anna L. Macready; Rosalind Fallaize; Manuela Baur; Franz F. Roos; Igor Bendik; Keith Grimaldi; Santiago Navas-Carretero; Rodrigo San-Cristobal; Peter Weber; Christian A. Drevon; Yannis Manios; Iwona Traczyk; Eileen R. Gibney; Julie A. Lovegrove; Wim H. Saris; Hannelore Daniel; Mike Gibney; J. Alfredo Martinez; Lorraine Brennan; Tom R. Hill; John C. Mathers; Food4Me Study

doi:10.1002/mnfr.201600476

Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study

Katherine M. Livingstone, Carlos Celis-Morales, Ulrich Hoeller, Christina P. Lambrinou, George Moschonis, Anna L. Macready, Rosalind Fallaize, Manuela Baur, Franz F. Roos, Igor Bendik, Keith Grimaldi, Santiago Navas-Carretero, Rodrigo San-Cristobal, Peter Weber, Christian A. Drevon, Yannis Manios, Iwona Traczyk, Eileen R. Gibney, Julie A. Lovegrove, Wim H. SarisHannelore Daniel, Mike Gibney, J. Alfredo Martinez, Lorraine Brennan, Tom R. Hill, John C. Mathers^*, Food4Me Study

^*Corresponding author for this work

NUTRIM - Obesity, diabetes and cardiovascular health

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

ScopeLittle is known about diet- and environment-gene interactions on 25-hydroxyvitamin D (25(OH)D concentration. This cross-sectional study aimed to investigate (i) predictors of 25(OH)D concentration and relationships with vitamin D genotypes and (ii) whether dietary vitamin D intake and sunlight exposure modified these relationships.

Methods and resultsParticipants from the Food4Me study (n = 1312; age 18-79) were genotyped for vitamin D receptor (VDR) and vitamin D binding protein at baseline and a genetic risk score was calculated. Dried blood spot samples were assayed for 25(OH)D concentration and dietary and lifestyle information collected. Circulating 25(OH)D concentration was lower with increasing genetic risk score, lower in females than males, higher in supplement users than non-users and higher in summer than winter. Carriage of the minor VDR allele was associated with lower 25(OH)D concentration in participants with the least sunlight exposure. Vitamin D genotype did not influence the relationship between vitamin D intake and 25(OH)D concentration.

ConclusionAge, sex, dietary vitamin D intake, country, sunlight exposure, season, and vitamin D genetic risk score were associated with circulating 25(OH)D concentration in a pan-European population. The relationship between VDR genotype and 25(OH)D concentration may be influenced by weekday sunlight exposure but not dietary vitamin D intake.

Original language	English
Article number	1600476
Number of pages	10
Journal	Molecular Nutrition & Food Research
Volume	61
Issue number	2
DOIs	https://doi.org/10.1002/mnfr.201600476
Publication status	Published - Feb 2017

Keywords

Diet
Environment-gene interaction
Food4Me
25-hydroxyvitamin D
Sunlight
Vitamin D receptor gene
D-BINDING PROTEIN
RANDOMIZED CONTROLLED-TRIAL
GENOME-WIDE ASSOCIATION
D DEFICIENCY
ULTRAVIOLET-RADIATION
PHYSICAL-ACTIVITY
DIETARY-INTAKE
DETERMINANTS
NUTRITION
ADULTS

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Livingstone, K. M., Celis-Morales, C., Hoeller, U., Lambrinou, C. P., Moschonis, G., Macready, A. L., Fallaize, R., Baur, M., Roos, F. F., Bendik, I., Grimaldi, K., Navas-Carretero, S., San-Cristobal, R., Weber, P., Drevon, C. A., Manios, Y., Traczyk, I., Gibney, E. R., Lovegrove, J. A., ... Food4Me Study (2017). Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study. Molecular Nutrition & Food Research, 61(2), Article 1600476. https://doi.org/10.1002/mnfr.201600476

