Vestibular implant stimulation: pulse amplitude modulation versus combined pulse rate and amplitude modulation

. The vestibular implant is a potential treatment approach for bilateral vestibulopathy patients. To restore gaze stabilization, the implant should elicit vestibulo-ocular reflexes (VORs) over a wide range of eye velocities. Different stimulation strategies to achieve this goal were previously described. Vestibular information can be encoded by modulating stimulation amplitude, rate, or a combination of both. In this study, combined rate and amplitude modulation was compared with amplitude modulation, to evaluate their potential for vestibular implant stimulation. . Nine subjects with a vestibulo-cochlear implant participated in this study. Three stimulation strategies were tested. The combined rate and amplitude modulation setting (baseline rate 50%) was compared with amplitude modulation (baseline rate 50%, and baseline rate equal to the maximum rate). The resulting VOR was evaluated. . Combining rate and amplitude modulation, or using amplitude modulation with a baseline equal to the maximum rate, both significantly increased peak eye velocities (PEVs). Misalignment increased with higher PEVs and higher pulse rate. No significant differences were found in PEVs and misalignment, between both stimulation strategies. Amplitude modulation with a baseline rate at 50%, demonstrated the lowest PEVs. . Combining rate and amplitude modulation, or amplitude modulation with a baseline equal to the maximum rate, can both be considered for future vestibular implant fitting.ClinicalTrials.gov Identifier: NCT04918745.