Abstract
The obese insulin-resistant state is often associated with low circulating concentration of vitamin D 25-hydroxyvitamin D3 [25(OH)D3]. Fat sequestration of vitamin D in the expanded obese adipose tissue mass has been pointed out as a plausible explanation for this circulating vitamin D deficiency. However, the putative mechanisms behind this hypovitaminosis D remain to be elucidated. The presence of vitamin D receptor and vitamin D-metabolizing enzymes in insulin-sensitive organs suggests that vitamin D may be involved in glucose and lipid metabolism and may be related to insulin sensitivity. Indeed, mainly in vitro studies support a role of vitamin D in regulating glucose and lipid metabolism in several insulin-sensitive tissues including adipose tissue, skeletal muscle, liver, as well as pancreatic insulin secretion. A potential role of vitamin D in gut barrier function and metabolism has also been suggested. This review summarizes recent knowledge on vitamin D deficiency in the aetiology of obesity-related insulin resistance and discusses potential underlying mechanisms. Finally, the role of vitamin D supplementation on insulin sensitivity and glycaemic control is discussed.
Original language | English |
---|---|
Article number | 3146 |
Number of pages | 10 |
Journal | Diabetes-metabolism Research and Reviews |
Volume | 35 |
Issue number | 5 |
DOIs | |
Publication status | Published - Jul 2019 |
Keywords
- adipose tissue
- insulin resistance
- obesity
- vitamin D
- vitamin D receptor
- SERUM 25-HYDROXYVITAMIN D
- FATTY LIVER-DISEASE
- SKELETAL-MUSCLE
- D-RECEPTOR
- GLYCEMIC CONTROL
- D SUPPLEMENTATION
- ADIPOSE-TISSUE
- 1-ALPHA,25-DIHYDROXYVITAMIN D-3
- LIPID-METABOLISM
- GENE-EXPRESSION