Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis.

J. Smolders, M.M.G.L. Thewissen, R. Theunissen, E. Peelen, S. Knippenberg, P.P.C.A. Menheere, J.W. Tervaert, R.M.M. Hupperts, J.G.M.C. Damoiseaux

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An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4(+) T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-gamma(+) CD4(+) T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4(+) T-cell compartment. (C) 2011 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)91-97
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 1 Jan 2011

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