Vitamin K status is not associated with cognitive decline in middle aged adults

E. G. H. M. van den Heuvel, N. M. van Schoor, C. Vermeer, R. M. L. Zwijsen, M. den Heijer, H. C. Comijs*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. Longitudinal study with six years follow-up. Community based. 599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years). Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning. Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p <0.05). In the group with a 25(OH)D concentration > 50 nmol/l, the highest tertile of dp-ucMGP (> 406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP. In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults.
Original languageEnglish
Pages (from-to)908-912
JournalJournal of Nutrition Health & Aging
Issue number9
Publication statusPublished - Nov 2015


  • Cognitive decline
  • speed of information processing
  • vitamin K status
  • desphopho-uncarboxylated matrix Gla-protein


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