Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study

A. J. van Ballegooijen; M. B. Snijder; M. Visser; K. van den Hurk; O. Kamp; J. M. Dekker; G. Nijpels; C. D. A. Stehouwer; R. M. A. Henry; W. J. Paulus; I. A. Brouwer

doi:10.1159/000336173

Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study

A. J. van Ballegooijen^*, M. B. Snijder, M. Visser, K. van den Hurk, O. Kamp, J. M. Dekker, G. Nijpels, C. D. A. Stehouwer, R. M. A. Henry, W. J. Paulus, I. A. Brouwer

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background and Aims: To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects. Methods: We included 256 subjects of the Hoorn Study, a population-based cohort. They underwent a standardized 2-dimensional echocardiogram at baseline between 2000 and 2001, and again between 2007 and 2009. We studied the association of 25(OH)D quartiles with echocardiographic measures of the left ventricular mass index (LVMI), left ventricular systolic function and markers of diastolic function using linear regression analyses. Results: At baseline, subjects had a mean age of 67.4 +/- 5.2 years and 41.4% had prior cardiovascular disease (CVD). Low serum 25(OH)D levels were only associated with higher LVMI at 8-year follow-up in subjects without prior CVD and in subjects with low kidney function (median estimated glomerular filtration rate

Original language	English
Pages (from-to)	69-77
Journal	Annals of Nutrition and Metabolism
Volume	60
Issue number	1
DOIs	https://doi.org/10.1159/000336173
Publication status	Published - 2012

Keywords

Vitamin D
Myocardial function
Myocardial structure
Epidemiology
Elderly

Access to Document

10.1159/000336173

Cite this

van Ballegooijen, A. J., Snijder, M. B., Visser, M., van den Hurk, K., Kamp, O., Dekker, J. M., Nijpels, G., Stehouwer, C. D. A., Henry, R. M. A., Paulus, W. J., & Brouwer, I. A. (2012). Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study. Annals of Nutrition and Metabolism, 60(1), 69-77. https://doi.org/10.1159/000336173

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title = "Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study",

abstract = "Background and Aims: To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects. Methods: We included 256 subjects of the Hoorn Study, a population-based cohort. They underwent a standardized 2-dimensional echocardiogram at baseline between 2000 and 2001, and again between 2007 and 2009. We studied the association of 25(OH)D quartiles with echocardiographic measures of the left ventricular mass index (LVMI), left ventricular systolic function and markers of diastolic function using linear regression analyses. Results: At baseline, subjects had a mean age of 67.4 +/- 5.2 years and 41.4% had prior cardiovascular disease (CVD). Low serum 25(OH)D levels were only associated with higher LVMI at 8-year follow-up in subjects without prior CVD and in subjects with low kidney function (median estimated glomerular filtration rate ",

keywords = "Vitamin D, Myocardial function, Myocardial structure, Epidemiology, Elderly",

author = "{van Ballegooijen}, {A. J.} and Snijder, {M. B.} and M. Visser and {van den Hurk}, K. and O. Kamp and Dekker, {J. M.} and G. Nijpels and Stehouwer, {C. D. A.} and Henry, {R. M. A.} and Paulus, {W. J.} and Brouwer, {I. A.}",

year = "2012",

doi = "10.1159/000336173",

language = "English",

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T1 - Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study

AU - van Ballegooijen, A. J.

AU - Snijder, M. B.

AU - Visser, M.

AU - van den Hurk, K.

AU - Kamp, O.

AU - Dekker, J. M.

AU - Nijpels, G.

AU - Stehouwer, C. D. A.

AU - Henry, R. M. A.

AU - Paulus, W. J.

AU - Brouwer, I. A.

PY - 2012

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N2 - Background and Aims: To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects. Methods: We included 256 subjects of the Hoorn Study, a population-based cohort. They underwent a standardized 2-dimensional echocardiogram at baseline between 2000 and 2001, and again between 2007 and 2009. We studied the association of 25(OH)D quartiles with echocardiographic measures of the left ventricular mass index (LVMI), left ventricular systolic function and markers of diastolic function using linear regression analyses. Results: At baseline, subjects had a mean age of 67.4 +/- 5.2 years and 41.4% had prior cardiovascular disease (CVD). Low serum 25(OH)D levels were only associated with higher LVMI at 8-year follow-up in subjects without prior CVD and in subjects with low kidney function (median estimated glomerular filtration rate

AB - Background and Aims: To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects. Methods: We included 256 subjects of the Hoorn Study, a population-based cohort. They underwent a standardized 2-dimensional echocardiogram at baseline between 2000 and 2001, and again between 2007 and 2009. We studied the association of 25(OH)D quartiles with echocardiographic measures of the left ventricular mass index (LVMI), left ventricular systolic function and markers of diastolic function using linear regression analyses. Results: At baseline, subjects had a mean age of 67.4 +/- 5.2 years and 41.4% had prior cardiovascular disease (CVD). Low serum 25(OH)D levels were only associated with higher LVMI at 8-year follow-up in subjects without prior CVD and in subjects with low kidney function (median estimated glomerular filtration rate

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KW - Myocardial structure

KW - Epidemiology

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