Vitamin D, vitamin D binding protein, lung function and structure in COPD

I. Berg, C. Hanson, H. Sayles, D. Romberger, A. Nelson, J. Meza, B. Miller, E.F.M. Wouters, W. MacNee, E.P. Rutten, E.A.P.M. Romme, J. Vestbo, L. Edwards, S. Rennard

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Abstract

RATIONALE: Vitamin D and vitamin D binding protein (DBP) have been with COPD and FEV1. There are limited data regarding emphysema and DBP. OBJECTIVE: This is a pilot study of a portion of the subjects in Evaluation of COPD Longitudinally to Identify Predictive Surrogate (ECLIPSE) study designed to examine the relationship between vitamin D DBP, FEV1 and emphysema in COPD patients. METHODS: We measured serum DBP in 498 ECLIPSE subjects. Subjects were distributed amongst smoker non-smoker controls, and GOLD stages 2, 3 and 4. Within each GOLD stage, subjects were equally divided amongst high and low emphysema burden. The associations between 25(OH)D, DBP, and free vitamin D with FEV1, CT- emphysema, biomarkers and clinical data including CT-measured bone were assessed. MEASUREMENTS: 25(OH)D and DBP were measured using tandem spectroscopy and competitive enzyme-linked immunosorbent assay, MAIN RESULT: 25(OH)D was correlated with FEV1 (p = 0.01) and with emphysema (p < 0.01). 25(OH)D was also associated with six-minute walk 0.02), bronchodilator response (p = 0.04), and Clara cell secretory (CC-16) (p = 0.01). 25(OH)D levels were not associated with CT-measured attenuation, however DBP was associated with bone attenuation in emphysema. DBP was not associated with FEV1 or emphysema. 25(OH)D and inversely associated (p = 0.01). CONCLUSION: This is the first study to demonstrate a relationship between emphysema and vitamin D. We also further evidence for a relationship between vitamin D and FEV1.
Original languageEnglish
Pages (from-to)1578-1588
JournalRespiratory Medicine
Volume107
Issue number10
DOIs
Publication statusPublished - 1 Jan 2013

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