TY - JOUR
T1 - Vitamin K status is not associated with cognitive decline in middle aged adults
AU - van den Heuvel, E. G. H. M.
AU - van Schoor, N. M.
AU - Vermeer, C.
AU - Zwijsen, R. M. L.
AU - den Heijer, M.
AU - Comijs, H. C.
PY - 2015/11
Y1 - 2015/11
N2 - The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. Longitudinal study with six years follow-up. Community based. 599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years). Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning. Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p <0.05). In the group with a 25(OH)D concentration > 50 nmol/l, the highest tertile of dp-ucMGP (> 406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP. In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults.
AB - The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. Longitudinal study with six years follow-up. Community based. 599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years). Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning. Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p <0.05). In the group with a 25(OH)D concentration > 50 nmol/l, the highest tertile of dp-ucMGP (> 406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP. In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults.
KW - Cognitive decline
KW - speed of information processing
KW - vitamin K status
KW - desphopho-uncarboxylated matrix Gla-protein
U2 - 10.1007/s12603-015-0579-8
DO - 10.1007/s12603-015-0579-8
M3 - Article
C2 - 26482692
SN - 1279-7707
VL - 19
SP - 908
EP - 912
JO - Journal of Nutrition Health & Aging
JF - Journal of Nutrition Health & Aging
IS - 9
ER -