Vitamin K in CKD Bone Disorders

M. Fusaro*, G. Cianciolo, P. Evenepoel, L. Schurgers, M. Plebani

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

11 Citations (Web of Science)
82 Downloads (Pure)

Abstract

Vitamin K is principally known because it is involved in blood coagulation. Furthermore, epidemiological studies showed that its deficit was associated with increased fragility fractures, vascular calcification and mortality. There are two main types of vitamin K vitamers: Phylloquinone (or PK) and Menaquinones (MKn). Vitamin K acts both as coenzyme of y-glutamyl carboxylase (GGCX) transforming undercarboxylated in carboxylated vitamin K-dependent proteins (e.g., Osteocalcin and Matrix Gla Protein) and as a ligand of the nuclear steroid and xenobiotic receptor (SXR) (in murine species Pregnane X Receptor: PXR), expressed in osteoblasts. It has been highlighted that the uremic state is a condition of greater vitamin K deficiency than the general population with resulting higher prevalence of bone fractures, vascular calcifications and mortality. The purpose of this literature review is to evaluate the protective role of Vitamin K in bone health in CKD patients.
Original languageEnglish
Pages (from-to)476-485
Number of pages10
JournalCalcified Tissue International
Volume108
Issue number4
Early online date6 Jan 2021
DOIs
Publication statusPublished - Apr 2021

Keywords

  • bone fractures
  • chronic kidney-disease
  • ckd
  • gamma-carboxyglutamic acid
  • gut microbiome
  • hemodialysis-patients
  • matrix gla protein
  • mortality
  • oral anticoagulants
  • osteocalcin
  • osteoporotic fractures
  • vascular calcifications
  • vertebral fractures
  • vitamin k
  • MORTALITY
  • VASCULAR CALCIFICATIONS
  • GAMMA-CARBOXYGLUTAMIC ACID
  • Matrix Gla protein
  • ORAL ANTICOAGULANTS
  • GUT MICROBIOME
  • CKD
  • Bone fractures
  • Vitamin K
  • Osteocalcin
  • MATRIX GLA PROTEIN
  • VERTEBRAL FRACTURES
  • OSTEOPOROTIC FRACTURES
  • HEMODIALYSIS-PATIENTS
  • CHRONIC KIDNEY-DISEASE

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