Vitamin K2 Needs an RDI Separate from Vitamin K1

Asim Cengiz Akbulut, Angelina Pavlic, Ploingarm Petsophonsakul, Maurice Halder, Katarzyna Maresz, Rafael Kramann, Leon Schurgers*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Vitamin K and its essential role in coagulation (vitamin K [Koagulation]) have been well established and accepted the world over. Many countries have a Recommended Daily Intake (RDI) for vitamin K based on early research, and its necessary role in the activation of vitamin K-dependent coagulation proteins is known. In the past few decades, the role of vitamin K-dependent proteins in processes beyond coagulation has been discovered. Various isoforms of vitamin K have been identified, and vitamin K2 specifically has been highlighted for its long half-life and extrahepatic activity, whereas the dietary form vitamin K1 has a shorter half-life. In this review, we highlight the specific activity of vitamin K2 based upon proposed frameworks necessary for a bioactive substance to be recommended for an RDI. Vitamin K2 meets all these criteria and should be considered for a specific dietary recommendation intake.

Original languageEnglish
Article number1852
Number of pages13
JournalNutrients
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • vitamin K
  • vitamin K1
  • vitamin K2
  • RDI
  • menaquinone
  • vitamin K-dependent proteins
  • PERFORMANCE LIQUID-CHROMATOGRAPHY
  • ORAL ANTICOAGULANT TREATMENT
  • POSTMENOPAUSAL WOMEN
  • DIETARY PHYLLOQUINONE
  • HEMODIALYSIS-PATIENTS
  • K SUPPLEMENTATION
  • QUANTITATIVE MEASUREMENT
  • FLUORESCENCE DETECTION
  • GAMMA-CARBOXYLATION
  • DOUBLE-BLIND

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