Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up

Anne-Hilde Muris; Joost Smolders; Linda Rolf; Lieke J. J. Klinkenberg; Noreen van der Linden; Steven Meex; Jan Damoiseaux; Raymond Hupperts

doi:10.1371/journal.pone.0156122

Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up

Anne-Hilde Muris^*, Joost Smolders, Linda Rolf, Lieke J. J. Klinkenberg, Noreen van der Linden, Steven Meex, Jan Damoiseaux, Raymond Hupperts

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background and Objective The risk of developing multiple sclerosis (MS) as well as MS disease activity is associated with vitamin D (25(OH) D) status. The relationship between the main functional disability hallmark of MS, disability progression, and 25(OH) D status is less well established though, especially not in MS patients with progressive disease. Methods This retrospective follow-up study included 554 MS patients with a serum baseline 25(OH) D level and Expanded Disability Status Scale (EDSS) with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25(OH) D status on relapse rate. Repeated measures linear regression analyses were performed to assess the effect on disability and disability progression. Results Baseline deseasonalized 25(OH) D status was associated with subsequent relapse risk (yes/no), but only in the younger MS patients (

Original language	English
Article number	e0156122
Journal	PLOS ONE
Volume	11
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0156122
Publication status	Published - 8 Jun 2016

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10.1371/journal.pone.0156122Licence: CC BY

Cite this

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title = "Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up",

abstract = "Background and Objective The risk of developing multiple sclerosis (MS) as well as MS disease activity is associated with vitamin D (25(OH) D) status. The relationship between the main functional disability hallmark of MS, disability progression, and 25(OH) D status is less well established though, especially not in MS patients with progressive disease. Methods This retrospective follow-up study included 554 MS patients with a serum baseline 25(OH) D level and Expanded Disability Status Scale (EDSS) with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25(OH) D status on relapse rate. Repeated measures linear regression analyses were performed to assess the effect on disability and disability progression. Results Baseline deseasonalized 25(OH) D status was associated with subsequent relapse risk (yes/no), but only in the younger MS patients (",

author = "Anne-Hilde Muris and Joost Smolders and Linda Rolf and Klinkenberg, {Lieke J. J.} and {van der Linden}, Noreen and Steven Meex and Jan Damoiseaux and Raymond Hupperts",

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T1 - Vitamin D Status Does Not Affect Disability Progression of Patients with Multiple Sclerosis over Three Year Follow-Up

AU - Muris, Anne-Hilde

AU - Smolders, Joost

AU - Rolf, Linda

AU - Klinkenberg, Lieke J. J.

AU - van der Linden, Noreen

AU - Meex, Steven

AU - Damoiseaux, Jan

AU - Hupperts, Raymond

PY - 2016/6/8

Y1 - 2016/6/8

N2 - Background and Objective The risk of developing multiple sclerosis (MS) as well as MS disease activity is associated with vitamin D (25(OH) D) status. The relationship between the main functional disability hallmark of MS, disability progression, and 25(OH) D status is less well established though, especially not in MS patients with progressive disease. Methods This retrospective follow-up study included 554 MS patients with a serum baseline 25(OH) D level and Expanded Disability Status Scale (EDSS) with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25(OH) D status on relapse rate. Repeated measures linear regression analyses were performed to assess the effect on disability and disability progression. Results Baseline deseasonalized 25(OH) D status was associated with subsequent relapse risk (yes/no), but only in the younger MS patients (

AB - Background and Objective The risk of developing multiple sclerosis (MS) as well as MS disease activity is associated with vitamin D (25(OH) D) status. The relationship between the main functional disability hallmark of MS, disability progression, and 25(OH) D status is less well established though, especially not in MS patients with progressive disease. Methods This retrospective follow-up study included 554 MS patients with a serum baseline 25(OH) D level and Expanded Disability Status Scale (EDSS) with a minimum follow-up of three years. Logistic regressions were performed to assess the effect of baseline 25(OH) D status on relapse rate. Repeated measures linear regression analyses were performed to assess the effect on disability and disability progression. Results Baseline deseasonalized 25(OH) D status was associated with subsequent relapse risk (yes/no), but only in the younger MS patients (

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DO - 10.1371/journal.pone.0156122

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