Abstract
Background. Chronic obstructive pulmonary disease (COPD) is associated with several extrapulmonary effects that contribute to the severity of the disease. Vitamin D is suggested to play a role in COPD and its related extrapulmonary effects. Aims. To determine the prevalence of vitamin D deficiency and its relation with bone density, muscle strength, and exercise capacity in patients with COPD. Methods. Our cross-sectional study included patients with moderate to very severe COPD. We collected data on lung function, body composition, bone density, quadriceps muscle strength, 6-minute walking distance, and plasma 25-hydroxyvitamin D (25(OH)D) concentration. Vitamin D deficiency was defined as plasma 25(OH)D concentration below 50 nmol/L. Results. In total, 151 COPD patients were included; 87 patients (58%) had vitamin D deficiency. Plasma 25(OH)D concentration was positively associated with bone density (P = 0.005) and 6-minute walking distance (P < 0.001) after adjustment for potential confounders. Plasma 25(OH)D concentration was not associated with quadriceps muscle strength. Conclusions. The majority of COPD patients had vitamin D deficiency. Plasma 25(OH)D concentration was positively associated with bone density and exercise capacity. Intervention studies are necessary to determine whether vitamin D supplementation is of benefit in the prevention or treatment of osteoporosis and poor exercise capacity in patients with COPD.
Original language | English |
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Pages (from-to) | 91-96 |
Number of pages | 6 |
Journal | Annals of Medicine |
Volume | 45 |
Issue number | 1 |
DOIs | |
Publication status | Published - Feb 2013 |
Keywords
- Bone density
- chronic obstructive pulmonary disease
- exercise capacity
- muscle strength
- osteoporosis
- vitamin D
- SERUM 25-HYDROXYVITAMIN D
- D DEFICIENCY
- PHYSICAL-ACTIVITY
- MUSCLE STRENGTH
- COPD
- OSTEOPOROSIS
- PREVENTION
- FRACTURES
- SUPPLEMENTATION
- DETERMINANTS