@article{69be030f169d4ead8e4839388b1e8ed9,

title = "Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study",

abstract = "ScopeLittle is known about diet- and environment-gene interactions on 25-hydroxyvitamin D (25(OH)D concentration. This cross-sectional study aimed to investigate (i) predictors of 25(OH)D concentration and relationships with vitamin D genotypes and (ii) whether dietary vitamin D intake and sunlight exposure modified these relationships.Methods and resultsParticipants from the Food4Me study (n = 1312; age 18-79) were genotyped for vitamin D receptor (VDR) and vitamin D binding protein at baseline and a genetic risk score was calculated. Dried blood spot samples were assayed for 25(OH)D concentration and dietary and lifestyle information collected. Circulating 25(OH)D concentration was lower with increasing genetic risk score, lower in females than males, higher in supplement users than non-users and higher in summer than winter. Carriage of the minor VDR allele was associated with lower 25(OH)D concentration in participants with the least sunlight exposure. Vitamin D genotype did not influence the relationship between vitamin D intake and 25(OH)D concentration.ConclusionAge, sex, dietary vitamin D intake, country, sunlight exposure, season, and vitamin D genetic risk score were associated with circulating 25(OH)D concentration in a pan-European population. The relationship between VDR genotype and 25(OH)D concentration may be influenced by weekday sunlight exposure but not dietary vitamin D intake.",

keywords = "Diet, Environment-gene interaction, Food4Me, 25-hydroxyvitamin D, Sunlight, Vitamin D receptor gene, D-BINDING PROTEIN, RANDOMIZED CONTROLLED-TRIAL, GENOME-WIDE ASSOCIATION, D DEFICIENCY, ULTRAVIOLET-RADIATION, PHYSICAL-ACTIVITY, DIETARY-INTAKE, DETERMINANTS, NUTRITION, ADULTS",

author = "Livingstone, {Katherine M.} and Carlos Celis-Morales and Ulrich Hoeller and Lambrinou, {Christina P.} and George Moschonis and Macready, {Anna L.} and Rosalind Fallaize and Manuela Baur and Roos, {Franz F.} and Igor Bendik and Keith Grimaldi and Santiago Navas-Carretero and Rodrigo San-Cristobal and Peter Weber and Drevon, {Christian A.} and Yannis Manios and Iwona Traczyk and Gibney, {Eileen R.} and Lovegrove, {Julie A.} and Saris, {Wim H.} and Hannelore Daniel and Mike Gibney and Martinez, {J. Alfredo} and Lorraine Brennan and Hill, {Tom R.} and Mathers, {John C.} and {Food4Me Study}",

year = "2017",

month = feb,

doi = "10.1002/mnfr.201600476",

language = "English",

volume = "61",

journal = "Molecular Nutrition & Food Research",

issn = "1613-4125",

publisher = "Wiley",

number = "2",

}

Livingstone, KM, Celis-Morales, C, Hoeller, U, Lambrinou, CP, Moschonis, G, Macready, AL, Fallaize, R, Baur, M, Roos, FF, Bendik, I, Grimaldi, K, Navas-Carretero, S, San-Cristobal, R, Weber, P, Drevon, CA, Manios, Y, Traczyk, I, Gibney, ER, Lovegrove, JA, Saris, WH, Daniel, H, Gibney, M, Martinez, JA, Brennan, L, Hill, TR, Mathers, JC & Food4Me Study 2017, 'Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study', Molecular Nutrition & Food Research, vol. 61, no. 2, 1600476. https://doi.org/10.1002/mnfr.201600476

Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study. / Livingstone, Katherine M.; Celis-Morales, Carlos; Hoeller, Ulrich et al.
In: Molecular Nutrition & Food Research, Vol. 61, No. 2, 1600476, 02.2017.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population

T2 - the Food4Me study

AU - Livingstone, Katherine M.

AU - Celis-Morales, Carlos

AU - Hoeller, Ulrich

AU - Lambrinou, Christina P.

AU - Moschonis, George

AU - Macready, Anna L.

AU - Fallaize, Rosalind

AU - Baur, Manuela

AU - Roos, Franz F.

AU - Bendik, Igor

AU - Grimaldi, Keith

AU - Navas-Carretero, Santiago

AU - San-Cristobal, Rodrigo

AU - Weber, Peter

AU - Drevon, Christian A.

AU - Manios, Yannis

AU - Traczyk, Iwona

AU - Gibney, Eileen R.

