Vitamin D in Relation to Myocardial Structure and Function after Eight Years of Follow-Up: The Hoorn Study

A. J. van Ballegooijen*, M. B. Snijder, M. Visser, K. van den Hurk, O. Kamp, J. M. Dekker, G. Nijpels, C. D. A. Stehouwer, R. M. A. Henry, W. J. Paulus, I. A. Brouwer

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Background and Aims: To investigate associations between baseline serum 25-hydroxyvitamin D [25(OH)D] levels and myocardial structure and function after 8 years of follow-up in older Dutch subjects. Methods: We included 256 subjects of the Hoorn Study, a population-based cohort. They underwent a standardized 2-dimensional echocardiogram at baseline between 2000 and 2001, and again between 2007 and 2009. We studied the association of 25(OH)D quartiles with echocardiographic measures of the left ventricular mass index (LVMI), left ventricular systolic function and markers of diastolic function using linear regression analyses. Results: At baseline, subjects had a mean age of 67.4 +/- 5.2 years and 41.4% had prior cardiovascular disease (CVD). Low serum 25(OH)D levels were only associated with higher LVMI at 8-year follow-up in subjects without prior CVD and in subjects with low kidney function (median estimated glomerular filtration rate
Original languageEnglish
Pages (from-to)69-77
JournalAnnals of Nutrition and Metabolism
Issue number1
Publication statusPublished - 2012


  • Vitamin D
  • Myocardial function
  • Myocardial structure
  • Epidemiology
  • Elderly

Cite this