Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up

Anne-Hilde Muris*, Joost Smolders, Linda Rolf, Lieke J. J. Klinkenberg, Noreen van der Linden, Steven Meex, Jan Damoiseaux, Raymond Hupperts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background and Objective The risk of developing multiple sclerosis (MS) as well as MS disease activity is associated with vitamin D (25(OH) D) status. The relationship between the main functional disability hallmark of MS, disability progression, and 25(OH) D status is less well established though, especially not in MS patients with progressive disease. Methods This retrospective follow-up study included 554 MS patients with a serum baseline 25(OH) D level and Expanded Disability Status Scale (EDSS) with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25(OH) D status on relapse rate. Repeated measures linear regression analyses were performed to assess the effect on disability and disability progression. Results Baseline deseasonalized 25(OH) D status was associated with subsequent relapse risk (yes/no), but only in the younger MS patients (
Original languageEnglish
Article numbere0156122
JournalPLOS ONE
Volume11
Issue number6
DOIs
Publication statusPublished - 8 Jun 2016

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