Abstract
Vitamin K and its essential role in coagulation (vitamin K [Koagulation]) have been well established and accepted the world over. Many countries have a Recommended Daily Intake (RDI) for vitamin K based on early research, and its necessary role in the activation of vitamin K-dependent coagulation proteins is known. In the past few decades, the role of vitamin K-dependent proteins in processes beyond coagulation has been discovered. Various isoforms of vitamin K have been identified, and vitamin K2 specifically has been highlighted for its long half-life and extrahepatic activity, whereas the dietary form vitamin K1 has a shorter half-life. In this review, we highlight the specific activity of vitamin K2 based upon proposed frameworks necessary for a bioactive substance to be recommended for an RDI. Vitamin K2 meets all these criteria and should be considered for a specific dietary recommendation intake.
Original language | English |
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Article number | 1852 |
Number of pages | 13 |
Journal | Nutrients |
Volume | 12 |
Issue number | 6 |
DOIs | |
Publication status | Published - Jun 2020 |
Keywords
- vitamin K
- vitamin K1
- vitamin K2
- RDI
- menaquinone
- vitamin K-dependent proteins
- PERFORMANCE LIQUID-CHROMATOGRAPHY
- ORAL ANTICOAGULANT TREATMENT
- POSTMENOPAUSAL WOMEN
- DIETARY PHYLLOQUINONE
- HEMODIALYSIS-PATIENTS
- K SUPPLEMENTATION
- QUANTITATIVE MEASUREMENT
- FLUORESCENCE DETECTION
- GAMMA-CARBOXYLATION
- DOUBLE-BLIND