Vitamin K-2-a neglected player in cardiovascular health: a narrative review

E. Hariri, N. Kassis, J.P. Iskandar, L.J. Schurgers, A. Saad, O. Abdelfattah, A. Bansal, T. Isogai, S.C. Harb, S. Kapadia*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Vitamin K-2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including increased arterial stiffness, vascular and valvular calcification, insulin resistance and heart failure indices which ultimately increase cardiovascular mortality. Supplementation of vitamin K-2 has been strongly associated with improved cardiovascular outcomes through its modification of systemic calcification and arterial stiffness. Although its direct effects on delaying the progression of vascular and valvular calcification is currently the subject of multiple randomised clinical trials, prior reports suggest potential improved survival among cardiac patients with vitamin K-2 supplementation. Strengthened by its affordability and Food and Drug Adminstration (FDA)-proven safety, vitamin K-2 supplementation is a viable and promising option to improve cardiovascular outcomes.
Original languageEnglish
Article numbere001715
Number of pages14
JournalOpen Heart
Volume8
Issue number2
DOIs
Publication statusPublished - 1 Nov 2021

Keywords

  • coronary vessels
  • atherosclerosis
  • heart valve diseases
  • pharmacology
  • clinical
  • biomarkers
  • MATRIX-GLA-PROTEIN
  • PHOSPHATE-INDUCED CALCIFICATION
  • GAMMA-CARBOXYGLUTAMIC ACID
  • CORONARY-ARTERY-DISEASE
  • K-DEPENDENT PROTECTION
  • CHRONIC KIDNEY-DISEASE
  • VASCULAR CALCIFICATION
  • MENAQUINONE-7 SUPPLEMENTATION
  • ANNULAR CALCIFICATION
  • HEMODIALYSIS-PATIENTS

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