Visualizing the Human Subcortex Using Ultra-high Field Magnetic Resonance Imaging

M. C. Keuken; B. R. Isaacs; R. Trampel; W. van der Zwaag; B. U. Forstmann

doi:10.1007/s10548-018-0638-7

Visualizing the Human Subcortex Using Ultra-high Field Magnetic Resonance Imaging

M. C. Keuken^*, B. R. Isaacs, R. Trampel, W. van der Zwaag, B. U. Forstmann

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

With the recent increased availability of ultra-high field (UHF) magnetic resonance imaging (MRI), substantial progress has been made in visualizing the human brain, which can now be done in extraordinary detail. This review provides an extensive overview of the use of UHF MRI in visualizing the human subcortex for both healthy and patient populations. The high inter-subject variability in size and location of subcortical structures limits the usability of atlases in the midbrain. Fortunately, the combined results of this review indicate that a large number of subcortical areas can be visualized in individual space using UHF MRI. Current limitations and potential solutions of UHF MRI for visualizing the subcortex are also discussed.

Original language	English
Pages (from-to)	513-545
Number of pages	33
Journal	Brain Topography
Volume	31
Issue number	4
DOIs	https://doi.org/10.1007/s10548-018-0638-7
Publication status	Published - 1 Jul 2018

Keywords

Subcortex
Ultra-high field
Magnetic resonance imaging
Review
DEEP-BRAIN-STIMULATION
7 T MRI
HIGH-RESOLUTION MRI
SUSCEPTIBILITY MAPPING QSM
HUMAN SUBTHALAMIC NUCLEUS
SEROTONIN TRANSPORTER AVAILABILITY
PROGRESSIVE SUPRANUCLEAR PALSY
PERCEPTUAL DECISION-MAKING
SMALL VESSEL DISEASE
IN-VIVO HISTOLOGY

Access to Document

10.1007/s10548-018-0638-7Licence: CC BY

https://link.springer.com/content/pdf/10.1007%2Fs10548-018-0638-7.pdf

Cite this

@article{1481b4fe19f3413b9227a0564d919f65,

title = "Visualizing the Human Subcortex Using Ultra-high Field Magnetic Resonance Imaging",

abstract = "With the recent increased availability of ultra-high field (UHF) magnetic resonance imaging (MRI), substantial progress has been made in visualizing the human brain, which can now be done in extraordinary detail. This review provides an extensive overview of the use of UHF MRI in visualizing the human subcortex for both healthy and patient populations. The high inter-subject variability in size and location of subcortical structures limits the usability of atlases in the midbrain. Fortunately, the combined results of this review indicate that a large number of subcortical areas can be visualized in individual space using UHF MRI. Current limitations and potential solutions of UHF MRI for visualizing the subcortex are also discussed.",

keywords = "Subcortex, Ultra-high field, Magnetic resonance imaging, Review, DEEP-BRAIN-STIMULATION, 7 T MRI, HIGH-RESOLUTION MRI, SUSCEPTIBILITY MAPPING QSM, HUMAN SUBTHALAMIC NUCLEUS, SEROTONIN TRANSPORTER AVAILABILITY, PROGRESSIVE SUPRANUCLEAR PALSY, PERCEPTUAL DECISION-MAKING, SMALL VESSEL DISEASE, IN-VIVO HISTOLOGY",

author = "Keuken, {M. C.} and Isaacs, {B. R.} and R. Trampel and {van der Zwaag}, W. and Forstmann, {B. U.}",

year = "2018",

month = jul,

day = "1",

doi = "10.1007/s10548-018-0638-7",

language = "English",

volume = "31",

pages = "513--545",

journal = "Brain Topography",

issn = "0896-0267",

publisher = "Springer, Cham",

number = "4",

}

TY - JOUR

T1 - Visualizing the Human Subcortex Using Ultra-high Field Magnetic Resonance Imaging

AU - Keuken, M. C.

AU - Isaacs, B. R.

AU - Trampel, R.

AU - van der Zwaag, W.

AU - Forstmann, B. U.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - With the recent increased availability of ultra-high field (UHF) magnetic resonance imaging (MRI), substantial progress has been made in visualizing the human brain, which can now be done in extraordinary detail. This review provides an extensive overview of the use of UHF MRI in visualizing the human subcortex for both healthy and patient populations. The high inter-subject variability in size and location of subcortical structures limits the usability of atlases in the midbrain. Fortunately, the combined results of this review indicate that a large number of subcortical areas can be visualized in individual space using UHF MRI. Current limitations and potential solutions of UHF MRI for visualizing the subcortex are also discussed.

AB - With the recent increased availability of ultra-high field (UHF) magnetic resonance imaging (MRI), substantial progress has been made in visualizing the human brain, which can now be done in extraordinary detail. This review provides an extensive overview of the use of UHF MRI in visualizing the human subcortex for both healthy and patient populations. The high inter-subject variability in size and location of subcortical structures limits the usability of atlases in the midbrain. Fortunately, the combined results of this review indicate that a large number of subcortical areas can be visualized in individual space using UHF MRI. Current limitations and potential solutions of UHF MRI for visualizing the subcortex are also discussed.

KW - Subcortex

KW - Ultra-high field

KW - Magnetic resonance imaging

KW - Review

KW - DEEP-BRAIN-STIMULATION

KW - 7 T MRI

KW - HIGH-RESOLUTION MRI

KW - SUSCEPTIBILITY MAPPING QSM

KW - HUMAN SUBTHALAMIC NUCLEUS

KW - SEROTONIN TRANSPORTER AVAILABILITY

KW - PROGRESSIVE SUPRANUCLEAR PALSY

KW - PERCEPTUAL DECISION-MAKING

KW - SMALL VESSEL DISEASE

KW - IN-VIVO HISTOLOGY

U2 - 10.1007/s10548-018-0638-7

DO - 10.1007/s10548-018-0638-7

M3 - (Systematic) Review article

C2 - 29497874

SN - 0896-0267

VL - 31

SP - 513

EP - 545

JO - Brain Topography

JF - Brain Topography

IS - 4

ER -