Vitamin D deficiency in the aetiology of obesity-related insulin resistance

Adriyan Pramono, Johan W. E. Jocken, Ellen E. Blaak*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

22 Citations (Web of Science)

Abstract

The obese insulin-resistant state is often associated with low circulating concentration of vitamin D 25-hydroxyvitamin D3 [25(OH)D3]. Fat sequestration of vitamin D in the expanded obese adipose tissue mass has been pointed out as a plausible explanation for this circulating vitamin D deficiency. However, the putative mechanisms behind this hypovitaminosis D remain to be elucidated. The presence of vitamin D receptor and vitamin D-metabolizing enzymes in insulin-sensitive organs suggests that vitamin D may be involved in glucose and lipid metabolism and may be related to insulin sensitivity. Indeed, mainly in vitro studies support a role of vitamin D in regulating glucose and lipid metabolism in several insulin-sensitive tissues including adipose tissue, skeletal muscle, liver, as well as pancreatic insulin secretion. A potential role of vitamin D in gut barrier function and metabolism has also been suggested. This review summarizes recent knowledge on vitamin D deficiency in the aetiology of obesity-related insulin resistance and discusses potential underlying mechanisms. Finally, the role of vitamin D supplementation on insulin sensitivity and glycaemic control is discussed.

Original languageEnglish
Article number3146
Number of pages10
JournalDiabetes-metabolism Research and Reviews
Volume35
Issue number5
DOIs
Publication statusPublished - Jul 2019

Keywords

  • adipose tissue
  • insulin resistance
  • obesity
  • vitamin D
  • vitamin D receptor
  • SERUM 25-HYDROXYVITAMIN D
  • FATTY LIVER-DISEASE
  • SKELETAL-MUSCLE
  • D-RECEPTOR
  • GLYCEMIC CONTROL
  • D SUPPLEMENTATION
  • ADIPOSE-TISSUE
  • 1-ALPHA,25-DIHYDROXYVITAMIN D-3
  • LIPID-METABOLISM
  • GENE-EXPRESSION

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