AU - Lovegrove, Julie A.

AU - Saris, Wim H.

AU - Daniel, Hannelore

AU - Gibney, Mike

AU - Martinez, J. Alfredo

AU - Brennan, Lorraine

AU - Hill, Tom R.

AU - Mathers, John C.

AU - Food4Me Study

PY - 2017/2

Y1 - 2017/2

N2 - ScopeLittle is known about diet- and environment-gene interactions on 25-hydroxyvitamin D (25(OH)D concentration. This cross-sectional study aimed to investigate (i) predictors of 25(OH)D concentration and relationships with vitamin D genotypes and (ii) whether dietary vitamin D intake and sunlight exposure modified these relationships.Methods and resultsParticipants from the Food4Me study (n = 1312; age 18-79) were genotyped for vitamin D receptor (VDR) and vitamin D binding protein at baseline and a genetic risk score was calculated. Dried blood spot samples were assayed for 25(OH)D concentration and dietary and lifestyle information collected. Circulating 25(OH)D concentration was lower with increasing genetic risk score, lower in females than males, higher in supplement users than non-users and higher in summer than winter. Carriage of the minor VDR allele was associated with lower 25(OH)D concentration in participants with the least sunlight exposure. Vitamin D genotype did not influence the relationship between vitamin D intake and 25(OH)D concentration.ConclusionAge, sex, dietary vitamin D intake, country, sunlight exposure, season, and vitamin D genetic risk score were associated with circulating 25(OH)D concentration in a pan-European population. The relationship between VDR genotype and 25(OH)D concentration may be influenced by weekday sunlight exposure but not dietary vitamin D intake.

AB - ScopeLittle is known about diet- and environment-gene interactions on 25-hydroxyvitamin D (25(OH)D concentration. This cross-sectional study aimed to investigate (i) predictors of 25(OH)D concentration and relationships with vitamin D genotypes and (ii) whether dietary vitamin D intake and sunlight exposure modified these relationships.Methods and resultsParticipants from the Food4Me study (n = 1312; age 18-79) were genotyped for vitamin D receptor (VDR) and vitamin D binding protein at baseline and a genetic risk score was calculated. Dried blood spot samples were assayed for 25(OH)D concentration and dietary and lifestyle information collected. Circulating 25(OH)D concentration was lower with increasing genetic risk score, lower in females than males, higher in supplement users than non-users and higher in summer than winter. Carriage of the minor VDR allele was associated with lower 25(OH)D concentration in participants with the least sunlight exposure. Vitamin D genotype did not influence the relationship between vitamin D intake and 25(OH)D concentration.ConclusionAge, sex, dietary vitamin D intake, country, sunlight exposure, season, and vitamin D genetic risk score were associated with circulating 25(OH)D concentration in a pan-European population. The relationship between VDR genotype and 25(OH)D concentration may be influenced by weekday sunlight exposure but not dietary vitamin D intake.

KW - Diet

KW - Environment-gene interaction

KW - Food4Me

KW - 25-hydroxyvitamin D

KW - Sunlight

KW - Vitamin D receptor gene

KW - D-BINDING PROTEIN

KW - RANDOMIZED CONTROLLED-TRIAL

KW - GENOME-WIDE ASSOCIATION

KW - D DEFICIENCY

KW - ULTRAVIOLET-RADIATION

KW - PHYSICAL-ACTIVITY

KW - DIETARY-INTAKE

KW - DETERMINANTS

KW - NUTRITION

KW - ADULTS

U2 - 10.1002/mnfr.201600476

DO - 10.1002/mnfr.201600476

M3 - Article

SN - 1613-4125

VL - 61

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

IS - 2

M1 - 1600476

ER -

Livingstone KM, Celis-Morales C, Hoeller U, Lambrinou CP, Moschonis G, Macready AL et al. Weekday sunlight exposure, but not vitamin D intake, influences the association between vitamin D receptor genotype and circulating concentration 25-hydroxyvitamin D in a pan-European population: the Food4Me study. Molecular Nutrition & Food Research. 2017 Feb;61(2):1600476. doi: 10.1002/mnfr.201600476