Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis.

J. Smolders*, M.M.G.L. Thewissen, R. Theunissen, E. Peelen, S. Knippenberg, P.P.C.A. Menheere, J.W. Tervaert, R.M.M. Hupperts, J.G.M.C. Damoiseaux

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4(+) T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-gamma(+) CD4(+) T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4(+) T-cell compartment. (C) 2011 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)91-97
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - 1 Jan 2011

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