TY - JOUR
T1 - Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis.
AU - Smolders, J.
AU - Thewissen, M.M.G.L.
AU - Theunissen, R.
AU - Peelen, E.
AU - Knippenberg, S.
AU - Menheere, P.P.C.A.
AU - Tervaert, J.W.
AU - Hupperts, R.M.M.
AU - Damoiseaux, J.G.M.C.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4(+) T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-gamma(+) CD4(+) T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4(+) T-cell compartment. (C) 2011 Elsevier B.V. All rights reserved.
AB - An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4(+) T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-gamma(+) CD4(+) T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4(+) T-cell compartment. (C) 2011 Elsevier B.V. All rights reserved.
U2 - 10.1016/j.jneuroim.2011.03.012
DO - 10.1016/j.jneuroim.2011.03.012
M3 - Article
SN - 0165-5728
VL - 235
SP - 91
EP - 97
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -