@inbook{f457a80ddb6a4cfb9baab06c43829c51,
title = "Voltage-Gated Calcium Channels and Their Roles in Cardiac Electrophysiology",
abstract = "In cardiomyocytes voltage-gated Ca2+ channels are major players in cardiac cellular electrophysiology and cellular excitation-contraction coupling. Accordingly, Ca2+ channel dysfunction contributes to the development of cardiac arrhythmias and impaired cardiac contractile function. In addition, Ca2+ entry through voltage-gated Ca2+ channels is an important regulator of gene transcription and cardiac cellular metabolism. In order to fulfil these tasks reliably, Ca2+ channels are highly regulated by specific subunit compositions and various signaling pathways. This chapter provides an overview of the role of voltage-gated Ca2+ channels in cardiac cellular electrophysiology and summarizes their molecular composition, biophysical properties, and regulatory mechanisms, with a special focus on L-type Ca2+ channels.",
keywords = "Action potential, Arrhythmias, Calcium, Early afterdepolarizations, Excitation contraction coupling, Ion channels",
author = "Jordi Heijman and Molina, {Cristina E.} and Niels Voigt",
note = "Funding Information: Funding N.V. is supported by the DZHK, by the German Research Foundation (DFG VO 1568/3-1, IRTG1816 RP12, SFB1002 TPA13) and by the Else-Kr{\"o}ner-Fresenius Stiftung (EKFS 2016_A20). J.H. is supported by the Netherlands Organization for Scientific Research (NWO/ZonMw Veni 91616057). Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",
year = "2018",
month = jan,
day = "1",
doi = "10.1007/978-3-319-77812-9_4",
language = "English",
series = "Cardiac and Vascular Biology",
publisher = "Springer",
pages = "77--96",
editor = "Thomas, {Dierk } and Remme, {Carol Ann}",
booktitle = "Channelopathies in Heart Disease",
address = "United States",
}